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The map label for this gene is fadN [H]

Identifier: 54294240

GI number: 54294240

Start: 1458578

End: 1460947

Strand: Direct

Name: fadN [H]

Synonym: lpl1305

Alternate gene names: 54294240

Gene position: 1458578-1460947 (Clockwise)

Preceding gene: 54294239

Following gene: 54294241

Centisome position: 43.6

GC content: 39.41

Gene sequence:

>2370_bases
ATGCAGGAGCCTTTTTTCATTAAAAAAGTTGCGGTTTTAGGGGCTGGCGTCATGGGTGCTCAAATTGCAGCACACTGCGT
TAATGCCGGAATAGAGACTTTACTGTTTGATTTAGCTGGCAAAGAAGGGCCTAAAAACAGTTTGGTCGATAAAGCTATTG
CCAATTTAGGTAAACTAAAACCAACTCCTCTTGCAACTCCCCAAACCAATGAGTTATTACAAGCAAAGAATTACGCGGAA
AATTTGGAAGAGTTATCTTCTTGTGATTTAGTCATAGAGGCGATAGCGGAACGTATAGATTGGAAAGAGGACTTATACAA
GCGAATTTCGCCTTATTTATCTGATAAAACAATTTTAGTTAGTAATACATCAGGGCTAAGTATTAATAAGCTATGTGAGG
TATTACCTGCGCAGCATAGGTCCAATTTTTGTGGAGTCCATTTTTTTAATCCACCGCGTTACATGCATTTGGCAGAACTA
ATTCCTGCCAATACCACATCATCTGATTTGCTCGATTATTTGGAAACATGGTTAACCGAGTATTTGGGCAAAGGAGTTGT
GAGAGCGAAAGACACTCCCAATTTTATCGCAAATCGAATAGGAGTCTTTTCACTATTAACTACCTTGCATCATACTTTAG
CTATGAATATGGGAATTGATGAAGTGGATGCCTTGACTGGTCCATTATTAGGAAGACCGAAATCTGCAACTTTTCGTACC
ATGGATGTGGTTGGTTTGGATACTATGCAACACGTTATTAATACCATGCAGTCTCAATTAACTGGTGATCCATGGCATAA
AATGTTTATTCTGCCGGACTGGTTGAATGGTTTAATTAAGGAAGGTCATTTAGGGCAAAAATCTGGCCAAGGAATTTACC
GAAAAGCAGGTAAAGTAATAGAAGTTTATGATATTCAAACTGGTCAATATAGACCATCTCGAGCAGAAGTGAGTGATGAA
CTGAAAGCGATAATGGATATTAAAGATCCTGAAGCTCGAATGAAGAATTTAATGACATCAAATAATAAGCAAGCTCAATT
TTTGGCGGCTTGCTTTAGAGATTTATTCCATTACTGTGCGTATCATTTGGAAGAAATTGCTGATAATGCAAGAGATGTTG
ATCTGGCAATTCGCTGGGGATTTGGATGGTCGCAAGGACCATTTGAAACTTGGCAGCTTTCTGATTTACACAGTGTGACT
CGACAAATCGATGAATCAATACAGAATAATACGGCATTATCAGGCGCAAAACTACCTGAGTGGTTATATGAAATAAAGGA
ATTTTACACACGAGAAGGCGCTTATTCGCCTGGTAAAAACAATTATCACGCCAGAAGTCAGTTACCTGTTTACCATAAAC
AATTCTTCCATGACAGGGTATTAAAGGAGTCACATCATCCTGTTCATGTTATTTATGAAAATGAGGGTGTTTGTTTGTGG
TACTTAAAAGATGATGTGGCTGTGATTAGTTTTAAAAGCAAAGCCAATACAATTGGTCAATCAGTTCTCGATGGCATAGA
GACTGCTTTGGATATCGCAGAACGGGATTACCAGGGATTAATTATTTATCAACAAGATGCATCCAATTTTAGTTCAGGAG
CTGATCTACGTGGCGTCTCCAAATTATTAACAGATGGAACAATACAAGCGCTTGAACATATGGTAGAGCAATTTCAACGG
GTAGCAATGCGCTTAAAATATAGTTCAATTCCAACTGTAGCTGCTTTAAGAGGTCGAGCATTAGGAGGTGGTTGTGAATT
AATGATGCATTGTGATTCTATTGTTGCTGCTTTTGAATCTTATCCCGGTTTAGTTGAGGCTGGAGTCGGAGTTATACCTG
CTGGTGGTGGTTGCAAAGAGCTCGCTATGCGTTCAGCACATCATGCCCAACAAGCTGATTTATTAACTTTTATATTGCCA
GTTTTTCAGCAAATAGCAACTGCAAAAGTAGCTGCAAGTGCGGTGGAAGCCAGAAATATGGGATATCTGCGCGCGGCTGA
TTCTATTCTAATGCATGCTGATGAGGTTTTATATGCCTCTTTAGAAAAAATCAAAGCCATGCGAGCTGCTAATTATCTTC
CTCCTATGAAAAAACAACGATTTAAAGTGGCAGGTATAGAGGGGCATGCTCGATTACAATCCGGTCTAGTGAACTGGTTG
GAAGGTGGATTTATATCACAGCATGATTATTTTCTGGCGAATGAATTGGCGAAAGTGTTGTGTGGTGGGGATGTCAATCA
CGGAACCTTGGTTGATGAACAATGGATGCTAAAGTTGGAAAGAGAAGCATTCATAAAATTAGCCAATACATCATTAACCC
AAGCCAGAATCAGTCATCTGCTAGAGACTGGTAAACCACTGCGCAACTAA

Upstream 100 bases:

>100_bases
TCAACAGATTATTGCTCCTTTTAGCCAATGGTAAGTGCCTGTTACCTGTAAATCTCACTCATAGAGGTATCAATCGATTA
TTAACAAGAGGATAATAACA

Downstream 100 bases:

>100_bases
GCAAGGAGAATTAGGATGACTGACGTATATGTAGTTGACGTATTACGTACACCAGTAGGTAAAGCACCAAGAGGTGTTTT
TAAAAACACATTACCCGATG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 789; Mature: 789

Protein sequence:

>789_residues
MQEPFFIKKVAVLGAGVMGAQIAAHCVNAGIETLLFDLAGKEGPKNSLVDKAIANLGKLKPTPLATPQTNELLQAKNYAE
NLEELSSCDLVIEAIAERIDWKEDLYKRISPYLSDKTILVSNTSGLSINKLCEVLPAQHRSNFCGVHFFNPPRYMHLAEL
IPANTTSSDLLDYLETWLTEYLGKGVVRAKDTPNFIANRIGVFSLLTTLHHTLAMNMGIDEVDALTGPLLGRPKSATFRT
MDVVGLDTMQHVINTMQSQLTGDPWHKMFILPDWLNGLIKEGHLGQKSGQGIYRKAGKVIEVYDIQTGQYRPSRAEVSDE
LKAIMDIKDPEARMKNLMTSNNKQAQFLAACFRDLFHYCAYHLEEIADNARDVDLAIRWGFGWSQGPFETWQLSDLHSVT
RQIDESIQNNTALSGAKLPEWLYEIKEFYTREGAYSPGKNNYHARSQLPVYHKQFFHDRVLKESHHPVHVIYENEGVCLW
YLKDDVAVISFKSKANTIGQSVLDGIETALDIAERDYQGLIIYQQDASNFSSGADLRGVSKLLTDGTIQALEHMVEQFQR
VAMRLKYSSIPTVAALRGRALGGGCELMMHCDSIVAAFESYPGLVEAGVGVIPAGGGCKELAMRSAHHAQQADLLTFILP
VFQQIATAKVAASAVEARNMGYLRAADSILMHADEVLYASLEKIKAMRAANYLPPMKKQRFKVAGIEGHARLQSGLVNWL
EGGFISQHDYFLANELAKVLCGGDVNHGTLVDEQWMLKLEREAFIKLANTSLTQARISHLLETGKPLRN

Sequences:

>Translated_789_residues
MQEPFFIKKVAVLGAGVMGAQIAAHCVNAGIETLLFDLAGKEGPKNSLVDKAIANLGKLKPTPLATPQTNELLQAKNYAE
NLEELSSCDLVIEAIAERIDWKEDLYKRISPYLSDKTILVSNTSGLSINKLCEVLPAQHRSNFCGVHFFNPPRYMHLAEL
IPANTTSSDLLDYLETWLTEYLGKGVVRAKDTPNFIANRIGVFSLLTTLHHTLAMNMGIDEVDALTGPLLGRPKSATFRT
MDVVGLDTMQHVINTMQSQLTGDPWHKMFILPDWLNGLIKEGHLGQKSGQGIYRKAGKVIEVYDIQTGQYRPSRAEVSDE
LKAIMDIKDPEARMKNLMTSNNKQAQFLAACFRDLFHYCAYHLEEIADNARDVDLAIRWGFGWSQGPFETWQLSDLHSVT
RQIDESIQNNTALSGAKLPEWLYEIKEFYTREGAYSPGKNNYHARSQLPVYHKQFFHDRVLKESHHPVHVIYENEGVCLW
YLKDDVAVISFKSKANTIGQSVLDGIETALDIAERDYQGLIIYQQDASNFSSGADLRGVSKLLTDGTIQALEHMVEQFQR
VAMRLKYSSIPTVAALRGRALGGGCELMMHCDSIVAAFESYPGLVEAGVGVIPAGGGCKELAMRSAHHAQQADLLTFILP
VFQQIATAKVAASAVEARNMGYLRAADSILMHADEVLYASLEKIKAMRAANYLPPMKKQRFKVAGIEGHARLQSGLVNWL
EGGFISQHDYFLANELAKVLCGGDVNHGTLVDEQWMLKLEREAFIKLANTSLTQARISHLLETGKPLRN
>Mature_789_residues
MQEPFFIKKVAVLGAGVMGAQIAAHCVNAGIETLLFDLAGKEGPKNSLVDKAIANLGKLKPTPLATPQTNELLQAKNYAE
NLEELSSCDLVIEAIAERIDWKEDLYKRISPYLSDKTILVSNTSGLSINKLCEVLPAQHRSNFCGVHFFNPPRYMHLAEL
IPANTTSSDLLDYLETWLTEYLGKGVVRAKDTPNFIANRIGVFSLLTTLHHTLAMNMGIDEVDALTGPLLGRPKSATFRT
MDVVGLDTMQHVINTMQSQLTGDPWHKMFILPDWLNGLIKEGHLGQKSGQGIYRKAGKVIEVYDIQTGQYRPSRAEVSDE
LKAIMDIKDPEARMKNLMTSNNKQAQFLAACFRDLFHYCAYHLEEIADNARDVDLAIRWGFGWSQGPFETWQLSDLHSVT
RQIDESIQNNTALSGAKLPEWLYEIKEFYTREGAYSPGKNNYHARSQLPVYHKQFFHDRVLKESHHPVHVIYENEGVCLW
YLKDDVAVISFKSKANTIGQSVLDGIETALDIAERDYQGLIIYQQDASNFSSGADLRGVSKLLTDGTIQALEHMVEQFQR
VAMRLKYSSIPTVAALRGRALGGGCELMMHCDSIVAAFESYPGLVEAGVGVIPAGGGCKELAMRSAHHAQQADLLTFILP
VFQQIATAKVAASAVEARNMGYLRAADSILMHADEVLYASLEKIKAMRAANYLPPMKKQRFKVAGIEGHARLQSGLVNWL
EGGFISQHDYFLANELAKVLCGGDVNHGTLVDEQWMLKLEREAFIKLANTSLTQARISHLLETGKPLRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=296, Percent_Identity=31.7567567567568, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI296179427, Length=313, Percent_Identity=30.6709265175719, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI20127408, Length=294, Percent_Identity=27.891156462585, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI68989263, Length=428, Percent_Identity=23.5981308411215, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI261878539, Length=428, Percent_Identity=23.5981308411215, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1787661, Length=327, Percent_Identity=28.4403669724771, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1790281, Length=207, Percent_Identity=28.9855072463768, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788682, Length=250, Percent_Identity=26, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17549919, Length=300, Percent_Identity=30.6666666666667, Blast_Score=117, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17563036, Length=294, Percent_Identity=29.2517006802721, Blast_Score=114, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17553560, Length=298, Percent_Identity=27.5167785234899, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17558304, Length=407, Percent_Identity=28.009828009828, Blast_Score=107, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17508951, Length=419, Percent_Identity=27.2076372315036, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17508953, Length=419, Percent_Identity=27.2076372315036, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25144276, Length=295, Percent_Identity=31.1864406779661, Blast_Score=102, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71985923, Length=412, Percent_Identity=25.2427184466019, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71985930, Length=423, Percent_Identity=23.8770685579196, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921000, Length=444, Percent_Identity=25.2252252252252, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24583077, Length=444, Percent_Identity=25.2252252252252, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24583079, Length=444, Percent_Identity=25.2252252252252, Blast_Score=87, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 87737; Mature: 87737

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEPFFIKKVAVLGAGVMGAQIAAHCVNAGIETLLFDLAGKEGPKNSLVDKAIANLGKLK
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
PTPLATPQTNELLQAKNYAENLEELSSCDLVIEAIAERIDWKEDLYKRISPYLSDKTILV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEE
SNTSGLSINKLCEVLPAQHRSNFCGVHFFNPPRYMHLAELIPANTTSSDLLDYLETWLTE
ECCCCCCHHHHHHHHCHHHCCCCCEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
YLGKGVVRAKDTPNFIANRIGVFSLLTTLHHTLAMNMGIDEVDALTGPLLGRPKSATFRT
HHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEE
MDVVGLDTMQHVINTMQSQLTGDPWHKMFILPDWLNGLIKEGHLGQKSGQGIYRKAGKVI
EHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCCCCCCCHHHHCCCEE
EVYDIQTGQYRPSRAEVSDELKAIMDIKDPEARMKNLMTSNNKQAQFLAACFRDLFHYCA
EEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YHLEEIADNARDVDLAIRWGFGWSQGPFETWQLSDLHSVTRQIDESIQNNTALSGAKLPE
HHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHH
WLYEIKEFYTREGAYSPGKNNYHARSQLPVYHKQFFHDRVLKESHHPVHVIYENEGVCLW
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEE
YLKDDVAVISFKSKANTIGQSVLDGIETALDIAERDYQGLIIYQQDASNFSSGADLRGVS
EEECCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHH
KLLTDGTIQALEHMVEQFQRVAMRLKYSSIPTVAALRGRALGGGCELMMHCDSIVAAFES
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
YPGLVEAGVGVIPAGGGCKELAMRSAHHAQQADLLTFILPVFQQIATAKVAASAVEARNM
CCCHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GYLRAADSILMHADEVLYASLEKIKAMRAANYLPPMKKQRFKVAGIEGHARLQSGLVNWL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEECCCHHHHHHHHHHHHH
EGGFISQHDYFLANELAKVLCGGDVNHGTLVDEQWMLKLEREAFIKLANTSLTQARISHL
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LETGKPLRN
HHCCCCCCC
>Mature Secondary Structure
MQEPFFIKKVAVLGAGVMGAQIAAHCVNAGIETLLFDLAGKEGPKNSLVDKAIANLGKLK
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
PTPLATPQTNELLQAKNYAENLEELSSCDLVIEAIAERIDWKEDLYKRISPYLSDKTILV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEE
SNTSGLSINKLCEVLPAQHRSNFCGVHFFNPPRYMHLAELIPANTTSSDLLDYLETWLTE
ECCCCCCHHHHHHHHCHHHCCCCCEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
YLGKGVVRAKDTPNFIANRIGVFSLLTTLHHTLAMNMGIDEVDALTGPLLGRPKSATFRT
HHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEE
MDVVGLDTMQHVINTMQSQLTGDPWHKMFILPDWLNGLIKEGHLGQKSGQGIYRKAGKVI
EHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCCCCCCCHHHHCCCEE
EVYDIQTGQYRPSRAEVSDELKAIMDIKDPEARMKNLMTSNNKQAQFLAACFRDLFHYCA
EEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YHLEEIADNARDVDLAIRWGFGWSQGPFETWQLSDLHSVTRQIDESIQNNTALSGAKLPE
HHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHH
WLYEIKEFYTREGAYSPGKNNYHARSQLPVYHKQFFHDRVLKESHHPVHVIYENEGVCLW
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEE
YLKDDVAVISFKSKANTIGQSVLDGIETALDIAERDYQGLIIYQQDASNFSSGADLRGVS
EEECCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHH
KLLTDGTIQALEHMVEQFQRVAMRLKYSSIPTVAALRGRALGGGCELMMHCDSIVAAFES
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
YPGLVEAGVGVIPAGGGCKELAMRSAHHAQQADLLTFILPVFQQIATAKVAASAVEARNM
CCCHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GYLRAADSILMHADEVLYASLEKIKAMRAANYLPPMKKQRFKVAGIEGHARLQSGLVNWL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEECCCHHHHHHHHHHHHH
EGGFISQHDYFLANELAKVLCGGDVNHGTLVDEQWMLKLEREAFIKLANTSLTQARISHL
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LETGKPLRN
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]