Click here to switch to the map view.

The map label for this gene is mutA [H]

Identifier: 54025437

GI number: 54025437

Start: 3676254

End: 3678119

Strand: Reverse

Name: mutA [H]

Synonym: nfa34670

Alternate gene names: 54025437

Gene position: 3678119-3676254 (Counterclockwise)

Preceding gene: 54025439

Following gene: 54025436

Centisome position: 61.09

GC content: 73.85

Gene sequence:

>1866_bases
ATGCCGATTGCTTCAGATCCGTCTCCCGGCGCGGAGACGGTTCCGCAGTACGCCGCGTGGCGCAAGGGAGTGGCGGGCGT
GCTCGCCAAGGCGCGCAAGGTGGACGTGGCCGATCTGCCCGACGAGCCGGAACAGCTGCTCACGCAGACGACCTACGACG
GACTGGCCGTCGCCCCGCTCTACACGCGGCGCGACGAGCGCCCGGAGCCGCCGTTGCCCGGCGTCTTCCCGTTCGTGCGC
GGCCGGGACGCCACCCGTGACGTGCACCGGGGCTGGGACGTGTGCGCGGACATCACCGAAACCGATGCCGCCGCGGCGAA
TCGGGAGCTCCTCGCGGGGCTGGAGAACGGGCTGAGCGCCGTGCGGGTGGGCGTCGGCGAGCACGGCGTGCCCGTCGCCG
AACTGCCGACCGCCCTGCGCGGTCTGTTGTTCGAGCTCGCGCCGCTCAGCCTGGCCGCGGGCGCGGCCCTGCCCGAGGCC
GCCGCGCAGCTGTACGCGGTGCTCGACGACTACCGCGTCGACGACCGCGCGGCCATCCGGATCGGCCTCGGCGCCGCGCC
GCTGACCAGCCGCTTCGCCGGTGCGGCCGACGTCGACTCGGACCGGGCCGTCGAGCTGGCGAAGCAGGCCGTCGCCCGCA
CCGAGACGGTACGCGCGATCACCGTGGACGGCACGGTCTTCCACAACGCCGGCGCTTCCGACGCCCAGGAACTCGGCGCC
GCGGTGGCCGCCGGCCTCGAGTACCTGCGCGCGCTCACCGGCGCCGGTGTCGACATCGCCGACGCGCTGGGTCAGCTGGA
GTTCCGCCTCGCCGCCACCGACGACCAGTTCGCGACCATCGCGAAATTCCGCGCGGCGCGCACGGTCTGGGCGCGGGTCG
CGCACGTCTGCGGCGCGCCCGACTTCGGCGGCGCCCCCCAGCACGCGGTCACCTCGGCCGCGATGATGAGCAAGCGTGAT
CCGTGGGTGAACATGCTGCGCACCACGCTGGCCGCGTTCGGCGCGGGCGTCGGCGGGGCCGACTCGCTGACCGTGCTGCC
GTTCGACTGCGCGCTGCCGCCCGGCGAACTGGGCGTCTCGAAGTCGTTCTCCGATCGCATGGCGCGCAACACCCAGCTGC
TGCTGCTCGAGGAATCGCACCTCGGTCACGTGCAGGATCCCGGCGCGGGTTCCTGGTACATCGAGGACTACACCGCGAAG
CTCGCGGCCAAGGCCTGGGAGTTCATGCAGGAGCTGGAGAAGGCGGGCGGCTACCGCGCCGCGCTGGACGCCGGCCTGCT
CGCGCGGCGGATCGCCGAGACCAAGACGACCCGCGACGCCGATGTGGCGCACCGCAGGACCGCCGTCACCGGCGTCAACG
AATTCCCGAACCTGGCCGAGAAGCCGCTGTCGGCGCAGGCGCGCACGCCCGGCGAGATCGCCCGCTACGGCGCCGCCTTC
GAAGCGCTGCGCGACCGCTCCGACGCCTACCTCGAGGCCAACGGCGCGCGGCCGAAGGCCCTGCTGGTGCCGCTGGGCAC
GGTGGCCGAGCACAACGTGCGGGTCACCTTCATCGCGAACCTGCTCGCCTCGGGCGGCATCGAGTCGGTGAATCCGGGCC
CGCTCGAGGTGTCGGCCGTCGAGGCCGCCGCGAAGGAGGCGGGCGCGCCGATCGCGGTGCTGTGCGGTTCGGACGCGCGT
TACGGCGCGGAGGCCGGTGCGGCGGTGGCGGCGCTGCGCGCGGCCGGAGTGGAAACGGTGCTGCTGGCCGGCGCGGAGAA
GGCCGTCGCCGACCTCGACGCGGCGCAGCGCCCGGACGGCTTCCTCACCGCGAAGATCGACGCGGTGGCGCAACTGTCCG
GCCTGCTGGAGAAGGTGGGAGCCTGA

Upstream 100 bases:

>100_bases
GCTCGTTAACCAATGTGCTCGCTGAGCTGGGCGAATGCGAGGTATCGGGCGCACACACGAGGTGCGCGCCCCGTGGTCGA
GTGGAAGAGGGACAGCAGCT

Downstream 100 bases:

>100_bases
TGACCCTCAGTCACATCGAAGAACCGGGCGACGTGGCCCATCTGGTGGGCAACTTCGCCGAGGTGCCGCTGACCGAGCAC
GATCCCGAGCCCGCCGCGGT

Product: putative methylmalonyl-CoA mutase subunit beta

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 621; Mature: 620

Protein sequence:

>621_residues
MPIASDPSPGAETVPQYAAWRKGVAGVLAKARKVDVADLPDEPEQLLTQTTYDGLAVAPLYTRRDERPEPPLPGVFPFVR
GRDATRDVHRGWDVCADITETDAAAANRELLAGLENGLSAVRVGVGEHGVPVAELPTALRGLLFELAPLSLAAGAALPEA
AAQLYAVLDDYRVDDRAAIRIGLGAAPLTSRFAGAADVDSDRAVELAKQAVARTETVRAITVDGTVFHNAGASDAQELGA
AVAAGLEYLRALTGAGVDIADALGQLEFRLAATDDQFATIAKFRAARTVWARVAHVCGAPDFGGAPQHAVTSAAMMSKRD
PWVNMLRTTLAAFGAGVGGADSLTVLPFDCALPPGELGVSKSFSDRMARNTQLLLLEESHLGHVQDPGAGSWYIEDYTAK
LAAKAWEFMQELEKAGGYRAALDAGLLARRIAETKTTRDADVAHRRTAVTGVNEFPNLAEKPLSAQARTPGEIARYGAAF
EALRDRSDAYLEANGARPKALLVPLGTVAEHNVRVTFIANLLASGGIESVNPGPLEVSAVEAAAKEAGAPIAVLCGSDAR
YGAEAGAAVAALRAAGVETVLLAGAEKAVADLDAAQRPDGFLTAKIDAVAQLSGLLEKVGA

Sequences:

>Translated_621_residues
MPIASDPSPGAETVPQYAAWRKGVAGVLAKARKVDVADLPDEPEQLLTQTTYDGLAVAPLYTRRDERPEPPLPGVFPFVR
GRDATRDVHRGWDVCADITETDAAAANRELLAGLENGLSAVRVGVGEHGVPVAELPTALRGLLFELAPLSLAAGAALPEA
AAQLYAVLDDYRVDDRAAIRIGLGAAPLTSRFAGAADVDSDRAVELAKQAVARTETVRAITVDGTVFHNAGASDAQELGA
AVAAGLEYLRALTGAGVDIADALGQLEFRLAATDDQFATIAKFRAARTVWARVAHVCGAPDFGGAPQHAVTSAAMMSKRD
PWVNMLRTTLAAFGAGVGGADSLTVLPFDCALPPGELGVSKSFSDRMARNTQLLLLEESHLGHVQDPGAGSWYIEDYTAK
LAAKAWEFMQELEKAGGYRAALDAGLLARRIAETKTTRDADVAHRRTAVTGVNEFPNLAEKPLSAQARTPGEIARYGAAF
EALRDRSDAYLEANGARPKALLVPLGTVAEHNVRVTFIANLLASGGIESVNPGPLEVSAVEAAAKEAGAPIAVLCGSDAR
YGAEAGAAVAALRAAGVETVLLAGAEKAVADLDAAQRPDGFLTAKIDAVAQLSGLLEKVGA
>Mature_620_residues
PIASDPSPGAETVPQYAAWRKGVAGVLAKARKVDVADLPDEPEQLLTQTTYDGLAVAPLYTRRDERPEPPLPGVFPFVRG
RDATRDVHRGWDVCADITETDAAAANRELLAGLENGLSAVRVGVGEHGVPVAELPTALRGLLFELAPLSLAAGAALPEAA
AQLYAVLDDYRVDDRAAIRIGLGAAPLTSRFAGAADVDSDRAVELAKQAVARTETVRAITVDGTVFHNAGASDAQELGAA
VAAGLEYLRALTGAGVDIADALGQLEFRLAATDDQFATIAKFRAARTVWARVAHVCGAPDFGGAPQHAVTSAAMMSKRDP
WVNMLRTTLAAFGAGVGGADSLTVLPFDCALPPGELGVSKSFSDRMARNTQLLLLEESHLGHVQDPGAGSWYIEDYTAKL
AAKAWEFMQELEKAGGYRAALDAGLLARRIAETKTTRDADVAHRRTAVTGVNEFPNLAEKPLSAQARTPGEIARYGAAFE
ALRDRSDAYLEANGARPKALLVPLGTVAEHNVRVTFIANLLASGGIESVNPGPLEVSAVEAAAKEAGAPIAVLCGSDARY
GAEAGAAVAALRAAGVETVLLAGAEKAVADLDAAQRPDGFLTAKIDAVAQLSGLLEKVGA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=459, Percent_Identity=27.6688453159041, Blast_Score=129, Evalue=8e-30,
Organism=Escherichia coli, GI1789284, Length=442, Percent_Identity=30.0904977375566, Blast_Score=153, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI25144500, Length=449, Percent_Identity=25.8351893095768, Blast_Score=132, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 64602; Mature: 64471

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIASDPSPGAETVPQYAAWRKGVAGVLAKARKVDVADLPDEPEQLLTQTTYDGLAVAPL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEH
YTRRDERPEPPLPGVFPFVRGRDATRDVHRGWDVCADITETDAAAANRELLAGLENGLSA
HHCCCCCCCCCCCCCCHHHCCCCHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHCHHH
VRVGVGEHGVPVAELPTALRGLLFELAPLSLAAGAALPEAAAQLYAVLDDYRVDDRAAIR
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEE
IGLGAAPLTSRFAGAADVDSDRAVELAKQAVARTETVRAITVDGTVFHNAGASDAQELGA
EECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCEEEECCCCCHHHHHHH
AVAAGLEYLRALTGAGVDIADALGQLEFRLAATDDQFATIAKFRAARTVWARVAHVCGAP
HHHHHHHHHHHHHCCCCHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
DFGGAPQHAVTSAAMMSKRDPWVNMLRTTLAAFGAGVGGADSLTVLPFDCALPPGELGVS
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCC
KSFSDRMARNTQLLLLEESHLGHVQDPGAGSWYIEDYTAKLAAKAWEFMQELEKAGGYRA
CCHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHH
ALDAGLLARRIAETKTTRDADVAHRRTAVTGVNEFPNLAEKPLSAQARTPGEIARYGAAF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCHHHCCCCCCCCCCHHHHHHHHHH
EALRDRSDAYLEANGARPKALLVPLGTVAEHNVRVTFIANLLASGGIESVNPGPLEVSAV
HHHHCCCCCEEEECCCCCCEEEEECCCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCHHHH
EAAAKEAGAPIAVLCGSDARYGAEAGAAVAALRAAGVETVLLAGAEKAVADLDAAQRPDG
HHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCC
FLTAKIDAVAQLSGLLEKVGA
CEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PIASDPSPGAETVPQYAAWRKGVAGVLAKARKVDVADLPDEPEQLLTQTTYDGLAVAPL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEH
YTRRDERPEPPLPGVFPFVRGRDATRDVHRGWDVCADITETDAAAANRELLAGLENGLSA
HHCCCCCCCCCCCCCCHHHCCCCHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHCHHH
VRVGVGEHGVPVAELPTALRGLLFELAPLSLAAGAALPEAAAQLYAVLDDYRVDDRAAIR
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEE
IGLGAAPLTSRFAGAADVDSDRAVELAKQAVARTETVRAITVDGTVFHNAGASDAQELGA
EECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCEEEECCCCCHHHHHHH
AVAAGLEYLRALTGAGVDIADALGQLEFRLAATDDQFATIAKFRAARTVWARVAHVCGAP
HHHHHHHHHHHHHCCCCHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
DFGGAPQHAVTSAAMMSKRDPWVNMLRTTLAAFGAGVGGADSLTVLPFDCALPPGELGVS
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCC
KSFSDRMARNTQLLLLEESHLGHVQDPGAGSWYIEDYTAKLAAKAWEFMQELEKAGGYRA
CCHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHH
ALDAGLLARRIAETKTTRDADVAHRRTAVTGVNEFPNLAEKPLSAQARTPGEIARYGAAF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCHHHCCCCCCCCCCHHHHHHHHHH
EALRDRSDAYLEANGARPKALLVPLGTVAEHNVRVTFIANLLASGGIESVNPGPLEVSAV
HHHHCCCCCEEEECCCCCCEEEEECCCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCHHHH
EAAAKEAGAPIAVLCGSDARYGAEAGAAVAALRAAGVETVLLAGAEKAVADLDAAQRPDG
HHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCC
FLTAKIDAVAQLSGLLEKVGA
CEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]