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The map label for this gene is appC [H]

Identifier: 55980440

GI number: 55980440

Start: 440167

End: 441513

Strand: Direct

Name: appC [H]

Synonym: TTHA0471

Alternate gene names: 55980440

Gene position: 440167-441513 (Clockwise)

Preceding gene: 55980439

Following gene: 55980441

Centisome position: 23.8

GC content: 67.85

Gene sequence:

>1347_bases
ATGGACGCCCTCGCGCCGAAGTCGGAAAGCCTCTTCCAGGTGGCCTGGGCCCAGTTCCGCAGGCACCGCCTGGCGGTCTG
GGGCGGGCGCATCCTCCTGGTCCTCTACTTCGTGGCCGCCTTCGCCGGCTTTTTCAGCCCCTACGACCCCAACTACTACG
AGCTTTACCCCCCGAAGGGGCACCACCCGCCCACGCGGATCCACTTCGTGGACCCGGAGACGGGGAGGCTTTCCCGTCCC
TTCGTCTACGCCACCCGTCGCACCATTGACCCCGTTTCCCTCCAGCCCCGCTACGAGGAGGATCCGAGCCAGGGCAAGTT
CTACATCCGCTTCTTCGTCCGCACGCCGGACCAACCCTACACCATCTTCCGCGTCTTCCGCGCGGACCTGCGCCTCTTCG
GCGTGGACCCGCCGGGGAGGATCTTCCTCATGGGCACGGACAACTTTGGCCGGGACCTCTTCAGCCGCCTCGTCTACGGG
GCCCAGGTGTCCTTGACCATCGGCATCCTCTCCGCCCTGGTCTCCTTCGCCCTCGGCCTCCTCCTTGGGGGGATCGCGGG
GTTTTACGCCGGGCGGCCCTTTGTCCTCGCCCTTCCCCTTCGGGCCTGGCGGGGGCGGGGGCTCGTGCTTGGTCCCCTTT
CCTGGCTCCTTTGGGGCGGGCTTGCGGCGGGGGCCTTGTACCTCGCCTGGACCTACATCCGCCTCACAGGGTTCGGCTTC
TTCCAGGCCCTGGCCCTCCTTGCCGCCCTTTGGCTTGCGGGCTTCCTCGTCCTCACCCTGCCCTTTAGGCCCATCCAAGT
GGACGTGGACAACCTCATCATGCGGCTCGTGGAGGTGATCGCCGCCATCCCCACCCTCTTCCTCCTCATCTCCTTGCGGG
CCGTCTTCCCCGCCAACGTGGACCCTCTCACCACCTTCTACCTGGTGGTGGGGCTTCTCGGCTTCATCGGCTGGGGTGGG
CTCGCCCGGGTGGTGCGGGGGGTGGTGCTTTCGGTGCGGGAGCAGGACTACGTGCAGGCGGCTAGGGCCCTTGGGGCCTC
GGACGGCAGGATCCTGGCCCGGCACGTCCTCCCGGCCACGGCGAGCTACGTCATCGTGAGCCTCTCCCTCACCATCCCCG
GCTTCATCCTGGCTGAGTCGGGCCTGTCCTTCCTGGGCCTTGGGGTCACGGAGCCCTACACCAGCTGGGGCCTCCTCCTC
CAGGCGGCGCAGCAGGGGGGGTTCGCCAGCTTCGTGGACCGCCCCTGGGTGCTTTGGCCGGGCTTCTTCATCTTCGTCTC
CATCATGGCCTGGAACTTCGTGGGCGATGGCCTGAGGGACGCCTTTGACCCGAGGCGGCGGCAGTGA

Upstream 100 bases:

>100_bases
TTCCTCACCATGGGCTTGGTGCTCCTTATGATCGGCAACCTGCTTTCGGACCTGCTTCTCGCCTGGGTGGACCCCAGGAT
CCGCTACGAGTAGGAGGCTT

Downstream 100 bases:

>100_bases
GGGTGTTTTCTTTCGGAGGGGCATGGCGTATAACGGATGAGGTGGACTCAGGGCACCGCCCGGAGGAAACGGCATGGACG
AAAAGCGCCTTCTAGAGGTG

Product: peptide ABC transporter permease

Products: ADP; phosphate; oligopeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MDALAPKSESLFQVAWAQFRRHRLAVWGGRILLVLYFVAAFAGFFSPYDPNYYELYPPKGHHPPTRIHFVDPETGRLSRP
FVYATRRTIDPVSLQPRYEEDPSQGKFYIRFFVRTPDQPYTIFRVFRADLRLFGVDPPGRIFLMGTDNFGRDLFSRLVYG
AQVSLTIGILSALVSFALGLLLGGIAGFYAGRPFVLALPLRAWRGRGLVLGPLSWLLWGGLAAGALYLAWTYIRLTGFGF
FQALALLAALWLAGFLVLTLPFRPIQVDVDNLIMRLVEVIAAIPTLFLLISLRAVFPANVDPLTTFYLVVGLLGFIGWGG
LARVVRGVVLSVREQDYVQAARALGASDGRILARHVLPATASYVIVSLSLTIPGFILAESGLSFLGLGVTEPYTSWGLLL
QAAQQGGFASFVDRPWVLWPGFFIFVSIMAWNFVGDGLRDAFDPRRRQ

Sequences:

>Translated_448_residues
MDALAPKSESLFQVAWAQFRRHRLAVWGGRILLVLYFVAAFAGFFSPYDPNYYELYPPKGHHPPTRIHFVDPETGRLSRP
FVYATRRTIDPVSLQPRYEEDPSQGKFYIRFFVRTPDQPYTIFRVFRADLRLFGVDPPGRIFLMGTDNFGRDLFSRLVYG
AQVSLTIGILSALVSFALGLLLGGIAGFYAGRPFVLALPLRAWRGRGLVLGPLSWLLWGGLAAGALYLAWTYIRLTGFGF
FQALALLAALWLAGFLVLTLPFRPIQVDVDNLIMRLVEVIAAIPTLFLLISLRAVFPANVDPLTTFYLVVGLLGFIGWGG
LARVVRGVVLSVREQDYVQAARALGASDGRILARHVLPATASYVIVSLSLTIPGFILAESGLSFLGLGVTEPYTSWGLLL
QAAQQGGFASFVDRPWVLWPGFFIFVSIMAWNFVGDGLRDAFDPRRRQ
>Mature_448_residues
MDALAPKSESLFQVAWAQFRRHRLAVWGGRILLVLYFVAAFAGFFSPYDPNYYELYPPKGHHPPTRIHFVDPETGRLSRP
FVYATRRTIDPVSLQPRYEEDPSQGKFYIRFFVRTPDQPYTIFRVFRADLRLFGVDPPGRIFLMGTDNFGRDLFSRLVYG
AQVSLTIGILSALVSFALGLLLGGIAGFYAGRPFVLALPLRAWRGRGLVLGPLSWLLWGGLAAGALYLAWTYIRLTGFGF
FQALALLAALWLAGFLVLTLPFRPIQVDVDNLIMRLVEVIAAIPTLFLLISLRAVFPANVDPLTTFYLVVGLLGFIGWGG
LARVVRGVVLSVREQDYVQAARALGASDGRILARHVLPATASYVIVSLSLTIPGFILAESGLSFLGLGVTEPYTSWGLLL
QAAQQGGFASFVDRPWVLWPGFFIFVSIMAWNFVGDGLRDAFDPRRRQ

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787498, Length=180, Percent_Identity=40.5555555555556, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1787054, Length=179, Percent_Identity=36.8715083798883, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1789889, Length=177, Percent_Identity=34.4632768361582, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789964, Length=182, Percent_Identity=34.6153846153846, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787760, Length=177, Percent_Identity=31.638418079096, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788505, Length=182, Percent_Identity=33.5164835164835, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 49832; Mature: 49832

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDALAPKSESLFQVAWAQFRRHRLAVWGGRILLVLYFVAAFAGFFSPYDPNYYELYPPKG
CCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCC
HHPPTRIHFVDPETGRLSRPFVYATRRTIDPVSLQPRYEEDPSQGKFYIRFFVRTPDQPY
CCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCH
TIFRVFRADLRLFGVDPPGRIFLMGTDNFGRDLFSRLVYGAQVSLTIGILSALVSFALGL
HHHHHHHHHHHEEECCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LLGGIAGFYAGRPFVLALPLRAWRGRGLVLGPLSWLLWGGLAAGALYLAWTYIRLTGFGF
HHHHHHHHHCCCCEEEEEEHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FQALALLAALWLAGFLVLTLPFRPIQVDVDNLIMRLVEVIAAIPTLFLLISLRAVFPANV
HHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DPLTTFYLVVGLLGFIGWGGLARVVRGVVLSVREQDYVQAARALGASDGRILARHVLPAT
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
ASYVIVSLSLTIPGFILAESGLSFLGLGVTEPYTSWGLLLQAAQQGGFASFVDRPWVLWP
CCEEEEEEEHHCCCHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHCCCEEECC
GFFIFVSIMAWNFVGDGLRDAFDPRRRQ
HHHHHHHHHHHHHHCCHHHHHCCCCCCC
>Mature Secondary Structure
MDALAPKSESLFQVAWAQFRRHRLAVWGGRILLVLYFVAAFAGFFSPYDPNYYELYPPKG
CCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCC
HHPPTRIHFVDPETGRLSRPFVYATRRTIDPVSLQPRYEEDPSQGKFYIRFFVRTPDQPY
CCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCH
TIFRVFRADLRLFGVDPPGRIFLMGTDNFGRDLFSRLVYGAQVSLTIGILSALVSFALGL
HHHHHHHHHHHEEECCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LLGGIAGFYAGRPFVLALPLRAWRGRGLVLGPLSWLLWGGLAAGALYLAWTYIRLTGFGF
HHHHHHHHHCCCCEEEEEEHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FQALALLAALWLAGFLVLTLPFRPIQVDVDNLIMRLVEVIAAIPTLFLLISLRAVFPANV
HHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DPLTTFYLVVGLLGFIGWGGLARVVRGVVLSVREQDYVQAARALGASDGRILARHVLPAT
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
ASYVIVSLSLTIPGFILAESGLSFLGLGVTEPYTSWGLLLQAAQQGGFASFVDRPWVLWP
CCEEEEEEEHHCCCHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHCCCEEECC
GFFIFVSIMAWNFVGDGLRDAFDPRRRQ
HHHHHHHHHHHHHHCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; oligopeptides [Periplasm]; H2O [C]

Specific reaction: ATP + oligopeptides [Periplasm] + H2O = ADP + phosphate + oligopeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]