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The map label for this gene is thrB [H]

Identifier: 52143450

GI number: 52143450

Start: 1909434

End: 1910327

Strand: Direct

Name: thrB [H]

Synonym: BCZK1784

Alternate gene names: 52143450

Gene position: 1909434-1910327 (Clockwise)

Preceding gene: 52143451

Following gene: 52143449

Centisome position: 36.02

GC content: 36.8

Gene sequence:

>894_bases
GTGATACCACTAAGTATTCGTGTTCCTGCTAGTACAGCGAATGTTGGACCTGGATTTGATTCAGTAGGAATAGCTTTGTC
ATTGTATTTACATGTAGTAGTAAAAGAGAAGTCTGATAAATGGCAAGTGATCCATTCCTTTGAAGATTCAATTCCGACAG
ACGATAAAAATTTAATTGTTAGCACGGCATGTAAAGTATGTCCTTCTTTATCACCCCATATAATAGAAGTTACTAGTAAC
ATCCCACTAACAAGAGGTCTAGGAAGTAGTGCATCAGCAATTGTAGCTGGGATAGAGCTTGCGAATCAACTAGGCAAATT
GAACTTAACGACTGATCAAAAAGTTCAAATTGCTACAAATTTTGAAGGTCATCCTGATAATGTTGCTGCTTCTATATTAG
GAGGAACTGTAATCGGGGCACTTGATGGAAAGAATGTATCGGTTGTGAGAATTGAAAGTAAGGAATTAGGCGTAATTTCA
CTTATTCCAAATGAAGAGCTAAATACAGATGAAAGCCGTTCTGTATTACCAGATGTATTTCCGTTTCATGAAGCTGTTAA
GGCTAGTGCAATAAGTAATGTATTAGTAGCTGCTTTATGTCAAAAGAAATGGGAAGTTGTAGGGGAAATGATGGAAAGGG
ATCATTTTCACGAACCGTATCGTTTAGAGCTTATACCGTTATTACCATCTATTCGTAAATGTGCAAAAGAATTCGGTGCA
TACGGTACAGCGCTTAGCGGTGCAGGACCATCTATTTTTATATTAACGCCGTATGAGAAACGTCAAGAAATTGCTGAGCA
ATTAGCGAGAGTATTTACGTCTATGAAAGTGTGTGAGTTAGAAATTGATCATAGAGGGATTACTGTAAATAAAAAAGAAC
ATATTGGATTATAA

Upstream 100 bases:

>100_bases
AAGATCCTGATATCGCAATTTCTTCTAATACATTAGATATTGCAAGTGTCTCAAATAATATAGAACAAATTAAAGAGCAT
ATTAAAGGGGTGATTATGTC

Downstream 100 bases:

>100_bases
AGAGAGCTAGCATCGCTAGCTTTCTTTATGTTGTAAATATTTTTTATGTTTGCATATAAAAGAAAAATATTAATGTATAA
TTTAGTAAAGAGTGTATTAA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MIPLSIRVPASTANVGPGFDSVGIALSLYLHVVVKEKSDKWQVIHSFEDSIPTDDKNLIVSTACKVCPSLSPHIIEVTSN
IPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIATNFEGHPDNVAASILGGTVIGALDGKNVSVVRIESKELGVIS
LIPNEELNTDESRSVLPDVFPFHEAVKASAISNVLVAALCQKKWEVVGEMMERDHFHEPYRLELIPLLPSIRKCAKEFGA
YGTALSGAGPSIFILTPYEKRQEIAEQLARVFTSMKVCELEIDHRGITVNKKEHIGL

Sequences:

>Translated_297_residues
MIPLSIRVPASTANVGPGFDSVGIALSLYLHVVVKEKSDKWQVIHSFEDSIPTDDKNLIVSTACKVCPSLSPHIIEVTSN
IPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIATNFEGHPDNVAASILGGTVIGALDGKNVSVVRIESKELGVIS
LIPNEELNTDESRSVLPDVFPFHEAVKASAISNVLVAALCQKKWEVVGEMMERDHFHEPYRLELIPLLPSIRKCAKEFGA
YGTALSGAGPSIFILTPYEKRQEIAEQLARVFTSMKVCELEIDHRGITVNKKEHIGL
>Mature_297_residues
MIPLSIRVPASTANVGPGFDSVGIALSLYLHVVVKEKSDKWQVIHSFEDSIPTDDKNLIVSTACKVCPSLSPHIIEVTSN
IPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIATNFEGHPDNVAASILGGTVIGALDGKNVSVVRIESKELGVIS
LIPNEELNTDESRSVLPDVFPFHEAVKASAISNVLVAALCQKKWEVVGEMMERDHFHEPYRLELIPLLPSIRKCAKEFGA
YGTALSGAGPSIFILTPYEKRQEIAEQLARVFTSMKVCELEIDHRGITVNKKEHIGL

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=301, Percent_Identity=25.5813953488372, Blast_Score=96, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321814, Length=357, Percent_Identity=29.4117647058824, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 32137; Mature: 32137

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPLSIRVPASTANVGPGFDSVGIALSLYLHVVVKEKSDKWQVIHSFEDSIPTDDKNLIV
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHEEEEECCCCCCHHHHHHHHCCCCCCCHHHH
STACKVCPSLSPHIIEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIATN
HHHHHHCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHCCEECCCCCEEEEEEC
FEGHPDNVAASILGGTVIGALDGKNVSVVRIESKELGVISLIPNEELNTDESRSVLPDVF
CCCCCCHHHHHHHCCEEEEEECCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCHH
PFHEAVKASAISNVLVAALCQKKWEVVGEMMERDHFHEPYRLELIPLLPSIRKCAKEFGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCHHHHHHHHHHCC
YGTALSGAGPSIFILTPYEKRQEIAEQLARVFTSMKVCELEIDHRGITVNKKEHIGL
CCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEEEECCCCEEECCHHCCCC
>Mature Secondary Structure
MIPLSIRVPASTANVGPGFDSVGIALSLYLHVVVKEKSDKWQVIHSFEDSIPTDDKNLIV
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHEEEEECCCCCCHHHHHHHHCCCCCCCHHHH
STACKVCPSLSPHIIEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIATN
HHHHHHCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHCCEECCCCCEEEEEEC
FEGHPDNVAASILGGTVIGALDGKNVSVVRIESKELGVISLIPNEELNTDESRSVLPDVF
CCCCCCHHHHHHHCCEEEEEECCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCHH
PFHEAVKASAISNVLVAALCQKKWEVVGEMMERDHFHEPYRLELIPLLPSIRKCAKEFGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCHHHHHHHHHHCC
YGTALSGAGPSIFILTPYEKRQEIAEQLARVFTSMKVCELEIDHRGITVNKKEHIGL
CCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEEEECCCCEEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA