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The map label for this gene is fadD [C]

Identifier: 52841188

GI number: 52841188

Start: 1035062

End: 1036729

Strand: Direct

Name: fadD [C]

Synonym: lpg0953

Alternate gene names: 52841188

Gene position: 1035062-1036729 (Clockwise)

Preceding gene: 52841187

Following gene: 52841193

Centisome position: 30.46

GC content: 38.13

Gene sequence:

>1668_bases
ATGCCAAAAGAATCCAATTCCAATTCATTATTTGACTTACTGTTGAAAAATGAAAAAAATTCGGCAGACCGTGTGTATTT
AAGACAGCCAAAAAATGGAGTTTGGCATGAATACACCTGGTCGTCAGTGATGCTGCAGGCCAGAAAAGTAGCTGGTTTTT
TACACCATCTGGGGTTAAAAAAAGGCGATCATATTTCCATTATCTCAAAGAATTGCGCGGAATGGTTTATCACAGATTTT
GGAATTCATATTGCTGGCATGGTCAATGTTCCATTATTTGCCAATCAAAATGAGGAAAGCGCGCATTATGTTTTAGATCA
TGGGGATGTGAAACTAGTTTTCGTTGGAAAATTAGATGATCATCAACGAGTCAGGCAATTTATCCCTAAGAATTATCGCA
CAATTGGTTTTGATTACCATAAAGATTTGCAAGTTGATTACGAATGGTCTGATGTTCTGAAAAGTGACCCTATGATTAAC
CTGGTGGAGCCAGAGCCAGATGCGTTGTATACCATTATTTATTCATCCGGGACTTCGGGGGCACCCAAAGGAGCTATGTA
TACCAATCGGTCCATAGCCAATTACTTGACAGTTTTCCCCAAAGACTTGCTCAGAATCAGAGAGTTGGAACATTATAAAT
TAATATCTTATCTTCCCCTGGCCCATGTCTATGAGCGATCTGCCATCCAATTAGGCAGTGTTGCTATTAATGCATCGGTA
TCTTTTGTTGAAAGTCTGGAGAAGTTTGCAGAGAATTTAAGGGAAGTTAGTCCCACCTTTTTCACTGCAGTTCCACGCAT
TTGGGGAGTATTTAAGCAAAAAATTGAACAAAAACTGCCACCAGCCAAATTGAATTTTTTATTAAAAATTCCTCTTATAT
CCAGTTTGATAAAAAGAAAGATCATTCACAGTTTAGGATTAAGCGAGTGTACTAATTGTTTTAGTGGAGCATCTCATCTG
CCAATATCCATTATTGATTTTTTTGAAAAACTGGGAATATATATTCAGGAAGGATATGGTCAATCCGAGAATTTGGCTTA
TGCTACCTTATCGATGTTAAATGAGAGAAAACGTGGTTACGTTGGTACCCCGAGGTTGGAGGTTGAGATAAAAGTAGGCG
AAGAGAATGAATTGCTAATGAAGTGCCCTTGTCTAATGTCAGGTTATTACAAAAATGAACAAGCAACTAAAAATGCCTTT
ACAGAAGAGGGTTGGTTGCGAACAGGAGATGTTGTTGATGTTGATAATGAAGACAGAGTTAAAATATTAGGGAGACTTTC
TGAGAATTTTAAAAACCAGACAGGAGAGTTCATTGCTCCTTCGCCAATAGAAAAACTGTTTTCAGTGAACCCTATGTTAG
AACAACTGTGCCTGGTAGGTAGAGAGTTACCCAATAACGTTTTGTTAGTTACCTTGAATGAAGGGGTGCGTTTGGGTATG
CCAAAAGAGGAGATCACTCACTCATTGCAAGAAACCTTAAAACAAGTCAATTCCAAATTGGTTAAATACGAAAAAGTCAG
TCACATCCTTGTGCTGAAAGATGCCTGGACAACTGAAAATGATAAATTAACACCTACACTGAAAGTAAAGAGAAGGGTAG
TTGAAAAAGATTATGCCGAGTTAATCCAAAAGGCACTGCAGCAATCTCAGTCAATCGTTTGGGAATGA

Upstream 100 bases:

>100_bases
AGGCGATTCATGAGGGTGAAAATTGTGTTTTGCGAGAAAAAAATAATATTTTACAACTAGTTGGTCTAGAATAGTAATTA
AACAAGCTTAAGGAAGAGCT

Downstream 100 bases:

>100_bases
GGAGACAGTTTATTTAATAAAGAACTGATTTCAAATATTCGTTCCTCTGCTGACGTGCTGTCTAAAGTAAAGCGCAGACG
TTGCGGTCCTTCCATTTGAT

Product: AMP-binding protein

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MPKESNSNSLFDLLLKNEKNSADRVYLRQPKNGVWHEYTWSSVMLQARKVAGFLHHLGLKKGDHISIISKNCAEWFITDF
GIHIAGMVNVPLFANQNEESAHYVLDHGDVKLVFVGKLDDHQRVRQFIPKNYRTIGFDYHKDLQVDYEWSDVLKSDPMIN
LVEPEPDALYTIIYSSGTSGAPKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRKIIHSLGLSECTNCFSGASHL
PISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGYVGTPRLEVEIKVGEENELLMKCPCLMSGYYKNEQATKNAF
TEEGWLRTGDVVDVDNEDRVKILGRLSENFKNQTGEFIAPSPIEKLFSVNPMLEQLCLVGRELPNNVLLVTLNEGVRLGM
PKEEITHSLQETLKQVNSKLVKYEKVSHILVLKDAWTTENDKLTPTLKVKRRVVEKDYAELIQKALQQSQSIVWE

Sequences:

>Translated_555_residues
MPKESNSNSLFDLLLKNEKNSADRVYLRQPKNGVWHEYTWSSVMLQARKVAGFLHHLGLKKGDHISIISKNCAEWFITDF
GIHIAGMVNVPLFANQNEESAHYVLDHGDVKLVFVGKLDDHQRVRQFIPKNYRTIGFDYHKDLQVDYEWSDVLKSDPMIN
LVEPEPDALYTIIYSSGTSGAPKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRKIIHSLGLSECTNCFSGASHL
PISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGYVGTPRLEVEIKVGEENELLMKCPCLMSGYYKNEQATKNAF
TEEGWLRTGDVVDVDNEDRVKILGRLSENFKNQTGEFIAPSPIEKLFSVNPMLEQLCLVGRELPNNVLLVTLNEGVRLGM
PKEEITHSLQETLKQVNSKLVKYEKVSHILVLKDAWTTENDKLTPTLKVKRRVVEKDYAELIQKALQQSQSIVWE
>Mature_554_residues
PKESNSNSLFDLLLKNEKNSADRVYLRQPKNGVWHEYTWSSVMLQARKVAGFLHHLGLKKGDHISIISKNCAEWFITDFG
IHIAGMVNVPLFANQNEESAHYVLDHGDVKLVFVGKLDDHQRVRQFIPKNYRTIGFDYHKDLQVDYEWSDVLKSDPMINL
VEPEPDALYTIIYSSGTSGAPKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASVS
FVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRKIIHSLGLSECTNCFSGASHLP
ISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGYVGTPRLEVEIKVGEENELLMKCPCLMSGYYKNEQATKNAFT
EEGWLRTGDVVDVDNEDRVKILGRLSENFKNQTGEFIAPSPIEKLFSVNPMLEQLCLVGRELPNNVLLVTLNEGVRLGMP
KEEITHSLQETLKQVNSKLVKYEKVSHILVLKDAWTTENDKLTPTLKVKRRVVEKDYAELIQKALQQSQSIVWE

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42794760, Length=594, Percent_Identity=26.9360269360269, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI42794758, Length=594, Percent_Identity=26.9360269360269, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI42794756, Length=594, Percent_Identity=26.9360269360269, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI83745141, Length=595, Percent_Identity=25.3781512605042, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI40807491, Length=531, Percent_Identity=25.9887005649718, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI57165412, Length=576, Percent_Identity=27.2569444444444, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI57165410, Length=580, Percent_Identity=26.8965517241379, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI27477105, Length=617, Percent_Identity=22.8525121555916, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI42794754, Length=597, Percent_Identity=23.9530988274707, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI42794752, Length=597, Percent_Identity=23.9530988274707, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI4758332, Length=608, Percent_Identity=22.6973684210526, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI12669909, Length=608, Percent_Identity=22.6973684210526, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI156151445, Length=471, Percent_Identity=22.5053078556263, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1788107, Length=464, Percent_Identity=23.2758620689655, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17556552, Length=615, Percent_Identity=26.0162601626016, Blast_Score=188, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17510401, Length=580, Percent_Identity=26.551724137931, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17541856, Length=588, Percent_Identity=25.6802721088435, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI193204819, Length=621, Percent_Identity=26.8921095008052, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17564090, Length=558, Percent_Identity=22.2222222222222, Blast_Score=119, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI25147511, Length=603, Percent_Identity=22.5538971807629, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17553312, Length=620, Percent_Identity=22.741935483871, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI32563687, Length=468, Percent_Identity=25.2136752136752, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=467, Percent_Identity=25.2676659528908, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI133901848, Length=241, Percent_Identity=28.2157676348548, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=564, Percent_Identity=22.8723404255319, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71994690, Length=564, Percent_Identity=22.8723404255319, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71994703, Length=564, Percent_Identity=22.8723404255319, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17531443, Length=512, Percent_Identity=21.484375, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17559526, Length=488, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320852, Length=571, Percent_Identity=25.3940455341506, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323903, Length=433, Percent_Identity=27.0207852193995, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322182, Length=433, Percent_Identity=26.0969976905312, Blast_Score=114, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6324893, Length=451, Percent_Identity=24.6119733924612, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281366413, Length=569, Percent_Identity=25.3075571177504, Blast_Score=145, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24666501, Length=569, Percent_Identity=25.3075571177504, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24666497, Length=569, Percent_Identity=25.3075571177504, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI17933690, Length=620, Percent_Identity=23.7096774193548, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI62471681, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI62471687, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24586634, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI22026970, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI62471679, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI62471683, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI62471685, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24586636, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI62471689, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=2e-27,
Organism=Drosophila melanogaster, GI19921316, Length=623, Percent_Identity=22.1508828250401, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21355181, Length=568, Percent_Identity=23.943661971831, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 63313; Mature: 63181

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKESNSNSLFDLLLKNEKNSADRVYLRQPKNGVWHEYTWSSVMLQARKVAGFLHHLGLK
CCCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHCCC
KGDHISIISKNCAEWFITDFGIHIAGMVNVPLFANQNEESAHYVLDHGDVKLVFVGKLDD
CCCEEEEEHHHHHHHHHHHCCEEEEEEEECCEEECCCCCCCEEEEECCCEEEEEEECCCC
HQRVRQFIPKNYRTIGFDYHKDLQVDYEWSDVLKSDPMINLVEPEPDALYTIIYSSGTSG
HHHHHHHCCCCCEEECCCCCCCCEEEECHHHHHCCCCCEEEECCCCCEEEEEEEECCCCC
APKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEECHH
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECHHHHHHHHHH
IIHSLGLSECTNCFSGASHLPISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGY
HHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCC
VGTPRLEVEIKVGEENELLMKCPCLMSGYYKNEQATKNAFTEEGWLRTGDVVDVDNEDRV
CCCCEEEEEEEECCCCCEEEECCHHHCCCCCCCHHHHHHCCCCCCEECCCEEECCCCCHH
KILGRLSENFKNQTGEFIAPSPIEKLFSVNPMLEQLCLVGRELPNNVLLVTLNEGVRLGM
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
PKEEITHSLQETLKQVNSKLVKYEKVSHILVLKDAWTTENDKLTPTLKVKRRVVEKDYAE
CHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LIQKALQQSQSIVWE
HHHHHHHHHHCCCCC
>Mature Secondary Structure 
PKESNSNSLFDLLLKNEKNSADRVYLRQPKNGVWHEYTWSSVMLQARKVAGFLHHLGLK
CCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHCCC
KGDHISIISKNCAEWFITDFGIHIAGMVNVPLFANQNEESAHYVLDHGDVKLVFVGKLDD
CCCEEEEEHHHHHHHHHHHCCEEEEEEEECCEEECCCCCCCEEEEECCCEEEEEEECCCC
HQRVRQFIPKNYRTIGFDYHKDLQVDYEWSDVLKSDPMINLVEPEPDALYTIIYSSGTSG
HHHHHHHCCCCCEEECCCCCCCCEEEECHHHHHCCCCCEEEECCCCCEEEEEEEECCCCC
APKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEECHH
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECHHHHHHHHHH
IIHSLGLSECTNCFSGASHLPISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGY
HHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCC
VGTPRLEVEIKVGEENELLMKCPCLMSGYYKNEQATKNAFTEEGWLRTGDVVDVDNEDRV
CCCCEEEEEEEECCCCCEEEECCHHHCCCCCCCHHHHHHCCCCCCEECCCEEECCCCCHH
KILGRLSENFKNQTGEFIAPSPIEKLFSVNPMLEQLCLVGRELPNNVLLVTLNEGVRLGM
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
PKEEITHSLQETLKQVNSKLVKYEKVSHILVLKDAWTTENDKLTPTLKVKRRVVEKDYAE
CHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LIQKALQQSQSIVWE
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]