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The map label for this gene is oxa

Identifier: 53723018

GI number: 53723018

Start: 2701464

End: 2702273

Strand: Reverse

Name: oxa

Synonym: BPSS1997

Alternate gene names: 53723018

Gene position: 2702273-2701464 (Counterclockwise)

Preceding gene: 53723019

Following gene: 53723014

Centisome position: 85.16

GC content: 65.93

Gene sequence:

>810_bases
ATGAAATTCCGACACGCGCTGTCGAGCGCATTCGTTTTGCTGGGTTGCATCGCCGCGTCGGCGCATGCGAAGACGATCTG
CACGGCGATCGCCGATGCGGGCACGGGCAAGCTGCTGGTGCAGGACGGCGATTGCGGCCGCCGCGCATCGCCCGCGTCGA
CGTTCAAGATCGCGATCAGCCTGATGGGCTACGACGCAGGCTTCCTGCGCAACGAGCATGACCCGGTGCTGCCGTATCGC
GACAGTTACATCGCGTGGGGTGGCGAAGCATGGAAGCAGCCGACCGATCCGACGCGCTGGCTCAAGTATTCGGTCGTGTG
GTATTCGCAGCAGGTGGCGCACCATCTCGGCGCGCAGCGCTTCGCGCAGTATGCGAAGGCGTTCGGCTACGGCAATGCGG
ACGTGTCCGGCGATCCCGGCCAGAACAACGGCCTCGATCGCGCGTGGATCGGCTCGTCGCTGCAGATCTCGCCGCTCGAA
CAATTGGAATTCCTCGGCAAGATGCTCAATCGCAAGCTGCCCGTGTCGCCCACAGCCGTCGACATGACGGAGCGGATCGT
CGAATCGACGACGCTTGCCGACGGAACGGTGGTGCACGGCAAGACCGGCGTGTCCTATCCGCTGCTGGCCGACGGCACAC
GCGACTGGGCGCGTGGATCCGGCTGGTTCGTCGGCTGGATCGTGCGTGGCAAGCAGACGCTGGTGTTCGCGCGCCTCACG
CAGGACGAGCGCAAGCAGCCCGTTTCAGCCGGCATACGGACGCGCGAGGCCTTCCTGCGCGACTTGCCCCGGCTTCTCGC
CGCGCGCTGA

Upstream 100 bases:

>100_bases
TCGTATCCGTCGAGCGAACGAGTGGCGGCCGGCTATAGAATCGTCGCTTCGATCGTTCGGGCCGAACGATGAGCCATTCC
CCACTCTTTGCGGAACAACA

Downstream 100 bases:

>100_bases
CGCGACGGCGGGCCGGCGCGTCGGCGCGCTGTCCCGCTGCATGGCCGCGGTTCGCCGGGGCGCGGTCTTCGTGAACGGCA
AAAAGCGGCAGGCATCGCGA

Product: beta-lactamase precursor

Products: NA

Alternate protein names: Oxacillinase; Penicillinase [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIAISLMGYDAGFLRNEHDPVLPYR
DSYIAWGGEAWKQPTDPTRWLKYSVVWYSQQVAHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLE
QLEFLGKMLNRKLPVSPTAVDMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGWFVGWIVRGKQTLVFARLT
QDERKQPVSAGIRTREAFLRDLPRLLAAR

Sequences:

>Translated_269_residues
MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIAISLMGYDAGFLRNEHDPVLPYR
DSYIAWGGEAWKQPTDPTRWLKYSVVWYSQQVAHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLE
QLEFLGKMLNRKLPVSPTAVDMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGWFVGWIVRGKQTLVFARLT
QDERKQPVSAGIRTREAFLRDLPRLLAAR
>Mature_269_residues
MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIAISLMGYDAGFLRNEHDPVLPYR
DSYIAWGGEAWKQPTDPTRWLKYSVVWYSQQVAHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLE
QLEFLGKMLNRKLPVSPTAVDMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGWFVGWIVRGKQTLVFARLT
QDERKQPVSAGIRTREAFLRDLPRLLAAR

Specific function: Oxacillin-hydrolyzing beta-lactamase. Confers resistance to beta-lactam antibiotics but at a significantly lower level than the TEM bla gene product [H]

COG id: COG2602

COG function: function code V; Beta-lactamase class D

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-D beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR002137
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 29496; Mature: 29496

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00337 BETA_LACTAMASE_D

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIAIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEEE
LMGYDAGFLRNEHDPVLPYRDSYIAWGGEAWKQPTDPTRWLKYSVVWYSQQVAHHLGAQR
EECCCHHHHCCCCCCCCCCCCCEEEECCHHCCCCCCCHHHEEEEHHHHHHHHHHHHHHHH
FAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLEQLEFLGKMLNRKLPVSPTAV
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCEECHHHHHHHHHHHHCCCCCCCCCHH
DMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGWFVGWIVRGKQTLVFARLT
HHHHHHHHHHCCCCCEEEECCCCCCCCEEECCCCHHHCCCCEEEEEEEECCEEEEEEECC
QDERKQPVSAGIRTREAFLRDLPRLLAAR
HHHHCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIAIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEEE
LMGYDAGFLRNEHDPVLPYRDSYIAWGGEAWKQPTDPTRWLKYSVVWYSQQVAHHLGAQR
EECCCHHHHCCCCCCCCCCCCCEEEECCHHCCCCCCCHHHEEEEHHHHHHHHHHHHHHHH
FAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLEQLEFLGKMLNRKLPVSPTAV
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCEECHHHHHHHHHHHHCCCCCCCCCHH
DMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGWFVGWIVRGKQTLVFARLT
HHHHHHHHHHCCCCCEEEECCCCCCCCEEECCCCHHHCCCCEEEEEEEECCEEEEEEECC
QDERKQPVSAGIRTREAFLRDLPRLLAAR
HHHHCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9756755 [H]