Click here to switch to the map view.

The map label for this gene is hpt [H]

Identifier: 55980189

GI number: 55980189

Start: 215242

End: 215787

Strand: Direct

Name: hpt [H]

Synonym: TTHA0220

Alternate gene names: 55980189

Gene position: 215242-215787 (Clockwise)

Preceding gene: 55980188

Following gene: 55980190

Centisome position: 11.64

GC content: 64.84

Gene sequence:

>546_bases
ATGAAGGGCATGTTCACGCCGGGCAACGGACCCGTGCAGATCAGCGCCGAGGCCATAAAGAAGCGGGTGGAGGAGCTGGG
GGGGGAGATCGCCCGGGACTACCAGGGCAAGACCCCTCACCTGATCTGCGTCCTGAACGGGGCCTTTATCTTCATGGCCG
ACCTGGTGCGGGCCATCCCCCTGCCCCTCACCATGGACTTCATCGCCATCAGCTCCTACGGGAACGCCTTCAAGTCCAGC
GGGGAAGTGGAGCTTTTGAAGGACCTCCGCCTTCCCATCCACGGCCGGGACGTGATCGTGGTGGAGGACATCGTGGACAC
GGGGCTCACCCTCTCCTACCTTCTGGACTACCTCGAGGCCCGGAAGCCCGCCTCCGTCCGCGTGGCCGCCCTCCTCTCCA
AGCCCAGCCGCCGCCAGGTGGAGGTGCCCATCCACTACCTGGGCTTTGAGATTGAGGACGCCTACGTCTACGGCTACGGC
CTGGACCGGGCCCAGTTTGACCGCAACCTGCCCTTCATCACCTCCATCCGCCCGGAGGAGGAATGA

Upstream 100 bases:

>100_bases
TCCAGGTGGGGCCCATCCGCCTCGGGGACCTCCCCCCCGGGAAGTGGCGGAGGCTTTCCGAGAGGGAGGTCAAGGCCCTC
CTCCGGCTCGTGGGGCTAGA

Downstream 100 bases:

>100_bases
GGTACCTGGACCTTCTCACCGCCCTCTTCGCCACGGTCCTCCTCGTCTCCAACGTGGCCTCCACCAAGCTCGTGGTCCTG
GGGCCCTTCACCTTTGACGG

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MKGMFTPGNGPVQISAEAIKKRVEELGGEIARDYQGKTPHLICVLNGAFIFMADLVRAIPLPLTMDFIAISSYGNAFKSS
GEVELLKDLRLPIHGRDVIVVEDIVDTGLTLSYLLDYLEARKPASVRVAALLSKPSRRQVEVPIHYLGFEIEDAYVYGYG
LDRAQFDRNLPFITSIRPEEE

Sequences:

>Translated_181_residues
MKGMFTPGNGPVQISAEAIKKRVEELGGEIARDYQGKTPHLICVLNGAFIFMADLVRAIPLPLTMDFIAISSYGNAFKSS
GEVELLKDLRLPIHGRDVIVVEDIVDTGLTLSYLLDYLEARKPASVRVAALLSKPSRRQVEVPIHYLGFEIEDAYVYGYG
LDRAQFDRNLPFITSIRPEEE
>Mature_181_residues
MKGMFTPGNGPVQISAEAIKKRVEELGGEIARDYQGKTPHLICVLNGAFIFMADLVRAIPLPLTMDFIAISSYGNAFKSS
GEVELLKDLRLPIHGRDVIVVEDIVDTGLTLSYLLDYLEARKPASVRVAALLSKPSRRQVEVPIHYLGFEIEDAYVYGYG
LDRAQFDRNLPFITSIRPEEE

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=168, Percent_Identity=35.1190476190476, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI9910262, Length=169, Percent_Identity=34.9112426035503, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI87081689, Length=167, Percent_Identity=44.311377245509, Blast_Score=146, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17510817, Length=168, Percent_Identity=36.3095238095238, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20171; Mature: 20171

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGMFTPGNGPVQISAEAIKKRVEELGGEIARDYQGKTPHLICVLNGAFIFMADLVRAIP
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCC
LPLTMDFIAISSYGNAFKSSGEVELLKDLRLPIHGRDVIVVEDIVDTGLTLSYLLDYLEA
CCCEEHHEEEECCCCHHCCCCCEEEHHHCCCCCCCCCEEEEECHHCCCCHHHHHHHHHHC
RKPASVRVAALLSKPSRRQVEVPIHYLGFEIEDAYVYGYGLDRAQFDRNLPFITSIRPEE
CCCCCEEHEEECCCCCCCEEECCEEEEEEEEECEEEEEECCCHHHHCCCCCEEECCCCCC
E
C
>Mature Secondary Structure
MKGMFTPGNGPVQISAEAIKKRVEELGGEIARDYQGKTPHLICVLNGAFIFMADLVRAIP
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCC
LPLTMDFIAISSYGNAFKSSGEVELLKDLRLPIHGRDVIVVEDIVDTGLTLSYLLDYLEA
CCCEEHHEEEECCCCHHCCCCCEEEHHHCCCCCCCCCEEEEECHHCCCCHHHHHHHHHHC
RKPASVRVAALLSKPSRRQVEVPIHYLGFEIEDAYVYGYGLDRAQFDRNLPFITSIRPEE
CCCCCEEHEEECCCCCCCEEECCEEEEEEEEECEEEEEECCCHHHHCCCCCEEECCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1756169 [H]