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The map label for this gene is gdhII [H]

Identifier: 54294268

GI number: 54294268

Start: 1492119

End: 1492928

Strand: Direct

Name: gdhII [H]

Synonym: lpl1333

Alternate gene names: 54294268

Gene position: 1492119-1492928 (Clockwise)

Preceding gene: 54294267

Following gene: 54294269

Centisome position: 44.6

GC content: 37.65

Gene sequence:

>810_bases
ATGAATAAAGTCATTTTTATTACGGGTGGCAGCAGAGGAATTGGTAGAGAAATCGCTTTGAAGTTTGCAGCAAAAGATAA
AGCTAATATCGTTATTGCAGCGAAAACAGCAGAACCTCATCCTAAATTGGAAGGAACTATTTATTCAGTTGCAAAAGAAA
TTGAAGAGTTAGGCGGACAAGCCCTGCCTTTAATGGTTGATGTTAGAGATGAGCAACAGATCCAAAATGCGATCACTAAA
ACCATAGAAACTTTTGGAAGATTGGATGTATTAGTCAATAACGCGAGCGCAATCAATTTGACTGATACATTAAATACTCC
AATGAGGCGTTATGATCTCATGCAGAGCGTTAATGTCAGGTCAACGTTTGCATGTTCTCAAGCAGCCATTCCATATCTTT
TAAAAAGCGAGAATCCGCATATTCTGACTTTGTCTCCGCCTTTAAATATGGATAAAACCTGGTTTGCACCACATCTGGCT
TATACTATCAGTAAATACGGTATGAGCATGTGCACATTAGGCTTCGCTGAGGAATTTAAAGAGGCGGGAATCGCTGTTAA
TTCTTTATGGCCGAAAACTACTATAGCTACTGATGCCATAAGAGTTCATTTTCCCAGTGAGCTGTATATGGCAAGCAGAA
AGCCACTCATTATGGCTGATGCTGCTTATTGGATTATCAATCAACCATCAAAATCAATCACTGGAAATTTTTTTATTGAT
GAAGACGTATTAAAAAATAGTGGTGTCACTGATTTTTCTTGCTATGCTATGAACCCTAAAGTTCAACTTTGTCCTGATTT
ATTTTTATGA

Upstream 100 bases:

>100_bases
AGCGATTTATATCTACAGTGAGCTGGTTATACCCACCCTATGGTGCTTTTATGCGTATGTTTTTGGCTTGGGTTGGTGGT
ATCAAGTAGAAGGAGAAATC

Downstream 100 bases:

>100_bases
AGGTAGAAATCTATACTGATGGTGCATGTAAGGGAAATCCAGGACCTGGCGGCTGGGGCGTATTACTCCGATATAATGGT
AGAGAAAAAACTCTTCATGG

Product: short chain dehydrogenase

Products: NA

Alternate protein names: GLCDH-II [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MNKVIFITGGSRGIGREIALKFAAKDKANIVIAAKTAEPHPKLEGTIYSVAKEIEELGGQALPLMVDVRDEQQIQNAITK
TIETFGRLDVLVNNASAINLTDTLNTPMRRYDLMQSVNVRSTFACSQAAIPYLLKSENPHILTLSPPLNMDKTWFAPHLA
YTISKYGMSMCTLGFAEEFKEAGIAVNSLWPKTTIATDAIRVHFPSELYMASRKPLIMADAAYWIINQPSKSITGNFFID
EDVLKNSGVTDFSCYAMNPKVQLCPDLFL

Sequences:

>Translated_269_residues
MNKVIFITGGSRGIGREIALKFAAKDKANIVIAAKTAEPHPKLEGTIYSVAKEIEELGGQALPLMVDVRDEQQIQNAITK
TIETFGRLDVLVNNASAINLTDTLNTPMRRYDLMQSVNVRSTFACSQAAIPYLLKSENPHILTLSPPLNMDKTWFAPHLA
YTISKYGMSMCTLGFAEEFKEAGIAVNSLWPKTTIATDAIRVHFPSELYMASRKPLIMADAAYWIINQPSKSITGNFFID
EDVLKNSGVTDFSCYAMNPKVQLCPDLFL
>Mature_269_residues
MNKVIFITGGSRGIGREIALKFAAKDKANIVIAAKTAEPHPKLEGTIYSVAKEIEELGGQALPLMVDVRDEQQIQNAITK
TIETFGRLDVLVNNASAINLTDTLNTPMRRYDLMQSVNVRSTFACSQAAIPYLLKSENPHILTLSPPLNMDKTWFAPHLA
YTISKYGMSMCTLGFAEEFKEAGIAVNSLWPKTTIATDAIRVHFPSELYMASRKPLIMADAAYWIINQPSKSITGNFFID
EDVLKNSGVTDFSCYAMNPKVQLCPDLFL

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254986, Length=265, Percent_Identity=60.7547169811321, Blast_Score=314, Evalue=6e-86,
Organism=Homo sapiens, GI209862901, Length=214, Percent_Identity=29.4392523364486, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI19923983, Length=214, Percent_Identity=29.4392523364486, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI19923817, Length=205, Percent_Identity=24.390243902439, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI87082100, Length=209, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1789208, Length=191, Percent_Identity=28.2722513089005, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787905, Length=199, Percent_Identity=29.6482412060301, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787335, Length=204, Percent_Identity=29.9019607843137, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082160, Length=190, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788459, Length=192, Percent_Identity=28.6458333333333, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789378, Length=192, Percent_Identity=28.125, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=269, Percent_Identity=57.2490706319703, Blast_Score=322, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17558628, Length=268, Percent_Identity=54.1044776119403, Blast_Score=301, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17544670, Length=195, Percent_Identity=28.2051282051282, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=234, Percent_Identity=29.0598290598291, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=232, Percent_Identity=27.1551724137931, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=194, Percent_Identity=25.2577319587629, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=203, Percent_Identity=30.0492610837438, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=197, Percent_Identity=31.4720812182741, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=195, Percent_Identity=27.1794871794872, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=199, Percent_Identity=30.1507537688442, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=198, Percent_Identity=30.3030303030303, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=198, Percent_Identity=29.7979797979798, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=194, Percent_Identity=27.8350515463918, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=200, Percent_Identity=26.5, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21357673, Length=255, Percent_Identity=57.6470588235294, Blast_Score=316, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24644339, Length=209, Percent_Identity=32.5358851674641, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357041, Length=210, Percent_Identity=31.4285714285714, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571526, Length=209, Percent_Identity=31.1004784688995, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI23397609, Length=191, Percent_Identity=30.3664921465969, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI18859837, Length=225, Percent_Identity=28, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355319, Length=209, Percent_Identity=28.7081339712919, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.47 [H]

Molecular weight: Translated: 29772; Mature: 29772

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVIFITGGSRGIGREIALKFAAKDKANIVIAAKTAEPHPKLEGTIYSVAKEIEELGGQ
CCEEEEEECCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
ALPLMVDVRDEQQIQNAITKTIETFGRLDVLVNNASAINLTDTLNTPMRRYDLMQSVNVR
CCEEEEECCCHHHHHHHHHHHHHHHHCEEEEEECCCEEEEHHCCCCHHHHHHHHHHCCCC
STFACSQAAIPYLLKSENPHILTLSPPLNMDKTWFAPHLAYTISKYGMSMCTLGFAEEFK
HHHHHHHHCCCEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHH
EAGIAVNSLWPKTTIATDAIRVHFPSELYMASRKPLIMADAAYWIINQPSKSITGNFFID
HCCEEEECCCCCCEEEECEEEEECCHHHHHHCCCCEEEECCEEEEEECCCCCCCCCEEEC
EDVLKNSGVTDFSCYAMNPKVQLCPDLFL
HHHHHCCCCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MNKVIFITGGSRGIGREIALKFAAKDKANIVIAAKTAEPHPKLEGTIYSVAKEIEELGGQ
CCEEEEEECCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
ALPLMVDVRDEQQIQNAITKTIETFGRLDVLVNNASAINLTDTLNTPMRRYDLMQSVNVR
CCEEEEECCCHHHHHHHHHHHHHHHHCEEEEEECCCEEEEHHCCCCHHHHHHHHHHCCCC
STFACSQAAIPYLLKSENPHILTLSPPLNMDKTWFAPHLAYTISKYGMSMCTLGFAEEFK
HHHHHHHHCCCEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHH
EAGIAVNSLWPKTTIATDAIRVHFPSELYMASRKPLIMADAAYWIINQPSKSITGNFFID
HCCEEEECCCCCCEEEECEEEEECCHHHHHHCCCCEEEECCEEEEEECCCCCCCCCEEEC
EDVLKNSGVTDFSCYAMNPKVQLCPDLFL
HHHHHCCCCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA