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The map label for this gene is flp [H]

Identifier: 52784151

GI number: 52784151

Start: 302687

End: 304402

Strand: Direct

Name: flp [H]

Synonym: BLi00328

Alternate gene names: 52784151

Gene position: 302687-304402 (Clockwise)

Preceding gene: 52784148

Following gene: 52784158

Centisome position: 7.17

GC content: 47.49

Gene sequence:

>1716_bases
ATGAAACAGTCATTAAAGGCATTAAAAGGCTTTCGGGCATTCGCCGAAGAAAAAATGAAAGAGTGGAACGTTCCTGGAGC
CGCGGTTGCAGTCATTAAGGAAGACGAGATCATCATGGCGGAAGGGTTTGGATTCAGGGATAAAGAACGGAAATTAAAGG
TCAACCCGGAAACGGTATTTGCGATCGGTTCCGCCTCCAAGGCATTTACAACGGCGGCGATGGCGGTATTGGCTGATGAA
GGGAAAATGGAGTGGGATAAGCCGGTAAGGGAATATCTCCCTGAGTTTAAGATGCACGATCCGGTAGCAACTGAACGGAT
GACTCCCCGTGATCTTGCGTGCCATCGTTCTGGTCTCCCAAGACACGAAATGATGTGGTACAATTCCTCCTTTTCAAGGG
AGGAGCTTTTCAGACGGATCCGCTACCTTGAGCCGAATCAGGATTTTCGATCAAAGTGGCAGTATCAGAACCTGATGTAT
ATGACGGCTGGTTATCTTGCTGGAAGAATAGCGGGGACGACATGGGAGGATCTTGTTCATGAGCGGCTTTTCAAACCTTT
GCATATGACATCCAGCAGCTTTTCGGTCGAAGATATGCAAAAGCTTTCCGATTTTGCCTTTCCATATCAAGAGAACAACG
GAACGGTTGAAAAAATACCTTTTCGTAATATCGATGCGATCGGGCCGGCTGGGTCGATTAATTCCAATGCCGTGGATATG
GCAAATTGGCTGCTTCTTCAGCTTGGCAGCGAGAAATTCAACGGGGTTTTATCAGATGGAAGCCTTCATGAACTGCATAC
GCCTTGCATTTCCTGCGACTCCATTATTAAAGCGAAGGAGCTTCCGGTCTGCAGCTATGGACTCGGCTGGTTTGTGGAAC
CGTACCGCGGTCGCCATATGATTCATCATGGCGGAAATATCGACGGCTTTTCATCGCTTGTCGCTTTCATGCCTTATGAA
AAGATCGGCATTGTCATTTTGACAAATATGAACGGCAGCTTTCTTCCAAATGTTCTGGCGTACAACATTTTTGACCGCTT
GCTTGGATTGGAAGAGATCGATTGGAGCGGCCGGCTGAAAGGCGAAGCGGAAAAAATAATGAAAGCCGCTTTAGGAGTGG
ATCGAACCGCGGATCTTACCAAAATTGAAGGAACGAATCCTTCTCATGCCCTGAAGGACTACACAGGTGTATATGAGCAT
CCCGGCTACGGCGAAATCAAAATAGAGCTTAAAGACGGCGTGTTACAGGCGCTCTTCAATTCGTTTGTGATGCCTTTGAA
GCATTATCATTACAATATATTCGAGATGAAAATGCCGCTCACGGAGATGGCGATGCTCGCATCATTCGACACCGATATAC
ACGGACATATCAGCCGCCTTTCCATACCGTTTGAAATGGCGGAAGGCGCTAGAGAAATCGAATTTGTCAGGAAGCCGGAT
CAGCAATTGTACGACCCTGAATTTCTTGCTTCTTTAACAGGGAAGTATGCATTGGGAGACGGAACAGATGTCGTTGTGTC
TCTCAGAAACAACCGGACGCTCTGGGTTTCATTGCCCGGTCAGCCTGATTACGAACTTGAACCTTACCGTGAGTTGACAT
TTCAAATAAAAAATCTGCCGGGATTCAGCGTCCGATTTGAAGCCGGCGATTCCGGACAGGTAACAGGTTTGCGCTTCATC
CAGCCGAATGGAGAATTTCCTGCTGTCCGGAAATAG

Upstream 100 bases:

>100_bases
TACAAATTTTTTCTAAATGAAACCATTTGGGCGAACAAACGTATGAAATACGGACACCATGAACCGTCATAAGACTCTTA
AATCAAGTGAGGAGAGTAAG

Downstream 100 bases:

>100_bases
CAGCAAAGGACATATTTCGATTTATTTCCCGAGAAATATACAGGTGTGAGCCAGTCTGGTCACTTCTGGACGGCTTCCAG
TAATAAATCCGCCAGATGAA

Product: hypothetical protein

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MKQSLKALKGFRAFAEEKMKEWNVPGAAVAVIKEDEIIMAEGFGFRDKERKLKVNPETVFAIGSASKAFTTAAMAVLADE
GKMEWDKPVREYLPEFKMHDPVATERMTPRDLACHRSGLPRHEMMWYNSSFSREELFRRIRYLEPNQDFRSKWQYQNLMY
MTAGYLAGRIAGTTWEDLVHERLFKPLHMTSSSFSVEDMQKLSDFAFPYQENNGTVEKIPFRNIDAIGPAGSINSNAVDM
ANWLLLQLGSEKFNGVLSDGSLHELHTPCISCDSIIKAKELPVCSYGLGWFVEPYRGRHMIHHGGNIDGFSSLVAFMPYE
KIGIVILTNMNGSFLPNVLAYNIFDRLLGLEEIDWSGRLKGEAEKIMKAALGVDRTADLTKIEGTNPSHALKDYTGVYEH
PGYGEIKIELKDGVLQALFNSFVMPLKHYHYNIFEMKMPLTEMAMLASFDTDIHGHISRLSIPFEMAEGAREIEFVRKPD
QQLYDPEFLASLTGKYALGDGTDVVVSLRNNRTLWVSLPGQPDYELEPYRELTFQIKNLPGFSVRFEAGDSGQVTGLRFI
QPNGEFPAVRK

Sequences:

>Translated_571_residues
MKQSLKALKGFRAFAEEKMKEWNVPGAAVAVIKEDEIIMAEGFGFRDKERKLKVNPETVFAIGSASKAFTTAAMAVLADE
GKMEWDKPVREYLPEFKMHDPVATERMTPRDLACHRSGLPRHEMMWYNSSFSREELFRRIRYLEPNQDFRSKWQYQNLMY
MTAGYLAGRIAGTTWEDLVHERLFKPLHMTSSSFSVEDMQKLSDFAFPYQENNGTVEKIPFRNIDAIGPAGSINSNAVDM
ANWLLLQLGSEKFNGVLSDGSLHELHTPCISCDSIIKAKELPVCSYGLGWFVEPYRGRHMIHHGGNIDGFSSLVAFMPYE
KIGIVILTNMNGSFLPNVLAYNIFDRLLGLEEIDWSGRLKGEAEKIMKAALGVDRTADLTKIEGTNPSHALKDYTGVYEH
PGYGEIKIELKDGVLQALFNSFVMPLKHYHYNIFEMKMPLTEMAMLASFDTDIHGHISRLSIPFEMAEGAREIEFVRKPD
QQLYDPEFLASLTGKYALGDGTDVVVSLRNNRTLWVSLPGQPDYELEPYRELTFQIKNLPGFSVRFEAGDSGQVTGLRFI
QPNGEFPAVRK
>Mature_571_residues
MKQSLKALKGFRAFAEEKMKEWNVPGAAVAVIKEDEIIMAEGFGFRDKERKLKVNPETVFAIGSASKAFTTAAMAVLADE
GKMEWDKPVREYLPEFKMHDPVATERMTPRDLACHRSGLPRHEMMWYNSSFSREELFRRIRYLEPNQDFRSKWQYQNLMY
MTAGYLAGRIAGTTWEDLVHERLFKPLHMTSSSFSVEDMQKLSDFAFPYQENNGTVEKIPFRNIDAIGPAGSINSNAVDM
ANWLLLQLGSEKFNGVLSDGSLHELHTPCISCDSIIKAKELPVCSYGLGWFVEPYRGRHMIHHGGNIDGFSSLVAFMPYE
KIGIVILTNMNGSFLPNVLAYNIFDRLLGLEEIDWSGRLKGEAEKIMKAALGVDRTADLTKIEGTNPSHALKDYTGVYEH
PGYGEIKIELKDGVLQALFNSFVMPLKHYHYNIFEMKMPLTEMAMLASFDTDIHGHISRLSIPFEMAEGAREIEFVRKPD
QQLYDPEFLASLTGKYALGDGTDVVVSLRNNRTLWVSLPGQPDYELEPYRELTFQIKNLPGFSVRFEAGDSGQVTGLRFI
QPNGEFPAVRK

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI26051231, Length=119, Percent_Identity=33.6134453781513, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI239747261, Length=344, Percent_Identity=21.8023255813953, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI239752721, Length=344, Percent_Identity=21.8023255813953, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI239741085, Length=344, Percent_Identity=21.8023255813953, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790593, Length=331, Percent_Identity=25.0755287009063, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17550934, Length=316, Percent_Identity=24.6835443037975, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115533026, Length=375, Percent_Identity=24, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 64743; Mature: 64743

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSLKALKGFRAFAEEKMKEWNVPGAAVAVIKEDEIIMAEGFGFRDKERKLKVNPETVF
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCCCEEEECCCEEE
AIGSASKAFTTAAMAVLADEGKMEWDKPVREYLPEFKMHDPVATERMTPRDLACHRSGLP
EECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCHHCCCCCHHHHHHHCCCC
RHEMMWYNSSFSREELFRRIRYLEPNQDFRSKWQYQNLMYMTAGYLAGRIAGTTWEDLVH
CHHEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
ERLFKPLHMTSSSFSVEDMQKLSDFAFPYQENNGTVEKIPFRNIDAIGPAGSINSNAVDM
HHHCCCHHCCCCCCCHHHHHHHHHHCCCEECCCCCEEECCCCCCCCCCCCCCCCCCHHHH
ANWLLLQLGSEKFNGVLSDGSLHELHTPCISCDSIIKAKELPVCSYGLGWFVEPYRGRHM
HHHHHHHCCCHHHCCEECCCCHHHHCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCEE
IHHGGNIDGFSSLVAFMPYEKIGIVILTNMNGSFLPNVLAYNIFDRLLGLEEIDWSGRLK
EECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHCCCCCCCC
GEAEKIMKAALGVDRTADLTKIEGTNPSHALKDYTGVYEHPGYGEIKIELKDGVLQALFN
CHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHH
SFVMPLKHYHYNIFEMKMPLTEMAMLASFDTDIHGHISRLSIPFEMAEGAREIEFVRKPD
HHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCHHCCHHHEECCHHHHCCCHHHHHHCCCH
QQLYDPEFLASLTGKYALGDGTDVVVSLRNNRTLWVSLPGQPDYELEPYRELTFQIKNLP
HHHCCHHHHHHHCCCEEECCCCEEEEEEECCCEEEEECCCCCCCCCCCHHEEHEEEECCC
GFSVRFEAGDSGQVTGLRFIQPNGEFPAVRK
CCEEEEECCCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKQSLKALKGFRAFAEEKMKEWNVPGAAVAVIKEDEIIMAEGFGFRDKERKLKVNPETVF
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCCCEEEECCCEEE
AIGSASKAFTTAAMAVLADEGKMEWDKPVREYLPEFKMHDPVATERMTPRDLACHRSGLP
EECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCHHCCCCCHHHHHHHCCCC
RHEMMWYNSSFSREELFRRIRYLEPNQDFRSKWQYQNLMYMTAGYLAGRIAGTTWEDLVH
CHHEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
ERLFKPLHMTSSSFSVEDMQKLSDFAFPYQENNGTVEKIPFRNIDAIGPAGSINSNAVDM
HHHCCCHHCCCCCCCHHHHHHHHHHCCCEECCCCCEEECCCCCCCCCCCCCCCCCCHHHH
ANWLLLQLGSEKFNGVLSDGSLHELHTPCISCDSIIKAKELPVCSYGLGWFVEPYRGRHM
HHHHHHHCCCHHHCCEECCCCHHHHCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCEE
IHHGGNIDGFSSLVAFMPYEKIGIVILTNMNGSFLPNVLAYNIFDRLLGLEEIDWSGRLK
EECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHCCCCCCCC
GEAEKIMKAALGVDRTADLTKIEGTNPSHALKDYTGVYEHPGYGEIKIELKDGVLQALFN
CHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHH
SFVMPLKHYHYNIFEMKMPLTEMAMLASFDTDIHGHISRLSIPFEMAEGAREIEFVRKPD
HHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCHHCCHHHEECCHHHHCCCHHHHHHCCCH
QQLYDPEFLASLTGKYALGDGTDVVVSLRNNRTLWVSLPGQPDYELEPYRELTFQIKNLP
HHHCCHHHHHHHCCCEEECCCCEEEEEEECCCEEEEECCCCCCCCCCCHHEEHEEEECCC
GFSVRFEAGDSGQVTGLRFIQPNGEFPAVRK
CCEEEEECCCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA