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The map label for this gene is folB [H]

Identifier: 52842246

GI number: 52842246

Start: 2271861

End: 2272199

Strand: Direct

Name: folB [H]

Synonym: lpg2029

Alternate gene names: 52842246

Gene position: 2271861-2272199 (Clockwise)

Preceding gene: 52842244

Following gene: 52842250

Centisome position: 66.86

GC content: 37.17

Gene sequence:

>339_bases
ATGGATACTTTAAATATTACAGCTCTCAGTGTTGAAACAAAAATTGGTGTTTATGGGTGGGAGCAGCGTATTAATCAACG
ATTATTAATTGATATATCCATTCCCTTTGACTTTAAAGATTGCAAGGATAATTTGTCCAATACACTGGATTACGCTGCTT
TGTGCCAGACAGTAACCCAATTTGTAGAGTCAACTTCGTTTCAATTAATTGAAACGGTAGCGGAACAAATTGCACAATTA
ATCAAGCAAAAGTACCCTGTTACTAAGGTTTCCGTCGCTGTTACAAAGCCCCATGCTGTAAAAAACGCTGCGGGAATCCA
AGTAGTTGTAAACAGATAA

Upstream 100 bases:

>100_bases
ATGAGAAAATTTAGATAAATTAAATGGATGATTTTAAAAATTTTAAACAAAAAGATTGAGGATTTTTCGTAGGTCCTGAT
AAATTATTAATGGATATCAA

Downstream 100 bases:

>100_bases
TCTGAAAGGAGCAATCTTCTTTGATTAAATGATTACCCTTTATCCGCCAACGCTGCGCACCATGCCGTTCAGGTGCTCTG
TTTTGGCAAGGTTCATTTGA

Product: dihydroneopterin aldolase FolB, putative kinase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 112; Mature: 112

Protein sequence:

>112_residues
MDTLNITALSVETKIGVYGWEQRINQRLLIDISIPFDFKDCKDNLSNTLDYAALCQTVTQFVESTSFQLIETVAEQIAQL
IKQKYPVTKVSVAVTKPHAVKNAAGIQVVVNR

Sequences:

>Translated_112_residues
MDTLNITALSVETKIGVYGWEQRINQRLLIDISIPFDFKDCKDNLSNTLDYAALCQTVTQFVESTSFQLIETVAEQIAQL
IKQKYPVTKVSVAVTKPHAVKNAAGIQVVVNR
>Mature_112_residues
MDTLNITALSVETKIGVYGWEQRINQRLLIDISIPFDFKDCKDNLSNTLDYAALCQTVTQFVESTSFQLIETVAEQIAQL
IKQKYPVTKVSVAVTKPHAVKNAAGIQVVVNR

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=114, Percent_Identity=39.4736842105263, Blast_Score=89, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 12500; Mature: 12500

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTLNITALSVETKIGVYGWEQRINQRLLIDISIPFDFKDCKDNLSNTLDYAALCQTVTQ
CCCCEEEEEEEECCCCEECHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
FVESTSFQLIETVAEQIAQLIKQKYPVTKVSVAVTKPHAVKNAAGIQVVVNR
HHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHCCCCCEEEEEEC
>Mature Secondary Structure
MDTLNITALSVETKIGVYGWEQRINQRLLIDISIPFDFKDCKDNLSNTLDYAALCQTVTQ
CCCCEEEEEEEECCCCEECHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
FVESTSFQLIETVAEQIAQLIKQKYPVTKVSVAVTKPHAVKNAAGIQVVVNR
HHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]