Click here to switch to the map view.

The map label for this gene is hepT [H]

Identifier: 54027096

GI number: 54027096

Start: 5423497

End: 5424534

Strand: Reverse

Name: hepT [H]

Synonym: nfa51220

Alternate gene names: 54027096

Gene position: 5424534-5423497 (Counterclockwise)

Preceding gene: 54027100

Following gene: 54027095

Centisome position: 90.09

GC content: 70.52

Gene sequence:

>1038_bases
ATGAGCACATCGGCAGTGAGTGGCTCGGCAGTGAGTGGCTCGAGCACGGTGGTGGCCGGGGTCGAACTCGGTGACGCCGA
GCTCGCCGCGACCGTGCGCAACGGCCTCGAAGAGGTCGAGAAGCTGCTGATCGCCGAACTCTCCGACGGCGAGGACTTCC
TCCAGGACGCGGCGCTGCACCTGGCAAAGGCCGGCGGCAAGCGGTTCCGCCCGCTGTTCACCATCCTCACCGGCCAGCTC
GGCCCGCGCCCCACCGACCCGGCGCTGATCACCGCGGGCACCGTCGTGGAACTGGTGCACCTGGCCACCCTCTACCACGA
CGATGTGATGGACGAGGCGACCATGCGCCGCGGCGCCCCGAGCGTGAACTCCCGCTGGGGCAACAACATCGCCATCCTGG
CCGGCGACTACCTGTTCGCGCACGCCTCCCGGCTCACCTCCACGCTGGGCCCCGACGCGGTGCGCATCATCGCCGAGACC
TTCGCCGAACTGGTCACCGGCCAGATGCGCGAGACGATGGGCGCACGCGAGTCCCAGGACCCCGTCGAGCACTACCTGCG
CGTGGTCTGGGAGAAGACGGGCTCGCTGATCGCGGCCGCGGGCCGGTTCGGCGGCACCTTCTCCGGCGCCGACACCGCGC
ACATCGAGCGGCTGGCCCGGCTCGGCGACGCGGTCGGCACCGCCTTCCAGATCTCCGACGACATCATCGACATCTCCTCG
GCCTCCGAGCAGTCCGGCAAGACGCCCGGCACCGACCTGCGCGAGGGTGTGCACACGCTGCCGGTGCTCTACGCGTTGCG
CGAGGAAGGCGCCGAGGCCGACCGCCTGCGCACCCTGCTCGACCATCCGCTGCACAGCGACGACGAGGTGGCCGAAGCAC
TCGAGCTGCTCGGCCGCTCCCAGGGCATGGTGCTGGCCAAGGAGAAGCTGCAGTCCTACGCCGACCAGGCCTACGCGGAA
CTGGCCGCGCTGCCCTCCGGCCCGGCCAACGACGCCCTCGAGCAACTGGTCCGCTACACCATCGAACGAGTCGGCTGA

Upstream 100 bases:

>100_bases
AGTGGCACGCCGCCCGACCAGGCCGTCGCCGCGTGTGGAAAAGTGTGCCGGACACGCTAGGTTCTCTACCGTGGGGTCGG
ACGCGGCACTGGGAGACGAG

Downstream 100 bases:

>100_bases
GCCGGGTCGGCGCCCCGGAGGCGGCAGCGCAGTGTGACCACGGAGGGCGCCCCGGCTCGGGCCGGTCGGATACGGCCTGA
GCGGGTCAGCGCCCGGAGGC

Product: putative polyprenyl diphosphate synthase

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSTSAVSGSAVSGSSTVVAGVELGDAELAATVRNGLEEVEKLLIAELSDGEDFLQDAALHLAKAGGKRFRPLFTILTGQL
GPRPTDPALITAGTVVELVHLATLYHDDVMDEATMRRGAPSVNSRWGNNIAILAGDYLFAHASRLTSTLGPDAVRIIAET
FAELVTGQMRETMGARESQDPVEHYLRVVWEKTGSLIAAAGRFGGTFSGADTAHIERLARLGDAVGTAFQISDDIIDISS
ASEQSGKTPGTDLREGVHTLPVLYALREEGAEADRLRTLLDHPLHSDDEVAEALELLGRSQGMVLAKEKLQSYADQAYAE
LAALPSGPANDALEQLVRYTIERVG

Sequences:

>Translated_345_residues
MSTSAVSGSAVSGSSTVVAGVELGDAELAATVRNGLEEVEKLLIAELSDGEDFLQDAALHLAKAGGKRFRPLFTILTGQL
GPRPTDPALITAGTVVELVHLATLYHDDVMDEATMRRGAPSVNSRWGNNIAILAGDYLFAHASRLTSTLGPDAVRIIAET
FAELVTGQMRETMGARESQDPVEHYLRVVWEKTGSLIAAAGRFGGTFSGADTAHIERLARLGDAVGTAFQISDDIIDISS
ASEQSGKTPGTDLREGVHTLPVLYALREEGAEADRLRTLLDHPLHSDDEVAEALELLGRSQGMVLAKEKLQSYADQAYAE
LAALPSGPANDALEQLVRYTIERVG
>Mature_344_residues
STSAVSGSAVSGSSTVVAGVELGDAELAATVRNGLEEVEKLLIAELSDGEDFLQDAALHLAKAGGKRFRPLFTILTGQLG
PRPTDPALITAGTVVELVHLATLYHDDVMDEATMRRGAPSVNSRWGNNIAILAGDYLFAHASRLTSTLGPDAVRIIAETF
AELVTGQMRETMGARESQDPVEHYLRVVWEKTGSLIAAAGRFGGTFSGADTAHIERLARLGDAVGTAFQISDDIIDISSA
SEQSGKTPGTDLREGVHTLPVLYALREEGAEADRLRTLLDHPLHSDDEVAEALELLGRSQGMVLAKEKLQSYADQAYAEL
AALPSGPANDALEQLVRYTIERVG

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=315, Percent_Identity=29.5238095238095, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI4758430, Length=209, Percent_Identity=29.1866028708134, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI83700220, Length=209, Percent_Identity=29.1866028708134, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1789578, Length=309, Percent_Identity=30.42071197411, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786623, Length=243, Percent_Identity=32.0987654320988, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17505681, Length=311, Percent_Identity=29.903536977492, Blast_Score=140, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6319475, Length=295, Percent_Identity=28.8135593220339, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6325188, Length=231, Percent_Identity=26.4069264069264, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24651612, Length=293, Percent_Identity=31.740614334471, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281365769, Length=278, Percent_Identity=28.4172661870504, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24660002, Length=278, Percent_Identity=28.4172661870504, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 36673; Mature: 36541

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSAVSGSAVSGSSTVVAGVELGDAELAATVRNGLEEVEKLLIAELSDGEDFLQDAALH
CCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LAKAGGKRFRPLFTILTGQLGPRPTDPALITAGTVVELVHLATLYHDDVMDEATMRRGAP
HHHHCCCHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SVNSRWGNNIAILAGDYLFAHASRLTSTLGPDAVRIIAETFAELVTGQMRETMGARESQD
CCCCCCCCEEEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PVEHYLRVVWEKTGSLIAAAGRFGGTFSGADTAHIERLARLGDAVGTAFQISDDIIDISS
HHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCEEECCC
ASEQSGKTPGTDLREGVHTLPVLYALREEGAEADRLRTLLDHPLHSDDEVAEALELLGRS
CCHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
QGMVLAKEKLQSYADQAYAELAALPSGPANDALEQLVRYTIERVG
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STSAVSGSAVSGSSTVVAGVELGDAELAATVRNGLEEVEKLLIAELSDGEDFLQDAALH
CCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LAKAGGKRFRPLFTILTGQLGPRPTDPALITAGTVVELVHLATLYHDDVMDEATMRRGAP
HHHHCCCHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SVNSRWGNNIAILAGDYLFAHASRLTSTLGPDAVRIIAETFAELVTGQMRETMGARESQD
CCCCCCCCEEEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PVEHYLRVVWEKTGSLIAAAGRFGGTFSGADTAHIERLARLGDAVGTAFQISDDIIDISS
HHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCEEECCC
ASEQSGKTPGTDLREGVHTLPVLYALREEGAEADRLRTLLDHPLHSDDEVAEALELLGRS
CCHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
QGMVLAKEKLQSYADQAYAELAALPSGPANDALEQLVRYTIERVG
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]