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The map label for this gene is prs [H]

Identifier: 52841257

GI number: 52841257

Start: 1120610

End: 1121521

Strand: Direct

Name: prs [H]

Synonym: lpg1023

Alternate gene names: 52841257

Gene position: 1120610-1121521 (Clockwise)

Preceding gene: 52841256

Following gene: 52841258

Centisome position: 32.98

GC content: 42.21

Gene sequence:

>912_bases
TTGAAGCCCTTGTTATTTTCATTATTTGATTCTTCAGAAATCGCTGGGCGATTACAAGAAAGCCTGCAAGTGGAGGTGGG
GGATGTGACTTTTCATCGCTTTCCAGATACGGAGTGGTACTTAAAAATCAATTCAGAGGTTAATAATCGCAGTCTTATGG
TAGTGGACAGTTTAAACCAGCCGGATGAAAAAATACTGCCTTTGTTGTTTTTTGCCAAAACGGCTAAAGAGTTAGGGGCT
CGAAAAGTTGGATTGATTGCTCCTTATCTTTCCTACCTACGGCAAGATAAACGTTTTCACGAAGGAGAAGGAATTACTTC
ACGTTATTTTGCGGACATTTTATCCACTTCATTCGATTGGCTCATGACCATTGATCCGCACTTGCACCGCTATCACTCTT
TAGATGAAATCTACTCAATTCCCACTTTTGTTTTGCATGCCACATCGATGATTGCCACATGGATTAAACATCATGTTCCT
AAGCCAATTCTTATTGGTCCTGATATGGAAAGTGAACAGTGGGTTGCCGATATTGCAGAGAAAGGTTCTTTTTCTTATGC
GATTTTGGAAAAGATTCGACGTGGTGATAAAGAGGTGACTATTTCAGTACCCACTATTCCTGAGCTCGAATCCTCGACAC
TCGTGCTCGTCGATGACATCATTTCCACCGCCAGAACCATGGTAGAGACGGTGAAGCATTTACACCAAGCAGGGGGCAAG
TCCATCGTTTGTATTGGTGTGCATGCGCTGTTTGCAGAAGACGCTTATTCTTTATTATCTGAGATGAAAGGGGTGCAAGT
CATCACGTGTAATACCATTCATCATATCACCAATGCGATTGATGTGAGTGATTTGGCTGTGGACGTTCTGGTCCAAAACA
AACTGGCCGCTTTAAAAAGTAAGCGTAAATGA

Upstream 100 bases:

>100_bases
AGCCTTTGTTTACAATTCATTCGGAGTCTTTAGGGGAGCTCCATTACGCCTGTGATTTACTTCGCGATAAACAAGACATC
ATTATTTTAGGAGAAAACCC

Downstream 100 bases:

>100_bases
GTTGATTATTATTACAAGGAGTATCCATGTTGAAAGCCTTTAGAATGATTGCAGTGCTTATTGGGTTAATCGGAGGACCA
TTCTTTTTGAGTTCCTGCGA

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKPLLFSLFDSSEIAGRLQESLQVEVGDVTFHRFPDTEWYLKINSEVNNRSLMVVDSLNQPDEKILPLLFFAKTAKELGA
RKVGLIAPYLSYLRQDKRFHEGEGITSRYFADILSTSFDWLMTIDPHLHRYHSLDEIYSIPTFVLHATSMIATWIKHHVP
KPILIGPDMESEQWVADIAEKGSFSYAILEKIRRGDKEVTISVPTIPELESSTLVLVDDIISTARTMVETVKHLHQAGGK
SIVCIGVHALFAEDAYSLLSEMKGVQVITCNTIHHITNAIDVSDLAVDVLVQNKLAALKSKRK

Sequences:

>Translated_303_residues
MKPLLFSLFDSSEIAGRLQESLQVEVGDVTFHRFPDTEWYLKINSEVNNRSLMVVDSLNQPDEKILPLLFFAKTAKELGA
RKVGLIAPYLSYLRQDKRFHEGEGITSRYFADILSTSFDWLMTIDPHLHRYHSLDEIYSIPTFVLHATSMIATWIKHHVP
KPILIGPDMESEQWVADIAEKGSFSYAILEKIRRGDKEVTISVPTIPELESSTLVLVDDIISTARTMVETVKHLHQAGGK
SIVCIGVHALFAEDAYSLLSEMKGVQVITCNTIHHITNAIDVSDLAVDVLVQNKLAALKSKRK
>Mature_303_residues
MKPLLFSLFDSSEIAGRLQESLQVEVGDVTFHRFPDTEWYLKINSEVNNRSLMVVDSLNQPDEKILPLLFFAKTAKELGA
RKVGLIAPYLSYLRQDKRFHEGEGITSRYFADILSTSFDWLMTIDPHLHRYHSLDEIYSIPTFVLHATSMIATWIKHHVP
KPILIGPDMESEQWVADIAEKGSFSYAILEKIRRGDKEVTISVPTIPELESSTLVLVDDIISTARTMVETVKHLHQAGGK
SIVCIGVHALFAEDAYSLLSEMKGVQVITCNTIHHITNAIDVSDLAVDVLVQNKLAALKSKRK

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI28557709, Length=274, Percent_Identity=24.8175182481752, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI84875539, Length=278, Percent_Identity=24.8201438848921, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI4506129, Length=275, Percent_Identity=24.3636363636364, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4506127, Length=274, Percent_Identity=24.0875912408759, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1787458, Length=274, Percent_Identity=25.5474452554745, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17554704, Length=283, Percent_Identity=25.0883392226148, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI25149168, Length=279, Percent_Identity=24.7311827956989, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17554702, Length=274, Percent_Identity=24.8175182481752, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71989924, Length=279, Percent_Identity=24.7311827956989, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319403, Length=268, Percent_Identity=23.134328358209, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6321776, Length=265, Percent_Identity=23.3962264150943, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6320946, Length=266, Percent_Identity=22.1804511278195, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355239, Length=274, Percent_Identity=25.9124087591241, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI45551540, Length=297, Percent_Identity=24.2424242424242, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34113; Mature: 34113

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLLFSLFDSSEIAGRLQESLQVEVGDVTFHRFPDTEWYLKINSEVNNRSLMVVDSLNQ
CCCCEEHHHCCHHHHHHHHHHHEEEECCEEEEECCCCEEEEEECCCCCCCEEEEEECCCC
PDEKILPLLFFAKTAKELGARKVGLIAPYLSYLRQDKRFHEGEGITSRYFADILSTSFDW
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCE
LMTIDPHLHRYHSLDEIYSIPTFVLHATSMIATWIKHHVPKPILIGPDMESEQWVADIAE
EEEECHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHH
KGSFSYAILEKIRRGDKEVTISVPTIPELESSTLVLVDDIISTARTMVETVKHLHQAGGK
CCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCC
SIVCIGVHALFAEDAYSLLSEMKGVQVITCNTIHHITNAIDVSDLAVDVLVQNKLAALKS
EEEEEEHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
KRK
CCC
>Mature Secondary Structure
MKPLLFSLFDSSEIAGRLQESLQVEVGDVTFHRFPDTEWYLKINSEVNNRSLMVVDSLNQ
CCCCEEHHHCCHHHHHHHHHHHEEEECCEEEEECCCCEEEEEECCCCCCCEEEEEECCCC
PDEKILPLLFFAKTAKELGARKVGLIAPYLSYLRQDKRFHEGEGITSRYFADILSTSFDW
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCE
LMTIDPHLHRYHSLDEIYSIPTFVLHATSMIATWIKHHVPKPILIGPDMESEQWVADIAE
EEEECHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHH
KGSFSYAILEKIRRGDKEVTISVPTIPELESSTLVLVDDIISTARTMVETVKHLHQAGGK
CCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCC
SIVCIGVHALFAEDAYSLLSEMKGVQVITCNTIHHITNAIDVSDLAVDVLVQNKLAALKS
EEEEEEHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
KRK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]