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The map label for this gene is mmgB [H]

Identifier: 52787645

GI number: 52787645

Start: 3792458

End: 3793321

Strand: Reverse

Name: mmgB [H]

Synonym: BLi03967

Alternate gene names: 52787645

Gene position: 3793321-3792458 (Counterclockwise)

Preceding gene: 52787646

Following gene: 52787644

Centisome position: 89.83

GC content: 50.12

Gene sequence:

>864_bases
ATGAAAAAAGACACGATCATGGTCATCGGAGCCGGCCAGATGGGGTCCGGGATCGCTCAGGTCTCTGCCCAGGCCGGATA
CAATGTTTACATGTATGACGTATCACCTGAACAAATTGAAAAAGGAATGAAGCGCATTTCCGGCCAGCTTTTCAGACAGG
CGGAAAAAGGCAAGCTGCCGCATGAAGATGTGAAGCAAATCTACCAGCGCCTTTCTCCGTCGGCTGCGCTCGACGAAGCG
CGGGAAGCTTTTCTCATCATTGAAGCGGCTGTTGAACAAATGGACGTAAAAAAAGACATTTTCACGCGGCTTGATGAAGT
GACCGAAGACTCAGCGATATTGGCATCAAATACATCGTCCCTGTCGATTACGGAACTTGCTGCCGTCACAAAAAAACCTC
AAAACGTCATCGGCATGCATTTTATGAACCCGGTTCCCGTCATGCAGCTTGTCGAAGTCATCAGGGGGCTTGAGACGAGC
GGCGAAACATATGAAACCGTCGTGGCTGCGGCGGAGCGGATGAACAAGGTTCCGATAGAGGTGCGGGATTTCCCGGGATT
TATCTCCAACCGCATCTTAATGCCGATGATTAATGAGGCGGTTTTTGCACTTTATGAAGGCATCGCCGAGAAAGAAAGCA
TAGACGGAATCATGAAGCTTGGCATGAACCATCCGATGGGCCCGTTGGCTCTCGCCGATCTGATCGGTCTGGATACGTGT
CTGTATATTATGGAGACGCTGCATGAAGGCTTTGGCGACGATAAGTACAGGCCTTGTCCGCTCCTTAAACAATATGTCAG
CGCAGGACGACTCGGAAAGAAAACGGGCAGAGGGTTTTATACGTATGAAAAGCAGCCGACATAA

Upstream 100 bases:

>100_bases
ATTAAAACGGCGCGGCGGCGGTATAGGGATTGCTGCCATTTGCAGCGGCGGCGGCCAGGGAGACGCCGTGATGATCGAGG
TATAAAAAGGGGGATTTCAG

Downstream 100 bases:

>100_bases
GGAGGGGTGAGCTTGAATTTTCAGTTTACAGAAGAGCAGACCCGCATGCAGAAGGTTGTAAGGGATTTTGTCAAACAGGA
GGTCGCTCCTTTTGTACCTG

Product: MmgB

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MKKDTIMVIGAGQMGSGIAQVSAQAGYNVYMYDVSPEQIEKGMKRISGQLFRQAEKGKLPHEDVKQIYQRLSPSAALDEA
REAFLIIEAAVEQMDVKKDIFTRLDEVTEDSAILASNTSSLSITELAAVTKKPQNVIGMHFMNPVPVMQLVEVIRGLETS
GETYETVVAAAERMNKVPIEVRDFPGFISNRILMPMINEAVFALYEGIAEKESIDGIMKLGMNHPMGPLALADLIGLDTC
LYIMETLHEGFGDDKYRPCPLLKQYVSAGRLGKKTGRGFYTYEKQPT

Sequences:

>Translated_287_residues
MKKDTIMVIGAGQMGSGIAQVSAQAGYNVYMYDVSPEQIEKGMKRISGQLFRQAEKGKLPHEDVKQIYQRLSPSAALDEA
REAFLIIEAAVEQMDVKKDIFTRLDEVTEDSAILASNTSSLSITELAAVTKKPQNVIGMHFMNPVPVMQLVEVIRGLETS
GETYETVVAAAERMNKVPIEVRDFPGFISNRILMPMINEAVFALYEGIAEKESIDGIMKLGMNHPMGPLALADLIGLDTC
LYIMETLHEGFGDDKYRPCPLLKQYVSAGRLGKKTGRGFYTYEKQPT
>Mature_287_residues
MKKDTIMVIGAGQMGSGIAQVSAQAGYNVYMYDVSPEQIEKGMKRISGQLFRQAEKGKLPHEDVKQIYQRLSPSAALDEA
REAFLIIEAAVEQMDVKKDIFTRLDEVTEDSAILASNTSSLSITELAAVTKKPQNVIGMHFMNPVPVMQLVEVIRGLETS
GETYETVVAAAERMNKVPIEVRDFPGFISNRILMPMINEAVFALYEGIAEKESIDGIMKLGMNHPMGPLALADLIGLDTC
LYIMETLHEGFGDDKYRPCPLLKQYVSAGRLGKKTGRGFYTYEKQPT

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=40.7665505226481, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=39.344262295082, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI20127408, Length=280, Percent_Identity=36.0714285714286, Blast_Score=175, Evalue=3e-44,
Organism=Homo sapiens, GI261878539, Length=293, Percent_Identity=33.4470989761092, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=33.7883959044369, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI115430219, Length=231, Percent_Identity=29.4372294372294, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1787661, Length=282, Percent_Identity=40.0709219858156, Blast_Score=217, Evalue=8e-58,
Organism=Escherichia coli, GI1790281, Length=266, Percent_Identity=35.3383458646617, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1788682, Length=262, Percent_Identity=35.4961832061069, Blast_Score=150, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17553560, Length=285, Percent_Identity=39.6491228070175, Blast_Score=213, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI17549919, Length=292, Percent_Identity=38.6986301369863, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17563036, Length=295, Percent_Identity=39.6610169491525, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI25144276, Length=280, Percent_Identity=34.6428571428571, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17508953, Length=280, Percent_Identity=34.6428571428571, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17508951, Length=280, Percent_Identity=34.6428571428571, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17558304, Length=280, Percent_Identity=33.9285714285714, Blast_Score=160, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71985923, Length=279, Percent_Identity=31.5412186379928, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71985930, Length=282, Percent_Identity=29.4326241134752, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI193203623, Length=195, Percent_Identity=21.5384615384615, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=195, Percent_Identity=21.5384615384615, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24583077, Length=283, Percent_Identity=34.982332155477, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24583079, Length=283, Percent_Identity=34.982332155477, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI19921000, Length=283, Percent_Identity=34.982332155477, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45549573, Length=239, Percent_Identity=28.8702928870293, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI20129993, Length=225, Percent_Identity=26.6666666666667, Blast_Score=87, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31764; Mature: 31764

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKDTIMVIGAGQMGSGIAQVSAQAGYNVYMYDVSPEQIEKGMKRISGQLFRQAEKGKLP
CCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
HEDVKQIYQRLSPSAALDEAREAFLIIEAAVEQMDVKKDIFTRLDEVTEDSAILASNTSS
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
LSITELAAVTKKPQNVIGMHFMNPVPVMQLVEVIRGLETSGETYETVVAAAERMNKVPIE
CHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCE
VRDFPGFISNRILMPMINEAVFALYEGIAEKESIDGIMKLGMNHPMGPLALADLIGLDTC
EECCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LYIMETLHEGFGDDKYRPCPLLKQYVSAGRLGKKTGRGFYTYEKQPT
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHCCCCCEECCCCCC
>Mature Secondary Structure
MKKDTIMVIGAGQMGSGIAQVSAQAGYNVYMYDVSPEQIEKGMKRISGQLFRQAEKGKLP
CCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
HEDVKQIYQRLSPSAALDEAREAFLIIEAAVEQMDVKKDIFTRLDEVTEDSAILASNTSS
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
LSITELAAVTKKPQNVIGMHFMNPVPVMQLVEVIRGLETSGETYETVVAAAERMNKVPIE
CHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCE
VRDFPGFISNRILMPMINEAVFALYEGIAEKESIDGIMKLGMNHPMGPLALADLIGLDTC
EECCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LYIMETLHEGFGDDKYRPCPLLKQYVSAGRLGKKTGRGFYTYEKQPT
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]