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The map label for this gene is hemE [H]

Identifier: 52784864

GI number: 52784864

Start: 1090978

End: 1092042

Strand: Direct

Name: hemE [H]

Synonym: BLi01092

Alternate gene names: 52784864

Gene position: 1090978-1092042 (Clockwise)

Preceding gene: 52784863

Following gene: 52784865

Centisome position: 25.84

GC content: 50.52

Gene sequence:

>1065_bases
ATGATGAAAAACGACAAGGCTTTTAATGACACATTCTTAAAAGCATGCCGAGGAGAAAAGGCCGCCCATGTACCGGTATG
GTACATGAGGCAGGCCGGAAGATCACAGCCTGAGTACAGAGCGCTCAAGGAAAAGTACGGTCTGTTTGAAATTACGCATC
AGCCCGAATTGTGCGCTTATGTGACAAGGCTGCCCGTCGAACAGTACGATGTCGATGCGGCGATACTTTATAAAGACATA
ATGACACCGCTTCCAGGTATTGGCGTTGACGTCGAAATTAAAAACGGGATCGGCCCTGTCATCGATCAGCCGATTACATC
TCTCGCAGATGTTGAAAAACTCGGCGAACTCGATCCGCAAGAGCATATTCCATATGTGCTGGAGACGATCAGGCTGTTGA
CGGAAGAACAGCTGAACGTTCCGCTGATCGGTTTTACAGGGGCGCCCTTTACATTGGCCAGCTATATGATCGAAGGCGGC
CCGTCCAAAAACTACAATAAAACAAAAGCGTTTATGTACAGCCAGCCTGCTGCATGGGATCTTTTGATGAAAAAGCTCGG
GAAGATGGCGGCTGTATACGTCAAAGCTCAAATCCGCGCCGGCGCCAAAGCCATCCAGGTGTTCGATTCCTGGGTCGGCG
CGCTGAACGCCGGTGATTACTGCCGCTACATCAAACCGACGATGGACGTTCTTTTCAAAGAGTTGAAAAAAGAAGACGTG
CCGCTGATTATGTTCGGGGTCGGCGCAAGCCACCTCGCGACTGAATGGCACGATCTTGACCTCGACGTCGTCGGGCTGGA
TTGGCGGATGAGCGTACAGGAAGCCAGGGATAAAGGGCTGACAAAAACGCTCCAGGGAAATTTGGATCCTTCGATCCTGC
TTGCCCCGTGGGAAGTCATCGAAGAAAGGACGAAAGCCATTCTCGATCAGGGCATGCAGACGGACCGGTTTATTTTCAAC
CTCGGACACGGGATCTTTCCAGAAGTGAGTCCCGACACACTGAAAAAATTGACGGCATTTGTTCATGAGTATTCCGCCTC
AAAAAAATCGAGCCTGATCACATGA

Upstream 100 bases:

>100_bases
TTGAACAATAAGTCTCATGAGTATACCGTTCAATAAAAAAACGGTATATTGGAAGGAGTAATTTTGCGAACGTATGGTTG
CAGCTTGAAAGGTGGATATC

Downstream 100 bases:

>100_bases
GCATTTCAGTTGGTCTTTTCAATATAAACTGTCAAAATACGTATAGATCATGATCTTTAAAGAGGTGTTCACGTTGGGTA
AAAAGAAAATGGGGCTTCTT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MMKNDKAFNDTFLKACRGEKAAHVPVWYMRQAGRSQPEYRALKEKYGLFEITHQPELCAYVTRLPVEQYDVDAAILYKDI
MTPLPGIGVDVEIKNGIGPVIDQPITSLADVEKLGELDPQEHIPYVLETIRLLTEEQLNVPLIGFTGAPFTLASYMIEGG
PSKNYNKTKAFMYSQPAAWDLLMKKLGKMAAVYVKAQIRAGAKAIQVFDSWVGALNAGDYCRYIKPTMDVLFKELKKEDV
PLIMFGVGASHLATEWHDLDLDVVGLDWRMSVQEARDKGLTKTLQGNLDPSILLAPWEVIEERTKAILDQGMQTDRFIFN
LGHGIFPEVSPDTLKKLTAFVHEYSASKKSSLIT

Sequences:

>Translated_354_residues
MMKNDKAFNDTFLKACRGEKAAHVPVWYMRQAGRSQPEYRALKEKYGLFEITHQPELCAYVTRLPVEQYDVDAAILYKDI
MTPLPGIGVDVEIKNGIGPVIDQPITSLADVEKLGELDPQEHIPYVLETIRLLTEEQLNVPLIGFTGAPFTLASYMIEGG
PSKNYNKTKAFMYSQPAAWDLLMKKLGKMAAVYVKAQIRAGAKAIQVFDSWVGALNAGDYCRYIKPTMDVLFKELKKEDV
PLIMFGVGASHLATEWHDLDLDVVGLDWRMSVQEARDKGLTKTLQGNLDPSILLAPWEVIEERTKAILDQGMQTDRFIFN
LGHGIFPEVSPDTLKKLTAFVHEYSASKKSSLIT
>Mature_354_residues
MMKNDKAFNDTFLKACRGEKAAHVPVWYMRQAGRSQPEYRALKEKYGLFEITHQPELCAYVTRLPVEQYDVDAAILYKDI
MTPLPGIGVDVEIKNGIGPVIDQPITSLADVEKLGELDPQEHIPYVLETIRLLTEEQLNVPLIGFTGAPFTLASYMIEGG
PSKNYNKTKAFMYSQPAAWDLLMKKLGKMAAVYVKAQIRAGAKAIQVFDSWVGALNAGDYCRYIKPTMDVLFKELKKEDV
PLIMFGVGASHLATEWHDLDLDVVGLDWRMSVQEARDKGLTKTLQGNLDPSILLAPWEVIEERTKAILDQGMQTDRFIFN
LGHGIFPEVSPDTLKKLTAFVHEYSASKKSSLIT

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=350, Percent_Identity=36.5714285714286, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI2367337, Length=344, Percent_Identity=39.2441860465116, Blast_Score=243, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6320252, Length=360, Percent_Identity=32.5, Blast_Score=187, Evalue=2e-48,
Organism=Drosophila melanogaster, GI19921920, Length=355, Percent_Identity=37.1830985915493, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=37.2093023255814, Blast_Score=223, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39717; Mature: 39717

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKNDKAFNDTFLKACRGEKAAHVPVWYMRQAGRSQPEYRALKEKYGLFEITHQPELCAY
CCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHCCEEEECCCCHHHHH
VTRLPVEQYDVDAAILYKDIMTPLPGIGVDVEIKNGIGPVIDQPITSLADVEKLGELDPQ
HHHCCHHHHCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCH
EHIPYVLETIRLLTEEQLNVPLIGFTGAPFTLASYMIEGGPSKNYNKTKAFMYSQPAAWD
HHCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCCCCCCHHHEEECCCHHHH
LLMKKLGKMAAVYVKAQIRAGAKAIQVFDSWVGALNAGDYCRYIKPTMDVLFKELKKEDV
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
PLIMFGVGASHLATEWHDLDLDVVGLDWRMSVQEARDKGLTKTLQGNLDPSILLAPWEVI
CEEEEECCHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCHHHHCCCCCCCEEECCHHHH
EERTKAILDQGMQTDRFIFNLGHGIFPEVSPDTLKKLTAFVHEYSASKKSSLIT
HHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure
MMKNDKAFNDTFLKACRGEKAAHVPVWYMRQAGRSQPEYRALKEKYGLFEITHQPELCAY
CCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHCCEEEECCCCHHHHH
VTRLPVEQYDVDAAILYKDIMTPLPGIGVDVEIKNGIGPVIDQPITSLADVEKLGELDPQ
HHHCCHHHHCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCH
EHIPYVLETIRLLTEEQLNVPLIGFTGAPFTLASYMIEGGPSKNYNKTKAFMYSQPAAWD
HHCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCCCCCCHHHEEECCCHHHH
LLMKKLGKMAAVYVKAQIRAGAKAIQVFDSWVGALNAGDYCRYIKPTMDVLFKELKKEDV
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
PLIMFGVGASHLATEWHDLDLDVVGLDWRMSVQEARDKGLTKTLQGNLDPSILLAPWEVI
CEEEEECCHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCHHHHCCCCCCCEEECCHHHH
EERTKAILDQGMQTDRFIFNLGHGIFPEVSPDTLKKLTAFVHEYSASKKSSLIT
HHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377 [H]