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The map label for this gene is ezrA

Identifier: 52786831

GI number: 52786831

Start: 2989684

End: 2991378

Strand: Reverse

Name: ezrA

Synonym: BLi03105

Alternate gene names: 52786831

Gene position: 2991378-2989684 (Counterclockwise)

Preceding gene: 52786833

Following gene: 52786827

Centisome position: 70.84

GC content: 47.08

Gene sequence:

>1695_bases
ATGGAGTTTGTCATTGGCTTACTGGCGTTATTTTTAATCTTATTCGCTACGGGCTACTTATTCAGAAAAAATATATATAA
AGAGATCGACCGTTTAGAAGCTTGGAAAATCGAAATCATGAACCGTTCGATTGTGGAAGAGATGTCAAAAATCAAGCATC
TGAAAATGACGGGGCAGACTGAGGAATTCTTTGAAAGATGGCGCCGGGAATGGGATGAAATCGTCACCTCGCATATGCCC
AAAGTCGAAGAGCTTCTGTTTGAAGCCGAGGATTGCGCCGACAAATACCGTTTTCAAAAATCGAAACAGGTGCTCGCGCA
TATTGAGAATCTTTTATCAGCGGCTGAGTCCAACATTGAAGACATCTTAAAGGAAATCGCCGATCTTGTCTCAAGCGAAG
AGCAGAACCGCAAAGAAATCGAAGAGGTAAAAGAACGTTATACAAAAGTGCGGAAAAACCTTTTGGCATACAGCCACCTG
TACGGAGACCTCTATGCGAAAATTGAAGCCGACCTCGATACCGTGTGGGAAGGCATTAAACAGTTTGAAGAGGAAACAGA
AGGCGGAAATTACATAGAAGCCAGAAAGGTGCTGCTTGCCCAAGACCGTTTGCTTGAAGAGCTTCAATCATACATAGACG
ATGTGCCGAAACTGCTTGCCAGCTGCAAGCAGACAGTTCCGCAGGAAATCGCAAAATTGAAAGCCGGCTATCAGGAAATG
ATCGATAAAGGGTATAAGCTCGATCATATTCAAGTGGAGAAGGAGCTCGAAAACCTTTTGAAAGAATTGAAGCGCGCTGA
AGATGCGCTTTTGGACGAGCTTGATTTAGAGGAAGCCGCCGCAATCGTGCAGATCATTGATGAAACGATCCAGACGCTGT
ATAACCAGCTCGAGCATGAAGTCGAAGCAGGGCAGGAAATTTTGGGCAAAGTGCCTGAGCTTGCCGCTGCATTGGAAAAG
CTTGAAGCCTCCAAAAAGGATACCGAAGCTGAAACCGAGCTCGTCAAGAAAGGCTACAGACTGACTACCGGCGAACTGGA
GAAGCAGCAGTCATATGAAAAGCGCCTTGAAATGATCGAAAAGCAGTTCGAACAAGTGAGAGAAAGGCTTGATCAGAAAC
ATGTCGCCTACTCGCTGTTAAAAGAAGAGCTTGCCGATATCGAAAAGCAGATGGAAGCCGCGCAACGGGAGCATGACGAA
TACAGGGACATGCTGCAAATGCTGAGAAAAGAAGAGCTTCAGGCAAGAGAGCTTCTCAAGCAATTGAAGCAGACAATCAA
GGATACGGCGCGCAGCCTGGAGAAAAGCAATGTTCCAGGCATCCCGGAGGCCATAACCGAAAAGATCCGACAGTCGCAGA
CGACTGTGCAGAAAGTGACAGAACAGTTGAATGAGCTGCCGCTGAACATGGATGCGGTGAACGAACGTCTTCAAGAGGCG
GAACAGCTTGTCACGGAAGTGAAAACAAAGACGGACGAACTGGTTGAACTGGTTTTGCTGATCGAACGCATCATTCAATA
TGGCAACCGCTTCAGAAGCCAGGACCGTATCCTTTCCGAACAGCTGAAAGAAGCAGAAAACTGTTTTTACGCATATCAGT
ATGAAGAGGCTTACGACATAGCCGCCAGAGCGGTGGAAAAAGCGTCGCCTGGAGCAGTGGCCCGGCTTGAAGCGGACGCG
AAGCAGCCTGAATAA

Upstream 100 bases:

>100_bases
ATCATAAGAACAATGAAAACGATAGTTTAACTTCATTTTTACATAACAATTTCAAATATCATACCCTGACAGAACAAGAT
AAACAGCAAGGGGGCTCATT

Downstream 100 bases:

>100_bases
AGCAAAAACCCGGCATGTAAAGATGAACTGACCCGTTAAAATGAGACTTAGAAAAAACACCTATGCTGCCTGTCCCCTGT
ATTCCAGTGGGGACAGGTAG

Product: septation ring formation regulator EzrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
MEFVIGLLALFLILFATGYLFRKNIYKEIDRLEAWKIEIMNRSIVEEMSKIKHLKMTGQTEEFFERWRREWDEIVTSHMP
KVEELLFEAEDCADKYRFQKSKQVLAHIENLLSAAESNIEDILKEIADLVSSEEQNRKEIEEVKERYTKVRKNLLAYSHL
YGDLYAKIEADLDTVWEGIKQFEEETEGGNYIEARKVLLAQDRLLEELQSYIDDVPKLLASCKQTVPQEIAKLKAGYQEM
IDKGYKLDHIQVEKELENLLKELKRAEDALLDELDLEEAAAIVQIIDETIQTLYNQLEHEVEAGQEILGKVPELAAALEK
LEASKKDTEAETELVKKGYRLTTGELEKQQSYEKRLEMIEKQFEQVRERLDQKHVAYSLLKEELADIEKQMEAAQREHDE
YRDMLQMLRKEELQARELLKQLKQTIKDTARSLEKSNVPGIPEAITEKIRQSQTTVQKVTEQLNELPLNMDAVNERLQEA
EQLVTEVKTKTDELVELVLLIERIIQYGNRFRSQDRILSEQLKEAENCFYAYQYEEAYDIAARAVEKASPGAVARLEADA
KQPE

Sequences:

>Translated_564_residues
MEFVIGLLALFLILFATGYLFRKNIYKEIDRLEAWKIEIMNRSIVEEMSKIKHLKMTGQTEEFFERWRREWDEIVTSHMP
KVEELLFEAEDCADKYRFQKSKQVLAHIENLLSAAESNIEDILKEIADLVSSEEQNRKEIEEVKERYTKVRKNLLAYSHL
YGDLYAKIEADLDTVWEGIKQFEEETEGGNYIEARKVLLAQDRLLEELQSYIDDVPKLLASCKQTVPQEIAKLKAGYQEM
IDKGYKLDHIQVEKELENLLKELKRAEDALLDELDLEEAAAIVQIIDETIQTLYNQLEHEVEAGQEILGKVPELAAALEK
LEASKKDTEAETELVKKGYRLTTGELEKQQSYEKRLEMIEKQFEQVRERLDQKHVAYSLLKEELADIEKQMEAAQREHDE
YRDMLQMLRKEELQARELLKQLKQTIKDTARSLEKSNVPGIPEAITEKIRQSQTTVQKVTEQLNELPLNMDAVNERLQEA
EQLVTEVKTKTDELVELVLLIERIIQYGNRFRSQDRILSEQLKEAENCFYAYQYEEAYDIAARAVEKASPGAVARLEADA
KQPE
>Mature_564_residues
MEFVIGLLALFLILFATGYLFRKNIYKEIDRLEAWKIEIMNRSIVEEMSKIKHLKMTGQTEEFFERWRREWDEIVTSHMP
KVEELLFEAEDCADKYRFQKSKQVLAHIENLLSAAESNIEDILKEIADLVSSEEQNRKEIEEVKERYTKVRKNLLAYSHL
YGDLYAKIEADLDTVWEGIKQFEEETEGGNYIEARKVLLAQDRLLEELQSYIDDVPKLLASCKQTVPQEIAKLKAGYQEM
IDKGYKLDHIQVEKELENLLKELKRAEDALLDELDLEEAAAIVQIIDETIQTLYNQLEHEVEAGQEILGKVPELAAALEK
LEASKKDTEAETELVKKGYRLTTGELEKQQSYEKRLEMIEKQFEQVRERLDQKHVAYSLLKEELADIEKQMEAAQREHDE
YRDMLQMLRKEELQARELLKQLKQTIKDTARSLEKSNVPGIPEAITEKIRQSQTTVQKVTEQLNELPLNMDAVNERLQEA
EQLVTEVKTKTDELVELVLLIERIIQYGNRFRSQDRILSEQLKEAENCFYAYQYEEAYDIAARAVEKASPGAVARLEADA
KQPE

Specific function: Negative regulator of ftsZ ring formation; modulates the frequency and position of ftsZ ring formation. Inhibits ftsZ ring formation at polar sites. Interacts either with ftsZ or with one of its binding partners to promote depolymerization

COG id: COG4477

COG function: function code D; Negative regulator of septation ring formation

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein. Note=Colocalized with ftsZ to the nascent septal site (By similarity)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ezrA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EZRA_BACLD (Q65G47)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_080247.1
- RefSeq:   YP_092660.1
- ProteinModelPortal:   Q65G47
- STRING:   Q65G47
- EnsemblBacteria:   EBBACT00000057831
- EnsemblBacteria:   EBBACT00000058915
- GeneID:   3029023
- GeneID:   3098786
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi03105
- KEGG:   bli:BL00433
- NMPDR:   fig|279010.5.peg.92
- eggNOG:   COG4477
- GeneTree:   EBGT00050000000289
- HOGENOM:   HBG345654
- OMA:   MDIQELH
- ProtClustDB:   PRK04778
- BioCyc:   BLIC279010-1:BLI03105-MONOMER
- BioCyc:   BLIC279010:BL00433-MONOMER
- HAMAP:   MF_00728
- InterPro:   IPR010379

Pfam domain/function: PF06160 EzrA

EC number: NA

Molecular weight: Translated: 65817; Mature: 65817

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf83e010)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFVIGLLALFLILFATGYLFRKNIYKEIDRLEAWKIEIMNRSIVEEMSKIKHLKMTGQT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EEFFERWRREWDEIVTSHMPKVEELLFEAEDCADKYRFQKSKQVLAHIENLLSAAESNIE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
DILKEIADLVSSEEQNRKEIEEVKERYTKVRKNLLAYSHLYGDLYAKIEADLDTVWEGIK
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFEEETEGGNYIEARKVLLAQDRLLEELQSYIDDVPKLLASCKQTVPQEIAKLKAGYQEM
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDKGYKLDHIQVEKELENLLKELKRAEDALLDELDLEEAAAIVQIIDETIQTLYNQLEHE
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VEAGQEILGKVPELAAALEKLEASKKDTEAETELVKKGYRLTTGELEKQQSYEKRLEMIE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KQFEQVRERLDQKHVAYSLLKEELADIEKQMEAAQREHDEYRDMLQMLRKEELQARELLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLKQTIKDTARSLEKSNVPGIPEAITEKIRQSQTTVQKVTEQLNELPLNMDAVNERLQEA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
EQLVTEVKTKTDELVELVLLIERIIQYGNRFRSQDRILSEQLKEAENCFYAYQYEEAYDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARAVEKASPGAVARLEADAKQPE
HHHHHHHCCCCCHHHCCCCCCCCH
>Mature Secondary Structure
MEFVIGLLALFLILFATGYLFRKNIYKEIDRLEAWKIEIMNRSIVEEMSKIKHLKMTGQT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EEFFERWRREWDEIVTSHMPKVEELLFEAEDCADKYRFQKSKQVLAHIENLLSAAESNIE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
DILKEIADLVSSEEQNRKEIEEVKERYTKVRKNLLAYSHLYGDLYAKIEADLDTVWEGIK
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFEEETEGGNYIEARKVLLAQDRLLEELQSYIDDVPKLLASCKQTVPQEIAKLKAGYQEM
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDKGYKLDHIQVEKELENLLKELKRAEDALLDELDLEEAAAIVQIIDETIQTLYNQLEHE
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VEAGQEILGKVPELAAALEKLEASKKDTEAETELVKKGYRLTTGELEKQQSYEKRLEMIE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KQFEQVRERLDQKHVAYSLLKEELADIEKQMEAAQREHDEYRDMLQMLRKEELQARELLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLKQTIKDTARSLEKSNVPGIPEAITEKIRQSQTTVQKVTEQLNELPLNMDAVNERLQEA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
EQLVTEVKTKTDELVELVLLIERIIQYGNRFRSQDRILSEQLKEAENCFYAYQYEEAYDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARAVEKASPGAVARLEADAKQPE
HHHHHHHCCCCCHHHCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA