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The map label for this gene is mvaB [H]

Identifier: 54294717

GI number: 54294717

Start: 2008035

End: 2008943

Strand: Direct

Name: mvaB [H]

Synonym: lpl1794

Alternate gene names: 54294717

Gene position: 2008035-2008943 (Clockwise)

Preceding gene: 54294716

Following gene: 54294718

Centisome position: 60.02

GC content: 39.71

Gene sequence:

>909_bases
ATGGACTATCCTCAGCATGTGACAATAATCGAAGTAGGTCCTAGAGATGGCTTACAAAATGAACCATCTTTTCTCCATAG
TGATAAAAAAATTGAATTAATCAATTTACTCAGTCAGACAGGGCTGAAAGAGATAGAAGTCACCAGTTTTGTTTCAGCAA
AAGCAATTCCACAGCTAGCTGATAATGAAGAAGTATTTCAATGTATTAATAAGACTCCCTCCATCAACTACTCTGCCCTG
GTTCCAAACGAACGAGGAATGCTTAAAGCTCTGGAAATGGGAGTACAAAATATTGCAGTATTCACTGCTGCAAGTGAATT
ATTCAATCAACGCAATATTAATTGTTCTATTAAGGAAAGTATAGAACGCTTTAAACCTGTTTTAGCATTAGCAAAAACTA
ATCAAATTAGAGTGAGAGGCTATATCTCCTGCGTATTAGGCTGCCCCTATGAAGGATATATACAACCGAGCCAGGTTGTT
AGTGTCACTAAAATGCTTCTTGATCTGGGCGTACATGAAATTTCGTTGGGAGATACTATTGGCGTAGGAACTCCCAAGCA
AACTCAGTTGCTTCTTGATGCCATACTGCCCGTAATTCCCATCACACAATTAGCTATGCATTTCCACGATACTTATGGAC
AAGCCGTAGCAAATATTTATACCTCTCTGGAGTATGGAGTTAGCCGCTTTGACAGCTCTGTTGCGGGTCTTGGAGGGTGT
CCATATGCCCGAGGAGCCAGCGGCAATGTTGCAACAGAAGATGTACTTTATTTGATGCATGGATTGGGGATTGATACAGG
TATAGATATATTCAAAATTGTTGCTGCCGGAGATATGATTTGTAAAGCATTAGGACGAAAAAATCAATCCAAAGTAGCTA
ATGCTATGCTAGCCAATCCATGTAGTTAG

Upstream 100 bases:

>100_bases
GATGGTATATTATCAGATATTTTTTATTCTGTAGGTTCCCAAGTGAGTGAGGGAGCAGAACTGTTAGCACTTAGCGAATC
GGATACTTAAGAGAATATTT

Downstream 100 bases:

>100_bases
AAAGTTCCATCAGTATTAGCTTTCATAGCTACTAAAAATAGGAAACTTAAAGAGAAGCACCCGGTTTTATGCTAGCCTAT
ACTTATAAATAAATTATTGA

Product: hypothetical protein

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MDYPQHVTIIEVGPRDGLQNEPSFLHSDKKIELINLLSQTGLKEIEVTSFVSAKAIPQLADNEEVFQCINKTPSINYSAL
VPNERGMLKALEMGVQNIAVFTAASELFNQRNINCSIKESIERFKPVLALAKTNQIRVRGYISCVLGCPYEGYIQPSQVV
SVTKMLLDLGVHEISLGDTIGVGTPKQTQLLLDAILPVIPITQLAMHFHDTYGQAVANIYTSLEYGVSRFDSSVAGLGGC
PYARGASGNVATEDVLYLMHGLGIDTGIDIFKIVAAGDMICKALGRKNQSKVANAMLANPCS

Sequences:

>Translated_302_residues
MDYPQHVTIIEVGPRDGLQNEPSFLHSDKKIELINLLSQTGLKEIEVTSFVSAKAIPQLADNEEVFQCINKTPSINYSAL
VPNERGMLKALEMGVQNIAVFTAASELFNQRNINCSIKESIERFKPVLALAKTNQIRVRGYISCVLGCPYEGYIQPSQVV
SVTKMLLDLGVHEISLGDTIGVGTPKQTQLLLDAILPVIPITQLAMHFHDTYGQAVANIYTSLEYGVSRFDSSVAGLGGC
PYARGASGNVATEDVLYLMHGLGIDTGIDIFKIVAAGDMICKALGRKNQSKVANAMLANPCS
>Mature_302_residues
MDYPQHVTIIEVGPRDGLQNEPSFLHSDKKIELINLLSQTGLKEIEVTSFVSAKAIPQLADNEEVFQCINKTPSINYSAL
VPNERGMLKALEMGVQNIAVFTAASELFNQRNINCSIKESIERFKPVLALAKTNQIRVRGYISCVLGCPYEGYIQPSQVV
SVTKMLLDLGVHEISLGDTIGVGTPKQTQLLLDAILPVIPITQLAMHFHDTYGQAVANIYTSLEYGVSRFDSSVAGLGGC
PYARGASGNVATEDVLYLMHGLGIDTGIDIFKIVAAGDMICKALGRKNQSKVANAMLANPCS

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=292, Percent_Identity=55.4794520547945, Blast_Score=346, Evalue=1e-95,
Organism=Homo sapiens, GI109150427, Length=292, Percent_Identity=54.7945205479452, Blast_Score=342, Evalue=2e-94,
Organism=Homo sapiens, GI109150422, Length=292, Percent_Identity=54.7945205479452, Blast_Score=342, Evalue=2e-94,
Organism=Homo sapiens, GI260654708, Length=135, Percent_Identity=58.5185185185185, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17510563, Length=291, Percent_Identity=48.4536082474227, Blast_Score=299, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6320019, Length=246, Percent_Identity=26.4227642276423, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320071, Length=240, Percent_Identity=25.8333333333333, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24582381, Length=291, Percent_Identity=57.3883161512027, Blast_Score=359, Evalue=1e-99,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32703; Mature: 32703

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS01062 HMG_COA_LYASE ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYPQHVTIIEVGPRDGLQNEPSFLHSDKKIELINLLSQTGLKEIEVTSFVSAKAIPQLA
CCCCCEEEEEEECCCCCCCCCCHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
DNEEVFQCINKTPSINYSALVPNERGMLKALEMGVQNIAVFTAASELFNQRNINCSIKES
CCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
IERFKPVLALAKTNQIRVRGYISCVLGCPYEGYIQPSQVVSVTKMLLDLGVHEISLGDTI
HHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCEE
GVGTPKQTQLLLDAILPVIPITQLAMHFHDTYGQAVANIYTSLEYGVSRFDSSVAGLGGC
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCC
PYARGASGNVATEDVLYLMHGLGIDTGIDIFKIVAAGDMICKALGRKNQSKVANAMLANP
CCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
CS
CC
>Mature Secondary Structure
MDYPQHVTIIEVGPRDGLQNEPSFLHSDKKIELINLLSQTGLKEIEVTSFVSAKAIPQLA
CCCCCEEEEEEECCCCCCCCCCHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
DNEEVFQCINKTPSINYSALVPNERGMLKALEMGVQNIAVFTAASELFNQRNINCSIKES
CCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
IERFKPVLALAKTNQIRVRGYISCVLGCPYEGYIQPSQVVSVTKMLLDLGVHEISLGDTI
HHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCEE
GVGTPKQTQLLLDAILPVIPITQLAMHFHDTYGQAVANIYTSLEYGVSRFDSSVAGLGGC
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCC
PYARGASGNVATEDVLYLMHGLGIDTGIDIFKIVAAGDMICKALGRKNQSKVANAMLANP
CCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
CS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]