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The map label for this gene is bioC

Identifier: 52842541

GI number: 52842541

Start: 2634644

End: 2635648

Strand: Reverse

Name: bioC

Synonym: lpg2331

Alternate gene names: 52842541

Gene position: 2635648-2634644 (Counterclockwise)

Preceding gene: 52842543

Following gene: 52842536

Centisome position: 77.57

GC content: 40.0

Gene sequence:

>1005_bases
ATGCAATTAGAGCAAACTGCAAGTTGGCTTTTGTGGAACTGGTTGCAAAGAGTGCATATTGAAGGTAAACGTAAGTTCTG
TGTTATACTTAATAATTTTTGGAGCACGATAGTTGGATTTCCAGCATTTAATTTTTCCCTGGTCTTTATAATGACGGTCA
ACAATGAAATAAGCAAGGCATTTAGCAAACATGCCGATGACTATGAGCGTGTGGCCAAAGTTCAAAAAGAAATCGGCAGT
CGTTTGTTTGAGCGATTACAATATTTGAAAATTGCTCCTCGACGAATTCTTGATTTGGGGTGTGGGCCTGGATTTTTTTC
AAAAGAATTGGCTTTGTTATATCCGAAAGCGCAGATTGTTGGAATGGATTTGTCGTTTGCCATGTTAGAGCAAGCCAGGA
AAAAACAGGGTTGGCGTCGTAAATGGCCTTTAGTCAGTGCCGATATGCAGAAAATGCCTTTTGCAACAGGCGCTTTTGAT
TTGGTTTTTGCTAACCAGGTTATTCATTGGAGTAGCTCATTAGGCATGGTTTTTCGGGAACTTAATCGTGTAATGAATGT
CAACGGATGCTTAATGTTTACTACCTTGGGTCCTGATACCTTCAAGGAATTACAAACGGCCTGGTCTGCCGCTAATCAAT
ATGCTCATGTTAATGAATTTGTTGATATGCATGATATTGGAGATTGTCTGATTGCCGAGCATTTCATGGACCCAGTCATT
GACATGGAATTACTGTCTATACATTACGAGACCCTTCCCCAATTGCTATTAGCTCTAAAAACTCAAGGGGTAAGAAATAT
TAATCCTAAACGAAATCACGGGCTCACAGGTAAAAGTGCATGGAAACAATTTGAAGCACAATACGCTACAATGCGTACTA
CTACTGGCAAATATCCCTTAACTTATGAAGTAGTTTATGGGCAAGCCTGGAAGGGTGCGCAACGTAAAATGGAGCAAGGT
ATAGAAACCTGGATTCCTGTTTCGCGTGTTGTTAAAAAATCCTAA

Upstream 100 bases:

>100_bases
GGGCCTTTTTCTAACGCATTGACCACAAACCAGATACGTATCATCAGAAAGGGGGTAGGCACAGTATTGACAGCAAGATC
CAAGTTGTTTCATAAACTCC

Downstream 100 bases:

>100_bases
TTTAAAACGGATATCAATCGGATTGTCCGGTGCATCAATGGTGTCAAGACAAATTGCTACGATTTTGTAATTGTTTTGTT
AATTCAATTAATGCAGCCGC

Product: biotin synthase BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MQLEQTASWLLWNWLQRVHIEGKRKFCVILNNFWSTIVGFPAFNFSLVFIMTVNNEISKAFSKHADDYERVAKVQKEIGS
RLFERLQYLKIAPRRILDLGCGPGFFSKELALLYPKAQIVGMDLSFAMLEQARKKQGWRRKWPLVSADMQKMPFATGAFD
LVFANQVIHWSSSLGMVFRELNRVMNVNGCLMFTTLGPDTFKELQTAWSAANQYAHVNEFVDMHDIGDCLIAEHFMDPVI
DMELLSIHYETLPQLLLALKTQGVRNINPKRNHGLTGKSAWKQFEAQYATMRTTTGKYPLTYEVVYGQAWKGAQRKMEQG
IETWIPVSRVVKKS

Sequences:

>Translated_334_residues
MQLEQTASWLLWNWLQRVHIEGKRKFCVILNNFWSTIVGFPAFNFSLVFIMTVNNEISKAFSKHADDYERVAKVQKEIGS
RLFERLQYLKIAPRRILDLGCGPGFFSKELALLYPKAQIVGMDLSFAMLEQARKKQGWRRKWPLVSADMQKMPFATGAFD
LVFANQVIHWSSSLGMVFRELNRVMNVNGCLMFTTLGPDTFKELQTAWSAANQYAHVNEFVDMHDIGDCLIAEHFMDPVI
DMELLSIHYETLPQLLLALKTQGVRNINPKRNHGLTGKSAWKQFEAQYATMRTTTGKYPLTYEVVYGQAWKGAQRKMEQG
IETWIPVSRVVKKS
>Mature_334_residues
MQLEQTASWLLWNWLQRVHIEGKRKFCVILNNFWSTIVGFPAFNFSLVFIMTVNNEISKAFSKHADDYERVAKVQKEIGS
RLFERLQYLKIAPRRILDLGCGPGFFSKELALLYPKAQIVGMDLSFAMLEQARKKQGWRRKWPLVSADMQKMPFATGAFD
LVFANQVIHWSSSLGMVFRELNRVMNVNGCLMFTTLGPDTFKELQTAWSAANQYAHVNEFVDMHDIGDCLIAEHFMDPVI
DMELLSIHYETLPQLLLALKTQGVRNINPKRNHGLTGKSAWKQFEAQYATMRTTTGKYPLTYEVVYGQAWKGAQRKMEQG
IETWIPVSRVVKKS

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=262, Percent_Identity=25.5725190839695, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1786994, Length=240, Percent_Identity=28.75, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17535003, Length=252, Percent_Identity=23.8095238095238, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922210, Length=247, Percent_Identity=26.3157894736842, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 38500; Mature: 38500

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLEQTASWLLWNWLQRVHIEGKRKFCVILNNFWSTIVGFPAFNFSLVFIMTVNNEISKA
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCEEEEEEEEECHHHHHH
FSKHADDYERVAKVQKEIGSRLFERLQYLKIAPRRILDLGCGPGFFSKELALLYPKAQIV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHCCHHHEECCHHEE
GMDLSFAMLEQARKKQGWRRKWPLVSADMQKMPFATGAFDLVFANQVIHWSSSLGMVFRE
ECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LNRVMNVNGCLMFTTLGPDTFKELQTAWSAANQYAHVNEFVDMHDIGDCLIAEHFMDPVI
HHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
DMELLSIHYETLPQLLLALKTQGVRNINPKRNHGLTGKSAWKQFEAQYATMRTTTGKYPL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCE
TYEVVYGQAWKGAQRKMEQGIETWIPVSRVVKKS
EEEEEECCCCHHHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure
MQLEQTASWLLWNWLQRVHIEGKRKFCVILNNFWSTIVGFPAFNFSLVFIMTVNNEISKA
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCEEEEEEEEECHHHHHH
FSKHADDYERVAKVQKEIGSRLFERLQYLKIAPRRILDLGCGPGFFSKELALLYPKAQIV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHCCHHHEECCHHEE
GMDLSFAMLEQARKKQGWRRKWPLVSADMQKMPFATGAFDLVFANQVIHWSSSLGMVFRE
ECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LNRVMNVNGCLMFTTLGPDTFKELQTAWSAANQYAHVNEFVDMHDIGDCLIAEHFMDPVI
HHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
DMELLSIHYETLPQLLLALKTQGVRNINPKRNHGLTGKSAWKQFEAQYATMRTTTGKYPL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCE
TYEVVYGQAWKGAQRKMEQGIETWIPVSRVVKKS
EEEEEECCCCHHHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3058702; 9278503 [H]