Click here to switch to the map view.

The map label for this gene is thrC [H]

Identifier: 52143451

GI number: 52143451

Start: 1908379

End: 1909437

Strand: Direct

Name: thrC [H]

Synonym: BCZK1783

Alternate gene names: 52143451

Gene position: 1908379-1909437 (Clockwise)

Preceding gene: 52143453

Following gene: 52143450

Centisome position: 36.0

GC content: 39.94

Gene sequence:

>1059_bases
ATGTATAAAGGACTATTAAACCAATATGCTTCTTATTTACCGGTAAATGAAAACACACCAGATGTGAGCTTAATGGAAGG
AAATACACCCCTTATTCCGTTATTAAACATATCAAAACAATTAGGGATTCAGTTATACGGGAAGTATGAAGGAGCGAATC
CGACAGGTTCTTTTAAAGATCGAGGCATGGTAATGGCTGTTGCGAAGGCGAAAGAAGAAGGTTCGGAGGCAATCATTTGT
GCATCGACAGGTAATACATCAGCATCGGCTGCCGCATACGCGGCACGCCTTGGAATGAAATGTATTATCGTAATACCGGA
AGGAAAGATTGCACATGGAAAATTAGCACAAGCAGTTGCGTATGGTGCTGAAATCATTTCAATAGAAGGAAATTTTGATG
ATGCATTAAAGGCTGTAAGAAATATCGCTGCGGAAGAGCCGATTACGTTAGTAAACTCAGTGAATCCTTATCGAATTGAA
GGGCAAAAAACAGCAGCGTTTGAAATTTGTGATCAGTTGCAACGTGCACCAGATGTTCTAGCGATCCCTGTTGGGAATGC
CGGAAATATTACAGCGTACTGGAAAGGTTTCTGTGAATATGAGAAAGAAAAAGGTTATAAAAAGCCAAGAATTCACGGAT
TTGAAGCGGAAGGAGCAGCTGCAATTGTAAAAGGGCATGTAATTGACGAGCCAGAAACAATTGCAACTGCGATTCGCATC
GGTAACCCAGCAAGTTGGTCATATGCGGTAGAGGCTGCTGAGCAATCTCACGGCGAAATAGATATGGTATCAGATGAAGA
GATTTTACATGCGTATAGATTATTAGCAAAAACGGAGGGGGTTTTTGCTGAGCCAGGATCAAATGCTTCATTAGCGGGTG
TAATGAAACATGTTCAATCTGGAAAAATCAAAAAGGGAGAAACAGTTGTTGCAGTTTTAACTGGAAATGGCTTGAAAGAT
CCTGATATCGCAATTTCTTCTAATACATTAGATATTGCAAGTGTCTCAAATAATATAGAACAAATTAAAGAGCATATTAA
AGGGGTGATTATGTCGTGA

Upstream 100 bases:

>100_bases
CATCAAACTTCAAAGTATCAATTCGAACGAGTTTTAGGGGCTATAGAAGATGTCGCAAGTGAAATAAACAGTTACTACAT
TATTGAGGAGGAAAAACAAT

Downstream 100 bases:

>100_bases
TACCACTAAGTATTCGTGTTCCTGCTAGTACAGCGAATGTTGGACCTGGATTTGATTCAGTAGGAATAGCTTTGTCATTG
TATTTACATGTAGTAGTAAA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MYKGLLNQYASYLPVNENTPDVSLMEGNTPLIPLLNISKQLGIQLYGKYEGANPTGSFKDRGMVMAVAKAKEEGSEAIIC
ASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVAYGAEIISIEGNFDDALKAVRNIAAEEPITLVNSVNPYRIE
GQKTAAFEICDQLQRAPDVLAIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGHVIDEPETIATAIRI
GNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKTEGVFAEPGSNASLAGVMKHVQSGKIKKGETVVAVLTGNGLKD
PDIAISSNTLDIASVSNNIEQIKEHIKGVIMS

Sequences:

>Translated_352_residues
MYKGLLNQYASYLPVNENTPDVSLMEGNTPLIPLLNISKQLGIQLYGKYEGANPTGSFKDRGMVMAVAKAKEEGSEAIIC
ASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVAYGAEIISIEGNFDDALKAVRNIAAEEPITLVNSVNPYRIE
GQKTAAFEICDQLQRAPDVLAIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGHVIDEPETIATAIRI
GNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKTEGVFAEPGSNASLAGVMKHVQSGKIKKGETVVAVLTGNGLKD
PDIAISSNTLDIASVSNNIEQIKEHIKGVIMS
>Mature_352_residues
MYKGLLNQYASYLPVNENTPDVSLMEGNTPLIPLLNISKQLGIQLYGKYEGANPTGSFKDRGMVMAVAKAKEEGSEAIIC
ASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVAYGAEIISIEGNFDDALKAVRNIAAEEPITLVNSVNPYRIE
GQKTAAFEICDQLQRAPDVLAIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGHVIDEPETIATAIRI
GNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKTEGVFAEPGSNASLAGVMKHVQSGKIKKGETVVAVLTGNGLKD
PDIAISSNTLDIASVSNNIEQIKEHIKGVIMS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=322, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI295821200, Length=322, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI4557415, Length=322, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI11345492, Length=290, Percent_Identity=29.3103448275862, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI33469958, Length=277, Percent_Identity=25.6317689530686, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790207, Length=295, Percent_Identity=26.7796610169492, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367138, Length=223, Percent_Identity=28.2511210762332, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71991565, Length=308, Percent_Identity=27.5974025974026, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322631, Length=275, Percent_Identity=29.4545454545455, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24643623, Length=189, Percent_Identity=33.8624338624339, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20129101, Length=189, Percent_Identity=33.8624338624339, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 37475; Mature: 37475

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKGLLNQYASYLPVNENTPDVSLMEGNTPLIPLLNISKQLGIQLYGKYEGANPTGSFKD
CCHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCHHCCEEEEEEECCCCCCCCCCC
RGMVMAVAKAKEEGSEAIICASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVA
CCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
YGAEIISIEGNFDDALKAVRNIAAEEPITLVNSVNPYRIEGQKTAAFEICDQLQRAPDVL
CCEEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCEEECCCCHHHHHHHHHHHCCCCEE
AIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGHVIDEPETIATAIRI
EEECCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHEEEEEC
GNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKTEGVFAEPGSNASLAGVMKHVQS
CCCCCCHHEEEHHHHCCCCEEEECCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHC
GKIKKGETVVAVLTGNGLKDPDIAISSNTLDIASVSNNIEQIKEHIKGVIMS
CCCCCCCEEEEEEECCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYKGLLNQYASYLPVNENTPDVSLMEGNTPLIPLLNISKQLGIQLYGKYEGANPTGSFKD
CCHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCHHCCEEEEEEECCCCCCCCCCC
RGMVMAVAKAKEEGSEAIICASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVA
CCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
YGAEIISIEGNFDDALKAVRNIAAEEPITLVNSVNPYRIEGQKTAAFEICDQLQRAPDVL
CCEEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCEEECCCCHHHHHHHHHHHCCCCEE
AIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGHVIDEPETIATAIRI
EEECCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHEEEEEC
GNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKTEGVFAEPGSNASLAGVMKHVQS
CCCCCCHHEEEHHHHCCCCEEEECCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHC
GKIKKGETVVAVLTGNGLKDPDIAISSNTLDIASVSNNIEQIKEHIKGVIMS
CCCCCCCEEEEEEECCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3186450; 8768250 [H]