Click here to switch to the map view.

The map label for this gene is rnhA [H]

Identifier: 54294269

GI number: 54294269

Start: 1492925

End: 1493356

Strand: Direct

Name: rnhA [H]

Synonym: lpl1334

Alternate gene names: 54294269

Gene position: 1492925-1493356 (Clockwise)

Preceding gene: 54294268

Following gene: 54294270

Centisome position: 44.62

GC content: 39.81

Gene sequence:

>432_bases
ATGAAGGTAGAAATCTATACTGATGGTGCATGTAAGGGAAATCCAGGACCTGGCGGCTGGGGCGTATTACTCCGATATAA
TGGTAGAGAAAAAACTCTTCATGGAGGAGAGCCGCAAACTACCAATAATCGCATGGAATTAATGGCAGCAATTAAGGGGC
TGGAAGCATTAAAACGTCCTTGTGAGGTGGATTTGTATACCGACTCCCAATATTTGCAGCAAGGAATGAAGGAATGGATC
AAAACATGGAAAAGAAATGGTTGGCGTAACTCCAAGAAAGAGTTGGTTAAAAATGCGGAATTATGGAAATCATTAGATAA
TCTGGCTTCTATTCATAATATTAATTGGCATTGGGTTAAAGGGCACTCAGGTCATTTGGAAAATGATTTGGTTGATGCTT
TGGCAAATTTGGGTATTGAGGAATTATCATAG

Upstream 100 bases:

>100_bases
ATTTTTTTATTGATGAAGACGTATTAAAAAATAGTGGTGTCACTGATTTTTCTTGCTATGCTATGAACCCTAAAGTTCAA
CTTTGTCCTGATTTATTTTT

Downstream 100 bases:

>100_bases
AGTTATGAGACAAGTTATATTAGATACTGAAACGACTGGTATTGGACCTGAACAGGGACATAGAGTAATTGAAATAGGTT
GTATTGAGCTCATTGATAGA

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 143; Mature: 143

Protein sequence:

>143_residues
MKVEIYTDGACKGNPGPGGWGVLLRYNGREKTLHGGEPQTTNNRMELMAAIKGLEALKRPCEVDLYTDSQYLQQGMKEWI
KTWKRNGWRNSKKELVKNAELWKSLDNLASIHNINWHWVKGHSGHLENDLVDALANLGIEELS

Sequences:

>Translated_143_residues
MKVEIYTDGACKGNPGPGGWGVLLRYNGREKTLHGGEPQTTNNRMELMAAIKGLEALKRPCEVDLYTDSQYLQQGMKEWI
KTWKRNGWRNSKKELVKNAELWKSLDNLASIHNINWHWVKGHSGHLENDLVDALANLGIEELS
>Mature_143_residues
MKVEIYTDGACKGNPGPGGWGVLLRYNGREKTLHGGEPQTTNNRMELMAAIKGLEALKRPCEVDLYTDSQYLQQGMKEWI
KTWKRNGWRNSKKELVKNAELWKSLDNLASIHNINWHWVKGHSGHLENDLVDALANLGIEELS

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=154, Percent_Identity=34.4155844155844, Blast_Score=78, Evalue=3e-15,
Organism=Escherichia coli, GI1786408, Length=134, Percent_Identity=60.4477611940298, Blast_Score=175, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI115532542, Length=141, Percent_Identity=36.1702127659575, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45552509, Length=149, Percent_Identity=34.2281879194631, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137476, Length=149, Percent_Identity=34.2281879194631, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 16256; Mature: 16256

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVEIYTDGACKGNPGPGGWGVLLRYNGREKTLHGGEPQTTNNRMELMAAIKGLEALKRP
CEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
CEVDLYTDSQYLQQGMKEWIKTWKRNGWRNSKKELVKNAELWKSLDNLASIHNINWHWVK
CCEEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
GHSGHLENDLVDALANLGIEELS
CCCCCCHHHHHHHHHHCCHHHCC
>Mature Secondary Structure
MKVEIYTDGACKGNPGPGGWGVLLRYNGREKTLHGGEPQTTNNRMELMAAIKGLEALKRP
CEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
CEVDLYTDSQYLQQGMKEWIKTWKRNGWRNSKKELVKNAELWKSLDNLASIHNINWHWVK
CCEEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
GHSGHLENDLVDALANLGIEELS
CCCCCCHHHHHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA