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The map label for this gene is appB [H]

Identifier: 55980439

GI number: 55980439

Start: 439161

End: 440159

Strand: Direct

Name: appB [H]

Synonym: TTHA0470

Alternate gene names: 55980439

Gene position: 439161-440159 (Clockwise)

Preceding gene: 55980438

Following gene: 55980440

Centisome position: 23.74

GC content: 64.16

Gene sequence:

>999_bases
ATGTCTTGGAAAGCCATGGCGAGCTACATCCTCAAGCGCATTCTCTCCCTGATCCCCACCTTCTTCGGGGCCACCTTCCT
CGCCTTCCTCATCATCCAGATGGCCCCCGGGGACTACCTGACCCAGCTGGAGCTGGACCCTAAGGTCACCCCCGAGACCA
TCGCCCGGCTCCGCGCCCAGTTCGGCCTGGACCGCCCCTTCCACGAGCAGTACCTCCTCTGGATGCACAACCTCCTCCAC
CTCAACCTGGGCTACTCCTTCGCCTACCAGGCCCCGGTGCTGGAGATCGTCTGGCCCAGGGTCCTAAACTCCATGGTTCT
GGTGGTCCCCTCCACGGTCCTCCTCTTCCTCATCGCCGTGCCCGTGGGCGTCTACGGGGCTTTGCGCCAGTACTCCTTGG
GGGACCGGGTGGTCTCCTTCCTCGCCTATTTGGGCCTCGCCATCCCCAACTTCTTCCTGGCCCTCATCCTCATGTACCTG
GTGCTCCAGGTCTACTTCCGCACGGGGGTTATGGTCTTCCCGGTTTCGGGGATGACCTCCAGCGGGTTTGAGCAGTTCTC
CTTCTGGCAAAAGGTGGTGGACGTGGCCTGGCACGCGGTTTTGCCCATCGTCGTCCTCACCACGAGCGACATCGCCGGGT
TCTCCCGCATCATGCGGGGGCAGATGCTGGAGGCCCTCTCCCAGGACTACGTCCGCACCGCCCGGGCCAAGGGGCTTCCC
GAGCGGGTGGTGGTGTACAAGCACGCCCTGAGGAACGCCATCATCCCCATCGTGGCCAACATCGGCGGGATCCTGCCCAC
CTTGATCTCGGGGGCCGGCCTCGTGGAGGTGGTCACGGCCTGGCCCGGGATCACCCCCCTTCTCCTGGACGCCATCTCCC
AGCAAGACCTCTACGTGGTCGCGGGCTTCCTCACCATGGGCTTGGTGCTCCTTATGATCGGCAACCTGCTTTCGGACCTG
CTTCTCGCCTGGGTGGACCCCAGGATCCGCTACGAGTAG

Upstream 100 bases:

>100_bases
CCATCATCTCCAGCATCTGGGGCTCCCGTGAGGTGGAGCTCACCTTCATCAAGAAGTGAGCTAGCTTGACGCTCATCCCC
GGGGCCGGGCCGCCCCGGGG

Downstream 100 bases:

>100_bases
GAGGCTTATGGACGCCCTCGCGCCGAAGTCGGAAAGCCTCTTCCAGGTGGCCTGGGCCCAGTTCCGCAGGCACCGCCTGG
CGGTCTGGGGCGGGCGCATC

Product: peptide ABC transporter permease

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSWKAMASYILKRILSLIPTFFGATFLAFLIIQMAPGDYLTQLELDPKVTPETIARLRAQFGLDRPFHEQYLLWMHNLLH
LNLGYSFAYQAPVLEIVWPRVLNSMVLVVPSTVLLFLIAVPVGVYGALRQYSLGDRVVSFLAYLGLAIPNFFLALILMYL
VLQVYFRTGVMVFPVSGMTSSGFEQFSFWQKVVDVAWHAVLPIVVLTTSDIAGFSRIMRGQMLEALSQDYVRTARAKGLP
ERVVVYKHALRNAIIPIVANIGGILPTLISGAGLVEVVTAWPGITPLLLDAISQQDLYVVAGFLTMGLVLLMIGNLLSDL
LLAWVDPRIRYE

Sequences:

>Translated_332_residues
MSWKAMASYILKRILSLIPTFFGATFLAFLIIQMAPGDYLTQLELDPKVTPETIARLRAQFGLDRPFHEQYLLWMHNLLH
LNLGYSFAYQAPVLEIVWPRVLNSMVLVVPSTVLLFLIAVPVGVYGALRQYSLGDRVVSFLAYLGLAIPNFFLALILMYL
VLQVYFRTGVMVFPVSGMTSSGFEQFSFWQKVVDVAWHAVLPIVVLTTSDIAGFSRIMRGQMLEALSQDYVRTARAKGLP
ERVVVYKHALRNAIIPIVANIGGILPTLISGAGLVEVVTAWPGITPLLLDAISQQDLYVVAGFLTMGLVLLMIGNLLSDL
LLAWVDPRIRYE
>Mature_331_residues
SWKAMASYILKRILSLIPTFFGATFLAFLIIQMAPGDYLTQLELDPKVTPETIARLRAQFGLDRPFHEQYLLWMHNLLHL
NLGYSFAYQAPVLEIVWPRVLNSMVLVVPSTVLLFLIAVPVGVYGALRQYSLGDRVVSFLAYLGLAIPNFFLALILMYLV
LQVYFRTGVMVFPVSGMTSSGFEQFSFWQKVVDVAWHAVLPIVVLTTSDIAGFSRIMRGQMLEALSQDYVRTARAKGLPE
RVVVYKHALRNAIIPIVANIGGILPTLISGAGLVEVVTAWPGITPLLLDAISQQDLYVVAGFLTMGLVLLMIGNLLSDLL
LAWVDPRIRYE

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG0601

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789965, Length=338, Percent_Identity=36.6863905325444, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1789888, Length=329, Percent_Identity=34.9544072948328, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI1787053, Length=328, Percent_Identity=33.2317073170732, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1788504, Length=367, Percent_Identity=27.2479564032698, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1787497, Length=328, Percent_Identity=31.4024390243902, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1787761, Length=336, Percent_Identity=31.547619047619, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787550, Length=280, Percent_Identity=25.7142857142857, Blast_Score=112, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 37036; Mature: 36905

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SWKAMASYILKRILSLIPTFFGATFLAFLIIQMAPGDYLTQLELDPKVTPETIARLRAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCCCHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]