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The map label for this gene is tesB [H]

Identifier: 54025674

GI number: 54025674

Start: 3919097

End: 3919915

Strand: Reverse

Name: tesB [H]

Synonym: nfa37040

Alternate gene names: 54025674

Gene position: 3919915-3919097 (Counterclockwise)

Preceding gene: 54025675

Following gene: 54025673

Centisome position: 65.1

GC content: 68.62

Gene sequence:

>819_bases
ATGGCGACCATCGAAGAGGCACTGGAGATCGAACGCCTCGAGCGGGACATCTTCCGTGGCGCGTCCACGAAGACGCAGCT
GGAGCGAACGTTCGGCGGCCAGGTGGCGGGTCAGGCACTGGTGTCCGCGGTGCGCACGGTGGAACCCCGGTTCCAGGTGC
ACTCGCTGCACGGCTATTTCCTGCGCCCGGGCAATCCGCAGCAGCCCACCGTGTACCTGGTGGAACGCATCCGCGACGGG
CGTTCGTTCTGCACCCGCCGGGTCACCGGTGTGCAGGACGGCGCCGCCATCTTCACCATGTCGGCCTCGTTCCACATCGG
TGACACCGGCCCCGCCCACCAGGACGAGATGCCCGAGGTCGCCGCGCCCGACGACCTGCCCGACGCGCAGACCTCCATGA
GTCCCGAGCGGTTGTGGGCGATGCGCGAGTGGGAGCACTGGGACATCAGGATGGTCCCGCAGGAGTCTGTGGTGCGCAGG
CCGGGGGTGGTCGCCCAGCAGCAGGTGTGGTTCCGCTACCGGCAGCCGCTGCCCGACGATCCGCTGTTCCACGTCTGCAC
GCTGGCCTACATGAGCGACATGACGCTGCTCGGCTCGTCGAAGGTGATCCACCCCGACGAGCCGACCCAGAACGCCTCGC
TCGACCACGCCATGTGGTTCCTGCGTCCGTTCCGCGCCGACGACTGGCTGCTCTACGACCAGGCCTCGCCCTCGGCGGGC
TTCGGTCGCGGCCTGACCTCCGGCAAGATCTACAACCGGGCCGGTGAACTGGTCGCCGCGGTGATGCAGGAGGGCCTGAT
CCGCACGTTGCGCTCGTGA

Upstream 100 bases:

>100_bases
ACGTGGAGGAGATCCCGCAGCCGCACCGGCTCGCTGAGCGCGGCTGGTGATCGGGACCGGGATGAACGGGCCCGGGCATC
GCACGGGCTAATCTCAGCGC

Downstream 100 bases:

>100_bases
CCGGGCGTGAGCCGGGCCACAGCGCGGCCGCTCGTAAGCTGGGCCGGGTGAACCAGACCTCGGTGTCCGCACCCGCCGCC
GAGCCGCAGGCGGCCCCGTC

Product: putative acyl-CoA thioesterase

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MATIEEALEIERLERDIFRGASTKTQLERTFGGQVAGQALVSAVRTVEPRFQVHSLHGYFLRPGNPQQPTVYLVERIRDG
RSFCTRRVTGVQDGAAIFTMSASFHIGDTGPAHQDEMPEVAAPDDLPDAQTSMSPERLWAMREWEHWDIRMVPQESVVRR
PGVVAQQQVWFRYRQPLPDDPLFHVCTLAYMSDMTLLGSSKVIHPDEPTQNASLDHAMWFLRPFRADDWLLYDQASPSAG
FGRGLTSGKIYNRAGELVAAVMQEGLIRTLRS

Sequences:

>Translated_272_residues
MATIEEALEIERLERDIFRGASTKTQLERTFGGQVAGQALVSAVRTVEPRFQVHSLHGYFLRPGNPQQPTVYLVERIRDG
RSFCTRRVTGVQDGAAIFTMSASFHIGDTGPAHQDEMPEVAAPDDLPDAQTSMSPERLWAMREWEHWDIRMVPQESVVRR
PGVVAQQQVWFRYRQPLPDDPLFHVCTLAYMSDMTLLGSSKVIHPDEPTQNASLDHAMWFLRPFRADDWLLYDQASPSAG
FGRGLTSGKIYNRAGELVAAVMQEGLIRTLRS
>Mature_271_residues
ATIEEALEIERLERDIFRGASTKTQLERTFGGQVAGQALVSAVRTVEPRFQVHSLHGYFLRPGNPQQPTVYLVERIRDGR
SFCTRRVTGVQDGAAIFTMSASFHIGDTGPAHQDEMPEVAAPDDLPDAQTSMSPERLWAMREWEHWDIRMVPQESVVRRP
GVVAQQQVWFRYRQPLPDDPLFHVCTLAYMSDMTLLGSSKVIHPDEPTQNASLDHAMWFLRPFRADDWLLYDQASPSAGF
GRGLTSGKIYNRAGELVAAVMQEGLIRTLRS

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=284, Percent_Identity=38.0281690140845, Blast_Score=175, Evalue=3e-44,
Organism=Escherichia coli, GI1786657, Length=270, Percent_Identity=41.8518518518518, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17558508, Length=306, Percent_Identity=35.9477124183007, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71988741, Length=291, Percent_Identity=33.6769759450172, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17531889, Length=282, Percent_Identity=32.2695035460993, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI115532456, Length=282, Percent_Identity=31.9148936170213, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17531885, Length=280, Percent_Identity=31.4285714285714, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71982224, Length=280, Percent_Identity=30.7142857142857, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI212645202, Length=266, Percent_Identity=29.6992481203008, Blast_Score=114, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 30697; Mature: 30566

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIEEALEIERLERDIFRGASTKTQLERTFGGQVAGQALVSAVRTVEPRFQVHSLHGYF
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEECCEEE
LRPGNPQQPTVYLVERIRDGRSFCTRRVTGVQDGAAIFTMSASFHIGDTGPAHQDEMPEV
ECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECEEECCCCCCCCCCCCCCC
AAPDDLPDAQTSMSPERLWAMREWEHWDIRMVPQESVVRRPGVVAQQQVWFRYRQPLPDD
CCCCCCCCCHHCCCHHHHHHHHCCCCCCEEECCHHHHHHCCCCHHHHHHHHHHCCCCCCC
PLFHVCTLAYMSDMTLLGSSKVIHPDEPTQNASLDHAMWFLRPFRADDWLLYDQASPSAG
HHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCC
FGRGLTSGKIYNRAGELVAAVMQEGLIRTLRS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATIEEALEIERLERDIFRGASTKTQLERTFGGQVAGQALVSAVRTVEPRFQVHSLHGYF
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEECCEEE
LRPGNPQQPTVYLVERIRDGRSFCTRRVTGVQDGAAIFTMSASFHIGDTGPAHQDEMPEV
ECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECEEECCCCCCCCCCCCCCC
AAPDDLPDAQTSMSPERLWAMREWEHWDIRMVPQESVVRRPGVVAQQQVWFRYRQPLPDD
CCCCCCCCCHHCCCHHHHHHHHCCCCCCEEECCHHHHHHCCCCHHHHHHHHHHCCCCCCC
PLFHVCTLAYMSDMTLLGSSKVIHPDEPTQNASLDHAMWFLRPFRADDWLLYDQASPSAG
HHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCC
FGRGLTSGKIYNRAGELVAAVMQEGLIRTLRS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]