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The map label for this gene is hom [H]

Identifier: 52143453

GI number: 52143453

Start: 1907091

End: 1908386

Strand: Direct

Name: hom [H]

Synonym: BCZK1782

Alternate gene names: 52143453

Gene position: 1907091-1908386 (Clockwise)

Preceding gene: 52143456

Following gene: 52143451

Centisome position: 35.98

GC content: 36.03

Gene sequence:

>1296_bases
ATGAATAACGTTATTCATGTAGGGGTGTTAGGATTAGGTACGGTCGGAAGTGGTGTTGTCCATATTTTGAAAGAACATTA
TAAAAAAATTGCACTTGATACAGGGTACGAAGTGAAGGTGAAGACAGTCGTTGTACGTGATTTAGAAAAAGAACGTGATG
TTTGTATCGATGGAATCGTAGTAACAAGTCATGTTGATGAAGTTCTAAATGATTCAAATATTGATATTGTAGTAGAGGTA
ATGGGCGGAATTGAAGAAGCGAAGCAGCATATTGTTAAGGCTTTACGAAATAAGAAACATGTCGTGACAGCAAATAAAGA
TTTAATGGCTGTATACGGTGCAGAGCTTTTGCAACTGGCGAACGATAATGATTGTGATTTATGTTATGAAGCAAGTGTAG
CCGGTGGTATTCCAGTGTTAAGAGGACTAACAGACGGATTAGCTTCAGATCAAATTGAAAAAATAATGGGAATCGTAAAT
GGAACAACAAATTATATGTTAACAAAGATGAGTCAAAAGGGATGGTCGTATGAAGAGGCTTTACAAGAAGCGCAAAAATT
AGGTTTTGCAGAATCGGATCCGACAGCGGATGTAGACGGATTAGATGCAGCGAGAAAAGTAGCAATCCTTGCAAATTTAG
GTTTTTCGATGAATGTTTCTTTGGATGATGTGCAAGTAAGAGGGATTCGAAAGGTTGAAAAAGAAGATTTACAAATGGCT
GAAAAGTTAGGGTTTACTATGAAGTTAATTGGTAAAGCAGAGAAACAGGGATCAGCTATTCATTTAAGTGTAGAACCGAC
ACTTTTACCAAGCCATCATCCATTGTCAAATGTAAATAATGAATTTAATGCAGTGTATGTTCACGGGCAAGCGGTAGGAG
AAGTGATGTTTTACGGACCTGGAGCAGGTAAATTGCCGACTGGTTCTGCAGTAGTAAGTGATATTATTTCAATCGTTAAA
AATATGAATCAAGTTCCGAAAAATAAAAGTGTGTTAAAAGAACCAGAGCCATACAAATTACAAGGGGATGAAGAAGTCGT
TTCGAAATATTTCTTACGTATTTCACTACGAGATGAGCCAGGGATGTTACAAAAAATAACAGAATGTTTCGTTAATTATT
CTGTAAGTTTAAAAGAAGTTATTCAATTACCTTTAAATCGTGAACTTGCAGAAGTCGTTGTTGTGACACATCAAACTTCA
AAGTATCAATTCGAACGAGTTTTAGGGGCTATAGAAGATGTCGCAAGTGAAATAAACAGTTACTACATTATTGAGGAGGA
AAAACAATATGTATAA

Upstream 100 bases:

>100_bases
CGATTTGTACGTACGGAAATAACCACCACCTGCATGATTAAAAAGCAGAGCAAGGTGAGTGGTAAAGATAAATAATAAAA
TTGTAGGAGGAGATTAGAAG

Downstream 100 bases:

>100_bases
AGGACTATTAAACCAATATGCTTCTTATTTACCGGTAAATGAAAACACACCAGATGTGAGCTTAATGGAAGGAAATACAC
CCCTTATTCCGTTATTAAAC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNNVIHVGVLGLGTVGSGVVHILKEHYKKIALDTGYEVKVKTVVVRDLEKERDVCIDGIVVTSHVDEVLNDSNIDIVVEV
MGGIEEAKQHIVKALRNKKHVVTANKDLMAVYGAELLQLANDNDCDLCYEASVAGGIPVLRGLTDGLASDQIEKIMGIVN
GTTNYMLTKMSQKGWSYEEALQEAQKLGFAESDPTADVDGLDAARKVAILANLGFSMNVSLDDVQVRGIRKVEKEDLQMA
EKLGFTMKLIGKAEKQGSAIHLSVEPTLLPSHHPLSNVNNEFNAVYVHGQAVGEVMFYGPGAGKLPTGSAVVSDIISIVK
NMNQVPKNKSVLKEPEPYKLQGDEEVVSKYFLRISLRDEPGMLQKITECFVNYSVSLKEVIQLPLNRELAEVVVVTHQTS
KYQFERVLGAIEDVASEINSYYIIEEEKQYV

Sequences:

>Translated_431_residues
MNNVIHVGVLGLGTVGSGVVHILKEHYKKIALDTGYEVKVKTVVVRDLEKERDVCIDGIVVTSHVDEVLNDSNIDIVVEV
MGGIEEAKQHIVKALRNKKHVVTANKDLMAVYGAELLQLANDNDCDLCYEASVAGGIPVLRGLTDGLASDQIEKIMGIVN
GTTNYMLTKMSQKGWSYEEALQEAQKLGFAESDPTADVDGLDAARKVAILANLGFSMNVSLDDVQVRGIRKVEKEDLQMA
EKLGFTMKLIGKAEKQGSAIHLSVEPTLLPSHHPLSNVNNEFNAVYVHGQAVGEVMFYGPGAGKLPTGSAVVSDIISIVK
NMNQVPKNKSVLKEPEPYKLQGDEEVVSKYFLRISLRDEPGMLQKITECFVNYSVSLKEVIQLPLNRELAEVVVVTHQTS
KYQFERVLGAIEDVASEINSYYIIEEEKQYV
>Mature_431_residues
MNNVIHVGVLGLGTVGSGVVHILKEHYKKIALDTGYEVKVKTVVVRDLEKERDVCIDGIVVTSHVDEVLNDSNIDIVVEV
MGGIEEAKQHIVKALRNKKHVVTANKDLMAVYGAELLQLANDNDCDLCYEASVAGGIPVLRGLTDGLASDQIEKIMGIVN
GTTNYMLTKMSQKGWSYEEALQEAQKLGFAESDPTADVDGLDAARKVAILANLGFSMNVSLDDVQVRGIRKVEKEDLQMA
EKLGFTMKLIGKAEKQGSAIHLSVEPTLLPSHHPLSNVNNEFNAVYVHGQAVGEVMFYGPGAGKLPTGSAVVSDIISIVK
NMNQVPKNKSVLKEPEPYKLQGDEEVVSKYFLRISLRDEPGMLQKITECFVNYSVSLKEVIQLPLNRELAEVVVVTHQTS
KYQFERVLGAIEDVASEINSYYIIEEEKQYV

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=256, Percent_Identity=27.734375, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790376, Length=355, Percent_Identity=23.3802816901408, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=128, Percent_Identity=30.46875, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47368; Mature: 47368

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNVIHVGVLGLGTVGSGVVHILKEHYKKIALDTGYEVKVKTVVVRDLEKERDVCIDGIV
CCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEHHHHHHCCCEECCEE
VTSHVDEVLNDSNIDIVVEVMGGIEEAKQHIVKALRNKKHVVTANKDLMAVYGAELLQLA
EHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHC
NDNDCDLCYEASVAGGIPVLRGLTDGLASDQIEKIMGIVNGTTNYMLTKMSQKGWSYEEA
CCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEHHHCCCCHHHH
LQEAQKLGFAESDPTADVDGLDAARKVAILANLGFSMNVSLDDVQVRGIRKVEKEDLQMA
HHHHHHCCCCCCCCCCCCCCHHHHHHEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHH
EKLGFTMKLIGKAEKQGSAIHLSVEPTLLPSHHPLSNVNNEFNAVYVHGQAVGEVMFYGP
HHCCCHHEEHHHHCCCCCEEEEEECCEECCCCCCCCCCCCCCEEEEEECCEECEEEEECC
GAGKLPTGSAVVSDIISIVKNMNQVPKNKSVLKEPEPYKLQGDEEVVSKYFLRISLRDEP
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCHHHHHHHHEEEEECCCC
GMLQKITECFVNYSVSLKEVIQLPLNRELAEVVVVTHQTSKYQFERVLGAIEDVASEINS
CHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCC
YYIIEEEKQYV
EEEEECCCCCC
>Mature Secondary Structure
MNNVIHVGVLGLGTVGSGVVHILKEHYKKIALDTGYEVKVKTVVVRDLEKERDVCIDGIV
CCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEHHHHHHCCCEECCEE
VTSHVDEVLNDSNIDIVVEVMGGIEEAKQHIVKALRNKKHVVTANKDLMAVYGAELLQLA
EHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHC
NDNDCDLCYEASVAGGIPVLRGLTDGLASDQIEKIMGIVNGTTNYMLTKMSQKGWSYEEA
CCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEHHHCCCCHHHH
LQEAQKLGFAESDPTADVDGLDAARKVAILANLGFSMNVSLDDVQVRGIRKVEKEDLQMA
HHHHHHCCCCCCCCCCCCCCHHHHHHEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHH
EKLGFTMKLIGKAEKQGSAIHLSVEPTLLPSHHPLSNVNNEFNAVYVHGQAVGEVMFYGP
HHCCCHHEEHHHHCCCCCEEEEEECCEECCCCCCCCCCCCCCEEEEEECCEECEEEEECC
GAGKLPTGSAVVSDIISIVKNMNQVPKNKSVLKEPEPYKLQGDEEVVSKYFLRISLRDEP
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCHHHHHHHHEEEEECCCC
GMLQKITECFVNYSVSLKEVIQLPLNRELAEVVVVTHQTSKYQFERVLGAIEDVASEINS
CHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCC
YYIIEEEKQYV
EEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]