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The map label for this gene is tynA

Identifier: 52843104

GI number: 52843104

Start: 3292396

End: 3294330

Strand: Reverse

Name: tynA

Synonym: lpg2910

Alternate gene names: 52843104

Gene position: 3294330-3292396 (Counterclockwise)

Preceding gene: 52843105

Following gene: 52843102

Centisome position: 96.96

GC content: 44.39

Gene sequence:

>1935_bases
ATGCATGTGTTAGATCCCTTAACTCTTGAAGAAATTCAGGAAAGTTGTGATATTTTAAAACGAGAAAAAGAGCTCTCCGA
CAGTTATCGGTTTGCCTGGGTGATGACTTACGAACCGCCTCAACAAGAAGTTTTGCATTCAAGTGATACCGATTTCGACC
GTTGTGCTTTTCTCTCTGTTTTTAATAAAAAAACGAATGAAACCTTTGAAGCAGTCGTAAACCTCAACAGTAAAAAAGTC
GTGGAATGGAAACAGATTGTCTTCGAAGCCCCGCCTTATGGTAAGCCGCCTATTTTAATTGAGGATTTTCAAAAATGTGA
GCAAATCGTTAAAGCCGATCCGACCTGGAGAGCCGCGATGGAAAAGCGTGGGCTTGATGATGAACAAATTGACAACATTC
AAGTAGACGCATTTTCTGCCGGCTATTTTGATGAAGAGGAGGAGAGAGAACAACGGATTGTCAAAGGGATAAGTTTTTAC
CGTGATAATTTAAAGGATAATGGTTATGCCCGTCCCATTGAAGGGGTTGTCGCGATAGTAGACCTTGGCAATGAGAAGGT
ATTGCGTGTCATTGATGACGGCCGCAACGTCCCAATTCCTAAAGAAAAAATCAATTACGATTCGGATTCTTATCCTGAAA
AACGCAAAGACTTAAAACCACTGGATATTATTCAAGCAGAAGGGCCAAGTTTTAAAGTAAACGGCTGGGAAGTCAATTGG
CAAAATTGGTCATTCCATGTTGGGTTTACGCCGCGTGAGGGATTGGTTTTGCACCAGATCAAATACCTGGATGAAGGGAA
AGAAAGGCCAATTATTTACCGGGCCAGTGTGACGGATATGATAGTCCCCTATGCGGACCCTTCCGTGAGTCATTACTGGA
AAAGCGCTTTTGATGCGGGTGAATATGGTCTTGGCAAATTGGCAAATGAACTAAAGCTCGGATGTGATTGTTTAGGCAAC
ATTTATTATTTTGACGTTCCTGCGGCGGATGACTTCGGCAATTCCAGATTGATTAAAAACGCGATTTGCATGCACGAGGA
AGACGCGGGCACCCTGTGGAAGCATTATGAAACACGCAACAGCACCTTTGAGGTTCGCCGTGCTCGTGAGCTGGTCGTCA
GCTTTTTTACTACGATAGGTAACTACGACTATGGCTTTTACTGGCGATTTGGACAGGATGGCAGCCTCAAACTGGAAATA
AAACTGACTGGTATTGTACAAACAGCGGCAATATTTCCTGAGGCTCAGTATGAATGGGGAGGGAAATTGACACCGGAGCT
GGCAGCACCTACGCATCAGCATTTTTTCAATGCCCGCCTTCATATGATGGTTGATGGTGAAAAGAACTCATTCAGTGAGC
ACGAGTTTTATCCTATCGCCATGGGTGGAAAAAATCCCTATGGAAATGCGTTTGGCAGCAGCCAGAAAACATTTGAACAT
GAAGGTGAGGCAGCCCGCTCGGCTTGTGCGCAAACCCAGAGAACCTGGAAGATATTCAATCCCAATAGCGTCAATGGCAT
TGGCACAGCACCCGCTTATAAACTGGAATTGCCAGAAACCCCCTTACTGCTGGCAGATGAAGAGAGTTATATTTATAAAC
GCGGGGGATTTGCCAGCAAGCAGGTGTGGGTAACACAATATGATCCTCAAGAAAAATACGCGGCAGGAGATTACCCCAAT
CAGAGTTCCGGGGGTTGTGGTTTGCCTGCGTACATCAAACAGAACCGTAAAATTGACAATGAAAATTTGGTTTTGTGGGT
AACGCTGGGGTCTACGCATTTTCCAAGACCCGAAGACTTTCCGGTCATGCCTACTTCGATCATTTCTGCCAAGCTGCATC
CTTTTGGTTTTTTTAAGAGGAATCCGGCTATGGATCTTCCTCAAGGCAAAGTACAGGAAAAAGGGGATACCTGCTGTTCT
TCATTAACTTATTAA

Upstream 100 bases:

>100_bases
TCCCGCTATTTTTTATTTCTATCCAATTATTTCAACGCACTGTCTCTTTAATTAACGTAAAGAGCAATATCAGTTTTTTT
AATATGTAAAGGATGTCAAT

Downstream 100 bases:

>100_bases
TGGATTGGAACCAAGCACCTTCTTGAGGAGAGGGTGCTTTCCTGTTGGAGCTTAAAAATCAAAATCTCTCAGGACTTACG
AAAAACCCCAATCTCTATGT

Product: tyramine oxidase

Products: NA

Alternate protein names: Copper amine oxidase [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MHVLDPLTLEEIQESCDILKREKELSDSYRFAWVMTYEPPQQEVLHSSDTDFDRCAFLSVFNKKTNETFEAVVNLNSKKV
VEWKQIVFEAPPYGKPPILIEDFQKCEQIVKADPTWRAAMEKRGLDDEQIDNIQVDAFSAGYFDEEEEREQRIVKGISFY
RDNLKDNGYARPIEGVVAIVDLGNEKVLRVIDDGRNVPIPKEKINYDSDSYPEKRKDLKPLDIIQAEGPSFKVNGWEVNW
QNWSFHVGFTPREGLVLHQIKYLDEGKERPIIYRASVTDMIVPYADPSVSHYWKSAFDAGEYGLGKLANELKLGCDCLGN
IYYFDVPAADDFGNSRLIKNAICMHEEDAGTLWKHYETRNSTFEVRRARELVVSFFTTIGNYDYGFYWRFGQDGSLKLEI
KLTGIVQTAAIFPEAQYEWGGKLTPELAAPTHQHFFNARLHMMVDGEKNSFSEHEFYPIAMGGKNPYGNAFGSSQKTFEH
EGEAARSACAQTQRTWKIFNPNSVNGIGTAPAYKLELPETPLLLADEESYIYKRGGFASKQVWVTQYDPQEKYAAGDYPN
QSSGGCGLPAYIKQNRKIDNENLVLWVTLGSTHFPRPEDFPVMPTSIISAKLHPFGFFKRNPAMDLPQGKVQEKGDTCCS
SLTY

Sequences:

>Translated_644_residues
MHVLDPLTLEEIQESCDILKREKELSDSYRFAWVMTYEPPQQEVLHSSDTDFDRCAFLSVFNKKTNETFEAVVNLNSKKV
VEWKQIVFEAPPYGKPPILIEDFQKCEQIVKADPTWRAAMEKRGLDDEQIDNIQVDAFSAGYFDEEEEREQRIVKGISFY
RDNLKDNGYARPIEGVVAIVDLGNEKVLRVIDDGRNVPIPKEKINYDSDSYPEKRKDLKPLDIIQAEGPSFKVNGWEVNW
QNWSFHVGFTPREGLVLHQIKYLDEGKERPIIYRASVTDMIVPYADPSVSHYWKSAFDAGEYGLGKLANELKLGCDCLGN
IYYFDVPAADDFGNSRLIKNAICMHEEDAGTLWKHYETRNSTFEVRRARELVVSFFTTIGNYDYGFYWRFGQDGSLKLEI
KLTGIVQTAAIFPEAQYEWGGKLTPELAAPTHQHFFNARLHMMVDGEKNSFSEHEFYPIAMGGKNPYGNAFGSSQKTFEH
EGEAARSACAQTQRTWKIFNPNSVNGIGTAPAYKLELPETPLLLADEESYIYKRGGFASKQVWVTQYDPQEKYAAGDYPN
QSSGGCGLPAYIKQNRKIDNENLVLWVTLGSTHFPRPEDFPVMPTSIISAKLHPFGFFKRNPAMDLPQGKVQEKGDTCCS
SLTY
>Mature_644_residues
MHVLDPLTLEEIQESCDILKREKELSDSYRFAWVMTYEPPQQEVLHSSDTDFDRCAFLSVFNKKTNETFEAVVNLNSKKV
VEWKQIVFEAPPYGKPPILIEDFQKCEQIVKADPTWRAAMEKRGLDDEQIDNIQVDAFSAGYFDEEEEREQRIVKGISFY
RDNLKDNGYARPIEGVVAIVDLGNEKVLRVIDDGRNVPIPKEKINYDSDSYPEKRKDLKPLDIIQAEGPSFKVNGWEVNW
QNWSFHVGFTPREGLVLHQIKYLDEGKERPIIYRASVTDMIVPYADPSVSHYWKSAFDAGEYGLGKLANELKLGCDCLGN
IYYFDVPAADDFGNSRLIKNAICMHEEDAGTLWKHYETRNSTFEVRRARELVVSFFTTIGNYDYGFYWRFGQDGSLKLEI
KLTGIVQTAAIFPEAQYEWGGKLTPELAAPTHQHFFNARLHMMVDGEKNSFSEHEFYPIAMGGKNPYGNAFGSSQKTFEH
EGEAARSACAQTQRTWKIFNPNSVNGIGTAPAYKLELPETPLLLADEESYIYKRGGFASKQVWVTQYDPQEKYAAGDYPN
QSSGGCGLPAYIKQNRKIDNENLVLWVTLGSTHFPRPEDFPVMPTSIISAKLHPFGFFKRNPAMDLPQGKVQEKGDTCCS
SLTY

Specific function: Oxidizes histamine. Other amines including phenethylamine, tyramine, tryptamine, putrescine, and benzylamine also serve as substrate [H]

COG id: COG3733

COG function: function code Q; Cu2+-containing amine oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the copper/topaquinone oxidase family [H]

Homologues:

Organism=Homo sapiens, GI73486661, Length=423, Percent_Identity=26.241134751773, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI60498984, Length=480, Percent_Identity=25.4166666666667, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4502119, Length=408, Percent_Identity=24.0196078431373, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI60498982, Length=471, Percent_Identity=25.2653927813163, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1787651, Length=646, Percent_Identity=31.733746130031, Blast_Score=325, Evalue=4e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000269
- InterPro:   IPR015798
- InterPro:   IPR016182
- InterPro:   IPR015800
- InterPro:   IPR015801
- InterPro:   IPR015802 [H]

Pfam domain/function: PF01179 Cu_amine_oxid; PF02727 Cu_amine_oxidN2; PF02728 Cu_amine_oxidN3 [H]

EC number: =1.4.3.22 [H]

Molecular weight: Translated: 73421; Mature: 73421

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS01164 COPPER_AMINE_OXID_1 ; PS01165 COPPER_AMINE_OXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVLDPLTLEEIQESCDILKREKELSDSYRFAWVMTYEPPQQEVLHSSDTDFDRCAFLSV
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHCCCCCCHHHHHHHHH
FNKKTNETFEAVVNLNSKKVVEWKQIVFEAPPYGKPPILIEDFQKCEQIVKADPTWRAAM
HCCCCCHHHHHHHCCCCCHHHHHHHHHEECCCCCCCCEEHHHHHHHHHHHCCCCHHHHHH
EKRGLDDEQIDNIQVDAFSAGYFDEEEEREQRIVKGISFYRDNLKDNGYARPIEGVVAIV
HHCCCCHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
DLGNEKVLRVIDDGRNVPIPKEKINYDSDSYPEKRKDLKPLDIIQAEGPSFKVNGWEVNW
ECCCCEEEEEEECCCCCCCCHHHCCCCCCCCCHHHHCCCCEEEEECCCCCEEECCEEEEE
QNWSFHVGFTPREGLVLHQIKYLDEGKERPIIYRASVTDMIVPYADPSVSHYWKSAFDAG
CCEEEEECCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHCCCC
EYGLGKLANELKLGCDCLGNIYYFDVPAADDFGNSRLIKNAICMHEEDAGTLWKHYETRN
CCCHHHHHHHHHHCHHEECCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCC
STFEVRRARELVVSFFTTIGNYDYGFYWRFGQDGSLKLEIKLTGIVQTAAIFPEAQYEWG
CHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEEEEEEEHHHCCCCCCCCC
GKLTPELAAPTHQHFFNARLHMMVDGEKNSFSEHEFYPIAMGGKNPYGNAFGSSQKTFEH
CCCCHHHCCCCHHHHHCCEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHH
EGEAARSACAQTQRTWKIFNPNSVNGIGTAPAYKLELPETPLLLADEESYIYKRGGFASK
CCHHHHHHHHHHHCEEEEECCCCCCCCCCCCEEEEECCCCCEEEECCCCEEEECCCCCCC
QVWVTQYDPQEKYAAGDYPNQSSGGCGLPAYIKQNRKIDNENLVLWVTLGSTHFPRPEDF
EEEEEECCCHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCC
PVMPTSIISAKLHPFGFFKRNPAMDLPQGKVQEKGDTCCSSLTY
CCCCHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MHVLDPLTLEEIQESCDILKREKELSDSYRFAWVMTYEPPQQEVLHSSDTDFDRCAFLSV
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHCCCCCCHHHHHHHHH
FNKKTNETFEAVVNLNSKKVVEWKQIVFEAPPYGKPPILIEDFQKCEQIVKADPTWRAAM
HCCCCCHHHHHHHCCCCCHHHHHHHHHEECCCCCCCCEEHHHHHHHHHHHCCCCHHHHHH
EKRGLDDEQIDNIQVDAFSAGYFDEEEEREQRIVKGISFYRDNLKDNGYARPIEGVVAIV
HHCCCCHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
DLGNEKVLRVIDDGRNVPIPKEKINYDSDSYPEKRKDLKPLDIIQAEGPSFKVNGWEVNW
ECCCCEEEEEEECCCCCCCCHHHCCCCCCCCCHHHHCCCCEEEEECCCCCEEECCEEEEE
QNWSFHVGFTPREGLVLHQIKYLDEGKERPIIYRASVTDMIVPYADPSVSHYWKSAFDAG
CCEEEEECCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHCCCC
EYGLGKLANELKLGCDCLGNIYYFDVPAADDFGNSRLIKNAICMHEEDAGTLWKHYETRN
CCCHHHHHHHHHHCHHEECCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCC
STFEVRRARELVVSFFTTIGNYDYGFYWRFGQDGSLKLEIKLTGIVQTAAIFPEAQYEWG
CHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEEEEEEEHHHCCCCCCCCC
GKLTPELAAPTHQHFFNARLHMMVDGEKNSFSEHEFYPIAMGGKNPYGNAFGSSQKTFEH
CCCCHHHCCCCHHHHHCCEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHH
EGEAARSACAQTQRTWKIFNPNSVNGIGTAPAYKLELPETPLLLADEESYIYKRGGFASK
CCHHHHHHHHHHHCEEEEECCCCCCCCCCCCEEEEECCCCCEEEECCCCEEEECCCCCCC
QVWVTQYDPQEKYAAGDYPNQSSGGCGLPAYIKQNRKIDNENLVLWVTLGSTHFPRPEDF
EEEEEECCCHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCC
PVMPTSIISAKLHPFGFFKRNPAMDLPQGKVQEKGDTCCSSLTY
CCCCHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7876243 [H]