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The map label for this gene is yusK [H]

Identifier: 52787156

GI number: 52787156

Start: 3307025

End: 3308200

Strand: Reverse

Name: yusK [H]

Synonym: BLi03465

Alternate gene names: 52787156

Gene position: 3308200-3307025 (Counterclockwise)

Preceding gene: 52787157

Following gene: 52787155

Centisome position: 78.34

GC content: 54.08

Gene sequence:

>1176_bases
ATGAAAGAGGCAGTTATTGTATCGGGGGCGAGAACCCCGATCGGAAAAGCAAAAAAAGGCTCATTGAGGACTGTCCGTCC
CGATGATTTAGGCGCATATGCGGTGAGAGAGACGCTGAAAAGAGCGGGCGGTTATGAAGGGAATATCGATGATTTGATCA
TCGGCTGCGCTACGCCGGAAGCCGAACAAGGCTTGAATATGGCGCGCAATATCGGCGCGCTTGCCGGTCTGCCGCACACA
GTTCCGGCCGTTACGATCAACAGATATTGTTCATCAGGACTTCAATCAATCGCTTACGGGGCCGAAAAAATCATGCTTGG
AGCTGCTGACACGATCATTGCAGGCGGCGCCGAATCGATGAGCATCGTGCCGATGATGGGTCATATCGTCAGACCGAACG
CGGCTCTGGCGGAAACGGCTCCTGAATATTATATGGGAATGGGCCATACGGCTGAACAGGTTGCCGTCAAATACGGCGTT
TCCAGGGAGGACCAAGATGCATTTGCCGTCAACAGCCATCAAAAAGCAGCCAAGGCGATCGCGGAAGGAAAGTTCGAAGA
TGAAATCGTCCCGGTGGACGTCACCGTCAGAGAAGTGGATGAACATCATAACCTGAAGGAGCGGACGTTTACTTTCTCTG
CCGATGAAGGTGTACGCCCGGGGACAACCAAAGACGTTCTGTCAACGTTGAAACCGGCGTTTTCGGCAAACGGCTCGGTT
ACGGCAGGGAATTCCTCGCAGACGAGCGACGGGGCTGCCGCAGTGATGATCATGGACAGAGAAAAAGCGGACGCACTCGG
GTTAAAGCCCCTCGCAAAATTTCGTTCGTTCGCAGTCGGCGGCGTTCCGCCGGAAGTGATGGGCATCGGCCCTGTGGAAG
CAGTCCCAAGGGCGCTGAAGATGGCGGGACTTGAGCTGTCGGATATCGGTTTATTCGAATTAAATGAGGCGTTTGCATCG
CAAGCGATCCAGGTCATCAGGTCGCTTGGCATTGATGAAGAAAAAGTCAATGTCAACGGCGGAGCGATTGCGCTCGGACA
TCCGCTCGGCTGCACGGGTACAAAGCTGACGCTGACATTGATCCACGAAATGCGCCGGAGAAGCGAGCAATTCGGCATTG
TGACGATGTGTATCGGCGGAGGCATGGGAGCAGCAGGGGTATTCGAATTAGTTTAA

Upstream 100 bases:

>100_bases
GAGAAGCGTTTCTGAGCCTTGTGAGCGAACCGAAATCGCAGGCGAGAATGCAGCATATGCTTGTGAAAGGCAAACCTTTG
CGTAATTAGGAGGGAAAATA

Downstream 100 bases:

>100_bases
TCACAAGGGGGATGGAACAATGGAACAAACAAAAGATCATATGAAAAAAGGCGGCGCCTTTCTGATCGAAGAGGTAACGG
CTGATCAGATGTTCACACCG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKEAVIVSGARTPIGKAKKGSLRTVRPDDLGAYAVRETLKRAGGYEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPHT
VPAVTINRYCSSGLQSIAYGAEKIMLGAADTIIAGGAESMSIVPMMGHIVRPNAALAETAPEYYMGMGHTAEQVAVKYGV
SREDQDAFAVNSHQKAAKAIAEGKFEDEIVPVDVTVREVDEHHNLKERTFTFSADEGVRPGTTKDVLSTLKPAFSANGSV
TAGNSSQTSDGAAAVMIMDREKADALGLKPLAKFRSFAVGGVPPEVMGIGPVEAVPRALKMAGLELSDIGLFELNEAFAS
QAIQVIRSLGIDEEKVNVNGGAIALGHPLGCTGTKLTLTLIHEMRRRSEQFGIVTMCIGGGMGAAGVFELV

Sequences:

>Translated_391_residues
MKEAVIVSGARTPIGKAKKGSLRTVRPDDLGAYAVRETLKRAGGYEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPHT
VPAVTINRYCSSGLQSIAYGAEKIMLGAADTIIAGGAESMSIVPMMGHIVRPNAALAETAPEYYMGMGHTAEQVAVKYGV
SREDQDAFAVNSHQKAAKAIAEGKFEDEIVPVDVTVREVDEHHNLKERTFTFSADEGVRPGTTKDVLSTLKPAFSANGSV
TAGNSSQTSDGAAAVMIMDREKADALGLKPLAKFRSFAVGGVPPEVMGIGPVEAVPRALKMAGLELSDIGLFELNEAFAS
QAIQVIRSLGIDEEKVNVNGGAIALGHPLGCTGTKLTLTLIHEMRRRSEQFGIVTMCIGGGMGAAGVFELV
>Mature_391_residues
MKEAVIVSGARTPIGKAKKGSLRTVRPDDLGAYAVRETLKRAGGYEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPHT
VPAVTINRYCSSGLQSIAYGAEKIMLGAADTIIAGGAESMSIVPMMGHIVRPNAALAETAPEYYMGMGHTAEQVAVKYGV
SREDQDAFAVNSHQKAAKAIAEGKFEDEIVPVDVTVREVDEHHNLKERTFTFSADEGVRPGTTKDVLSTLKPAFSANGSV
TAGNSSQTSDGAAAVMIMDREKADALGLKPLAKFRSFAVGGVPPEVMGIGPVEAVPRALKMAGLELSDIGLFELNEAFAS
QAIQVIRSLGIDEEKVNVNGGAIALGHPLGCTGTKLTLTLIHEMRRRSEQFGIVTMCIGGGMGAAGVFELV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=47.1938775510204, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI167614485, Length=401, Percent_Identity=38.6533665835411, Blast_Score=275, Evalue=7e-74,
Organism=Homo sapiens, GI148539872, Length=395, Percent_Identity=39.746835443038, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI4557237, Length=405, Percent_Identity=34.5679012345679, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI4504327, Length=436, Percent_Identity=33.256880733945, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=34.6153846153846, Blast_Score=178, Evalue=6e-45,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=47.7272727272727, Blast_Score=341, Evalue=4e-95,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=45.320197044335, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1787663, Length=410, Percent_Identity=44.390243902439, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI87082165, Length=403, Percent_Identity=42.1836228287841, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI1788683, Length=419, Percent_Identity=34.8448687350835, Blast_Score=198, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI133906874, Length=402, Percent_Identity=39.0547263681592, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17535921, Length=408, Percent_Identity=36.5196078431373, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI25147385, Length=400, Percent_Identity=33.25, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17551802, Length=439, Percent_Identity=30.751708428246, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=389, Percent_Identity=30.8483290488432, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=41.2658227848101, Blast_Score=274, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6325229, Length=401, Percent_Identity=36.1596009975062, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24655093, Length=398, Percent_Identity=41.7085427135678, Blast_Score=292, Evalue=2e-79,
Organism=Drosophila melanogaster, GI17648125, Length=401, Percent_Identity=39.6508728179551, Blast_Score=252, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24640423, Length=397, Percent_Identity=35.7682619647355, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI17137578, Length=432, Percent_Identity=32.1759259259259, Blast_Score=180, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40949; Mature: 40949

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEAVIVSGARTPIGKAKKGSLRTVRPDDLGAYAVRETLKRAGGYEGNIDDLIIGCATPE
CCCCEEEECCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCC
AEQGLNMARNIGALAGLPHTVPAVTINRYCSSGLQSIAYGAEKIMLGAADTIIAGGAESM
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHEEEECCHHEEECCCCCE
SIVPMMGHIVRPNAALAETAPEYYMGMGHTAEQVAVKYGVSREDQDAFAVNSHQKAAKAI
EEHHHHHHEECCCCHHHHCCHHHHHCCCCCHHHHHHHHCCCCCCCCCCEECCHHHHHHHH
AEGKFEDEIVPVDVTVREVDEHHNLKERTFTFSADEGVRPGTTKDVLSTLKPAFSANGSV
HCCCCCCCEEEEEEEHHHHHHHCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCE
TAGNSSQTSDGAAAVMIMDREKADALGLKPLAKFRSFAVGGVPPEVMGIGPVEAVPRALK
ECCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHH
MAGLELSDIGLFELNEAFASQAIQVIRSLGIDEEKVNVNGGAIALGHPLGCTGTKLTLTL
HCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCCCHHHHHH
IHEMRRRSEQFGIVTMCIGGGMGAAGVFELV
HHHHHHHHHHCCEEEEEECCCCCCCHHHHCC
>Mature Secondary Structure
MKEAVIVSGARTPIGKAKKGSLRTVRPDDLGAYAVRETLKRAGGYEGNIDDLIIGCATPE
CCCCEEEECCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCC
AEQGLNMARNIGALAGLPHTVPAVTINRYCSSGLQSIAYGAEKIMLGAADTIIAGGAESM
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHEEEECCHHEEECCCCCE
SIVPMMGHIVRPNAALAETAPEYYMGMGHTAEQVAVKYGVSREDQDAFAVNSHQKAAKAI
EEHHHHHHEECCCCHHHHCCHHHHHCCCCCHHHHHHHHCCCCCCCCCCEECCHHHHHHHH
AEGKFEDEIVPVDVTVREVDEHHNLKERTFTFSADEGVRPGTTKDVLSTLKPAFSANGSV
HCCCCCCCEEEEEEEHHHHHHHCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCE
TAGNSSQTSDGAAAVMIMDREKADALGLKPLAKFRSFAVGGVPPEVMGIGPVEAVPRALK
ECCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHH
MAGLELSDIGLFELNEAFASQAIQVIRSLGIDEEKVNVNGGAIALGHPLGCTGTKLTLTL
HCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCCCHHHHHH
IHEMRRRSEQFGIVTMCIGGGMGAAGVFELV
HHHHHHHHHHCCEEEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]