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The map label for this gene is dprE1 [H]

Identifier: 52842021

GI number: 52842021

Start: 2000166

End: 2001461

Strand: Direct

Name: dprE1 [H]

Synonym: lpg1794

Alternate gene names: 52842021

Gene position: 2000166-2001461 (Clockwise)

Preceding gene: 52842003

Following gene: 52842022

Centisome position: 58.87

GC content: 36.65

Gene sequence:

>1296_bases
ATGCGCAGCAAAAGAATCTTATTAACTAATTTTACCCGCGCAATTTATAGTGAATCCTGTTGTATAAGGCCAGACACAGA
AAAAGAACTTATTCACTATATTGCACAAAATCAGCCTAAAAACATGCTAACCAGGGGTGCAGGATTGAGTTACAGTGATA
GCTGTCTAAATCAAGACGGCCTGGTAATTGATACTAGTCGCTTTAATCATTTCATCGATTTTGATGTCGAAACAGGCATC
GTAGTATGTCAGGGTGGAACACCATTTAAGGATCTGTTTTTACTTCATGATGAATTCATTCCCCCAGTTCTCCCAGGCAC
AGCATTTGCCACTGTAGCAGGTGGAATAGCCCATGATGTTCATGGTAAAAATAACCATTCAGCGGGAAGTTTTGGACATC
ATATTTCTTGGTTTGATTTATTGATAGGCGATCAAATCATGCATTGTAGCCGCGAAAAAAATAGTGATCTATTTTTCGCA
ACTATAGCAGGTTTAGGTTTAACAGGCATTATTACACAAGTCGCTATTCGCCTTAAAAAAGCACCACGCCATCTGGCAAT
AAAAAATAAACCATTTGCATCTATCCAAGAATTAATTGCAGAAATGGCGACTTATGGTCTTCAGCAAGATTACCAAGTAG
CCTGGTTAGACTTGTTATACTCAGAACCCAGAGCCATTTTATCAACAGCAAATTATTGTGAATCGCCAAACTATCCTGAT
AAAAAATTAAAAATTTATAGCCTGCCTAAATTACCATTTGGACTTATCAAAAAATGGAACATGAAAGTATTTAATCAATA
TTTTTACTCCAGACAAAAAGAAAATGAAATGATGAGTCTCACCCAATACAATAATCCTCTGGATAAAATATCACATTGGA
ACCGACTCTACGGACCTAGAGGACTTATACAGTTTCAAGCCGTATTTGATCAAGATAAGGCAGCGCAAATTATTAATCAC
ATATTAGAGATTATTAGGACTCATAGTGCTACTCCAACCCTCACTGTCCTTAAACTATTTACACAGCCTGGGTTAGGTTT
GCTTTCGTTTTGTCGGCCTGGATTTACTCTGGCTATTGATTTTATTAATAATCCTCACGCCAAAAAAGCAATAAGCGCGA
TGAATCAATTCATTGCAGAAAACGATGGGTGTGTTTATTTGGCTAAGGATTTATTACTAAATCCAGAACAATATTTTACA
ATGTACGAAAATCAATCGAAATTTGCTCAAATACTTACAAAATATCGATGCCCCATGCGTTCAGATCTTGCGACACGTTT
AGGAATCATAAAATGA

Upstream 100 bases:

>100_bases
TATTTGATTTAATTATAGACATCCTATAGCCTTTGTTCCTGTTTCCATAATAAAAAAATCATGCGACACTCACTCAACTG
TCTATTTAAAAATTTCTGAT

Downstream 100 bases:

>100_bases
TGCAGAGGAAATGGGTTGTTTTAGGAGCTACTTCAGTTATTGCCGAACAATTCGCACATTTTGCTGCGCAAGCCGGTAAC
CATTTATGTTTAGTTGCACG

Product: oxidoreductase (L-gululonolactone oxidase)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MRSKRILLTNFTRAIYSESCCIRPDTEKELIHYIAQNQPKNMLTRGAGLSYSDSCLNQDGLVIDTSRFNHFIDFDVETGI
VVCQGGTPFKDLFLLHDEFIPPVLPGTAFATVAGGIAHDVHGKNNHSAGSFGHHISWFDLLIGDQIMHCSREKNSDLFFA
TIAGLGLTGIITQVAIRLKKAPRHLAIKNKPFASIQELIAEMATYGLQQDYQVAWLDLLYSEPRAILSTANYCESPNYPD
KKLKIYSLPKLPFGLIKKWNMKVFNQYFYSRQKENEMMSLTQYNNPLDKISHWNRLYGPRGLIQFQAVFDQDKAAQIINH
ILEIIRTHSATPTLTVLKLFTQPGLGLLSFCRPGFTLAIDFINNPHAKKAISAMNQFIAENDGCVYLAKDLLLNPEQYFT
MYENQSKFAQILTKYRCPMRSDLATRLGIIK

Sequences:

>Translated_431_residues
MRSKRILLTNFTRAIYSESCCIRPDTEKELIHYIAQNQPKNMLTRGAGLSYSDSCLNQDGLVIDTSRFNHFIDFDVETGI
VVCQGGTPFKDLFLLHDEFIPPVLPGTAFATVAGGIAHDVHGKNNHSAGSFGHHISWFDLLIGDQIMHCSREKNSDLFFA
TIAGLGLTGIITQVAIRLKKAPRHLAIKNKPFASIQELIAEMATYGLQQDYQVAWLDLLYSEPRAILSTANYCESPNYPD
KKLKIYSLPKLPFGLIKKWNMKVFNQYFYSRQKENEMMSLTQYNNPLDKISHWNRLYGPRGLIQFQAVFDQDKAAQIINH
ILEIIRTHSATPTLTVLKLFTQPGLGLLSFCRPGFTLAIDFINNPHAKKAISAMNQFIAENDGCVYLAKDLLLNPEQYFT
MYENQSKFAQILTKYRCPMRSDLATRLGIIK
>Mature_431_residues
MRSKRILLTNFTRAIYSESCCIRPDTEKELIHYIAQNQPKNMLTRGAGLSYSDSCLNQDGLVIDTSRFNHFIDFDVETGI
VVCQGGTPFKDLFLLHDEFIPPVLPGTAFATVAGGIAHDVHGKNNHSAGSFGHHISWFDLLIGDQIMHCSREKNSDLFFA
TIAGLGLTGIITQVAIRLKKAPRHLAIKNKPFASIQELIAEMATYGLQQDYQVAWLDLLYSEPRAILSTANYCESPNYPD
KKLKIYSLPKLPFGLIKKWNMKVFNQYFYSRQKENEMMSLTQYNNPLDKISHWNRLYGPRGLIQFQAVFDQDKAAQIINH
ILEIIRTHSATPTLTVLKLFTQPGLGLLSFCRPGFTLAIDFINNPHAKKAISAMNQFIAENDGCVYLAKDLLLNPEQYFT
MYENQSKFAQILTKYRCPMRSDLATRLGIIK

Specific function: Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007173
- InterPro:   IPR016166
- InterPro:   IPR016168
- InterPro:   IPR006094 [H]

Pfam domain/function: PF04030 ALO; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 48871; Mature: 48871

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSKRILLTNFTRAIYSESCCIRPDTEKELIHYIAQNQPKNMLTRGAGLSYSDSCLNQDG
CCCCEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCHHHCCCCC
LVIDTSRFNHFIDFDVETGIVVCQGGTPFKDLFLLHDEFIPPVLPGTAFATVAGGIAHDV
EEEECCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHCC
HGKNNHSAGSFGHHISWFDLLIGDQIMHCSREKNSDLFFATIAGLGLTGIITQVAIRLKK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHCCHHHHHHHHHHHHHH
APRHLAIKNKPFASIQELIAEMATYGLQQDYQVAWLDLLYSEPRAILSTANYCESPNYPD
CCCCEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
KKLKIYSLPKLPFGLIKKWNMKVFNQYFYSRQKENEMMSLTQYNNPLDKISHWNRLYGPR
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
GLIQFQAVFDQDKAAQIINHILEIIRTHSATPTLTVLKLFTQPGLGLLSFCRPGFTLAID
CCEEEHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHCCCCCEEEEE
FINNPHAKKAISAMNQFIAENDGCVYLAKDLLLNPEQYFTMYENQSKFAQILTKYRCPMR
CCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCHHHHHHHCCHHHHHHHHHHHCCCCH
SDLATRLGIIK
HHHHHHCCCCC
>Mature Secondary Structure
MRSKRILLTNFTRAIYSESCCIRPDTEKELIHYIAQNQPKNMLTRGAGLSYSDSCLNQDG
CCCCEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCHHHCCCCC
LVIDTSRFNHFIDFDVETGIVVCQGGTPFKDLFLLHDEFIPPVLPGTAFATVAGGIAHDV
EEEECCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHCC
HGKNNHSAGSFGHHISWFDLLIGDQIMHCSREKNSDLFFATIAGLGLTGIITQVAIRLKK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHCCHHHHHHHHHHHHHH
APRHLAIKNKPFASIQELIAEMATYGLQQDYQVAWLDLLYSEPRAILSTANYCESPNYPD
CCCCEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
KKLKIYSLPKLPFGLIKKWNMKVFNQYFYSRQKENEMMSLTQYNNPLDKISHWNRLYGPR
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
GLIQFQAVFDQDKAAQIINHILEIIRTHSATPTLTVLKLFTQPGLGLLSFCRPGFTLAID
CCEEEHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHCCCCCEEEEE
FINNPHAKKAISAMNQFIAENDGCVYLAKDLLLNPEQYFTMYENQSKFAQILTKYRCPMR
CCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCHHHHHHHCCHHHHHHHHHHHCCCCH
SDLATRLGIIK
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]