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The map label for this gene is 52843105

Identifier: 52843105

GI number: 52843105

Start: 3295187

End: 3296458

Strand: Reverse

Name: 52843105

Synonym: lpg2911

Alternate gene names: NA

Gene position: 3296458-3295187 (Counterclockwise)

Preceding gene: 52843107

Following gene: 52843104

Centisome position: 97.02

GC content: 39.31

Gene sequence:

>1272_bases
ATGAGTATTTTTCGTAGTGTATTAATAACGTTACTTTTTATTTCATCCGCAATGGCTGCAACTCCTGATCAGGTAACCTA
TTTGCCAGGTTGGGGTCCCATTAAGAACAATCAATATGCTGGATATTTTCCTGTTAATCCAAAAGCGGGATTATTTTATT
GGTTTGTAGAATCAAATAATCCATCTATGGATGCTCCCATTGTTTTATGGTTGAACGGTGGCCCAGGGGCAGCAAGTTTA
TATGGGTTTTTTATGGAAAACGGTCCTTATCAGGTGGATAAAAATGGGAAATTAACTGCCCGCAAAGATTCATGGACAAA
AGCAGCTAACTATTTGGTAATTGACCAACCGGCAGGAGTCGGTTACTCCTATGGTTCCTCAAAATCTTATGGCAGTGAAG
GGGAAGCTATTGATCAGTTACAAGGTGCATTACAGCTCATTTTTAAAAAACACCCAGAGCTCTATGGGAAACCTCTATTC
TTAGCTGGTGAATCTTACGCAGGAAAATACTTACCGCAGTTAGCTATTCGTCTTCTCAAAGATAAAAATATGAATCTAAA
AGGGCTATTATTAGGCGATCCTTGGATTAACCCCCGGCTACAGCAAAAAGCGAATATTGATTATGCCTATTATCACGGGC
TGATTGACAACAAAGCAAGAAAAAGAGTGCGAGTCTTATACGAAAACTGTGTTAAAGAAATTGATAAACAATCACCCTCC
ACATCAAAGGCAAACAAGACTTGTGAACAAATACAAGAATTTATAAAACAGGAGAGCGGAGGACTTAATTTAGCTAATAT
TGCAACGGGGGTTGAGCCAGAAGATACCAACATGGTCAACTATTTAAATCAAAAAGTAGTTAGAGAAGCGTTGCATATTC
CTGTGACTGTATCGGAATTCAAAACATTTAGTACGGCGGCGGCCAAAAAACTAGAAATAGGTGAACAAGATTCCGTGGCT
GACTTGTATCCACAATTGTTAGCGGCTGGCATTCGTATATTAATATATAATGGGCTAGAAGATGGAAAAGATTCAAATTT
TCTAAGTACTGAACTGCTGCTCGCTTCGCTCGATTGGCATGGCAAAAATGCATTTGCAAAAGCACCAACTTGCATATGGC
GCACTAACAATGAAGTGAGTGGATATGCGAAAGGAGCGGTTGGATTAACGCAGGTTAAAATTCGTGGTGCAGGCCATCTA
GCACCAATTGACCAGCCAGCAAGAGTTTTCGATTTATTCAAACATTTTATAAATGATAAACCCTTATGCTAG

Upstream 100 bases:

>100_bases
GGGTTCTAATGTAATGAACCGTCTTACCCACAATCCTTTGATGATGGATGGTTTGTTTCAGTGCGTGTAAAATATTCAAT
TTTATCAATAATGGATCCCC

Downstream 100 bases:

>100_bases
ATTTGGAGAAAGCTTGCTGCATTGATAAATTGAATTCACGAAAGTAATTTTTTAACTAAGCTTAACCACTCAAATAATTA
GACTAAATACTATTTATAGT

Product: serine carboxypeptidase

Products: NA

Alternate protein names: Peptidase; Serine Carboxypeptidase Eukaryotic Proteins

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MSIFRSVLITLLFISSAMAATPDQVTYLPGWGPIKNNQYAGYFPVNPKAGLFYWFVESNNPSMDAPIVLWLNGGPGAASL
YGFFMENGPYQVDKNGKLTARKDSWTKAANYLVIDQPAGVGYSYGSSKSYGSEGEAIDQLQGALQLIFKKHPELYGKPLF
LAGESYAGKYLPQLAIRLLKDKNMNLKGLLLGDPWINPRLQQKANIDYAYYHGLIDNKARKRVRVLYENCVKEIDKQSPS
TSKANKTCEQIQEFIKQESGGLNLANIATGVEPEDTNMVNYLNQKVVREALHIPVTVSEFKTFSTAAAKKLEIGEQDSVA
DLYPQLLAAGIRILIYNGLEDGKDSNFLSTELLLASLDWHGKNAFAKAPTCIWRTNNEVSGYAKGAVGLTQVKIRGAGHL
APIDQPARVFDLFKHFINDKPLC

Sequences:

>Translated_423_residues
MSIFRSVLITLLFISSAMAATPDQVTYLPGWGPIKNNQYAGYFPVNPKAGLFYWFVESNNPSMDAPIVLWLNGGPGAASL
YGFFMENGPYQVDKNGKLTARKDSWTKAANYLVIDQPAGVGYSYGSSKSYGSEGEAIDQLQGALQLIFKKHPELYGKPLF
LAGESYAGKYLPQLAIRLLKDKNMNLKGLLLGDPWINPRLQQKANIDYAYYHGLIDNKARKRVRVLYENCVKEIDKQSPS
TSKANKTCEQIQEFIKQESGGLNLANIATGVEPEDTNMVNYLNQKVVREALHIPVTVSEFKTFSTAAAKKLEIGEQDSVA
DLYPQLLAAGIRILIYNGLEDGKDSNFLSTELLLASLDWHGKNAFAKAPTCIWRTNNEVSGYAKGAVGLTQVKIRGAGHL
APIDQPARVFDLFKHFINDKPLC
>Mature_422_residues
SIFRSVLITLLFISSAMAATPDQVTYLPGWGPIKNNQYAGYFPVNPKAGLFYWFVESNNPSMDAPIVLWLNGGPGAASLY
GFFMENGPYQVDKNGKLTARKDSWTKAANYLVIDQPAGVGYSYGSSKSYGSEGEAIDQLQGALQLIFKKHPELYGKPLFL
AGESYAGKYLPQLAIRLLKDKNMNLKGLLLGDPWINPRLQQKANIDYAYYHGLIDNKARKRVRVLYENCVKEIDKQSPST
SKANKTCEQIQEFIKQESGGLNLANIATGVEPEDTNMVNYLNQKVVREALHIPVTVSEFKTFSTAAAKKLEIGEQDSVAD
LYPQLLAAGIRILIYNGLEDGKDSNFLSTELLLASLDWHGKNAFAKAPTCIWRTNNEVSGYAKGAVGLTQVKIRGAGHLA
PIDQPARVFDLFKHFINDKPLC

Specific function: Unknown

COG id: COG2939

COG function: function code E; Carboxypeptidase C (cathepsin A)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI83641876, Length=408, Percent_Identity=33.0882352941176, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI83641874, Length=408, Percent_Identity=33.0882352941176, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI189163485, Length=460, Percent_Identity=29.5652173913043, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI119395729, Length=460, Percent_Identity=29.5652173913043, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI262527235, Length=459, Percent_Identity=28.5403050108932, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI11055992, Length=417, Percent_Identity=25.6594724220624, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17533883, Length=481, Percent_Identity=28.4823284823285, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17535025, Length=472, Percent_Identity=29.4491525423729, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17555824, Length=286, Percent_Identity=34.6153846153846, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17533155, Length=463, Percent_Identity=27.4298056155508, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI212650589, Length=481, Percent_Identity=27.2349272349272, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71993767, Length=215, Percent_Identity=35.3488372093023, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17531675, Length=225, Percent_Identity=31.1111111111111, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32566661, Length=453, Percent_Identity=24.7240618101545, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17533609, Length=265, Percent_Identity=28.3018867924528, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321235, Length=469, Percent_Identity=27.9317697228145, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323955, Length=412, Percent_Identity=29.126213592233, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319615, Length=408, Percent_Identity=28.1862745098039, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24648275, Length=406, Percent_Identity=30.2955665024631, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21356389, Length=406, Percent_Identity=30.2955665024631, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24648272, Length=406, Percent_Identity=30.2955665024631, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24584516, Length=398, Percent_Identity=30.6532663316583, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24654839, Length=429, Percent_Identity=27.039627039627, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24584514, Length=399, Percent_Identity=26.5664160401003, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI19923012, Length=427, Percent_Identity=24.3559718969555, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 46789; Mature: 46658

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS00131 CARBOXYPEPT_SER_SER ; PS00560 CARBOXYPEPT_SER_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFRSVLITLLFISSAMAATPDQVTYLPGWGPIKNNQYAGYFPVNPKAGLFYWFVESNN
CHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEECCCCCCCEEEEEEECCC
PSMDAPIVLWLNGGPGAASLYGFFMENGPYQVDKNGKLTARKDSWTKAANYLVIDQPAGV
CCCCCCEEEEECCCCCHHHHHHHHHCCCCEEECCCCCEEECCCCHHHHCCEEEEECCCCC
GYSYGSSKSYGSEGEAIDQLQGALQLIFKKHPELYGKPLFLAGESYAGKYLPQLAIRLLK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHCCCEEEECCCCCHHHHHHHHHHHHH
DKNMNLKGLLLGDPWINPRLQQKANIDYAYYHGLIDNKARKRVRVLYENCVKEIDKQSPS
CCCCCEEEEEECCCCCCCCHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCC
TSKANKTCEQIQEFIKQESGGLNLANIATGVEPEDTNMVNYLNQKVVREALHIPVTVSEF
CCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEHHHH
KTFSTAAAKKLEIGEQDSVADLYPQLLAAGIRILIYNGLEDGKDSNFLSTELLLASLDWH
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHEECCCC
GKNAFAKAPTCIWRTNNEVSGYAKGAVGLTQVKIRGAGHLAPIDQPARVFDLFKHFINDK
CCCCCCCCCEEEEECCCCCCCEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCC
PLC
CCC
>Mature Secondary Structure 
SIFRSVLITLLFISSAMAATPDQVTYLPGWGPIKNNQYAGYFPVNPKAGLFYWFVESNN
HHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEECCCCCCCEEEEEEECCC
PSMDAPIVLWLNGGPGAASLYGFFMENGPYQVDKNGKLTARKDSWTKAANYLVIDQPAGV
CCCCCCEEEEECCCCCHHHHHHHHHCCCCEEECCCCCEEECCCCHHHHCCEEEEECCCCC
GYSYGSSKSYGSEGEAIDQLQGALQLIFKKHPELYGKPLFLAGESYAGKYLPQLAIRLLK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHCCCEEEECCCCCHHHHHHHHHHHHH
DKNMNLKGLLLGDPWINPRLQQKANIDYAYYHGLIDNKARKRVRVLYENCVKEIDKQSPS
CCCCCEEEEEECCCCCCCCHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCC
TSKANKTCEQIQEFIKQESGGLNLANIATGVEPEDTNMVNYLNQKVVREALHIPVTVSEF
CCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEHHHH
KTFSTAAAKKLEIGEQDSVADLYPQLLAAGIRILIYNGLEDGKDSNFLSTELLLASLDWH
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHEECCCC
GKNAFAKAPTCIWRTNNEVSGYAKGAVGLTQVKIRGAGHLAPIDQPARVFDLFKHFINDK
CCCCCCCCCEEEEECCCCCCCEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCC
PLC
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA