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The map label for this gene is IscS [H]

Identifier: 54294633

GI number: 54294633

Start: 1907161

End: 1908324

Strand: Reverse

Name: IscS [H]

Synonym: lpl1710

Alternate gene names: 54294633

Gene position: 1908324-1907161 (Counterclockwise)

Preceding gene: 54294634

Following gene: 54294632

Centisome position: 57.04

GC content: 41.67

Gene sequence:

>1164_bases
TTGGCAATAAAATCGATTTATTTTGATTATATGGCAACAACACCGGTTGATCCTCGCGTTGTTGAGCAAATGATAAAATA
TTTAGGCCCTGAAGGGGATTTTGGTAATCCTGCATCAGCAACTCATGAGTATGGGAGAGTTGCCTCTATGGCAGTTGAGC
AGGCACGCTCTCAAATTGCAGAAACTATTAATGCCTCACCCCAAGAAATAGTGTTTACATCAGGAGCTACAGAAGCAGAT
AATTTGGCGATTTTAGGAGCTGCACGGTTTTATAAAAATAAAGGAATGCATCTGGTTACTATGAGCACTGAACACAAAGC
TGTGCTTGACAGCTTTCACCAACTGGAAAAAGAAGGCTTTGAAGTCACTTACCTTAATCCGGAATCAGATGGTTTGTTGG
ATCTTGGAAAACTGGAATCTGCTCTTAGGTCAGATACTATTCTGGTTTCTGTCATGCATGTTAATAATGAAATTGGTGTC
ATCCAAGATATTGCATCTATTGGTGAGCTATTACGAAACAGGGGAATTATATTTCATGTTGACGCGGCTCAAAGTGCTGG
TAAATTGCCAATCGATTTGAGCCAGCTTTCAGTTGATTTGATGTCATTCTCTGCTCATAAAAATTATGGGCCTAAAGGTG
TAGGGGCTCTGTATGTCAGTCATAAGCCAAGGATTCGTTTACAGCCTTTAAGTTACGGTGGCGGGCATGAGGGTGGATTG
CGCTCAGGAACATTACCTACCCATCAAATTGTCGGCATGGGAGAGGCTTTTGCTATTGCAGAGGCTGATAGAATTCCTGA
ACAGACGCGTATTCTAAATTTACGCAAACAACTTTGGGACGGAATACGACATTTACCGGCTATTAAACTGAATGGACATG
AGCACAGGCGTATCGCTGGAAATCTGAATGTGAGTTTTGCTGGATTAAATGGAGATTCATTGCTGTTTGCTTTAAGTGAG
TTAGCGATATCAACTACTTCTGCCTGTTCTTCTGCCAGTATTCAACCATCTTATGTCTTAAGGGCAATTGGTTTGACTGA
TACAGAGGCGCAATCAACTATTCGCTTATCCATAGGACGCTTCACTTCCGAGGTGCAAATAAAGAGGGCAATTGATATAA
TTTGCACACAAGTGAGTCGGTTGCACGAATTATCGCCGTTATGA

Upstream 100 bases:

>100_bases
ATCAACCTTGAAAAAATGGAAGTTAGTATTTTAAGAGGTATGCTTAGCCAGGTTCAGAAATCATTGGAGTGGGCAAGGAA
AGACAATAGGAGCGATAGAA

Downstream 100 bases:

>100_bases
TGTATAATAAAATTGTACAGGATTATTTTTTTCAGCCACAACATATTGGTAAGCTGGATTTAAATGATCCTTTTGTAATA
GGTGTACAAAGTCAACCGAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MAIKSIYFDYMATTPVDPRVVEQMIKYLGPEGDFGNPASATHEYGRVASMAVEQARSQIAETINASPQEIVFTSGATEAD
NLAILGAARFYKNKGMHLVTMSTEHKAVLDSFHQLEKEGFEVTYLNPESDGLLDLGKLESALRSDTILVSVMHVNNEIGV
IQDIASIGELLRNRGIIFHVDAAQSAGKLPIDLSQLSVDLMSFSAHKNYGPKGVGALYVSHKPRIRLQPLSYGGGHEGGL
RSGTLPTHQIVGMGEAFAIAEADRIPEQTRILNLRKQLWDGIRHLPAIKLNGHEHRRIAGNLNVSFAGLNGDSLLFALSE
LAISTTSACSSASIQPSYVLRAIGLTDTEAQSTIRLSIGRFTSEVQIKRAIDIICTQVSRLHELSPL

Sequences:

>Translated_387_residues
MAIKSIYFDYMATTPVDPRVVEQMIKYLGPEGDFGNPASATHEYGRVASMAVEQARSQIAETINASPQEIVFTSGATEAD
NLAILGAARFYKNKGMHLVTMSTEHKAVLDSFHQLEKEGFEVTYLNPESDGLLDLGKLESALRSDTILVSVMHVNNEIGV
IQDIASIGELLRNRGIIFHVDAAQSAGKLPIDLSQLSVDLMSFSAHKNYGPKGVGALYVSHKPRIRLQPLSYGGGHEGGL
RSGTLPTHQIVGMGEAFAIAEADRIPEQTRILNLRKQLWDGIRHLPAIKLNGHEHRRIAGNLNVSFAGLNGDSLLFALSE
LAISTTSACSSASIQPSYVLRAIGLTDTEAQSTIRLSIGRFTSEVQIKRAIDIICTQVSRLHELSPL
>Mature_386_residues
AIKSIYFDYMATTPVDPRVVEQMIKYLGPEGDFGNPASATHEYGRVASMAVEQARSQIAETINASPQEIVFTSGATEADN
LAILGAARFYKNKGMHLVTMSTEHKAVLDSFHQLEKEGFEVTYLNPESDGLLDLGKLESALRSDTILVSVMHVNNEIGVI
QDIASIGELLRNRGIIFHVDAAQSAGKLPIDLSQLSVDLMSFSAHKNYGPKGVGALYVSHKPRIRLQPLSYGGGHEGGLR
SGTLPTHQIVGMGEAFAIAEADRIPEQTRILNLRKQLWDGIRHLPAIKLNGHEHRRIAGNLNVSFAGLNGDSLLFALSEL
AISTTSACSSASIQPSYVLRAIGLTDTEAQSTIRLSIGRFTSEVQIKRAIDIICTQVSRLHELSPL

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=386, Percent_Identity=50, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI156713448, Length=419, Percent_Identity=30.0715990453461, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI48994898, Length=382, Percent_Identity=60.7329842931937, Blast_Score=489, Evalue=1e-140,
Organism=Escherichia coli, GI1787970, Length=283, Percent_Identity=28.9752650176678, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789175, Length=396, Percent_Identity=24.7474747474747, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25143064, Length=386, Percent_Identity=50.259067357513, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17533177, Length=326, Percent_Identity=33.7423312883436, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319831, Length=384, Percent_Identity=50, Blast_Score=385, Evalue=1e-108,
Organism=Drosophila melanogaster, GI20129463, Length=385, Percent_Identity=50.3896103896104, Blast_Score=380, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42040; Mature: 41908

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKSIYFDYMATTPVDPRVVEQMIKYLGPEGDFGNPASATHEYGRVASMAVEQARSQIA
CCCHHEEHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ETINASPQEIVFTSGATEADNLAILGAARFYKNKGMHLVTMSTEHKAVLDSFHQLEKEGF
HHHCCCCCEEEEECCCCCCCCEEEEEHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCC
EVTYLNPESDGLLDLGKLESALRSDTILVSVMHVNNEIGVIQDIASIGELLRNRGIIFHV
EEEEECCCCCCCEEHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEE
DAAQSAGKLPIDLSQLSVDLMSFSAHKNYGPKGVGALYVSHKPRIRLQPLSYGGGHEGGL
ECCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCC
RSGTLPTHQIVGMGEAFAIAEADRIPEQTRILNLRKQLWDGIRHLPAIKLNGHEHRRIAG
CCCCCCCHHHCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEC
NLNVSFAGLNGDSLLFALSELAISTTSACSSASIQPSYVLRAIGLTDTEAQSTIRLSIGR
CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEECCCCCCCCCEEEEEECC
FTSEVQIKRAIDIICTQVSRLHELSPL
CCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AIKSIYFDYMATTPVDPRVVEQMIKYLGPEGDFGNPASATHEYGRVASMAVEQARSQIA
CCHHEEHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ETINASPQEIVFTSGATEADNLAILGAARFYKNKGMHLVTMSTEHKAVLDSFHQLEKEGF
HHHCCCCCEEEEECCCCCCCCEEEEEHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCC
EVTYLNPESDGLLDLGKLESALRSDTILVSVMHVNNEIGVIQDIASIGELLRNRGIIFHV
EEEEECCCCCCCEEHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEE
DAAQSAGKLPIDLSQLSVDLMSFSAHKNYGPKGVGALYVSHKPRIRLQPLSYGGGHEGGL
ECCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCC
RSGTLPTHQIVGMGEAFAIAEADRIPEQTRILNLRKQLWDGIRHLPAIKLNGHEHRRIAG
CCCCCCCHHHCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEC
NLNVSFAGLNGDSLLFALSELAISTTSACSSASIQPSYVLRAIGLTDTEAQSTIRLSIGR
CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEECCCCCCCCCEEEEEECC
FTSEVQIKRAIDIICTQVSRLHELSPL
CCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA