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The map label for this gene is acsA1 [H]

Identifier: 54294718

GI number: 54294718

Start: 2009100

End: 2011040

Strand: Direct

Name: acsA1 [H]

Synonym: lpl1795

Alternate gene names: 54294718

Gene position: 2009100-2011040 (Clockwise)

Preceding gene: 54294717

Following gene: 54294720

Centisome position: 60.05

GC content: 39.46

Gene sequence:

>1941_bases
ATGAACGATAAAGTATGGACACCTAAGAACCCTGAACAAACAAGAATGTGGCAATTTATGGATTTTGCCGCAAAAAAACA
TTGTCAAGTTTTTGAAAATTACCAGGACTTACATACCTGGTCAGTAAAGCATCCCGAATCATTCTGGGAAACTCTTTGCC
TTTTCTTTAAATTGAACTTTGATACACCACCTCACCAAATTCTGAATTACTATTCTGAAATGATTGAAGCACGTTGGTTT
TCAGGAGCACGCTTCAATTTCGCCCAAAAATTATTAACCCGCAGGGATAATCACCCTGCTCTAATAAGCCTTGATGAAAA
TGACTGCAAAAGTGTCATTAGCTATGCTGAGTTATATGAAAAAGTAGCTCAATGTGCTGCTGGCCTTAAAGCAGTTGGTG
TCACCACTGGCGACCGGGTGGCCGCAGTGATGCCTAATACTTCTTATACAATCATTGCCATGCTGGCAACAACTTCTTTG
GGAGCAATTTGGTCATCCTGCTCACCTGACTTTGGGACCCAGGCTGCGCTTGATCGAATAGGACAAATTGAACCTACAGT
ACTCTTTATTTGTGATGGTCATCAATATCAAGGTAAAAAACACAGCAGCTCAGAAAAGGTTATACAACTTCCTGCTGCGA
TTACCTCTCTAAGACATGTAGTTATTTGCCCGAATATTAATGAAGAAATTAATCTTGAGCAACTACCGTACGCGTCGTAT
TGGGATGATTTTATAAAACCGGTAAAAGAATGTGATTTTATTTCTCTGCCTTTCGATCATCCTGTTTATATTATGTTTTC
TTCAGGAACAACAGGTAAACCTAAATGTATTGTCCATGGCGCAGGAGGAACTTTAATTCAGCATCTGAAAGAATTAGGTC
TTCATTCAGATATTAAATCCACAGACAATTTATGTTTTTATACAACGTGTGGTTGGATGATGTGGAACTGGACTGTTTCT
GCTTTGGCATTGGGAGCTACTATCACTCTGTATGAAGGTTCTCCAACCTACCCCACAGATAATAGAATGTTTCGACTGAT
AGATGAAGAAAACGTCACAGTATTTGGAACCAGTGCCAAATTCATATCTGCTATAGAAAAAGCAGGGGTAAAACCAAAAA
GTGAATTTCAATTATCCGAGTTGCGCTGTATCTTGTCTACCGGCTCCCCTCTTCTACCTAAAAATTATGATTTCGTCTAT
GAACATATTAAAAAAGATCTGCAATTAAGCTCTATTTCAGGAGGAACGGATATTATTTCTTGTTTTGCATTGGGAAATCC
CATTCTACCGGTTTATAGGGGTGAATTACAATGCATTGGATTAGGTATGGAAGTTGCGGTGTATGATGAGCAAGGCCATT
CAATCAAGCAAAAACGTGGTGAGTTGGTTTGTACCAAACCCTTCCCTTCCATGCCAGTCTGTTTTTGGAATGATAAGGAT
AGACAAGCATATAAACATGCTTATTTTGAGCGCTTCCCAGGGGTGTGGGCACATGGCGATTTCGCTGAAATAACTGCTCA
CAATGGATTAATTATTCATGGACGTTCCGACGCTATATTAAACCCGGGAGGAGTTCGTATAGGAACAGCTGAAATTTACA
GACAAGTTGAAAAAGTAGATGATGTTGTTGATAGTATAGTCATTGGGCAAGATTGGCAGGATGATGTACGAGTTGTTTTA
TTCGTTAAATTGCGTGAGGGGAAAAAACTGGACGATGAATTAATCAGTCTGATTAAAACAACCATTAGAAAAAATGCCTC
ACCACGACATGTGCCAGCTAAAATACTACAAGTCCCAGACATTCCTAAAACTCTTAGCGGGAAAGTAGTGGAGCTCGCCG
TCAGGCAAGTTGTTCATGGTCAATCAGTAAGTAACTTACAGTCATTGTCAAACCCGCAAGCATTAGAATATTTTAAAGAC
AGGAACGAATTGAAAAGCTAA

Upstream 100 bases:

>100_bases
GCACCCGGTTTTATGCTAGCCTATACTTATAAATAAATTATTGATGAAGTTTTCCAGTGCAATACCCATCATTAAAAACA
GAACTATGAGAGAAATTTTC

Downstream 100 bases:

>100_bases
AATTGCATGAAAATAGCTATTTTCAACACGAATCCACATTAAAATTCATCTCATATCAACCAATAGAAAGGGCAACTGCA
TGAGTTGCCCTTTCATGTAA

Product: acetoacetyl-CoA synthetase

Products: NA

Alternate protein names: Acetoacetate--CoA ligase 1; Acyl-activating enzyme 1 [H]

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MNDKVWTPKNPEQTRMWQFMDFAAKKHCQVFENYQDLHTWSVKHPESFWETLCLFFKLNFDTPPHQILNYYSEMIEARWF
SGARFNFAQKLLTRRDNHPALISLDENDCKSVISYAELYEKVAQCAAGLKAVGVTTGDRVAAVMPNTSYTIIAMLATTSL
GAIWSSCSPDFGTQAALDRIGQIEPTVLFICDGHQYQGKKHSSSEKVIQLPAAITSLRHVVICPNINEEINLEQLPYASY
WDDFIKPVKECDFISLPFDHPVYIMFSSGTTGKPKCIVHGAGGTLIQHLKELGLHSDIKSTDNLCFYTTCGWMMWNWTVS
ALALGATITLYEGSPTYPTDNRMFRLIDEENVTVFGTSAKFISAIEKAGVKPKSEFQLSELRCILSTGSPLLPKNYDFVY
EHIKKDLQLSSISGGTDIISCFALGNPILPVYRGELQCIGLGMEVAVYDEQGHSIKQKRGELVCTKPFPSMPVCFWNDKD
RQAYKHAYFERFPGVWAHGDFAEITAHNGLIIHGRSDAILNPGGVRIGTAEIYRQVEKVDDVVDSIVIGQDWQDDVRVVL
FVKLREGKKLDDELISLIKTTIRKNASPRHVPAKILQVPDIPKTLSGKVVELAVRQVVHGQSVSNLQSLSNPQALEYFKD
RNELKS

Sequences:

>Translated_646_residues
MNDKVWTPKNPEQTRMWQFMDFAAKKHCQVFENYQDLHTWSVKHPESFWETLCLFFKLNFDTPPHQILNYYSEMIEARWF
SGARFNFAQKLLTRRDNHPALISLDENDCKSVISYAELYEKVAQCAAGLKAVGVTTGDRVAAVMPNTSYTIIAMLATTSL
GAIWSSCSPDFGTQAALDRIGQIEPTVLFICDGHQYQGKKHSSSEKVIQLPAAITSLRHVVICPNINEEINLEQLPYASY
WDDFIKPVKECDFISLPFDHPVYIMFSSGTTGKPKCIVHGAGGTLIQHLKELGLHSDIKSTDNLCFYTTCGWMMWNWTVS
ALALGATITLYEGSPTYPTDNRMFRLIDEENVTVFGTSAKFISAIEKAGVKPKSEFQLSELRCILSTGSPLLPKNYDFVY
EHIKKDLQLSSISGGTDIISCFALGNPILPVYRGELQCIGLGMEVAVYDEQGHSIKQKRGELVCTKPFPSMPVCFWNDKD
RQAYKHAYFERFPGVWAHGDFAEITAHNGLIIHGRSDAILNPGGVRIGTAEIYRQVEKVDDVVDSIVIGQDWQDDVRVVL
FVKLREGKKLDDELISLIKTTIRKNASPRHVPAKILQVPDIPKTLSGKVVELAVRQVVHGQSVSNLQSLSNPQALEYFKD
RNELKS
>Mature_646_residues
MNDKVWTPKNPEQTRMWQFMDFAAKKHCQVFENYQDLHTWSVKHPESFWETLCLFFKLNFDTPPHQILNYYSEMIEARWF
SGARFNFAQKLLTRRDNHPALISLDENDCKSVISYAELYEKVAQCAAGLKAVGVTTGDRVAAVMPNTSYTIIAMLATTSL
GAIWSSCSPDFGTQAALDRIGQIEPTVLFICDGHQYQGKKHSSSEKVIQLPAAITSLRHVVICPNINEEINLEQLPYASY
WDDFIKPVKECDFISLPFDHPVYIMFSSGTTGKPKCIVHGAGGTLIQHLKELGLHSDIKSTDNLCFYTTCGWMMWNWTVS
ALALGATITLYEGSPTYPTDNRMFRLIDEENVTVFGTSAKFISAIEKAGVKPKSEFQLSELRCILSTGSPLLPKNYDFVY
EHIKKDLQLSSISGGTDIISCFALGNPILPVYRGELQCIGLGMEVAVYDEQGHSIKQKRGELVCTKPFPSMPVCFWNDKD
RQAYKHAYFERFPGVWAHGDFAEITAHNGLIIHGRSDAILNPGGVRIGTAEIYRQVEKVDDVVDSIVIGQDWQDDVRVVL
FVKLREGKKLDDELISLIKTTIRKNASPRHVPAKILQVPDIPKTLSGKVVELAVRQVVHGQSVSNLQSLSNPQALEYFKD
RNELKS

Specific function: Involved in poly-3-hydroxybutyrate degradation. Activates acetoacetate to acetoacetyl-CoA [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI31982927, Length=653, Percent_Identity=42.572741194487, Blast_Score=556, Evalue=1e-158,
Organism=Homo sapiens, GI8923896, Length=693, Percent_Identity=24.3867243867244, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI253970489, Length=699, Percent_Identity=24.1773962804006, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI28416953, Length=631, Percent_Identity=25.0396196513471, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI13375727, Length=632, Percent_Identity=24.0506329113924, Blast_Score=157, Evalue=4e-38,
Organism=Homo sapiens, GI38505220, Length=588, Percent_Identity=20.578231292517, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI122937307, Length=553, Percent_Identity=22.2423146473779, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI115511026, Length=565, Percent_Identity=20.8849557522124, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790505, Length=637, Percent_Identity=23.861852433281, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1786529, Length=661, Percent_Identity=23.4493192133132, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17569507, Length=646, Percent_Identity=35.2941176470588, Blast_Score=414, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71983001, Length=651, Percent_Identity=25.4992319508449, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71982997, Length=636, Percent_Identity=25.6289308176101, Blast_Score=170, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6323182, Length=656, Percent_Identity=26.0670731707317, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6319264, Length=672, Percent_Identity=26.9345238095238, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24667955, Length=656, Percent_Identity=27.8963414634146, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI62472339, Length=573, Percent_Identity=28.2722513089005, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24667959, Length=523, Percent_Identity=27.7246653919694, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21355225, Length=626, Percent_Identity=25.3993610223642, Blast_Score=155, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005914
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.16 [H]

Molecular weight: Translated: 72664; Mature: 72664

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKVWTPKNPEQTRMWQFMDFAAKKHCQVFENYQDLHTWSVKHPESFWETLCLFFKLNF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHEECCCCHHHHHHHHHHHEEECC
DTPPHQILNYYSEMIEARWFSGARFNFAQKLLTRRDNHPALISLDENDCKSVISYAELYE
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHH
KVAQCAAGLKAVGVTTGDRVAAVMPNTSYTIIAMLATTSLGAIWSSCSPDFGTQAALDRI
HHHHHHCCCEEEECCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHH
GQIEPTVLFICDGHQYQGKKHSSSEKVIQLPAAITSLRHVVICPNINEEINLEQLPYASY
CCCCCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHCCEEEECCCCCCCCCHHHCCCHHH
WDDFIKPVKECDFISLPFDHPVYIMFSSGTTGKPKCIVHGAGGTLIQHLKELGLHSDIKS
HHHHHHHHHHCCEEECCCCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCC
TDNLCFYTTCGWMMWNWTVSALALGATITLYEGSPTYPTDNRMFRLIDEENVTVFGTSAK
CCCEEEEEECCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEECCCEEEEECCHH
FISAIEKAGVKPKSEFQLSELRCILSTGSPLLPKNYDFVYEHIKKDLQLSSISGGTDIIS
HHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCEEECCCCCHHHHH
CFALGNPILPVYRGELQCIGLGMEVAVYDEQGHSIKQKRGELVCTKPFPSMPVCFWNDKD
HHHCCCCCCEEECCCEEEEEECEEEEEECCCCCHHHHCCCCEEEECCCCCCCEEEECCCH
RQAYKHAYFERFPGVWAHGDFAEITAHNGLIIHGRSDAILNPGGVRIGTAEIYRQVEKVD
HHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEECCCCCEECCCCCEECHHHHHHHHHHHH
DVVDSIVIGQDWQDDVRVVLFVKLREGKKLDDELISLIKTTIRKNASPRHVPAKILQVPD
HHHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCC
IPKTLSGKVVELAVRQVVHGQSVSNLQSLSNPQALEYFKDRNELKS
CCCHHCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNDKVWTPKNPEQTRMWQFMDFAAKKHCQVFENYQDLHTWSVKHPESFWETLCLFFKLNF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHEECCCCHHHHHHHHHHHEEECC
DTPPHQILNYYSEMIEARWFSGARFNFAQKLLTRRDNHPALISLDENDCKSVISYAELYE
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHH
KVAQCAAGLKAVGVTTGDRVAAVMPNTSYTIIAMLATTSLGAIWSSCSPDFGTQAALDRI
HHHHHHCCCEEEECCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHH
GQIEPTVLFICDGHQYQGKKHSSSEKVIQLPAAITSLRHVVICPNINEEINLEQLPYASY
CCCCCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHCCEEEECCCCCCCCCHHHCCCHHH
WDDFIKPVKECDFISLPFDHPVYIMFSSGTTGKPKCIVHGAGGTLIQHLKELGLHSDIKS
HHHHHHHHHHCCEEECCCCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCC
TDNLCFYTTCGWMMWNWTVSALALGATITLYEGSPTYPTDNRMFRLIDEENVTVFGTSAK
CCCEEEEEECCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEECCCEEEEECCHH
FISAIEKAGVKPKSEFQLSELRCILSTGSPLLPKNYDFVYEHIKKDLQLSSISGGTDIIS
HHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCEEECCCCCHHHHH
CFALGNPILPVYRGELQCIGLGMEVAVYDEQGHSIKQKRGELVCTKPFPSMPVCFWNDKD
HHHCCCCCCEEECCCEEEEEECEEEEEECCCCCHHHHCCCCEEEECCCCCCCEEEECCCH
RQAYKHAYFERFPGVWAHGDFAEITAHNGLIIHGRSDAILNPGGVRIGTAEIYRQVEKVD
HHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEECCCCCEECCCCCEECHHHHHHHHHHHH
DVVDSIVIGQDWQDDVRVVLFVKLREGKKLDDELISLIKTTIRKNASPRHVPAKILQVPD
HHHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCC
IPKTLSGKVVELAVRQVVHGQSVSNLQSLSNPQALEYFKDRNELKS
CCCHHCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10735852; 11481430 [H]