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The map label for this gene is panB [H]

Identifier: 55980376

GI number: 55980376

Start: 386614

End: 387399

Strand: Direct

Name: panB [H]

Synonym: TTHA0407

Alternate gene names: 55980376

Gene position: 386614-387399 (Clockwise)

Preceding gene: 55980373

Following gene: 55980377

Centisome position: 20.9

GC content: 71.12

Gene sequence:

>786_bases
GTGCGGCGCACGGTGAAGGACTTCCGCAACGCCAAGGGCCAGCGGCTCGTCTACCTCACCGCCTACGACTACCCCACGGC
CCGCCTGGCCGAGGCGGCCGGGGTGGACGCCATTTTGGTGGGGGACTCCTTGGGGATGGTGGTCCTGGGCTACCCCTCCA
CGGTGCCCGTGACCTTGGAGGAGATGCTCCACCACACCAAGGCCGCCCGCAGGGGGGCCCCGGAGACCTTTCTCGTGGCC
GACCTCCCCTACCTCGCCTACGCCACCCTGGACCGGGCCCTCCTCGCCGCGGAGCGCCTCCTCAAGGAGGGGGGGGCGGA
CGCGGTGAAGCTGGAGGGGGGCGAGGAGGTGGCGGAGATCGTCCAGGGCCTGGTGCGGGCGGGGGTCCCGGTCCTGGGCC
ACGTGGGCCTCACCCCCCAGACGGCGAGCCAGCTTGGCGGCTACAAGCTCCAAGGCCGGCGCCCGGAGGAGGCGGAGCGC
ATTCTCAAGGGGGCCTTGGCCTTGGAGGAGGCCGGGGCCTACGGCGTGGTCTTGGAGATGGTGCCCGCCCGCCTGGCCAA
GGAGGTCACCGAGAGGCTTTCCGTCCACACCGTGGGGATCGGGGCCGGGCCCCACACGGACGCCCAGGTCCTCGTCTTCC
ACGACGTGGTGGGGCTCTACGGCGACTTCAAGCCTCGCTTCGTGAAGCGCTACCTGGAGGCGGGCAGGCTCATCCAGGAG
GCCTTGAGCCGGTACGCGCAGGAGGTCCGGGAAGGGGTCTTCCCCGGGGAGGAGCATAGTTTCTGA

Upstream 100 bases:

>100_bases
CCGGAGCTTTTGCTTCAGGCGCTCCTGGCCGATGTACTCGTCCAGGGTCTTGGGCCTAAGGGCGAGGTCTTCCACGCTCC
TCCATGATAGCCTTATTCCC

Downstream 100 bases:

>100_bases
AAAACTCCGCTGAAAACCCGGCCCCTTAAGGGGTAGAATGGGCTTTCGTGGTGCGCTTTCGTAGGGAAGGGGTGCGTCTG
GACCAGGCGGTGGCGGAGGC

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MRRTVKDFRNAKGQRLVYLTAYDYPTARLAEAAGVDAILVGDSLGMVVLGYPSTVPVTLEEMLHHTKAARRGAPETFLVA
DLPYLAYATLDRALLAAERLLKEGGADAVKLEGGEEVAEIVQGLVRAGVPVLGHVGLTPQTASQLGGYKLQGRRPEEAER
ILKGALALEEAGAYGVVLEMVPARLAKEVTERLSVHTVGIGAGPHTDAQVLVFHDVVGLYGDFKPRFVKRYLEAGRLIQE
ALSRYAQEVREGVFPGEEHSF

Sequences:

>Translated_261_residues
MRRTVKDFRNAKGQRLVYLTAYDYPTARLAEAAGVDAILVGDSLGMVVLGYPSTVPVTLEEMLHHTKAARRGAPETFLVA
DLPYLAYATLDRALLAAERLLKEGGADAVKLEGGEEVAEIVQGLVRAGVPVLGHVGLTPQTASQLGGYKLQGRRPEEAER
ILKGALALEEAGAYGVVLEMVPARLAKEVTERLSVHTVGIGAGPHTDAQVLVFHDVVGLYGDFKPRFVKRYLEAGRLIQE
ALSRYAQEVREGVFPGEEHSF
>Mature_261_residues
MRRTVKDFRNAKGQRLVYLTAYDYPTARLAEAAGVDAILVGDSLGMVVLGYPSTVPVTLEEMLHHTKAARRGAPETFLVA
DLPYLAYATLDRALLAAERLLKEGGADAVKLEGGEEVAEIVQGLVRAGVPVLGHVGLTPQTASQLGGYKLQGRRPEEAER
ILKGALALEEAGAYGVVLEMVPARLAKEVTERLSVHTVGIGAGPHTDAQVLVFHDVVGLYGDFKPRFVKRYLEAGRLIQE
ALSRYAQEVREGVFPGEEHSF

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=248, Percent_Identity=50.4032258064516, Blast_Score=244, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6319653, Length=270, Percent_Identity=34.8148148148148, Blast_Score=176, Evalue=3e-45,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28243; Mature: 28243

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRTVKDFRNAKGQRLVYLTAYDYPTARLAEAAGVDAILVGDSLGMVVLGYPSTVPVTLE
CCCCHHHHHCCCCCEEEEEEECCCCHHHHHHHCCCCEEEECCCCCEEEEECCCCCCHHHH
EMLHHTKAARRGAPETFLVADLPYLAYATLDRALLAAERLLKEGGADAVKLEGGEEVAEI
HHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHH
VQGLVRAGVPVLGHVGLTPQTASQLGGYKLQGRRPEEAERILKGALALEEAGAYGVVLEM
HHHHHHCCCCCEECCCCCCHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
VPARLAKEVTERLSVHTVGIGAGPHTDAQVLVFHDVVGLYGDFKPRFVKRYLEAGRLIQE
HHHHHHHHHHHHHHHEEEEECCCCCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ALSRYAQEVREGVFPGEEHSF
HHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRRTVKDFRNAKGQRLVYLTAYDYPTARLAEAAGVDAILVGDSLGMVVLGYPSTVPVTLE
CCCCHHHHHCCCCCEEEEEEECCCCHHHHHHHCCCCEEEECCCCCEEEEECCCCCCHHHH
EMLHHTKAARRGAPETFLVADLPYLAYATLDRALLAAERLLKEGGADAVKLEGGEEVAEI
HHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHH
VQGLVRAGVPVLGHVGLTPQTASQLGGYKLQGRRPEEAERILKGALALEEAGAYGVVLEM
HHHHHHCCCCCEECCCCCCHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
VPARLAKEVTERLSVHTVGIGAGPHTDAQVLVFHDVVGLYGDFKPRFVKRYLEAGRLIQE
HHHHHHHHHHHHHHHEEEEECCCCCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ALSRYAQEVREGVFPGEEHSF
HHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA