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The map label for this gene is accA1 [H]

Identifier: 54294716

GI number: 54294716

Start: 2006060

End: 2008024

Strand: Direct

Name: accA1 [H]

Synonym: lpl1793

Alternate gene names: 54294716

Gene position: 2006060-2008024 (Clockwise)

Preceding gene: 54294715

Following gene: 54294717

Centisome position: 59.96

GC content: 39.29

Gene sequence:

>1965_bases
ATGTTTAATAAAATATTAATTGCTAACCGAGGCGAAATAGCCTGTCGAATCATTAAAACAGCAAATTCTATGGGTATTCA
GGCTGTTGCCGTTTATTCAGCAGCAGATAGAAATAGCCTTCACGTGCGATTAGCCGATAGCGCCTGTTATATTGGAGAAG
CACCAGCTAAAGAAAGTTATCTGAATATTGACCATATTATTCAGGCAGCTAAAGAAAGTGGGGCACAAGCCATCCATCCT
GGCTATGGATTTTTATCTGAAAATCCTGATTTTGCCAAAGCCTGTGAACAAGCGGGCATTGTTTTCATCGGTCCTTCCAT
TAAAGCAATGGAAGCAATGGCATCCAAACAATTAGCTAAACAACTTCTTGAAAAAACGAAAGTCCCACTTACACCGGGCT
ATCATGGCGTTGAACAGTCTGAAGAAAAGTTGTTGAGCGAAGCTAAAAAAATTGGATTTCCAGTACTGATTAAAGCTGCT
AATGGTGGTGGTGGAAAAGGAATGCGAGCAGTACATGATGAAAAGGAATTTCATGATGCATTAGCAGGAGCCAAAAGAGA
ATCTATGACCTCCTTTGCGGATGATACTATGATAATTGAACGATTAGTTCTTAATCCTCGTCATGTTGAAGTGCAAATCA
TGGCAGATAATCATGGAAATGTTGTACATTTGTTTGAAAGAGATTGTTCCATTCAGCGCAGGCATCAAAAAATTATCGAG
GAAGCCCCTGCTCCCAATTTATCGCCCGTGCTTCGGCAAAGGCTGGCAGAAGCAGCCTGTGAAGTAGCCCGCTCTATCAA
CTACAGAGGAGCTGGAACAGTAGAGTTTTTGTTAGATGGTGAAGATAAATTCTACTTTATGGAAATGAATACAAGACTTC
AAGTAGAACATCCTGTCACAGAAATGATTACAGGACTTGATCTTGTCGCTTGGCAAATAAAAATTGCAGCGAATGACACA
TTACCTTTGCTTCAAAATCAAATTCAAGCTCAAGGCCATGCAATTGAGTGCCGTATTTACGCTGAAGATCCTTATCAGGG
TTTTATACCCTCTATTGGCCAACTTCAATTCTTAAAAGAACCCTCTGGAGATGGCATACGCATTGATACAGGTGTTTCTT
TGTCTTCAGAAATAACAAGGTATTATGATCCCATGATAGCCAAACTGATTGCCTGGGGACATAATCGTGAAGAAGCATTA
TATAGATTGGAGCGTAGCCTGGCTCACTATGACATTGGCGGGGTAAAAACAAATATACCCTTTCTACGAGCCATTTGCCA
ACATGTAAAATTTAAAGAGGCAAAATTAAGTACTGATTTTTTAGAGAAAGAAAACATAAATCTGCCTAAACCAGATAATC
AATTAGGTATGATCCTGGCCATAAGTTGTGATTATTTAGGTATGATTAATCGCACTACGGATCCCTTGTTGCAAGATGCA
TTTGGCTGGCAAATGCATCTTTCCAGCCATTGGATATGGCGTTATCAATTGAACTCCACGATAATTGAAGCTCAGATTAC
ACCTATAGATAATAAAAAATTTAAAGCAAAAATTGAAAACAAGGAAATGGTCATCTATGCCAGATATGACATTGACCAGC
TTATTATTGAAATTGATCAAAAATCAGTGAAAGCCAGAGTAGAAAACAAAGATCACCATCTGATCTTCTATACTGACAAA
GGCCAACTTTCAATCGAACGCTTCTACTGGAGTAAACTGGATGCTCAAACTTCCGCCCATAAAGGCCAGTTAACCGCGCC
AATGCCTGCCACTGTCGTTGCTATTTTAAAAAATATTGGTGAACAGGTAAAAGCTGGTGAAAGCTTAATTGTACTTGAGG
CAATGAAAATGGAACACACCATTCATGCTCCAATCGATGGTATATTATCAGATATTTTTTATTCTGTAGGTTCCCAAGTG
AGTGAGGGAGCAGAACTGTTAGCACTTAGCGAATCGGATACTTAA

Upstream 100 bases:

>100_bases
GCTTCTCTGATTGCCCATAAAAGAGTATCTGATGAAGGGCAAGAAGGGCTTAAAGCATTTCTCAATAAAGAAATACCCAA
CTGGAATAAAGGTTCTGGAC

Downstream 100 bases:

>100_bases
GAGAATATTTATGGACTATCCTCAGCATGTGACAATAATCGAAGTAGGTCCTAGAGATGGCTTACAAAATGAACCATCTT
TTCTCCATAGTGATAAAAAA

Product: hypothetical protein

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 654; Mature: 654

Protein sequence:

>654_residues
MFNKILIANRGEIACRIIKTANSMGIQAVAVYSAADRNSLHVRLADSACYIGEAPAKESYLNIDHIIQAAKESGAQAIHP
GYGFLSENPDFAKACEQAGIVFIGPSIKAMEAMASKQLAKQLLEKTKVPLTPGYHGVEQSEEKLLSEAKKIGFPVLIKAA
NGGGGKGMRAVHDEKEFHDALAGAKRESMTSFADDTMIIERLVLNPRHVEVQIMADNHGNVVHLFERDCSIQRRHQKIIE
EAPAPNLSPVLRQRLAEAACEVARSINYRGAGTVEFLLDGEDKFYFMEMNTRLQVEHPVTEMITGLDLVAWQIKIAANDT
LPLLQNQIQAQGHAIECRIYAEDPYQGFIPSIGQLQFLKEPSGDGIRIDTGVSLSSEITRYYDPMIAKLIAWGHNREEAL
YRLERSLAHYDIGGVKTNIPFLRAICQHVKFKEAKLSTDFLEKENINLPKPDNQLGMILAISCDYLGMINRTTDPLLQDA
FGWQMHLSSHWIWRYQLNSTIIEAQITPIDNKKFKAKIENKEMVIYARYDIDQLIIEIDQKSVKARVENKDHHLIFYTDK
GQLSIERFYWSKLDAQTSAHKGQLTAPMPATVVAILKNIGEQVKAGESLIVLEAMKMEHTIHAPIDGILSDIFYSVGSQV
SEGAELLALSESDT

Sequences:

>Translated_654_residues
MFNKILIANRGEIACRIIKTANSMGIQAVAVYSAADRNSLHVRLADSACYIGEAPAKESYLNIDHIIQAAKESGAQAIHP
GYGFLSENPDFAKACEQAGIVFIGPSIKAMEAMASKQLAKQLLEKTKVPLTPGYHGVEQSEEKLLSEAKKIGFPVLIKAA
NGGGGKGMRAVHDEKEFHDALAGAKRESMTSFADDTMIIERLVLNPRHVEVQIMADNHGNVVHLFERDCSIQRRHQKIIE
EAPAPNLSPVLRQRLAEAACEVARSINYRGAGTVEFLLDGEDKFYFMEMNTRLQVEHPVTEMITGLDLVAWQIKIAANDT
LPLLQNQIQAQGHAIECRIYAEDPYQGFIPSIGQLQFLKEPSGDGIRIDTGVSLSSEITRYYDPMIAKLIAWGHNREEAL
YRLERSLAHYDIGGVKTNIPFLRAICQHVKFKEAKLSTDFLEKENINLPKPDNQLGMILAISCDYLGMINRTTDPLLQDA
FGWQMHLSSHWIWRYQLNSTIIEAQITPIDNKKFKAKIENKEMVIYARYDIDQLIIEIDQKSVKARVENKDHHLIFYTDK
GQLSIERFYWSKLDAQTSAHKGQLTAPMPATVVAILKNIGEQVKAGESLIVLEAMKMEHTIHAPIDGILSDIFYSVGSQV
SEGAELLALSESDT
>Mature_654_residues
MFNKILIANRGEIACRIIKTANSMGIQAVAVYSAADRNSLHVRLADSACYIGEAPAKESYLNIDHIIQAAKESGAQAIHP
GYGFLSENPDFAKACEQAGIVFIGPSIKAMEAMASKQLAKQLLEKTKVPLTPGYHGVEQSEEKLLSEAKKIGFPVLIKAA
NGGGGKGMRAVHDEKEFHDALAGAKRESMTSFADDTMIIERLVLNPRHVEVQIMADNHGNVVHLFERDCSIQRRHQKIIE
EAPAPNLSPVLRQRLAEAACEVARSINYRGAGTVEFLLDGEDKFYFMEMNTRLQVEHPVTEMITGLDLVAWQIKIAANDT
LPLLQNQIQAQGHAIECRIYAEDPYQGFIPSIGQLQFLKEPSGDGIRIDTGVSLSSEITRYYDPMIAKLIAWGHNREEAL
YRLERSLAHYDIGGVKTNIPFLRAICQHVKFKEAKLSTDFLEKENINLPKPDNQLGMILAISCDYLGMINRTTDPLLQDA
FGWQMHLSSHWIWRYQLNSTIIEAQITPIDNKKFKAKIENKEMVIYARYDIDQLIIEIDQKSVKARVENKDHHLIFYTDK
GQLSIERFYWSKLDAQTSAHKGQLTAPMPATVVAILKNIGEQVKAGESLIVLEAMKMEHTIHAPIDGILSDIFYSVGSQV
SEGAELLALSESDT

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=676, Percent_Identity=45.1183431952663, Blast_Score=582, Evalue=1e-166,
Organism=Homo sapiens, GI65506442, Length=677, Percent_Identity=38.9955686853767, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI189095269, Length=677, Percent_Identity=38.9955686853767, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI295821183, Length=657, Percent_Identity=40.6392694063927, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI106049528, Length=482, Percent_Identity=41.701244813278, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049295, Length=482, Percent_Identity=41.701244813278, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049292, Length=482, Percent_Identity=41.701244813278, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI38679960, Length=518, Percent_Identity=30.6949806949807, Blast_Score=256, Evalue=5e-68,
Organism=Homo sapiens, GI38679977, Length=518, Percent_Identity=30.6949806949807, Blast_Score=256, Evalue=7e-68,
Organism=Homo sapiens, GI38679967, Length=518, Percent_Identity=30.6949806949807, Blast_Score=256, Evalue=7e-68,
Organism=Homo sapiens, GI38679971, Length=518, Percent_Identity=30.6949806949807, Blast_Score=255, Evalue=7e-68,
Organism=Homo sapiens, GI38679974, Length=518, Percent_Identity=30.6949806949807, Blast_Score=255, Evalue=8e-68,
Organism=Homo sapiens, GI134142062, Length=523, Percent_Identity=31.5487571701721, Blast_Score=254, Evalue=2e-67,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=46.7415730337079, Blast_Score=399, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=659, Percent_Identity=43.5508345978756, Blast_Score=525, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17567343, Length=681, Percent_Identity=39.647577092511, Blast_Score=488, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17562816, Length=487, Percent_Identity=43.1211498973306, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71997168, Length=533, Percent_Identity=30.0187617260788, Blast_Score=211, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71997163, Length=533, Percent_Identity=30.0187617260788, Blast_Score=211, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI133931226, Length=508, Percent_Identity=30.1181102362205, Blast_Score=206, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=45.9641255605381, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=43.9732142857143, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=44.9664429530201, Blast_Score=357, Evalue=3e-99,
Organism=Saccharomyces cerevisiae, GI6323863, Length=694, Percent_Identity=29.3948126801153, Blast_Score=278, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6324343, Length=724, Percent_Identity=27.7624309392265, Blast_Score=244, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24651757, Length=673, Percent_Identity=43.2392273402675, Blast_Score=540, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24651759, Length=636, Percent_Identity=42.2955974842767, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=44.3693693693694, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=44.3693693693694, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=44.3693693693694, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=44.3693693693694, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=44.3693693693694, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=44.3693693693694, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=44.3693693693694, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=44.3693693693694, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=44.3693693693694, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=44.3693693693694, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI161076409, Length=529, Percent_Identity=31.1909262759924, Blast_Score=261, Evalue=1e-69,
Organism=Drosophila melanogaster, GI161076407, Length=529, Percent_Identity=31.1909262759924, Blast_Score=261, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24586460, Length=529, Percent_Identity=31.1909262759924, Blast_Score=261, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24586458, Length=529, Percent_Identity=31.1909262759924, Blast_Score=261, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 72992; Mature: 72992

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKILIANRGEIACRIIKTANSMGIQAVAVYSAADRNSLHVRLADSACYIGEAPAKESY
CCCEEEEECCCCEEEEEEECCCCCCEEEEEEEECCCCCCEEEEEECCEEECCCCCCCCCC
LNIDHIIQAAKESGAQAIHPGYGFLSENPDFAKACEQAGIVFIGPSIKAMEAMASKQLAK
CCHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHHH
QLLEKTKVPLTPGYHGVEQSEEKLLSEAKKIGFPVLIKAANGGGGKGMRAVHDEKEFHDA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHCCHHHHHHH
LAGAKRESMTSFADDTMIIERLVLNPRHVEVQIMADNHGNVVHLFERDCSIQRRHQKIIE
HHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
EAPAPNLSPVLRQRLAEAACEVARSINYRGAGTVEFLLDGEDKFYFMEMNTRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCHH
EMITGLDLVAWQIKIAANDTLPLLQNQIQAQGHAIECRIYAEDPYQGFIPSIGQLQFLKE
HHHCCCEEEEEEEEEECCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEEEC
PSGDGIRIDTGVSLSSEITRYYDPMIAKLIAWGHNREEALYRLERSLAHYDIGGVKTNIP
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCH
FLRAICQHVKFKEAKLSTDFLEKENINLPKPDNQLGMILAISCDYLGMINRTTDPLLQDA
HHHHHHHHCCHHHHHCCHHHHHHCCCCCCCCCCCCCEEEEEECCHHHCCCCCCCHHHHHH
FGWQMHLSSHWIWRYQLNSTIIEAQITPIDNKKFKAKIENKEMVIYARYDIDQLIIEIDQ
CCCEEEECCCEEEEEEECCEEEEEEECCCCCCEEEEEECCCEEEEEEECCHHHHHHHHHH
KSVKARVENKDHHLIFYTDKGQLSIERFYWSKLDAQTSAHKGQLTAPMPATVVAILKNIG
HHHHHHCCCCCCEEEEEECCCCEEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
EQVKAGESLIVLEAMKMEHTIHAPIDGILSDIFYSVGSQVSEGAELLALSESDT
HHHHCCCCEEEEEEHHHCCEECCCHHHHHHHHHHHHCCHHCCCCEEEEEECCCC
>Mature Secondary Structure
MFNKILIANRGEIACRIIKTANSMGIQAVAVYSAADRNSLHVRLADSACYIGEAPAKESY
CCCEEEEECCCCEEEEEEECCCCCCEEEEEEEECCCCCCEEEEEECCEEECCCCCCCCCC
LNIDHIIQAAKESGAQAIHPGYGFLSENPDFAKACEQAGIVFIGPSIKAMEAMASKQLAK
CCHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHHH
QLLEKTKVPLTPGYHGVEQSEEKLLSEAKKIGFPVLIKAANGGGGKGMRAVHDEKEFHDA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHCCHHHHHHH
LAGAKRESMTSFADDTMIIERLVLNPRHVEVQIMADNHGNVVHLFERDCSIQRRHQKIIE
HHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
EAPAPNLSPVLRQRLAEAACEVARSINYRGAGTVEFLLDGEDKFYFMEMNTRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCHH
EMITGLDLVAWQIKIAANDTLPLLQNQIQAQGHAIECRIYAEDPYQGFIPSIGQLQFLKE
HHHCCCEEEEEEEEEECCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEEEC
PSGDGIRIDTGVSLSSEITRYYDPMIAKLIAWGHNREEALYRLERSLAHYDIGGVKTNIP
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCH
FLRAICQHVKFKEAKLSTDFLEKENINLPKPDNQLGMILAISCDYLGMINRTTDPLLQDA
HHHHHHHHCCHHHHHCCHHHHHHCCCCCCCCCCCCCEEEEEECCHHHCCCCCCCHHHHHH
FGWQMHLSSHWIWRYQLNSTIIEAQITPIDNKKFKAKIENKEMVIYARYDIDQLIIEIDQ
CCCEEEECCCEEEEEEECCEEEEEEECCCCCCEEEEEECCCEEEEEEECCHHHHHHHHHH
KSVKARVENKDHHLIFYTDKGQLSIERFYWSKLDAQTSAHKGQLTAPMPATVVAILKNIG
HHHHHHCCCCCCEEEEEECCCCEEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
EQVKAGESLIVLEAMKMEHTIHAPIDGILSDIFYSVGSQVSEGAELLALSESDT
HHHHCCCCEEEEEEHHHCCEECCCHHHHHHHHHHHHCCHHCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]