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The map label for this gene is htpX

Identifier: 54027095

GI number: 54027095

Start: 5422207

End: 5423094

Strand: Reverse

Name: htpX

Synonym: nfa51210

Alternate gene names: 54027095

Gene position: 5423094-5422207 (Counterclockwise)

Preceding gene: 54027096

Following gene: 54027093

Centisome position: 90.07

GC content: 71.17

Gene sequence:

>888_bases
ATGCACGGGCGCGGTTACGCGAACGGTCTCAAGACGTTCGGCCTGATGGTCGGGCTCTCGGCGTTGATCGTCTTCGCCGG
GGCCATGTTCCGCAACACCACGATTCTCGTCGTCGCGATCCTGCTGGCCGTCGGGATGAACGCGTGGGCCTACTTCAACA
GCGACCGCATCGCCCTGCGCGCGATGCACGCGCTACCGGTCAGCGAACTCGAGGCGCCGGTGATGTACCGGATCGTGCGA
GAACTCGCGACCGCCGCGCGCCAGCCCATGCCGCGGCTCTACATCAGCCCCACGAACGCGCCCAACGCGTTCGCCACCGG
GCGTAACCCGCGCCACGCCGCGGTCTGCTGCACCAGCGGCATCCTGCAGATCCTCGACGAGCGCGAGCTGCGCGCCGTGC
TCGGGCACGAGCTCTCGCACGTCTACAACCGCGACATCCTGATCTCCTCGATCGCGGGCGCGCTGGCCGCCGTGGTCTCC
GGCCTGGCGAATCTCGCGTTCTTCGCCGGCGCCTTCGGTGGCCGCGGCAACGGCGAGGGCCCCAGCATGCTGGGTGTGTT
GTTGGTCTCGTTGCTCGGCCCGATCGCCGCCACCCTGGTGAAGCTCGCGGTCTCGCGCTCGCGGGAGTACGAGGCGGACC
GCTCCGGCGCCGAACTCACCGGCGACCCGCTCGCGCTCGCCTCCGCGCTGCGCAAGCTCGAACGCGGCACCCAGGCCGCG
CCGCTGCCGCCGGAACCGCAGCTGACCGCGCAGTCGCACCTGATGATCGCCAATCCGTTCCGCGCGGGCGAACGGGCCGC
CCGACTGTTCTCCACCCACCCGCCGATGGCCGAGCGGATCGCCCGGCTCGAGGAGATGGCGGGCGGGCGGTCCGGCGGCT
ACCGGTAG

Upstream 100 bases:

>100_bases
AACGCAGCCTGAGCCGGGTCGGCGCCCGGAACTCCGGTGACTTCCGGTTCGTTGTCGGTATGTCAACGATCGACGGACGG
GGGAGTGGGCAGGGAGGCGT

Downstream 100 bases:

>100_bases
TTCACGAACTGCAGGGCGATCCCGAAGTCCTCGCTCTTGAGCAGCGCGATGACCGCCTGTAGGTCGTCGCGCTTCTTGCT
GCTCACCCGCAGCTCGTCGC

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MHGRGYANGLKTFGLMVGLSALIVFAGAMFRNTTILVVAILLAVGMNAWAYFNSDRIALRAMHALPVSELEAPVMYRIVR
ELATAARQPMPRLYISPTNAPNAFATGRNPRHAAVCCTSGILQILDERELRAVLGHELSHVYNRDILISSIAGALAAVVS
GLANLAFFAGAFGGRGNGEGPSMLGVLLVSLLGPIAATLVKLAVSRSREYEADRSGAELTGDPLALASALRKLERGTQAA
PLPPEPQLTAQSHLMIANPFRAGERAARLFSTHPPMAERIARLEEMAGGRSGGYR

Sequences:

>Translated_295_residues
MHGRGYANGLKTFGLMVGLSALIVFAGAMFRNTTILVVAILLAVGMNAWAYFNSDRIALRAMHALPVSELEAPVMYRIVR
ELATAARQPMPRLYISPTNAPNAFATGRNPRHAAVCCTSGILQILDERELRAVLGHELSHVYNRDILISSIAGALAAVVS
GLANLAFFAGAFGGRGNGEGPSMLGVLLVSLLGPIAATLVKLAVSRSREYEADRSGAELTGDPLALASALRKLERGTQAA
PLPPEPQLTAQSHLMIANPFRAGERAARLFSTHPPMAERIARLEEMAGGRSGGYR
>Mature_295_residues
MHGRGYANGLKTFGLMVGLSALIVFAGAMFRNTTILVVAILLAVGMNAWAYFNSDRIALRAMHALPVSELEAPVMYRIVR
ELATAARQPMPRLYISPTNAPNAFATGRNPRHAAVCCTSGILQILDERELRAVLGHELSHVYNRDILISSIAGALAAVVS
GLANLAFFAGAFGGRGNGEGPSMLGVLLVSLLGPIAATLVKLAVSRSREYEADRSGAELTGDPLALASALRKLERGTQAA
PLPPEPQLTAQSHLMIANPFRAGERAARLFSTHPPMAERIARLEEMAGGRSGGYR

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=276, Percent_Identity=28.9855072463768, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_NOCFA (Q5YPB8)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_121337.1
- ProteinModelPortal:   Q5YPB8
- MEROPS:   M48.004
- GeneID:   3110838
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa51210
- NMPDR:   fig|247156.1.peg.4919
- HOGENOM:   HBG739460
- OMA:   RRGAEIC
- ProtClustDB:   PRK03072
- BioCyc:   NFAR247156:NFA51210-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.- [C]

Molecular weight: Translated: 31350; Mature: 31350

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 137-137

Signals:

None

Transmembrane regions:

HASH(0x1c863ed8)-; HASH(0x1d82574c)-; HASH(0x1ed3aefc)-; HASH(0x217b71a8)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGRGYANGLKTFGLMVGLSALIVFAGAMFRNTTILVVAILLAVGMNAWAYFNSDRIALR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCHHHHH
AMHALPVSELEAPVMYRIVRELATAARQPMPRLYISPTNAPNAFATGRNPRHAAVCCTSG
HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHH
ILQILDERELRAVLGHELSHVYNRDILISSIAGALAAVVSGLANLAFFAGAFGGRGNGEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PSMLGVLLVSLLGPIAATLVKLAVSRSREYEADRSGAELTGDPLALASALRKLERGTQAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
PLPPEPQLTAQSHLMIANPFRAGERAARLFSTHPPMAERIARLEEMAGGRSGGYR
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCH
>Mature Secondary Structure
MHGRGYANGLKTFGLMVGLSALIVFAGAMFRNTTILVVAILLAVGMNAWAYFNSDRIALR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCHHHHH
AMHALPVSELEAPVMYRIVRELATAARQPMPRLYISPTNAPNAFATGRNPRHAAVCCTSG
HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHH
ILQILDERELRAVLGHELSHVYNRDILISSIAGALAAVVSGLANLAFFAGAFGGRGNGEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PSMLGVLLVSLLGPIAATLVKLAVSRSREYEADRSGAELTGDPLALASALRKLERGTQAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
PLPPEPQLTAQSHLMIANPFRAGERAARLFSTHPPMAERIARLEEMAGGRSGGYR
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA