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The map label for this gene is fadA [H]

Identifier: 54294241

GI number: 54294241

Start: 1460963

End: 1462147

Strand: Direct

Name: fadA [H]

Synonym: lpl1306

Alternate gene names: 54294241

Gene position: 1460963-1462147 (Clockwise)

Preceding gene: 54294240

Following gene: 54294242

Centisome position: 43.67

GC content: 40.93

Gene sequence:

>1185_bases
ATGACTGACGTATATGTAGTTGACGTATTACGTACACCAGTAGGTAAAGCACCAAGAGGTGTTTTTAAAAACACATTACC
CGATGATTTATTGGCTCATACTATAAAATGTTTAATACATAGACATCAAAACATTGATTGGCAAGAGATAGCTGACGTAG
TAATAGGTTGTGCAATGCCAGAAGCGGAACAAGGTATGAATGTAGCAAGAATCGCTTCTTTATTGGCTGATCTTCCACAA
TCTGTTCCGGCAATGACTATTAATCGTTTTTGCTCATCTGGCATACAAAGTATAGTTACTGCAGCAGATACAATCCGTAA
TCAGGAGGCTCATTTAGCACTAGGTGGCGGTGTCGAAAGCATGTCCATGGTACCTATGGGTGGAAATAAATACACGGCGA
ATCCATCCATTTTTAATGATGAGCACGTTGCTATAGCTTATGGCATGGGGATTACAGCAGAAAACGTTGCCAAACGTTGG
GAAATTACTCGAGAGCAACAGGATGAATTTGCAATAGAAAGTCACAAAAAAGCAATTGCAGCGCAGGAAAGACTCGATTT
CAACGCTGAAATAAGTCCTATCGAAATATCAGTTAGATGTCCTGATCTGAATACTTCAAAGGTTGAAATAAAGAAAAAAT
TGATAAATAAGGACGAAGGGCCTAGAGCAGATACCTCTTATGAAGCTATTTCTAAATTAAAACCCGTATTTTCTTTAAAA
GGGACAGTGACAGCAGGAAATAGTTCTCAGATGAGTGACGGAGCCGGAATTGCATTATTAGCCAGTGAGAAGGCTTTAAA
ACAGTATGATTTAAAACCTTTAGGCCGTTTAATGAGCTATGCTGTTGCGGGAGTACCGCCTGAAATCATGGGAATCGGAC
CAGTAAAGGCAATTCCTATGGCGCTAAAGCGCGCTGGAATTACTTTAGATCAATTGGATTGGATTGAATTGAATGAAGCT
TTTGCTGCCCAAGCTTTGGCGGTTATTAAAGACCTTGACCTACCCGGAGAGAAAGTTAACCCTTTAGGTGGGGCTATTGC
TTTGGGACATCCTTTAGGAGCAACGGGTACCATAAGAACAGCTACATTACTACATGGATTGAGAAGAACAAAAGGGCGCT
ACGGTATGGTAACCATGTGTATTGGAACCGGAATGGGCGCTGCTGCAATATTTGAAGCGTTATAG

Upstream 100 bases:

>100_bases
AGCATTCATAAAATTAGCCAATACATCATTAACCCAAGCCAGAATCAGTCATCTGCTAGAGACTGGTAAACCACTGCGCA
ACTAAGCAAGGAGAATTAGG

Downstream 100 bases:

>100_bases
AAGATATAATCCAGATTTAAATTCTATACACTATTGTAGTTTAAAGAATTGTAATGCTTCCCGTGTTTATTTTATAAATA
CGGGAAGAAAATTGTTAATC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTDVYVVDVLRTPVGKAPRGVFKNTLPDDLLAHTIKCLIHRHQNIDWQEIADVVIGCAMPEAEQGMNVARIASLLADLPQ
SVPAMTINRFCSSGIQSIVTAADTIRNQEAHLALGGGVESMSMVPMGGNKYTANPSIFNDEHVAIAYGMGITAENVAKRW
EITREQQDEFAIESHKKAIAAQERLDFNAEISPIEISVRCPDLNTSKVEIKKKLINKDEGPRADTSYEAISKLKPVFSLK
GTVTAGNSSQMSDGAGIALLASEKALKQYDLKPLGRLMSYAVAGVPPEIMGIGPVKAIPMALKRAGITLDQLDWIELNEA
FAAQALAVIKDLDLPGEKVNPLGGAIALGHPLGATGTIRTATLLHGLRRTKGRYGMVTMCIGTGMGAAAIFEAL

Sequences:

>Translated_394_residues
MTDVYVVDVLRTPVGKAPRGVFKNTLPDDLLAHTIKCLIHRHQNIDWQEIADVVIGCAMPEAEQGMNVARIASLLADLPQ
SVPAMTINRFCSSGIQSIVTAADTIRNQEAHLALGGGVESMSMVPMGGNKYTANPSIFNDEHVAIAYGMGITAENVAKRW
EITREQQDEFAIESHKKAIAAQERLDFNAEISPIEISVRCPDLNTSKVEIKKKLINKDEGPRADTSYEAISKLKPVFSLK
GTVTAGNSSQMSDGAGIALLASEKALKQYDLKPLGRLMSYAVAGVPPEIMGIGPVKAIPMALKRAGITLDQLDWIELNEA
FAAQALAVIKDLDLPGEKVNPLGGAIALGHPLGATGTIRTATLLHGLRRTKGRYGMVTMCIGTGMGAAAIFEAL
>Mature_393_residues
TDVYVVDVLRTPVGKAPRGVFKNTLPDDLLAHTIKCLIHRHQNIDWQEIADVVIGCAMPEAEQGMNVARIASLLADLPQS
VPAMTINRFCSSGIQSIVTAADTIRNQEAHLALGGGVESMSMVPMGGNKYTANPSIFNDEHVAIAYGMGITAENVAKRWE
ITREQQDEFAIESHKKAIAAQERLDFNAEISPIEISVRCPDLNTSKVEIKKKLINKDEGPRADTSYEAISKLKPVFSLKG
TVTAGNSSQMSDGAGIALLASEKALKQYDLKPLGRLMSYAVAGVPPEIMGIGPVKAIPMALKRAGITLDQLDWIELNEAF
AAQALAVIKDLDLPGEKVNPLGGAIALGHPLGATGTIRTATLLHGLRRTKGRYGMVTMCIGTGMGAAAIFEAL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=46.8030690537084, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=40.4466501240695, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=38.7909319899244, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4557237, Length=406, Percent_Identity=33.2512315270936, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI4504327, Length=437, Percent_Identity=30.8924485125858, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI194353979, Length=244, Percent_Identity=35.655737704918, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=43.0730478589421, Blast_Score=288, Evalue=5e-79,
Organism=Escherichia coli, GI1787663, Length=409, Percent_Identity=40.8312958435208, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1788554, Length=407, Percent_Identity=41.2776412776413, Blast_Score=261, Evalue=4e-71,
Organism=Escherichia coli, GI87082165, Length=409, Percent_Identity=36.6748166259169, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1788683, Length=438, Percent_Identity=31.5068493150685, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI133906874, Length=402, Percent_Identity=38.5572139303483, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17535921, Length=407, Percent_Identity=35.6265356265356, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=32.8358208955224, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=440, Percent_Identity=31.3636363636364, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=29.7979797979798, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322031, Length=401, Percent_Identity=40.6483790523691, Blast_Score=257, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6325229, Length=407, Percent_Identity=34.3980343980344, Blast_Score=204, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24655093, Length=410, Percent_Identity=40, Blast_Score=271, Evalue=8e-73,
Organism=Drosophila melanogaster, GI17648125, Length=408, Percent_Identity=38.9705882352941, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24640423, Length=409, Percent_Identity=34.9633251833741, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI17137578, Length=436, Percent_Identity=30.9633027522936, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42162; Mature: 42031

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVYVVDVLRTPVGKAPRGVFKNTLPDDLLAHTIKCLIHRHQNIDWQEIADVVIGCAMP
CCCEEEEEEHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
EAEQGMNVARIASLLADLPQSVPAMTINRFCSSGIQSIVTAADTIRNQEAHLALGGGVES
CHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
MSMVPMGGNKYTANPSIFNDEHVAIAYGMGITAENVAKRWEITREQQDEFAIESHKKAIA
EEEEECCCCEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQERLDFNAEISPIEISVRCPDLNTSKVEIKKKLINKDEGPRADTSYEAISKLKPVFSLK
HHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCHHHCCC
GTVTAGNSSQMSDGAGIALLASEKALKQYDLKPLGRLMSYAVAGVPPEIMGIGPVKAIPM
CEEECCCCCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHH
ALKRAGITLDQLDWIELNEAFAAQALAVIKDLDLPGEKVNPLGGAIALGHPLGATGTIRT
HHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCHHH
ATLLHGLRRTKGRYGMVTMCIGTGMGAAAIFEAL
HHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHCC
>Mature Secondary Structure 
TDVYVVDVLRTPVGKAPRGVFKNTLPDDLLAHTIKCLIHRHQNIDWQEIADVVIGCAMP
CCEEEEEEHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
EAEQGMNVARIASLLADLPQSVPAMTINRFCSSGIQSIVTAADTIRNQEAHLALGGGVES
CHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
MSMVPMGGNKYTANPSIFNDEHVAIAYGMGITAENVAKRWEITREQQDEFAIESHKKAIA
EEEEECCCCEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQERLDFNAEISPIEISVRCPDLNTSKVEIKKKLINKDEGPRADTSYEAISKLKPVFSLK
HHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCHHHCCC
GTVTAGNSSQMSDGAGIALLASEKALKQYDLKPLGRLMSYAVAGVPPEIMGIGPVKAIPM
CEEECCCCCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHH
ALKRAGITLDQLDWIELNEAFAAQALAVIKDLDLPGEKVNPLGGAIALGHPLGATGTIRT
HHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCHHH
ATLLHGLRRTKGRYGMVTMCIGTGMGAAAIFEAL
HHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]