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The map label for this gene is mmgA [H]

Identifier: 52787646

GI number: 52787646

Start: 3793337

End: 3794515

Strand: Reverse

Name: mmgA [H]

Synonym: BLi03968

Alternate gene names: 52787646

Gene position: 3794515-3793337 (Counterclockwise)

Preceding gene: 52787647

Following gene: 52787645

Centisome position: 89.86

GC content: 55.05

Gene sequence:

>1179_bases
GTGGCGAGATCAGTTATTGCAGGCGGCGCACGCACGCCTTTTGGAAAACTCGGGGGCGCGCTTCAGTCAAAGACGGCTGC
GGAGCTCGGCGGAATCGCCGTAAAAGAGGCATTAAAACGTTCCGGTGTAAATCCTGAGGATGTCGATGAAGTCATCATGG
GCTCCGTACTTCAAGGCGGACAGGGGCAGCTGCCGTCGAGGCAGGCCGCGCGTTTTGCGGGACTCCCGTGGGACGTCAAA
ACGGAAACGATTAATAAAGTGTGCGCTTCAGGTTTAAGAAGCGTCACAATGGCGGATCAGATCATCAGGGCCGGTGATGC
GGAGGTCATTGCCGCCGGAGGTATGGAATCGATGTCAAACGCCCCTTATTTGCTTCAAAAAGCGAGGTGGGGGCTGAGGA
TGGGAGACGGGGCGGTTAAAGATTTGATGATCGCAGACGGGCTGACATGCTCATTTACGGGCGTTCACATGGGCTCCTAC
GGAAATGCCGCTGCGAAAGAGTTGGAGATTGCTAGGGAAGAGCAGGATCGGTGGGCGCTCAGGAGCCACATGCGAGCCGT
ACACGCTGCGGATTCAGGCGCGCTAGGAGAAGAGATCGTCCCGGTCAGCATCCAAGAGAAGCGGGACGGCGAATTAACGG
TCGATCAAGATGAAGCACCGCGGCGCGACACGTCAATGGAAAGGCTGTCAAAGCTTGCCCCGGTTTTTGACCATAATGGG
ACAATTACGGCGGGAAACGCGCCGGGGGTAAATGATGGGGCATGCTCACTTATCGTGATGAATGAAGACAAGGCAAAGGA
ACTCAATGTGAAGGCGCCGGCCGTCATTAAAGCGCACACATCAATTGCAGTCGAAGCAAAAGACTTTCCGAAAACCCCCG
GGCTTGTCATCAGAGAACTGCTTAACAAAACGGGAGCTGAGCTTTCTGATATCAAACTGTTTGAAATCAATGAAGCTTTC
GCTGCGGTTGCTTTGGCAAGCGGAAAGATCGCGGGTCTTGACATGGAGAAGGTCAATGTCAACGGCGGCGCCATTGCGAT
CGGCCATCCGATCGGCGCGAGCGGAGCAAGAATCATTTTAACGCTTATGTACGAATTAAAACGGCGCGGCGGCGGTATAG
GGATTGCTGCCATTTGCAGCGGCGGCGGCCAGGGAGACGCCGTGATGATCGAGGTATAA

Upstream 100 bases:

>100_bases
TAGACGGATTTCAGGTTTTAAATAAAGAAGGTGTGAGCCGGATCTCCGCCTTCTTTTATCTTCGGTATGTACAAATCATG
ATAAGGGGAGAGGATGTCAG

Downstream 100 bases:

>100_bases
AAAGGGGGATTTCAGATGAAAAAAGACACGATCATGGTCATCGGAGCCGGCCAGATGGGGTCCGGGATCGCTCAGGTCTC
TGCCCAGGCCGGATACAATG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MARSVIAGGARTPFGKLGGALQSKTAAELGGIAVKEALKRSGVNPEDVDEVIMGSVLQGGQGQLPSRQAARFAGLPWDVK
TETINKVCASGLRSVTMADQIIRAGDAEVIAAGGMESMSNAPYLLQKARWGLRMGDGAVKDLMIADGLTCSFTGVHMGSY
GNAAAKELEIAREEQDRWALRSHMRAVHAADSGALGEEIVPVSIQEKRDGELTVDQDEAPRRDTSMERLSKLAPVFDHNG
TITAGNAPGVNDGACSLIVMNEDKAKELNVKAPAVIKAHTSIAVEAKDFPKTPGLVIRELLNKTGAELSDIKLFEINEAF
AAVALASGKIAGLDMEKVNVNGGAIAIGHPIGASGARIILTLMYELKRRGGGIGIAAICSGGGQGDAVMIEV

Sequences:

>Translated_392_residues
MARSVIAGGARTPFGKLGGALQSKTAAELGGIAVKEALKRSGVNPEDVDEVIMGSVLQGGQGQLPSRQAARFAGLPWDVK
TETINKVCASGLRSVTMADQIIRAGDAEVIAAGGMESMSNAPYLLQKARWGLRMGDGAVKDLMIADGLTCSFTGVHMGSY
GNAAAKELEIAREEQDRWALRSHMRAVHAADSGALGEEIVPVSIQEKRDGELTVDQDEAPRRDTSMERLSKLAPVFDHNG
TITAGNAPGVNDGACSLIVMNEDKAKELNVKAPAVIKAHTSIAVEAKDFPKTPGLVIRELLNKTGAELSDIKLFEINEAF
AAVALASGKIAGLDMEKVNVNGGAIAIGHPIGASGARIILTLMYELKRRGGGIGIAAICSGGGQGDAVMIEV
>Mature_391_residues
ARSVIAGGARTPFGKLGGALQSKTAAELGGIAVKEALKRSGVNPEDVDEVIMGSVLQGGQGQLPSRQAARFAGLPWDVKT
ETINKVCASGLRSVTMADQIIRAGDAEVIAAGGMESMSNAPYLLQKARWGLRMGDGAVKDLMIADGLTCSFTGVHMGSYG
NAAAKELEIAREEQDRWALRSHMRAVHAADSGALGEEIVPVSIQEKRDGELTVDQDEAPRRDTSMERLSKLAPVFDHNGT
ITAGNAPGVNDGACSLIVMNEDKAKELNVKAPAVIKAHTSIAVEAKDFPKTPGLVIRELLNKTGAELSDIKLFEINEAFA
AVALASGKIAGLDMEKVNVNGGAIAIGHPIGASGARIILTLMYELKRRGGGIGIAAICSGGGQGDAVMIEV

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=388, Percent_Identity=44.3298969072165, Blast_Score=319, Evalue=2e-87,
Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=43.1876606683805, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=40.920716112532, Blast_Score=275, Evalue=7e-74,
Organism=Homo sapiens, GI4501853, Length=393, Percent_Identity=35.3689567430025, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4504327, Length=422, Percent_Identity=30.5687203791469, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=28.0205655526992, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=48.469387755102, Blast_Score=327, Evalue=9e-91,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=45.2685421994885, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI1787663, Length=399, Percent_Identity=39.8496240601504, Blast_Score=251, Evalue=4e-68,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=35.5889724310777, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1788683, Length=411, Percent_Identity=30.1703163017032, Blast_Score=174, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI25147385, Length=389, Percent_Identity=41.3881748071979, Blast_Score=295, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI133906874, Length=387, Percent_Identity=39.7932816537468, Blast_Score=274, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=39.5939086294416, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=32.1596244131455, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17535917, Length=391, Percent_Identity=34.0153452685422, Blast_Score=189, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=42.25, Blast_Score=299, Evalue=5e-82,
Organism=Saccharomyces cerevisiae, GI6322031, Length=344, Percent_Identity=32.5581395348837, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=43.7340153452685, Blast_Score=311, Evalue=7e-85,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=42.0918367346939, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI17648125, Length=388, Percent_Identity=37.1134020618557, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI17137578, Length=422, Percent_Identity=30.5687203791469, Blast_Score=171, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40859; Mature: 40728

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARSVIAGGARTPFGKLGGALQSKTAAELGGIAVKEALKRSGVNPEDVDEVIMGSVLQGG
CCCCEECCCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
QGQLPSRQAARFAGLPWDVKTETINKVCASGLRSVTMADQIIRAGDAEVIAAGGMESMSN
CCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCCC
APYLLQKARWGLRMGDGAVKDLMIADGLTCSFTGVHMGSYGNAAAKELEIAREEQDRWAL
CCHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
RSHMRAVHAADSGALGEEIVPVSIQEKRDGELTVDQDEAPRRDTSMERLSKLAPVFDHNG
HHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCC
TITAGNAPGVNDGACSLIVMNEDKAKELNVKAPAVIKAHTSIAVEAKDFPKTPGLVIREL
EEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCEEEEECCCCCCCCCHHHHHH
LNKTGAELSDIKLFEINEAFAAVALASGKIAGLDMEKVNVNGGAIAIGHPIGASGARIIL
HHHCCCCHHCEEEEEECHHHHHHHHHCCCEECCEEEEEECCCCEEEECCCCCCCCHHHHH
TLMYELKRRGGGIGIAAICSGGGQGDAVMIEV
HHHHHHHHCCCCEEEEEEECCCCCCCEEEEEC
>Mature Secondary Structure 
ARSVIAGGARTPFGKLGGALQSKTAAELGGIAVKEALKRSGVNPEDVDEVIMGSVLQGG
CCCEECCCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
QGQLPSRQAARFAGLPWDVKTETINKVCASGLRSVTMADQIIRAGDAEVIAAGGMESMSN
CCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCCC
APYLLQKARWGLRMGDGAVKDLMIADGLTCSFTGVHMGSYGNAAAKELEIAREEQDRWAL
CCHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
RSHMRAVHAADSGALGEEIVPVSIQEKRDGELTVDQDEAPRRDTSMERLSKLAPVFDHNG
HHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCC
TITAGNAPGVNDGACSLIVMNEDKAKELNVKAPAVIKAHTSIAVEAKDFPKTPGLVIREL
EEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCEEEEECCCCCCCCCHHHHHH
LNKTGAELSDIKLFEINEAFAAVALASGKIAGLDMEKVNVNGGAIAIGHPIGASGARIIL
HHHCCCCHHCEEEEEECHHHHHHHHHCCCEECCEEEEEECCCCEEEECCCCCCCCHHHHH
TLMYELKRRGGGIGIAAICSGGGQGDAVMIEV
HHHHHHHHCCCCEEEEEEECCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]