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The map label for this gene is nhaC [H]

Identifier: 52141373

GI number: 52141373

Start: 4002711

End: 4004084

Strand: Direct

Name: nhaC [H]

Synonym: BCZK3877

Alternate gene names: 52141373

Gene position: 4002711-4004084 (Clockwise)

Preceding gene: 52141380

Following gene: 52141370

Centisome position: 75.51

GC content: 36.17

Gene sequence:

>1374_bases
ATGGTTTCAAAAATTGAATCTGTTCTTTTAACAATTTTTATCTTTTTCTGTATTGGCTTTAGTGTTATCAAATTAGAAGT
TTCACCACACATCCCGATTTTATTTGGTATTGTTCTTTTATTAGCATTTGGATTTATGAAAAAAATTGATTGGTCTACTA
TGGAAAAAGGAATGATAAGTAGTATTTCAGCTGGTATTCCGTCTATTTTTATTTTCTTACTTGTAGGTGTATTAATTAGT
GTTTGGATCGCCGCTGGAACAATTCCAACTTTAATGGTATACGGCTTCCAGCTTGTATCTCCTAAAATCTTCATTCCAAC
TGTTTTTGTTGTTTGTGCAATTGTTGGAACAAGTATCGGTAGTGCCTTTACAACTGCTGCTACTGTAGGACTTGCCTTTA
TGGGTATGGGTAGTGCTCTCGGATACGATCCAGCTCTAATCGCTGGTGCAATTATTTCTGGTGCATTCTTTGGAGATAAA
ATGTCTCCTTTATCTGATACAACAAACTTAGCGCCAGCTGTAACAGGTGTAGATTTATTTGAGCACATTCGCAACATGCT
TTGGACAACAGTTCCAGCTTTCATTATTGCTTTTATCGCATTTTTCATTTTAGGAAGCGGTACTAGTGGAGATGTTGACT
TTACAAACTTCATTAGCGCATTAGAGAAAAATGCAACGATTTCTATCTTTACACTTATTCCAATTTTATTACTGTTCCTA
TTCGCATTTAAGAAGGTACCCGCAGTTCCAACATTACTTGCTGGAATTATAGTAGGGATCATTATCCTCTTTATATTTAA
ACCTAGTACTTCTTTAACTGATTTAATGAAAATTATGCAAGACGGTTACATTTCTAAAACTGGTATAAAAGATATTGATA
GCTTATTATCTCGCGGTGGCCTGCAAAGTATGATGATGTCAATCGCTCTTATTTTCCTAGCTCTTTGTATGGGAGGATTA
TTACAAGGGATGGGTATTATCACGAAGCTAATGAATATCATCTCTAGCTTCGTAAAAACTAGCACACGCTTAATCATCTC
TACTGCCTCAACTGCAATCGGTGTAAACTTCTTACTTGGTGAGCAGTACTTATCTATCGTCTTAACAGGACAAGCATTTG
CTAATAAATACGATGAAGTCGGTTTAGAACGTCGTAATTTATCACGTGTATTAGAAGACGCAGGTACAGTTATTAATCCC
CTCGTACCATGGGGAGTAAGTGGTGTATTCTTATCGAACGTCCTTGGTGTTCCGACATTTGATTACGTTCCATTCGCAAT
CTTCTGCTTAGCTTGTCCAATCGTAACAATTATTGTTGGTTTCACTGGATTTGGCCTTTCATGGAAGAAAGAAAAGGCAG
TAACAATTTCATAA

Upstream 100 bases:

>100_bases
GTAATTTGTCACAAAATTCTAAATTTTAGAAGGAAATAAACAATATTGGCGAATTTTATATAAAAAAGAGCTATTTTAGA
TTACTTAGGAGGGGAAAACA

Downstream 100 bases:

>100_bases
TATACGAAAAAGGATTACCTTAATCGGTAATCCTTTTTATATTTCTCGATTATCTATTTGCTTTCTTTCTTCTAAATAAC
AGAAGGAATCCAGCTCCGAT

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MVSKIESVLLTIFIFFCIGFSVIKLEVSPHIPILFGIVLLLAFGFMKKIDWSTMEKGMISSISAGIPSIFIFLLVGVLIS
VWIAAGTIPTLMVYGFQLVSPKIFIPTVFVVCAIVGTSIGSAFTTAATVGLAFMGMGSALGYDPALIAGAIISGAFFGDK
MSPLSDTTNLAPAVTGVDLFEHIRNMLWTTVPAFIIAFIAFFILGSGTSGDVDFTNFISALEKNATISIFTLIPILLLFL
FAFKKVPAVPTLLAGIIVGIIILFIFKPSTSLTDLMKIMQDGYISKTGIKDIDSLLSRGGLQSMMMSIALIFLALCMGGL
LQGMGIITKLMNIISSFVKTSTRLIISTASTAIGVNFLLGEQYLSIVLTGQAFANKYDEVGLERRNLSRVLEDAGTVINP
LVPWGVSGVFLSNVLGVPTFDYVPFAIFCLACPIVTIIVGFTGFGLSWKKEKAVTIS

Sequences:

>Translated_457_residues
MVSKIESVLLTIFIFFCIGFSVIKLEVSPHIPILFGIVLLLAFGFMKKIDWSTMEKGMISSISAGIPSIFIFLLVGVLIS
VWIAAGTIPTLMVYGFQLVSPKIFIPTVFVVCAIVGTSIGSAFTTAATVGLAFMGMGSALGYDPALIAGAIISGAFFGDK
MSPLSDTTNLAPAVTGVDLFEHIRNMLWTTVPAFIIAFIAFFILGSGTSGDVDFTNFISALEKNATISIFTLIPILLLFL
FAFKKVPAVPTLLAGIIVGIIILFIFKPSTSLTDLMKIMQDGYISKTGIKDIDSLLSRGGLQSMMMSIALIFLALCMGGL
LQGMGIITKLMNIISSFVKTSTRLIISTASTAIGVNFLLGEQYLSIVLTGQAFANKYDEVGLERRNLSRVLEDAGTVINP
LVPWGVSGVFLSNVLGVPTFDYVPFAIFCLACPIVTIIVGFTGFGLSWKKEKAVTIS
>Mature_457_residues
MVSKIESVLLTIFIFFCIGFSVIKLEVSPHIPILFGIVLLLAFGFMKKIDWSTMEKGMISSISAGIPSIFIFLLVGVLIS
VWIAAGTIPTLMVYGFQLVSPKIFIPTVFVVCAIVGTSIGSAFTTAATVGLAFMGMGSALGYDPALIAGAIISGAFFGDK
MSPLSDTTNLAPAVTGVDLFEHIRNMLWTTVPAFIIAFIAFFILGSGTSGDVDFTNFISALEKNATISIFTLIPILLLFL
FAFKKVPAVPTLLAGIIVGIIILFIFKPSTSLTDLMKIMQDGYISKTGIKDIDSLLSRGGLQSMMMSIALIFLALCMGGL
LQGMGIITKLMNIISSFVKTSTRLIISTASTAIGVNFLLGEQYLSIVLTGQAFANKYDEVGLERRNLSRVLEDAGTVINP
LVPWGVSGVFLSNVLGVPTFDYVPFAIFCLACPIVTIIVGFTGFGLSWKKEKAVTIS

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 48847; Mature: 48847

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]