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The map label for this gene is dxs [C]

Identifier: 52784316

GI number: 52784316

Start: 502455

End: 503405

Strand: Direct

Name: dxs [C]

Synonym: BLi00496

Alternate gene names: 52784316

Gene position: 502455-503405 (Clockwise)

Preceding gene: 52784315

Following gene: 52784317

Centisome position: 11.9

GC content: 48.37

Gene sequence:

>951_bases
ATGAATGAGGCGGCAAATGTAGAGCTGGACGCTGTTGAAATGAGGCAGGCATACAGCTCAGCCGTTTATGAACTGGCTCA
AGAAAACACGGACATCGTGGCCTTGGAAGCGGATTTGATGAGCTCGATCTCCATGGACAAAGTCAAACGGCGCATTCCCG
AGCAAGTGATCAATTGCGGTGTCATGGAAGCCAATATGATAGGGATTGCGGCCGGGCTTTCGTTAACCGGAAGAATCCCG
TTTGTTCACACGTTCGCTCAGTTTGCGACAAGACGCTGTTTTGACCAGCTGTTTGTTTCAGGTGCATATGCCAAAACAAA
CATTAAGATTCTCGGATCAGATTCGGGAATTACGGCTGAACATAACGGCGGAACCCATATGGCCTTTGAAGATTTGGGAC
TCGCCCGGCTGATCCCAAACGCCTTTGTTTATGAAGCAAGCGATGCGGCAATGCTCAAATTTTTGATCAAAAAGGCTGCG
GCAGAGTACGGCATTCACTATATCAGGACGATCAGAAAAAAGGCTGTCAGGCTTTATGATGAACACGAAACATTCGCAGA
CGGAAAAGCAAAAGTTCTCAAAGATGGCAGCGATGCGGCGCTGTTTGCCAGCGGCATCATGGTCGCCGAAGCTTTGCAGG
CGGCTGAACTGCTAAAAGAAAAAGGAATCGATGCAGCAGTGATCGATATGTATTGCATCAAGCCGATTGATCAAGAAACG
GTGGTTCGTTATGCACAAAAAACGAATGCGATTGTCACGGCTGAAAACCATAATGTCATAGGCGGATTGGGAAGCGCAGT
TGCGGAAGTGCTGAGTGAACATTATCCCGCGCCGCTTAAAAGAATCGGGGTTCATGAAGCCTTCGGGCAGGTCGGGACAA
TCGATTATTTGAAAAAATCTTACCGTTTGACCGCAGAACACATTGCACTGGCGGCGGAACAGCTCGTTTAA

Upstream 100 bases:

>100_bases
TTGAAAAAATGGAGAACAGCCACCACATTAGAGCAAATGAAGAGCAAAACCGCATGATCGAAAGGATCATTTTGACGCTT
GAAGAAAAGGAAGTGAGGGC

Downstream 100 bases:

>100_bases
GATTTCTTTGTCCTGGCCGATTTTTATATTAGAATAGATAAAAGCCTAAAAAAAGTGGAGGTATCTTAAATATCGTGTCA
GTCAGTCAAAGAAATCGAAT

Product: hypothetical protein

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MNEAANVELDAVEMRQAYSSAVYELAQENTDIVALEADLMSSISMDKVKRRIPEQVINCGVMEANMIGIAAGLSLTGRIP
FVHTFAQFATRRCFDQLFVSGAYAKTNIKILGSDSGITAEHNGGTHMAFEDLGLARLIPNAFVYEASDAAMLKFLIKKAA
AEYGIHYIRTIRKKAVRLYDEHETFADGKAKVLKDGSDAALFASGIMVAEALQAAELLKEKGIDAAVIDMYCIKPIDQET
VVRYAQKTNAIVTAENHNVIGGLGSAVAEVLSEHYPAPLKRIGVHEAFGQVGTIDYLKKSYRLTAEHIALAAEQLV

Sequences:

>Translated_316_residues
MNEAANVELDAVEMRQAYSSAVYELAQENTDIVALEADLMSSISMDKVKRRIPEQVINCGVMEANMIGIAAGLSLTGRIP
FVHTFAQFATRRCFDQLFVSGAYAKTNIKILGSDSGITAEHNGGTHMAFEDLGLARLIPNAFVYEASDAAMLKFLIKKAA
AEYGIHYIRTIRKKAVRLYDEHETFADGKAKVLKDGSDAALFASGIMVAEALQAAELLKEKGIDAAVIDMYCIKPIDQET
VVRYAQKTNAIVTAENHNVIGGLGSAVAEVLSEHYPAPLKRIGVHEAFGQVGTIDYLKKSYRLTAEHIALAAEQLV
>Mature_316_residues
MNEAANVELDAVEMRQAYSSAVYELAQENTDIVALEADLMSSISMDKVKRRIPEQVINCGVMEANMIGIAAGLSLTGRIP
FVHTFAQFATRRCFDQLFVSGAYAKTNIKILGSDSGITAEHNGGTHMAFEDLGLARLIPNAFVYEASDAAMLKFLIKKAA
AEYGIHYIRTIRKKAVRLYDEHETFADGKAKVLKDGSDAALFASGIMVAEALQAAELLKEKGIDAAVIDMYCIKPIDQET
VVRYAQKTNAIVTAENHNVIGGLGSAVAEVLSEHYPAPLKRIGVHEAFGQVGTIDYLKKSYRLTAEHIALAAEQLV

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=266, Percent_Identity=35.3383458646617, Blast_Score=161, Evalue=6e-40,
Organism=Homo sapiens, GI4507521, Length=266, Percent_Identity=35.3383458646617, Blast_Score=161, Evalue=6e-40,
Organism=Homo sapiens, GI225637461, Length=311, Percent_Identity=33.4405144694534, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI225637463, Length=311, Percent_Identity=33.4405144694534, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI225637459, Length=311, Percent_Identity=33.4405144694534, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI133778974, Length=302, Percent_Identity=31.4569536423841, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1786622, Length=296, Percent_Identity=27.027027027027, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17539652, Length=310, Percent_Identity=35.8064516129032, Blast_Score=178, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6319698, Length=300, Percent_Identity=24.6666666666667, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24645119, Length=311, Percent_Identity=32.1543408360129, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45551847, Length=311, Percent_Identity=32.1543408360129, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45550715, Length=311, Percent_Identity=32.1543408360129, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24666278, Length=269, Percent_Identity=34.9442379182156, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21358145, Length=237, Percent_Identity=28.6919831223629, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24650940, Length=237, Percent_Identity=28.6919831223629, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 34359; Mature: 34359

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEAANVELDAVEMRQAYSSAVYELAQENTDIVALEADLMSSISMDKVKRRIPEQVINCG
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHHHCCC
VMEANMIGIAAGLSLTGRIPFVHTFAQFATRRCFDQLFVSGAYAKTNIKILGSDSGITAE
CCHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCEEE
HNGGTHMAFEDLGLARLIPNAFVYEASDAAMLKFLIKKAAAEYGIHYIRTIRKKAVRLYD
CCCCCEEHHHHCCHHHHCCCHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EHETFADGKAKVLKDGSDAALFASGIMVAEALQAAELLKEKGIDAAVIDMYCIKPIDQET
HHHHHCCCCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHCCCCCHHH
VVRYAQKTNAIVTAENHNVIGGLGSAVAEVLSEHYPAPLKRIGVHEAFGQVGTIDYLKKS
HHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHH
YRLTAEHIALAAEQLV
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNEAANVELDAVEMRQAYSSAVYELAQENTDIVALEADLMSSISMDKVKRRIPEQVINCG
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHHHCCC
VMEANMIGIAAGLSLTGRIPFVHTFAQFATRRCFDQLFVSGAYAKTNIKILGSDSGITAE
CCHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCEEE
HNGGTHMAFEDLGLARLIPNAFVYEASDAAMLKFLIKKAAAEYGIHYIRTIRKKAVRLYD
CCCCCEEHHHHCCHHHHCCCHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EHETFADGKAKVLKDGSDAALFASGIMVAEALQAAELLKEKGIDAAVIDMYCIKPIDQET
HHHHHCCCCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHCCCCCHHH
VVRYAQKTNAIVTAENHNVIGGLGSAVAEVLSEHYPAPLKRIGVHEAFGQVGTIDYLKKS
HHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHH
YRLTAEHIALAAEQLV
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]