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The map label for this gene is ftsI4

Identifier: 52841847

GI number: 52841847

Start: 1787083

End: 1788993

Strand: Reverse

Name: ftsI4

Synonym: lpg1619

Alternate gene names: 52841847

Gene position: 1788993-1787083 (Counterclockwise)

Preceding gene: 52841848

Following gene: 52841846

Centisome position: 52.65

GC content: 38.36

Gene sequence:

>1911_bases
ATGTTATTAATAGAAATCGTATTGACTATTCATTGCCTGCTTCTTCTCAGTTCACTATTTATAGGGCGTGCCTGGCTAGC
AAATAAACCATCATTTAAATTGAAATTACTCCGTTTTTTATTGGCCAGTTGCATTATTTCACCAATAATAGTTCATTGTG
TAGACTCTGATCAAAAGCCTGAACGACAAAACTATGTATCATTTGATGCTTTGCAACAGTATGCAAAGCAATCCATATTT
AAGACAGAATCTTCAAAATTTAATCATGGATCGTCTTCTGCCTTTACATCAATGAATGTGAACTACTGTCAACTCTTAAG
CGTGATGTTTTTTTTAATCGTCTTGTTTCGTAGTTATCACTTGTTATCAGGTTTAGGTCGCTTGAAATTGATGTTGACTG
AAGCAATCCCATATCGAACTTCCGGAAAATTAGTTATTAAGGTTTCTCACCACTGCCATGTTCCTTTCTCAATATTGCTA
TTTAATAAAGCCTACATCGTATTGCCAGTATCCATATTTTCTTCTGCCATGAATGTGAGGATTGCTATTGCTCATGAAGG
GCAACACCATCGTAATGGAGATTGTTCATGGGCCTATTTTATCGAAATCATACGCATTATCTTCTTTGGAAACCCGGGTG
TAACTCAATGGTTTCGTGTTTTAGCAGATTTACAGGAATTGTCATGTGATGAAGTATTGGTTGGACATCAAAAAATTTCG
GCACATGACTATGGTCACTGTCTATTGCAAGTGGCAGAGGCAGTATCCCAATGCTCTCTGGCATCTAACCGGGAAATTGC
ATGCACGGTGGGTATGGCTTTGAACAAAGAAAACGAAGACTGCAAATTTATAATAAGGAGAATTTCAATGCTAACTGCTT
ATTCACCCAATGCATCCAGACCTTTGCTATTAGGGATAGTCTTTGCAGGATTTTCTATCCTGTCTCCAATCTGCGTTGCC
TATTCAACAGCAGGATCTTTGACGAGTTCCAGGGCAAAAGAAGTTGATATTTCTCATTTAGATCCCAGAATGCAGCAGAT
TGTGGAGAAACAAATTACGACAGCCGTCAAACAATATCATGCAAAATCTGGAGTAATTGCAATAGCTGATCCCCAAACAG
GCAATATCATTGCATTTGCTGAATCAAGTAAAAATAAGGGGCTAGAGAGCTGGAAATCACGTATTTTTTCACCCGGATCT
ACTATAAAACCTTTTATTGCAGCAGCTGCAATCAACTCTGGGAATAGCTCTGAAACAAAAAATTATGATTGTCATTCACC
TTATTACATAGCAGGCAAAACATTTACAAATTATAATTCCAATGTTGAATCAGCTTCCTTAGCAGATGCCATCGCAAAAT
CTATCAATGTATGCCTTATCAGAGTTTCTCAAGAGGCTGGAGTGCCGGTAATCCGTAAAAAGCTCACTGAATTTGGTTTT
GACATGAACAGTTGGTGGCAAGCGGATCAAAGTGACGATTTACAACTGGCAATGGCTGCACTTGGAGAGAATATCCCTGT
CACAATCGAATCGCTAATAAAATCTTATGCCATTCTTGCTAACAAAGGACATTCATTTGACAGGGGAAATAGTGCCATTA
TTTCAGAAACAAGCACTAACTCAATAAATCATATGCTTGAAAATGCTGTTACAAATGGCACTGGAAAACTCGCAGTTATT
CCTGGTGTTTCTGTAGCTGGTAAGACAGGAACTGTAATTGAAAATAATGATAAATATCTTGCTTTGTTTGCCGGGTATGT
GCCAGCTGATAATCCGCGTTATGTTTTATTAGTCGTGATTGAAGAGGGTTATTTCAGTAAAAATGGAAAGACATTAGTTT
CGGGAGGAGAATTGGCCGCACCGGTATTCCGAAATGTCGCAATGGATGCTCTGAGCAGTGCAAATCGATAA

Upstream 100 bases:

>100_bases
GACTTTTGTTAGCCAGAAAGTTACAGCATGATGACATTCAAGCCATTGAAGAAGCACTTAAACAATTAAACGCTGGTGAA
AAACAGCCAGAGGTGATGTA

Downstream 100 bases:

>100_bases
CTAGCTTATGGGTTTGCATATCCATATATTCAAAAATGTTGAGGTTGTTATGAAGAAAATAATTATATTTTTGTGTACAG
GATTATTATTTTGCGTCTCT

Product: cell division protein FtsI/penicillin binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MLLIEIVLTIHCLLLLSSLFIGRAWLANKPSFKLKLLRFLLASCIISPIIVHCVDSDQKPERQNYVSFDALQQYAKQSIF
KTESSKFNHGSSSAFTSMNVNYCQLLSVMFFLIVLFRSYHLLSGLGRLKLMLTEAIPYRTSGKLVIKVSHHCHVPFSILL
FNKAYIVLPVSIFSSAMNVRIAIAHEGQHHRNGDCSWAYFIEIIRIIFFGNPGVTQWFRVLADLQELSCDEVLVGHQKIS
AHDYGHCLLQVAEAVSQCSLASNREIACTVGMALNKENEDCKFIIRRISMLTAYSPNASRPLLLGIVFAGFSILSPICVA
YSTAGSLTSSRAKEVDISHLDPRMQQIVEKQITTAVKQYHAKSGVIAIADPQTGNIIAFAESSKNKGLESWKSRIFSPGS
TIKPFIAAAAINSGNSSETKNYDCHSPYYIAGKTFTNYNSNVESASLADAIAKSINVCLIRVSQEAGVPVIRKKLTEFGF
DMNSWWQADQSDDLQLAMAALGENIPVTIESLIKSYAILANKGHSFDRGNSAIISETSTNSINHMLENAVTNGTGKLAVI
PGVSVAGKTGTVIENNDKYLALFAGYVPADNPRYVLLVVIEEGYFSKNGKTLVSGGELAAPVFRNVAMDALSSANR

Sequences:

>Translated_636_residues
MLLIEIVLTIHCLLLLSSLFIGRAWLANKPSFKLKLLRFLLASCIISPIIVHCVDSDQKPERQNYVSFDALQQYAKQSIF
KTESSKFNHGSSSAFTSMNVNYCQLLSVMFFLIVLFRSYHLLSGLGRLKLMLTEAIPYRTSGKLVIKVSHHCHVPFSILL
FNKAYIVLPVSIFSSAMNVRIAIAHEGQHHRNGDCSWAYFIEIIRIIFFGNPGVTQWFRVLADLQELSCDEVLVGHQKIS
AHDYGHCLLQVAEAVSQCSLASNREIACTVGMALNKENEDCKFIIRRISMLTAYSPNASRPLLLGIVFAGFSILSPICVA
YSTAGSLTSSRAKEVDISHLDPRMQQIVEKQITTAVKQYHAKSGVIAIADPQTGNIIAFAESSKNKGLESWKSRIFSPGS
TIKPFIAAAAINSGNSSETKNYDCHSPYYIAGKTFTNYNSNVESASLADAIAKSINVCLIRVSQEAGVPVIRKKLTEFGF
DMNSWWQADQSDDLQLAMAALGENIPVTIESLIKSYAILANKGHSFDRGNSAIISETSTNSINHMLENAVTNGTGKLAVI
PGVSVAGKTGTVIENNDKYLALFAGYVPADNPRYVLLVVIEEGYFSKNGKTLVSGGELAAPVFRNVAMDALSSANR
>Mature_636_residues
MLLIEIVLTIHCLLLLSSLFIGRAWLANKPSFKLKLLRFLLASCIISPIIVHCVDSDQKPERQNYVSFDALQQYAKQSIF
KTESSKFNHGSSSAFTSMNVNYCQLLSVMFFLIVLFRSYHLLSGLGRLKLMLTEAIPYRTSGKLVIKVSHHCHVPFSILL
FNKAYIVLPVSIFSSAMNVRIAIAHEGQHHRNGDCSWAYFIEIIRIIFFGNPGVTQWFRVLADLQELSCDEVLVGHQKIS
AHDYGHCLLQVAEAVSQCSLASNREIACTVGMALNKENEDCKFIIRRISMLTAYSPNASRPLLLGIVFAGFSILSPICVA
YSTAGSLTSSRAKEVDISHLDPRMQQIVEKQITTAVKQYHAKSGVIAIADPQTGNIIAFAESSKNKGLESWKSRIFSPGS
TIKPFIAAAAINSGNSSETKNYDCHSPYYIAGKTFTNYNSNVESASLADAIAKSINVCLIRVSQEAGVPVIRKKLTEFGF
DMNSWWQADQSDDLQLAMAALGENIPVTIESLIKSYAILANKGHSFDRGNSAIISETSTNSINHMLENAVTNGTGKLAVI
PGVSVAGKTGTVIENNDKYLALFAGYVPADNPRYVLLVVIEEGYFSKNGKTLVSGGELAAPVFRNVAMDALSSANR

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=345, Percent_Identity=25.7971014492754, Blast_Score=86, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 69721; Mature: 69721

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIEIVLTIHCLLLLSSLFIGRAWLANKPSFKLKLLRFLLASCIISPIIVHCVDSDQKP
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ERQNYVSFDALQQYAKQSIFKTESSKFNHGSSSAFTSMNVNYCQLLSVMFFLIVLFRSYH
CHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
LLSGLGRLKLMLTEAIPYRTSGKLVIKVSHHCHVPFSILLFNKAYIVLPVSIFSSAMNVR
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEEECCEEEEEEHHHHHCCCEEE
IAIAHEGQHHRNGDCSWAYFIEIIRIIFFGNPGVTQWFRVLADLQELSCDEVLVGHQKIS
EEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCC
AHDYGHCLLQVAEAVSQCSLASNREIACTVGMALNKENEDCKFIIRRISMLTAYSPNASR
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCC
PLLLGIVFAGFSILSPICVAYSTAGSLTSSRAKEVDISHLDPRMQQIVEKQITTAVKQYH
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHCHHHCCCHHHCCHHHHHHHHHHHHHHHHHHH
AKSGVIAIADPQTGNIIAFAESSKNKGLESWKSRIFSPGSTIKPFIAAAAINSGNSSETK
HCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCHHHHHHEECCCCCCCCC
NYDCHSPYYIAGKTFTNYNSNVESASLADAIAKSINVCLIRVSQEAGVPVIRKKLTEFGF
CCCCCCCEEEECCEEECCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCC
DMNSWWQADQSDDLQLAMAALGENIPVTIESLIKSYAILANKGHSFDRGNSAIISETSTN
CCHHHCCCCCCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCH
SINHMLENAVTNGTGKLAVIPGVSVAGKTGTVIENNDKYLALFAGYVPADNPRYVLLVVI
HHHHHHHHHHCCCCCCEEEECCCEECCCCCCEEECCCCEEEEEECCCCCCCCCEEEEEEE
EEGYFSKNGKTLVSGGELAAPVFRNVAMDALSSANR
ECCEECCCCCEEECCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLLIEIVLTIHCLLLLSSLFIGRAWLANKPSFKLKLLRFLLASCIISPIIVHCVDSDQKP
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ERQNYVSFDALQQYAKQSIFKTESSKFNHGSSSAFTSMNVNYCQLLSVMFFLIVLFRSYH
CHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
LLSGLGRLKLMLTEAIPYRTSGKLVIKVSHHCHVPFSILLFNKAYIVLPVSIFSSAMNVR
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEEECCEEEEEEHHHHHCCCEEE
IAIAHEGQHHRNGDCSWAYFIEIIRIIFFGNPGVTQWFRVLADLQELSCDEVLVGHQKIS
EEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCC
AHDYGHCLLQVAEAVSQCSLASNREIACTVGMALNKENEDCKFIIRRISMLTAYSPNASR
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCC
PLLLGIVFAGFSILSPICVAYSTAGSLTSSRAKEVDISHLDPRMQQIVEKQITTAVKQYH
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHCHHHCCCHHHCCHHHHHHHHHHHHHHHHHHH
AKSGVIAIADPQTGNIIAFAESSKNKGLESWKSRIFSPGSTIKPFIAAAAINSGNSSETK
HCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCHHHHHHEECCCCCCCCC
NYDCHSPYYIAGKTFTNYNSNVESASLADAIAKSINVCLIRVSQEAGVPVIRKKLTEFGF
CCCCCCCEEEECCEEECCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCC
DMNSWWQADQSDDLQLAMAALGENIPVTIESLIKSYAILANKGHSFDRGNSAIISETSTN
CCHHHCCCCCCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCH
SINHMLENAVTNGTGKLAVIPGVSVAGKTGTVIENNDKYLALFAGYVPADNPRYVLLVVI
HHHHHHHHHHCCCCCCEEEECCCEECCCCCCEEECCCCEEEEEECCCCCCCCCEEEEEEE
EEGYFSKNGKTLVSGGELAAPVFRNVAMDALSSANR
ECCEECCCCCEEECCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]