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The map label for this gene is rnr [H]

Identifier: 52787326

GI number: 52787326

Start: 3470223

End: 3472526

Strand: Reverse

Name: rnr [H]

Synonym: BLi03641

Alternate gene names: 52787326

Gene position: 3472526-3470223 (Counterclockwise)

Preceding gene: 52787327

Following gene: 52787325

Centisome position: 82.24

GC content: 49.39

Gene sequence:

>2304_bases
GTGGAAAAAGAAGAATTTATGGATAAGCTTCTCTCCTTTATGAAAGAAGAAGCATATAAACCTCTTACAGTTCAGGAACT
GGAAGAGATGCTGGAAATCACCGATTCGGACGAATACAAAGAGCTCGTCAAAGCTCTTGTAACCCTTGAAGAAAAAGGGC
TTGTCGTCAGAACGAGAAGCAACCGCTACGGTTTGCCCGAAAAAATGAATCTGATCAAAGGGAAGGTGTCGGCGCACGCG
AAAGGCTTCGCGTTTGTCCTTCCCGAAGACTCCTCGCTTGACGATGTCTTCATTCCGCCGTCTGAGCTGAACACAGCAAT
GAACGGAGATACCGTGCTCGTCCGCCTGAGCACAGAATCCGGCGGTACAAAAAAAGAAGGGGCCATCATCCGCATCATCG
AGCGCAACATTCAGAAGATTGTCGGCACATACACAGAGACGAAAAACTTCGGCTTCGTCATTCCCGACGATAAAAAAATC
ACGAATGACATCTTTATTCCGAAGCACGCCAAAAACGGCGCCGTCGAGGGTCATAAAGTCGTCGTCCGCCTGACAAGCTA
TCCTGAAGGCCGGATGAGTGCAGAAGGGGAAGTCATCGAGATTCTCGGTCATAAAAACGATCCCGGCATCGACATTCTTT
CGATTATTCATAAGCACGGCCTCCCGGGAGACTTTCCGGCTGAGGCGATGGAACAGGCCGGCAATACGCCTGATACAATC
GATGAGAAAGATCTTGAAGGCAGACGGGATCTGCGCGATCAAACGATCGTCACGATCGACGGCGCAGATGCCAAAGACTT
GGACGATGCCGTTACCGTCACAAAACTCAAAAACGGCCATTATAAACTCGGCGTCCACATTGCCGACGTCAGCCATTATG
TAACGGAAGGATCTCCGATTGACCAGGAAGCGTATGAACGCGGCACGAGCGTCTACCTTGTCGACCGGGTGATTCCGATG
ATCCCGCACAGGCTGTCAAATGGAATCTGCTCCTTGAATCCGAAGGTCGACAGGCTGACAATGTCATGCGAAATGCTCAT
TAATCCTCAAGGGCAAGTCGTCGAGCACGAAATTTTTCAAAGCGTCATTAAAACGACCGAGCGGATGACTTATTCTGATG
TGAACAAAATTTTAGTCGATGATGATGAAGAGCTGAAACAGAAGTATGAGGCCCTTGTCCCGATGTTTAAAGACATGGAA
GACTTGGCTGCGATTCTGCGCGGCAAGCGGATGGAACGCGGAGCCGTCGACTTTGACTTTAAGGAAGCGAAGGTTCTCGT
CGACGAAGAAGGAAAAGCGAAGGACGTCGTCTTGAGAGAACGGTCGACTGCTGAAAAGCTGATTGAAGAATTTATGCTTG
TCGCCAATGAAACGGTCGCTGAGCACTTTCATTGGATGAATGTTCCGTTTATTTACCGGATTCACGAAGATCCAGATCAG
GAAAAGCTGCAGAGATTTTTGGAGTTCGTTACGACATTCGGCTATGTCGTCAAAGGAACGGCGGGAAGTATCCATCCGAA
AGCGCTGCAAAGCGTGCTTGAAGAAGTCAGGGATCGTCCTGAAGAAGCCGTAATTTCAACGGTTATGCTCAGGTCGATGA
AACAGGCGAAATACGATCCGCAAAGCCTGGGGCACTTCGGCTTGTCGACTGAATTCTACACGCATTTCACGTCTCCGATT
CGCCGCTATCCTGACTTAATCGTCCACAGACTGATCAGGACCTATTTGATTCAGGGCAAGACAGACGAAGCGACAAGGGA
AAAATGGGCCGAGAAACTGCCTGAGATCGCCGAGCATACGTCAAATATGGAACGCAATGCCGTAGATGCGGAGCGGGAAA
CGGACGATCTGAAAAAAACCGAATTTATGCTGGATAAGATCGGTGAAGAATTTGACGGCGTCATCAGCTCCGTCACGAAC
TTCGGCATGTTCGTCGAGCTGCCGAACACGATCGAAGGGCTTGTCCACGTCAGCTTTATGACGGATGATTTCTACCGTTA
TGATGAACAGCACTACGCGATGATCGGCGAGCGCACGGGCAACGTGTACCGGATCGGCGATGAGATTACGGTCCGCGTCG
TTGACGTCAATAAAGACGAGCGGAACATCGATTTTGAAATCGTCGGCATGAAAGGCTCCCGCCGCCGGCAGAAGCCGGAG
CCAAAGCAGAAAAAGGCTTCAAAAAGAGAGGCTCCATCGGCTGACAAAGGGGAATGGTTCACCAAGCCGAAAAAGAAAAA
AGTAAAGAAAAAACGCGGTTTTCAAAACGCGCCGAAACAAAAACGCAAGAAAAAGAAAAAATAG

Upstream 100 bases:

>100_bases
GGTCATGCCATCACATTGGATAAAGAACGCGAAACACTGCACAAGGATGTGTATCAATTTTTAGAAACGTTGGATTGGCA
GACATAAGGAGGTCTGATTA

Downstream 100 bases:

>100_bases
ACGGCACACGTCAAAAAAAGGGCGGCGAAATTGTAAGACGAACGTTCATTTGATAGAATAATACGTATTCGCCGCCCTTT
AGTGAGATTGAAGGCGGGAG

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 767; Mature: 767

Protein sequence:

>767_residues
MEKEEFMDKLLSFMKEEAYKPLTVQELEEMLEITDSDEYKELVKALVTLEEKGLVVRTRSNRYGLPEKMNLIKGKVSAHA
KGFAFVLPEDSSLDDVFIPPSELNTAMNGDTVLVRLSTESGGTKKEGAIIRIIERNIQKIVGTYTETKNFGFVIPDDKKI
TNDIFIPKHAKNGAVEGHKVVVRLTSYPEGRMSAEGEVIEILGHKNDPGIDILSIIHKHGLPGDFPAEAMEQAGNTPDTI
DEKDLEGRRDLRDQTIVTIDGADAKDLDDAVTVTKLKNGHYKLGVHIADVSHYVTEGSPIDQEAYERGTSVYLVDRVIPM
IPHRLSNGICSLNPKVDRLTMSCEMLINPQGQVVEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEALVPMFKDME
DLAAILRGKRMERGAVDFDFKEAKVLVDEEGKAKDVVLRERSTAEKLIEEFMLVANETVAEHFHWMNVPFIYRIHEDPDQ
EKLQRFLEFVTTFGYVVKGTAGSIHPKALQSVLEEVRDRPEEAVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPI
RRYPDLIVHRLIRTYLIQGKTDEATREKWAEKLPEIAEHTSNMERNAVDAERETDDLKKTEFMLDKIGEEFDGVISSVTN
FGMFVELPNTIEGLVHVSFMTDDFYRYDEQHYAMIGERTGNVYRIGDEITVRVVDVNKDERNIDFEIVGMKGSRRRQKPE
PKQKKASKREAPSADKGEWFTKPKKKKVKKKRGFQNAPKQKRKKKKK

Sequences:

>Translated_767_residues
MEKEEFMDKLLSFMKEEAYKPLTVQELEEMLEITDSDEYKELVKALVTLEEKGLVVRTRSNRYGLPEKMNLIKGKVSAHA
KGFAFVLPEDSSLDDVFIPPSELNTAMNGDTVLVRLSTESGGTKKEGAIIRIIERNIQKIVGTYTETKNFGFVIPDDKKI
TNDIFIPKHAKNGAVEGHKVVVRLTSYPEGRMSAEGEVIEILGHKNDPGIDILSIIHKHGLPGDFPAEAMEQAGNTPDTI
DEKDLEGRRDLRDQTIVTIDGADAKDLDDAVTVTKLKNGHYKLGVHIADVSHYVTEGSPIDQEAYERGTSVYLVDRVIPM
IPHRLSNGICSLNPKVDRLTMSCEMLINPQGQVVEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEALVPMFKDME
DLAAILRGKRMERGAVDFDFKEAKVLVDEEGKAKDVVLRERSTAEKLIEEFMLVANETVAEHFHWMNVPFIYRIHEDPDQ
EKLQRFLEFVTTFGYVVKGTAGSIHPKALQSVLEEVRDRPEEAVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPI
RRYPDLIVHRLIRTYLIQGKTDEATREKWAEKLPEIAEHTSNMERNAVDAERETDDLKKTEFMLDKIGEEFDGVISSVTN
FGMFVELPNTIEGLVHVSFMTDDFYRYDEQHYAMIGERTGNVYRIGDEITVRVVDVNKDERNIDFEIVGMKGSRRRQKPE
PKQKKASKREAPSADKGEWFTKPKKKKVKKKRGFQNAPKQKRKKKKK
>Mature_767_residues
MEKEEFMDKLLSFMKEEAYKPLTVQELEEMLEITDSDEYKELVKALVTLEEKGLVVRTRSNRYGLPEKMNLIKGKVSAHA
KGFAFVLPEDSSLDDVFIPPSELNTAMNGDTVLVRLSTESGGTKKEGAIIRIIERNIQKIVGTYTETKNFGFVIPDDKKI
TNDIFIPKHAKNGAVEGHKVVVRLTSYPEGRMSAEGEVIEILGHKNDPGIDILSIIHKHGLPGDFPAEAMEQAGNTPDTI
DEKDLEGRRDLRDQTIVTIDGADAKDLDDAVTVTKLKNGHYKLGVHIADVSHYVTEGSPIDQEAYERGTSVYLVDRVIPM
IPHRLSNGICSLNPKVDRLTMSCEMLINPQGQVVEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEALVPMFKDME
DLAAILRGKRMERGAVDFDFKEAKVLVDEEGKAKDVVLRERSTAEKLIEEFMLVANETVAEHFHWMNVPFIYRIHEDPDQ
EKLQRFLEFVTTFGYVVKGTAGSIHPKALQSVLEEVRDRPEEAVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPI
RRYPDLIVHRLIRTYLIQGKTDEATREKWAEKLPEIAEHTSNMERNAVDAERETDDLKKTEFMLDKIGEEFDGVISSVTN
FGMFVELPNTIEGLVHVSFMTDDFYRYDEQHYAMIGERTGNVYRIGDEITVRVVDVNKDERNIDFEIVGMKGSRRRQKPE
PKQKKASKREAPSADKGEWFTKPKKKKVKKKRGFQNAPKQKRKKKKK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=419, Percent_Identity=32.9355608591885, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI190014625, Length=469, Percent_Identity=29.8507462686567, Blast_Score=213, Evalue=8e-55,
Organism=Homo sapiens, GI190014623, Length=469, Percent_Identity=29.8507462686567, Blast_Score=212, Evalue=1e-54,
Organism=Homo sapiens, GI19115966, Length=572, Percent_Identity=28.6713286713287, Blast_Score=194, Evalue=4e-49,
Organism=Homo sapiens, GI219521928, Length=572, Percent_Identity=28.6713286713287, Blast_Score=193, Evalue=4e-49,
Organism=Escherichia coli, GI87082383, Length=696, Percent_Identity=39.6551724137931, Blast_Score=522, Evalue=1e-149,
Organism=Escherichia coli, GI1787542, Length=644, Percent_Identity=26.7080745341615, Blast_Score=167, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17553506, Length=530, Percent_Identity=29.0566037735849, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI212645896, Length=622, Percent_Identity=26.6881028938907, Blast_Score=185, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6324552, Length=556, Percent_Identity=29.8561151079137, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6320499, Length=420, Percent_Identity=22.8571428571429, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323943, Length=363, Percent_Identity=26.1707988980716, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24649634, Length=473, Percent_Identity=31.0782241014799, Blast_Score=219, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24654592, Length=410, Percent_Identity=31.7073170731707, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI19922976, Length=410, Percent_Identity=31.7073170731707, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24654597, Length=410, Percent_Identity=31.7073170731707, Blast_Score=193, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 87539; Mature: 87539

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKEEFMDKLLSFMKEEAYKPLTVQELEEMLEITDSDEYKELVKALVTLEEKGLVVRTRS
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECC
NRYGLPEKMNLIKGKVSAHAKGFAFVLPEDSSLDDVFIPPSELNTAMNGDTVLVRLSTES
CCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEECCHHHHCCCCCCCEEEEEEECCC
GGTKKEGAIIRIIERNIQKIVGTYTETKNFGFVIPDDKKITNDIFIPKHAKNGAVEGHKV
CCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEECCCCCCCCCCCCCEE
VVRLTSYPEGRMSAEGEVIEILGHKNDPGIDILSIIHKHGLPGDFPAEAMEQAGNTPDTI
EEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCC
DEKDLEGRRDLRDQTIVTIDGADAKDLDDAVTVTKLKNGHYKLGVHIADVSHYVTEGSPI
CCCCCCCHHCCCCCEEEEECCCCCCCCHHHHHHEEECCCCEEEEEEEEHHHHHHCCCCCC
DQEAYERGTSVYLVDRVIPMIPHRLSNGICSLNPKVDRLTMSCEMLINPQGQVVEHEIFQ
CHHHHHCCCEEEEHHHHHHHHHHHHCCCEEECCCCHHHHEEEEEEEECCCCCHHHHHHHH
SVIKTTERMTYSDVNKILVDDDEELKQKYEALVPMFKDMEDLAAILRGKRMERGAVDFDF
HHHHHHHHCCHHHCCCEECCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCC
KEAKVLVDEEGKAKDVVLRERSTAEKLIEEFMLVANETVAEHFHWMNVPFIYRIHEDPDQ
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
EKLQRFLEFVTTFGYVVKGTAGSIHPKALQSVLEEVRDRPEEAVISTVMLRSMKQAKYDP
HHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCH
QSLGHFGLSTEFYTHFTSPIRRYPDLIVHRLIRTYLIQGKTDEATREKWAEKLPEIAEHT
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
SNMERNAVDAERETDDLKKTEFMLDKIGEEFDGVISSVTNFGMFVELPNTIEGLVHVSFM
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHEEEEEE
TDDFYRYDEQHYAMIGERTGNVYRIGDEITVRVVDVNKDERNIDFEIVGMKGSRRRQKPE
CHHHHHHCCHHHHHHCCCCCCEEEECCEEEEEEEECCCCCCCCCEEEEECCCCCCCCCCC
PKQKKASKREAPSADKGEWFTKPKKKKVKKKRGFQNAPKQKRKKKKK
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MEKEEFMDKLLSFMKEEAYKPLTVQELEEMLEITDSDEYKELVKALVTLEEKGLVVRTRS
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECC
NRYGLPEKMNLIKGKVSAHAKGFAFVLPEDSSLDDVFIPPSELNTAMNGDTVLVRLSTES
CCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEECCHHHHCCCCCCCEEEEEEECCC
GGTKKEGAIIRIIERNIQKIVGTYTETKNFGFVIPDDKKITNDIFIPKHAKNGAVEGHKV
CCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEECCCCCCCCCCCCCEE
VVRLTSYPEGRMSAEGEVIEILGHKNDPGIDILSIIHKHGLPGDFPAEAMEQAGNTPDTI
EEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCC
DEKDLEGRRDLRDQTIVTIDGADAKDLDDAVTVTKLKNGHYKLGVHIADVSHYVTEGSPI
CCCCCCCHHCCCCCEEEEECCCCCCCCHHHHHHEEECCCCEEEEEEEEHHHHHHCCCCCC
DQEAYERGTSVYLVDRVIPMIPHRLSNGICSLNPKVDRLTMSCEMLINPQGQVVEHEIFQ
CHHHHHCCCEEEEHHHHHHHHHHHHCCCEEECCCCHHHHEEEEEEEECCCCCHHHHHHHH
SVIKTTERMTYSDVNKILVDDDEELKQKYEALVPMFKDMEDLAAILRGKRMERGAVDFDF
HHHHHHHHCCHHHCCCEECCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCC
KEAKVLVDEEGKAKDVVLRERSTAEKLIEEFMLVANETVAEHFHWMNVPFIYRIHEDPDQ
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
EKLQRFLEFVTTFGYVVKGTAGSIHPKALQSVLEEVRDRPEEAVISTVMLRSMKQAKYDP
HHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCH
QSLGHFGLSTEFYTHFTSPIRRYPDLIVHRLIRTYLIQGKTDEATREKWAEKLPEIAEHT
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
SNMERNAVDAERETDDLKKTEFMLDKIGEEFDGVISSVTNFGMFVELPNTIEGLVHVSFM
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHEEEEEE
TDDFYRYDEQHYAMIGERTGNVYRIGDEITVRVVDVNKDERNIDFEIVGMKGSRRRQKPE
CHHHHHHCCHHHHHHCCCCCCEEEECCEEEEEEEECCCCCCCCCEEEEECCCCCCCCCCC
PKQKKASKREAPSADKGEWFTKPKKKKVKKKRGFQNAPKQKRKKKKK
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]