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The map label for this gene is pntA [H]

Identifier: 54293853

GI number: 54293853

Start: 1020575

End: 1021708

Strand: Reverse

Name: pntA [H]

Synonym: lpl0909

Alternate gene names: 54293853

Gene position: 1021708-1020575 (Counterclockwise)

Preceding gene: 54293854

Following gene: 54293852

Centisome position: 30.54

GC content: 41.89

Gene sequence:

>1134_bases
ATGATGATTGCAACCTTAATGGAATCAGCTCAGGAAACGCGAGTAGCTATTACTCCCAACTCGGCCAAACAATACATAAA
ACTAGGCTATGAGATAGGGATTGAAAAAAACGCGGGGCTTAGCTCAGATTTTGCTAACGAAGAATTTGAAAAAGCTGGCG
CAATAATATTCGATAGTAAAAGTACATTACTCAAAAAAACACAAATTCTTTTATGTGTGAACGAACCTGATCCCAAAAAC
CTGAATGGCTTACCTCCAGATTCTCTAATAATCGGACATATAGATAATAACCCACTTAGCCCGCTTGTTAAGTGGTGTCT
GGATCAGAAAATAACATTATTTTCAATGAATCTCATTCCCAGGATAAGTCGTGCTCAAAGCATGGACAGCCTGTCGTCTC
AGGCTAACCTGGCTGGTTACAGAGCAGTTTTGGAAGCTGCGGCAACATTTCATAGAGCCATACCTATGATGATGACAGCA
GCAGGCATGATACAACCGGCCAAAGTACTTATTCTTGGTGCAGGAGTTGCAGGCTTGCAAGCCATAGCTACTGCGAAACG
TTTAGGTGCAGTGGTTTATGCCTTTGACGTAAGAAAGGCAGCCAAAGAACAGGTTGAAAGTTTAGGCGCTGAATTCATAG
AGGTAATGCAGGAGCAAGATAGTGAAACAGCTGGGGGATATGCCTCAGAAACAAGTGAAGAATATAAAAAACTTCAGGCT
GAACTCATTGATCAATACGCAAAAGCTGCCGACATGGTCATATCCACTGCCTTAATCCCAGGGCGTCAAGCTCCGGTTTT
ACTTTATAAAAAAACCGTCGAGCAAATGAAACCAGGTTCTGTCATTGTTGATCTCGCAACGTCTCGAGGTGGAAATTGTG
AACTCAGTGTTGCCGATAAAATCATCAAGCATGGTGACATTACTATAGTGGGATTGAGCAATATAGCAGGTCTCGTCCCT
GCTACGGCAAGTGACCTTTATTCTAATAATCTGGTTCATCTTATAAATCTTTTGGCAAAAAATCCGGCTGAACTTAACTT
AAATCCTGAAGATGAGATTATCCAGCAAGCCGTTCTTTGTCATAAAGGAACTTACCTGCCCTTTCAAGGAGTAAAGGAGA
AGCAAAATGCCTGA

Upstream 100 bases:

>100_bases
GCTTGTCCGGCTCCAAAGATCCAAAATTGGTACTTTATGCTGTAGAAAATTATTCTAAATTACAATAGGATAGAATAATA
ACGGTAATAAGGATTTTCCC

Downstream 100 bases:

>100_bases
GATTCATACACTTGATAATCCTTATATTACAATATTAACCATTTTCGTACTGGCCTGTTTTGTAGGTTATTATGTGGTTT
GGAAAGTAACACCAGCTTTA

Product: pyridine nucleotide transhydrogenase, alpha subunit

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MMIATLMESAQETRVAITPNSAKQYIKLGYEIGIEKNAGLSSDFANEEFEKAGAIIFDSKSTLLKKTQILLCVNEPDPKN
LNGLPPDSLIIGHIDNNPLSPLVKWCLDQKITLFSMNLIPRISRAQSMDSLSSQANLAGYRAVLEAAATFHRAIPMMMTA
AGMIQPAKVLILGAGVAGLQAIATAKRLGAVVYAFDVRKAAKEQVESLGAEFIEVMQEQDSETAGGYASETSEEYKKLQA
ELIDQYAKAADMVISTALIPGRQAPVLLYKKTVEQMKPGSVIVDLATSRGGNCELSVADKIIKHGDITIVGLSNIAGLVP
ATASDLYSNNLVHLINLLAKNPAELNLNPEDEIIQQAVLCHKGTYLPFQGVKEKQNA

Sequences:

>Translated_377_residues
MMIATLMESAQETRVAITPNSAKQYIKLGYEIGIEKNAGLSSDFANEEFEKAGAIIFDSKSTLLKKTQILLCVNEPDPKN
LNGLPPDSLIIGHIDNNPLSPLVKWCLDQKITLFSMNLIPRISRAQSMDSLSSQANLAGYRAVLEAAATFHRAIPMMMTA
AGMIQPAKVLILGAGVAGLQAIATAKRLGAVVYAFDVRKAAKEQVESLGAEFIEVMQEQDSETAGGYASETSEEYKKLQA
ELIDQYAKAADMVISTALIPGRQAPVLLYKKTVEQMKPGSVIVDLATSRGGNCELSVADKIIKHGDITIVGLSNIAGLVP
ATASDLYSNNLVHLINLLAKNPAELNLNPEDEIIQQAVLCHKGTYLPFQGVKEKQNA
>Mature_377_residues
MMIATLMESAQETRVAITPNSAKQYIKLGYEIGIEKNAGLSSDFANEEFEKAGAIIFDSKSTLLKKTQILLCVNEPDPKN
LNGLPPDSLIIGHIDNNPLSPLVKWCLDQKITLFSMNLIPRISRAQSMDSLSSQANLAGYRAVLEAAATFHRAIPMMMTA
AGMIQPAKVLILGAGVAGLQAIATAKRLGAVVYAFDVRKAAKEQVESLGAEFIEVMQEQDSETAGGYASETSEEYKKLQA
ELIDQYAKAADMVISTALIPGRQAPVLLYKKTVEQMKPGSVIVDLATSRGGNCELSVADKIIKHGDITIVGLSNIAGLVP
ATASDLYSNNLVHLINLLAKNPAELNLNPEDEIIQQAVLCHKGTYLPFQGVKEKQNA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=352, Percent_Identity=38.0681818181818, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI122939153, Length=352, Percent_Identity=38.0681818181818, Blast_Score=227, Evalue=2e-59,
Organism=Escherichia coli, GI1787887, Length=354, Percent_Identity=40.9604519774011, Blast_Score=270, Evalue=9e-74,
Organism=Caenorhabditis elegans, GI17550456, Length=353, Percent_Identity=41.0764872521246, Blast_Score=265, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 40610; Mature: 40610

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIATLMESAQETRVAITPNSAKQYIKLGYEIGIEKNAGLSSDFANEEFEKAGAIIFDSK
CCHHHHHHHHHHCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCEEECCC
STLLKKTQILLCVNEPDPKNLNGLPPDSLIIGHIDNNPLSPLVKWCLDQKITLFSMNLIP
HHHHEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEHHHHH
RISRAQSMDSLSSQANLAGYRAVLEAAATFHRAIPMMMTAAGMIQPAKVLILGAGVAGLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHH
AIATAKRLGAVVYAFDVRKAAKEQVESLGAEFIEVMQEQDSETAGGYASETSEEYKKLQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
ELIDQYAKAADMVISTALIPGRQAPVLLYKKTVEQMKPGSVIVDLATSRGGNCELSVADK
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHH
IIKHGDITIVGLSNIAGLVPATASDLYSNNLVHLINLLAKNPAELNLNPEDEIIQQAVLC
HHHCCCEEEEEHHHHHHHCCCCHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
HKGTYLPFQGVKEKQNA
HCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMIATLMESAQETRVAITPNSAKQYIKLGYEIGIEKNAGLSSDFANEEFEKAGAIIFDSK
CCHHHHHHHHHHCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCEEECCC
STLLKKTQILLCVNEPDPKNLNGLPPDSLIIGHIDNNPLSPLVKWCLDQKITLFSMNLIP
HHHHEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEHHHHH
RISRAQSMDSLSSQANLAGYRAVLEAAATFHRAIPMMMTAAGMIQPAKVLILGAGVAGLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHH
AIATAKRLGAVVYAFDVRKAAKEQVESLGAEFIEVMQEQDSETAGGYASETSEEYKKLQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
ELIDQYAKAADMVISTALIPGRQAPVLLYKKTVEQMKPGSVIVDLATSRGGNCELSVADK
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHH
IIKHGDITIVGLSNIAGLVPATASDLYSNNLVHLINLLAKNPAELNLNPEDEIIQQAVLC
HHHCCCEEEEEHHHHHHHCCCCHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
HKGTYLPFQGVKEKQNA
HCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]