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The map label for this gene is dctS [H]

Identifier: 51894434

GI number: 51894434

Start: 3525076

End: 3526551

Strand: Reverse

Name: dctS [H]

Synonym: STH3300

Alternate gene names: 51894434

Gene position: 3526551-3525076 (Counterclockwise)

Preceding gene: 51894435

Following gene: 51894433

Centisome position: 98.89

GC content: 68.56

Gene sequence:

>1476_bases
GTGAAGGAGGGAACGACCATCGCTGCGCAAGCGGGTGAGAGAGTCCCTTTGCCGTCCTGGCTAAGAGGACTGCTGGACCC
CTTGTCCGAGCCCGTGCTGCTGGTCGGGGCAGACGGCCGGATCCGGTACGGCAATCCCAGCGCCGGACGCCTGCTCGGAT
GCAGCCCTGAAGCGCTGCCCGGGCTGGCGGTCGGCGCTGTGTTACCCGATGGGGAAGCCCTTTTGGGCCGGCGACAGGAG
GACCCGTCGGACACTGACGCTGTCCGGCGGGACGGTGGGCGCATTCGGGTGGCCGTCACGGCGCGCCCCGGCCCGGAGGG
GCTGACCCAGCTGCTCCTGCGGCCGGTGGCCGAAGCGCCCGAAGGGCGGCTGCGGGAGAGCGATCCCCGATATCGGGCCG
TGGTGGAGGATCAGACGGACCTGATCCGGCGGTTTACCCCCGACGGCAGGCTGACCTTCGTGAACCCGGCCTTCTGCCGG
TACTTCGGCCGATCCGAGGAGGAGCTGCTCGGAAGCGACTTCATCCGGCTCATCCACCCCGAAGACCGGGAGGTGGTGCA
CCGGCAGCTGGCCGTGCTCTCGCCGGAGAACCCCACCACCGTCACCGAGGCGCGGATCCCGCGGCCCGACGGCGGGGTCG
GCTGGGTGCAGTTCGTCAACCGGGGGATCTTCGACGCCGAGGGCCGGCTCGTGGAGTGCCAGTCGGTGGGCCGGGACATC
ACCGCGCAGAAGGAGGCCGAGGCCCGCATCGCCGAGGCCCGGGAGGCGGTCAACCGGGCGGCGAGGGTGACGACCCTGGC
TATTATCGGCGGAGGAATCGTCCACGAGATCAACCAGCCCCTCAACGCGATCCGGGTTCTGGCGGAGACGGGGCTCTGCC
TGTTGGTGCAGGCCGATCCTCCGCAGGCCGACGAGATCGTGGCCATCCTGTCCCGCATCTCCCGCCAGGTGGACCGCATC
GACAGCATCGTCAACCACCTGCGGGATGTTCTGAAGAACAGCCGCAATCAGCGGTACGAGTACTGCGACCTGAACGAGGT
GGTGGAGCGGGCGCTGCTGCTCATGGACAACCGGATCCAGGCGCATGGCATCCGCCTGCGGCTGGAGAAGGCAGACCAGC
TTCCCAAGGTCTTCGGTTACAGCGTCAATCTGGAAGAGGTGGTGCTCAACCTTCTCAACAACGCGATGCAGGCCCTCGAC
GAGGTGGATTGGCCCCACAAGGAGATCGCCGTGCGCACGTGGGCAGACGACCGGGTTTACCTCGAGGTGGCAGACAACGG
CCCCGGCTTCGACCCGGCGATCCGCGAACGCGTCCTGGAGCCGTTCTTCACCACCAAGTCCGGCTCGTCGCTGGGGATGG
GGTTGCCCATCGTAAAGGCCATCGTGGAGAACGCGGACGGCCGCCTCGAGCTGGCCGACGCGCACGGGGGCGGGGCCGTC
GTCCGGGTATCGCTGCCCATCGCCACACCGCCGTGA

Upstream 100 bases:

>100_bases
GACAGGCCGCTCCTAAGACCTTTGGGTTAGAAAGAGTTTAACCTGACGATCTATTGGGCCGCGTCGCAGCCGAGGGATAT
AATCGAGCCGACCCCACCTC

Downstream 100 bases:

>100_bases
GGAAGGAGGCACGGACCTTGCGCATTCTGCTGGTGGATGACGACAGGGAGGGCAGGTCCTACCTCGCCCGATTCCTGACG
CTGGATGGCCACGCCGTCAC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MKEGTTIAAQAGERVPLPSWLRGLLDPLSEPVLLVGADGRIRYGNPSAGRLLGCSPEALPGLAVGAVLPDGEALLGRRQE
DPSDTDAVRRDGGRIRVAVTARPGPEGLTQLLLRPVAEAPEGRLRESDPRYRAVVEDQTDLIRRFTPDGRLTFVNPAFCR
YFGRSEEELLGSDFIRLIHPEDREVVHRQLAVLSPENPTTVTEARIPRPDGGVGWVQFVNRGIFDAEGRLVECQSVGRDI
TAQKEAEARIAEAREAVNRAARVTTLAIIGGGIVHEINQPLNAIRVLAETGLCLLVQADPPQADEIVAILSRISRQVDRI
DSIVNHLRDVLKNSRNQRYEYCDLNEVVERALLLMDNRIQAHGIRLRLEKADQLPKVFGYSVNLEEVVLNLLNNAMQALD
EVDWPHKEIAVRTWADDRVYLEVADNGPGFDPAIRERVLEPFFTTKSGSSLGMGLPIVKAIVENADGRLELADAHGGGAV
VRVSLPIATPP

Sequences:

>Translated_491_residues
MKEGTTIAAQAGERVPLPSWLRGLLDPLSEPVLLVGADGRIRYGNPSAGRLLGCSPEALPGLAVGAVLPDGEALLGRRQE
DPSDTDAVRRDGGRIRVAVTARPGPEGLTQLLLRPVAEAPEGRLRESDPRYRAVVEDQTDLIRRFTPDGRLTFVNPAFCR
YFGRSEEELLGSDFIRLIHPEDREVVHRQLAVLSPENPTTVTEARIPRPDGGVGWVQFVNRGIFDAEGRLVECQSVGRDI
TAQKEAEARIAEAREAVNRAARVTTLAIIGGGIVHEINQPLNAIRVLAETGLCLLVQADPPQADEIVAILSRISRQVDRI
DSIVNHLRDVLKNSRNQRYEYCDLNEVVERALLLMDNRIQAHGIRLRLEKADQLPKVFGYSVNLEEVVLNLLNNAMQALD
EVDWPHKEIAVRTWADDRVYLEVADNGPGFDPAIRERVLEPFFTTKSGSSLGMGLPIVKAIVENADGRLELADAHGGGAV
VRVSLPIATPP
>Mature_491_residues
MKEGTTIAAQAGERVPLPSWLRGLLDPLSEPVLLVGADGRIRYGNPSAGRLLGCSPEALPGLAVGAVLPDGEALLGRRQE
DPSDTDAVRRDGGRIRVAVTARPGPEGLTQLLLRPVAEAPEGRLRESDPRYRAVVEDQTDLIRRFTPDGRLTFVNPAFCR
YFGRSEEELLGSDFIRLIHPEDREVVHRQLAVLSPENPTTVTEARIPRPDGGVGWVQFVNRGIFDAEGRLVECQSVGRDI
TAQKEAEARIAEAREAVNRAARVTTLAIIGGGIVHEINQPLNAIRVLAETGLCLLVQADPPQADEIVAILSRISRQVDRI
DSIVNHLRDVLKNSRNQRYEYCDLNEVVERALLLMDNRIQAHGIRLRLEKADQLPKVFGYSVNLEEVVLNLLNNAMQALD
EVDWPHKEIAVRTWADDRVYLEVADNGPGFDPAIRERVLEPFFTTKSGSSLGMGLPIVKAIVENADGRLELADAHGGGAV
VRVSLPIATPP

Specific function: Member of the two-component regulatory system dctS/dctR involved in the transport of C4-dicarboxylates. DctS functions as a membrane-associated protein kinase that phosphorylates dctR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=392, Percent_Identity=26.7857142857143, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=27.2340425531915, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789808, Length=292, Percent_Identity=25, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786912, Length=269, Percent_Identity=27.5092936802974, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI48994928, Length=387, Percent_Identity=22.4806201550388, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53838; Mature: 53838

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEGTTIAAQAGERVPLPSWLRGLLDPLSEPVLLVGADGRIRYGNPSAGRLLGCSPEALP
CCCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCEEEECCCCCCCEECCCCCCCC
GLAVGAVLPDGEALLGRRQEDPSDTDAVRRDGGRIRVAVTARPGPEGLTQLLLRPVAEAP
CCEEEEECCCCHHHHCCCCCCCCCHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHCCC
EGRLRESDPRYRAVVEDQTDLIRRFTPDGRLTFVNPAFCRYFGRSEEELLGSDFIRLIHP
CCCCCCCCCCCEEEECCHHHHHHHCCCCCCEEEECHHHHHHHCCCHHHHHHHHHEEEECC
EDREVVHRQLAVLSPENPTTVTEARIPRPDGGVGWVQFVNRGIFDAEGRLVECQSVGRDI
CHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCCEEEHHHCCCCC
TAQKEAEARIAEAREAVNRAARVTTLAIIGGGIVHEINQPLNAIRVLAETGLCLLVQADP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEEECCC
PQADEIVAILSRISRQVDRIDSIVNHLRDVLKNSRNQRYEYCDLNEVVERALLLMDNRIQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEE
AHGIRLRLEKADQLPKVFGYSVNLEEVVLNLLNNAMQALDEVDWPHKEIAVRTWADDRVY
ECCEEEEECCHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCCEEE
LEVADNGPGFDPAIRERVLEPFFTTKSGSSLGMGLPIVKAIVENADGRLELADAHGGGAV
EEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCEE
VRVSLPIATPP
EEEEECCCCCC
>Mature Secondary Structure
MKEGTTIAAQAGERVPLPSWLRGLLDPLSEPVLLVGADGRIRYGNPSAGRLLGCSPEALP
CCCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCEEEECCCCCCCEECCCCCCCC
GLAVGAVLPDGEALLGRRQEDPSDTDAVRRDGGRIRVAVTARPGPEGLTQLLLRPVAEAP
CCEEEEECCCCHHHHCCCCCCCCCHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHCCC
EGRLRESDPRYRAVVEDQTDLIRRFTPDGRLTFVNPAFCRYFGRSEEELLGSDFIRLIHP
CCCCCCCCCCCEEEECCHHHHHHHCCCCCCEEEECHHHHHHHCCCHHHHHHHHHEEEECC
EDREVVHRQLAVLSPENPTTVTEARIPRPDGGVGWVQFVNRGIFDAEGRLVECQSVGRDI
CHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCCEEEHHHCCCCC
TAQKEAEARIAEAREAVNRAARVTTLAIIGGGIVHEINQPLNAIRVLAETGLCLLVQADP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEEECCC
PQADEIVAILSRISRQVDRIDSIVNHLRDVLKNSRNQRYEYCDLNEVVERALLLMDNRIQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEE
AHGIRLRLEKADQLPKVFGYSVNLEEVVLNLLNNAMQALDEVDWPHKEIAVRTWADDRVY
ECCEEEEECCHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCCEEE
LEVADNGPGFDPAIRERVLEPFFTTKSGSSLGMGLPIVKAIVENADGRLELADAHGGGAV
EEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCEE
VRVSLPIATPP
EEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8455557 [H]