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The map label for this gene is bioA [H]

Identifier: 53718007

GI number: 53718007

Start: 395651

End: 396997

Strand: Reverse

Name: bioA [H]

Synonym: BPSL0367

Alternate gene names: 53718007

Gene position: 396997-395651 (Counterclockwise)

Preceding gene: 53718008

Following gene: 53718006

Centisome position: 9.74

GC content: 69.78

Gene sequence:

>1347_bases
TTGAGCACACACGCAACCGACGACTGGGTCGCGCGCAGCCTGCGCGCGGTCTGGCATCCTTGCACGCAGATGAAGCACCA
CGAGCGGCTGCCGCTCATTCCGGTCGCGCGCGGCGAACGCGCGTGGCTGTTCGATCGCGCGGGCAATCGCTATCTCGACG
CGATCAGCTCGTGGTGGGTGAACCTGTTCGGCCACGCGAATCCGCGCATCAACGCGGCGCTCAAGCAGCAGCTCGACACG
CTCGAGCACGCGATGCTCGCCGGCTGCACGCACGAAAGCGCGATCGAGCTCGCCGAACGGCTCGCCGCGCGCACGCAGCA
CACGCTCGGCCATGCGTTCTTCGCGTCGGACGGCGCGTCGGCCGTCGAGATCGCGCTGAAGATGAGCTTTCACGCATGGC
GCAACCGCGGCCGCGGCGACAAGCGCGAATTCGTCTGCATCGCGAACGGTTACCACGGCGAGACGATCGGCGCGCTTGGC
GTGACCGATGTCGCGCTGTTCAAGGACGCCTACGATCCGCTGATTCGCGCGGCGCACGTCGTCGCTTCGCCGGACGCGCG
CGGCGCGCGCGACGGCGAAACCGCGGCCGACGTGGCCGCGCGCGCGCTCGGCGACGTGCGGCGCCTGTTCGCCGAGCGCG
GCGAGAAGATCGCCGCGCTGATCGTCGAGCCGCTCGTGCAGTGCGCGGCCGGCTTCGCGATGCACGATCCGTCGTACGTG
CGCGGCCTGCGCGCGCTGTGCGACGCGCACGACGTGCATCTGATCGCCGACGAGATCGCCGTCGGCTGCGGGCGCACCGG
CACGTTCTTCGCGTGCGAGCAGGCGCACGTGTGGCCCGATTTCCTGTGCCTGTCGAAAGGCATCAGCGGCGGCTATCTGC
CGCTGTCGCTCGTGCTCTCGCGCGATGCGATCTTCGATGCGTTCTACGACGACGACGTGACGCGCGGCTTCCTGCATTCG
CATTCGTACACGGGCAATCCGCTCGCGTGCCGCGCGGCCGTCGCGACGCTCGAGCTGTTCGACACCGACGACGTGCTCGC
CGAAAACGCACGCAAGTCCGCGCTGATGCGTGAGGCGCTCGCGCCGCTCGCGTCGCATCCGCACGTGCGCCACCTGCGCG
AGCGCGGCACGATCTTCGCGTTCGACGTCGCGCTCGAAGGCGACGCGGCGAGGACGTTCCCGCGCCGCTTCTTCGCGCAC
GCGCTCGCGCGCGAGACGCTGCTGCGCCCGATCGGCACGACGGTCTACCTGATGCCGCCTTACATCCTCGACGAAGGCGA
GATCGAATGGCTCGCCTCGCGCACGCGCGCGACGCTCGACGCAACGCTGTCGGAGGCCCACGCATGA

Upstream 100 bases:

>100_bases
GCGTTTTTCTTCGCCATCCGATCGTCCGCTTTTCCGCTGTCGATTCCGCATGAGCGAGCGGCGCTTCGCGCCCTCGACGC
GTTTTGGTCCCGGAGCAGTC

Downstream 100 bases:

>100_bases
ATCCGCTCGCCACGCTCGAACAAGGCCTCGCCGACATCGACGCGCAAGGGCTGCGCCGGTGCCGCCGCGTCGCGGACACC
GCGTGCGGCGCGCACATGAC

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSTHATDDWVARSLRAVWHPCTQMKHHERLPLIPVARGERAWLFDRAGNRYLDAISSWWVNLFGHANPRINAALKQQLDT
LEHAMLAGCTHESAIELAERLAARTQHTLGHAFFASDGASAVEIALKMSFHAWRNRGRGDKREFVCIANGYHGETIGALG
VTDVALFKDAYDPLIRAAHVVASPDARGARDGETAADVAARALGDVRRLFAERGEKIAALIVEPLVQCAAGFAMHDPSYV
RGLRALCDAHDVHLIADEIAVGCGRTGTFFACEQAHVWPDFLCLSKGISGGYLPLSLVLSRDAIFDAFYDDDVTRGFLHS
HSYTGNPLACRAAVATLELFDTDDVLAENARKSALMREALAPLASHPHVRHLRERGTIFAFDVALEGDAARTFPRRFFAH
ALARETLLRPIGTTVYLMPPYILDEGEIEWLASRTRATLDATLSEAHA

Sequences:

>Translated_448_residues
MSTHATDDWVARSLRAVWHPCTQMKHHERLPLIPVARGERAWLFDRAGNRYLDAISSWWVNLFGHANPRINAALKQQLDT
LEHAMLAGCTHESAIELAERLAARTQHTLGHAFFASDGASAVEIALKMSFHAWRNRGRGDKREFVCIANGYHGETIGALG
VTDVALFKDAYDPLIRAAHVVASPDARGARDGETAADVAARALGDVRRLFAERGEKIAALIVEPLVQCAAGFAMHDPSYV
RGLRALCDAHDVHLIADEIAVGCGRTGTFFACEQAHVWPDFLCLSKGISGGYLPLSLVLSRDAIFDAFYDDDVTRGFLHS
HSYTGNPLACRAAVATLELFDTDDVLAENARKSALMREALAPLASHPHVRHLRERGTIFAFDVALEGDAARTFPRRFFAH
ALARETLLRPIGTTVYLMPPYILDEGEIEWLASRTRATLDATLSEAHA
>Mature_447_residues
STHATDDWVARSLRAVWHPCTQMKHHERLPLIPVARGERAWLFDRAGNRYLDAISSWWVNLFGHANPRINAALKQQLDTL
EHAMLAGCTHESAIELAERLAARTQHTLGHAFFASDGASAVEIALKMSFHAWRNRGRGDKREFVCIANGYHGETIGALGV
TDVALFKDAYDPLIRAAHVVASPDARGARDGETAADVAARALGDVRRLFAERGEKIAALIVEPLVQCAAGFAMHDPSYVR
GLRALCDAHDVHLIADEIAVGCGRTGTFFACEQAHVWPDFLCLSKGISGGYLPLSLVLSRDAIFDAFYDDDVTRGFLHSH
SYTGNPLACRAAVATLELFDTDDVLAENARKSALMREALAPLASHPHVRHLRERGTIFAFDVALEGDAARTFPRRFFAHA
LARETLLRPIGTTVYLMPPYILDEGEIEWLASRTRATLDATLSEAHA

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=410, Percent_Identity=30, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI37574042, Length=365, Percent_Identity=26.5753424657534, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI226442705, Length=367, Percent_Identity=26.7029972752044, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI13994255, Length=381, Percent_Identity=26.246719160105, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI284507298, Length=319, Percent_Identity=30.4075235109718, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI226442709, Length=334, Percent_Identity=25.748502994012, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI24119277, Length=374, Percent_Identity=23.2620320855615, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786991, Length=444, Percent_Identity=36.9369369369369, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI145693181, Length=409, Percent_Identity=29.0953545232274, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789016, Length=356, Percent_Identity=30.6179775280899, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1789759, Length=316, Percent_Identity=30.379746835443, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788044, Length=316, Percent_Identity=31.3291139240506, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1787560, Length=407, Percent_Identity=29.97542997543, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786349, Length=309, Percent_Identity=26.2135922330097, Blast_Score=85, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI25144271, Length=410, Percent_Identity=25.1219512195122, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32564660, Length=339, Percent_Identity=28.9085545722714, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI25144274, Length=229, Percent_Identity=29.6943231441048, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=417, Percent_Identity=23.7410071942446, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=448, Percent_Identity=28.7946428571429, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324432, Length=370, Percent_Identity=25.9459459459459, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323470, Length=373, Percent_Identity=29.2225201072386, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21357415, Length=419, Percent_Identity=26.2529832935561, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI161085790, Length=389, Percent_Identity=25.706940874036, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21356575, Length=325, Percent_Identity=25.2307692307692, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28574759, Length=389, Percent_Identity=25.706940874036, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 49257; Mature: 49126

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00436 PEROXIDASE_2 ; PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTHATDDWVARSLRAVWHPCTQMKHHERLPLIPVARGERAWLFDRAGNRYLDAISSWWV
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHH
NLFGHANPRINAALKQQLDTLEHAMLAGCTHESAIELAERLAARTQHTLGHAFFASDGAS
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AVEIALKMSFHAWRNRGRGDKREFVCIANGYHGETIGALGVTDVALFKDAYDPLIRAAHV
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VASPDARGARDGETAADVAARALGDVRRLFAERGEKIAALIVEPLVQCAAGFAMHDPSYV
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHH
RGLRALCDAHDVHLIADEIAVGCGRTGTFFACEQAHVWPDFLCLSKGISGGYLPLSLVLS
HHHHHHHCCCCCEEEHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCHHHHHHHH
RDAIFDAFYDDDVTRGFLHSHSYTGNPLACRAAVATLELFDTDDVLAENARKSALMREAL
HHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
APLASHPHVRHLRERGTIFAFDVALEGDAARTFPRRFFAHALARETLLRPIGTTVYLMPP
HHHHCCCHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
YILDEGEIEWLASRTRATLDATLSEAHA
EEECCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STHATDDWVARSLRAVWHPCTQMKHHERLPLIPVARGERAWLFDRAGNRYLDAISSWWV
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHH
NLFGHANPRINAALKQQLDTLEHAMLAGCTHESAIELAERLAARTQHTLGHAFFASDGAS
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AVEIALKMSFHAWRNRGRGDKREFVCIANGYHGETIGALGVTDVALFKDAYDPLIRAAHV
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VASPDARGARDGETAADVAARALGDVRRLFAERGEKIAALIVEPLVQCAAGFAMHDPSYV
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHH
RGLRALCDAHDVHLIADEIAVGCGRTGTFFACEQAHVWPDFLCLSKGISGGYLPLSLVLS
HHHHHHHCCCCCEEEHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCHHHHHHHH
RDAIFDAFYDDDVTRGFLHSHSYTGNPLACRAAVATLELFDTDDVLAENARKSALMREAL
HHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
APLASHPHVRHLRERGTIFAFDVALEGDAARTFPRRFFAHALARETLLRPIGTTVYLMPP
HHHHCCCHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
YILDEGEIEWLASRTRATLDATLSEAHA
EEECCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]