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The map label for this gene is msrA

Identifier: 52843102

GI number: 52843102

Start: 3290460

End: 3291329

Strand: Reverse

Name: msrA

Synonym: lpg2908

Alternate gene names: 52843102

Gene position: 3291329-3290460 (Counterclockwise)

Preceding gene: 52843104

Following gene: 52843093

Centisome position: 96.87

GC content: 44.02

Gene sequence:

>870_bases
ATGAGTGACTACCTCGATAAAACCGCAAGCTTAACCCCAGCCATTAAAAGAATAGTGTGCGACAAAGCCACTGAATATCC
TCATACTGGCTCTTATAATCAAGTAGCGACTCATGGCACGTATTTATGCAGGCGCTGTGGTCTGGCGTTGTTTCGTGGTG
TCAGTCAATTTAGCTCAGGCTGTGGCTGGCCCAGTTTTGACGATGAAATAGCTAACGCTGTGGCAAGGAAACCGGATGCG
GATGGTCAGCGAACCGAGATATTATGCGCTCGTTGTGATGCTCACTTGGGGCATGTTTTCACAGGGGAATACATGACGTA
TAAGAATTTACGTCATTGCGTTAATTCCGCTTCATTGGATTTTGTCGCGGATAATGAAGTACTGGACACAGAAGAAGCCA
TCCTTGCAGGGGGGTGTTTTTGGGGAGTGGAATATTATTTAAAACGAACTCCCGGAGTATTAAAAGTCGAGTCGGGCTAT
ACAGGTGGCCATGTTTCAGAGCCAAGTTATGAGCAAGTATGCAGTGGTACTTCAGGGCATTATGAGGCTGTGCGCGTCGT
CTATGATGCTGCTAAAACTAATTATCATGACATTGTAAAACGATTTTTTGAAATTCACGACCCAACTCAGACCAATGGAC
AAGGTCCCGACTTGGGCCACCAATATTTAAGTGCCGTGTTTTATTTTAATCAGGAACAACGCCAGGAAGCGGAGTTATTG
ATTCAGTTATTAAAGAAAAGGGGGTATCAGGTTGTAACCCAATTATTGCAAGCACAACCCTTTTGGCCTGCTGAAGACTA
TCATCAAGATTACTATTTTAAACACCACAAAATTCCTTATTGCCATAAGTCAGTCGATCGTTTTGGCTAG

Upstream 100 bases:

>100_bases
ATTTTTCACTTTAAATCGTTCACTGACGGCTTCTGAGACTGATGGCATAGAGGGTGTTCAGGAGATTTTCTCATGAGTCG
AGTTTTCAAAGGAGCATGAA

Downstream 100 bases:

>100_bases
TTGTTCCGGAAGATTTAATCTCATCATAGTCGCACTGATTTAGAAGACAGACAACTATTGGCATATTCTTCAAGATCATC
TATTGCGCACGTGCTTTCAA

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSDYLDKTASLTPAIKRIVCDKATEYPHTGSYNQVATHGTYLCRRCGLALFRGVSQFSSGCGWPSFDDEIANAVARKPDA
DGQRTEILCARCDAHLGHVFTGEYMTYKNLRHCVNSASLDFVADNEVLDTEEAILAGGCFWGVEYYLKRTPGVLKVESGY
TGGHVSEPSYEQVCSGTSGHYEAVRVVYDAAKTNYHDIVKRFFEIHDPTQTNGQGPDLGHQYLSAVFYFNQEQRQEAELL
IQLLKKRGYQVVTQLLQAQPFWPAEDYHQDYYFKHHKIPYCHKSVDRFG

Sequences:

>Translated_289_residues
MSDYLDKTASLTPAIKRIVCDKATEYPHTGSYNQVATHGTYLCRRCGLALFRGVSQFSSGCGWPSFDDEIANAVARKPDA
DGQRTEILCARCDAHLGHVFTGEYMTYKNLRHCVNSASLDFVADNEVLDTEEAILAGGCFWGVEYYLKRTPGVLKVESGY
TGGHVSEPSYEQVCSGTSGHYEAVRVVYDAAKTNYHDIVKRFFEIHDPTQTNGQGPDLGHQYLSAVFYFNQEQRQEAELL
IQLLKKRGYQVVTQLLQAQPFWPAEDYHQDYYFKHHKIPYCHKSVDRFG
>Mature_288_residues
SDYLDKTASLTPAIKRIVCDKATEYPHTGSYNQVATHGTYLCRRCGLALFRGVSQFSSGCGWPSFDDEIANAVARKPDAD
GQRTEILCARCDAHLGHVFTGEYMTYKNLRHCVNSASLDFVADNEVLDTEEAILAGGCFWGVEYYLKRTPGVLKVESGYT
GGHVSEPSYEQVCSGTSGHYEAVRVVYDAAKTNYHDIVKRFFEIHDPTQTNGQGPDLGHQYLSAVFYFNQEQRQEAELLI
QLLKKRGYQVVTQLLQAQPFWPAEDYHQDYYFKHHKIPYCHKSVDRFG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=151, Percent_Identity=39.0728476821192, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI208609995, Length=151, Percent_Identity=39.0728476821192, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI301336164, Length=116, Percent_Identity=40.5172413793103, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI301336162, Length=116, Percent_Identity=40.5172413793103, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI73089054, Length=116, Percent_Identity=40.5172413793103, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI37620216, Length=116, Percent_Identity=40.5172413793103, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI117606353, Length=121, Percent_Identity=36.3636363636364, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI208609993, Length=103, Percent_Identity=38.8349514563107, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1790665, Length=170, Percent_Identity=41.1764705882353, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1788077, Length=114, Percent_Identity=42.1052631578947, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115532676, Length=115, Percent_Identity=39.1304347826087, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17553450, Length=115, Percent_Identity=39.1304347826087, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17533973, Length=155, Percent_Identity=29.0322580645161, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319816, Length=123, Percent_Identity=41.4634146341463, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=150, Percent_Identity=32.6666666666667, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI45553335, Length=117, Percent_Identity=43.5897435897436, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21356369, Length=117, Percent_Identity=43.5897435897436, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24645799, Length=117, Percent_Identity=43.5897435897436, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI221378664, Length=116, Percent_Identity=41.3793103448276, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24645804, Length=128, Percent_Identity=38.28125, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24645801, Length=128, Percent_Identity=38.28125, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI221378662, Length=123, Percent_Identity=39.8373983739837, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24664627, Length=147, Percent_Identity=29.9319727891156, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45553131, Length=142, Percent_Identity=30.2816901408451, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664631, Length=147, Percent_Identity=29.9319727891156, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.12; =1.8.4.11 [H]

Molecular weight: Translated: 32711; Mature: 32580

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCHHHHHHHHHCCCCCCCHHHCCCHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SDYLDKTASLTPAIKRIVCDKATEYPHTGSYNQVATHGTYLCRRCGLALFRGVSQFSSG
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
CGWPSFDDEIANAVARKPDADGQRTEILCARCDAHLGHVFTGEYMTYKNLRHCVNSASLD
CCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHCCCCCC
FVADNEVLDTEEAILAGGCFWGVEYYLKRTPGVLKVESGYTGGHVSEPSYEQVCSGTSGH
EEECCCHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCH
YEAVRVVYDAAKTNYHDIVKRFFEIHDPTQTNGQGPDLGHQYLSAVFYFNQEQRQEAELL
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHH
IQLLKKRGYQVVTQLLQAQPFWPAEDYHQDYYFKHHKIPYCHKSVDRFG
HHHHHHCCHHHHHHHHHCCCCCCCHHHCCCHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]