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The map label for this gene is atoC [H]

Identifier: 51894433

GI number: 51894433

Start: 3523544

End: 3525079

Strand: Reverse

Name: atoC [H]

Synonym: STH3299

Alternate gene names: 51894433

Gene position: 3525079-3523544 (Counterclockwise)

Preceding gene: 51894434

Following gene: 51894432

Centisome position: 98.85

GC content: 67.45

Gene sequence:

>1536_bases
GTGAGGAAGGAGGCACGGACCTTGCGCATTCTGCTGGTGGATGACGACAGGGAGGGCAGGTCCTACCTCGCCCGATTCCT
GACGCTGGATGGCCACGCCGTCACCGAGTGCGGCTCCGCGGAGGAGGCCCTCGAGGTCTACCGGCCAGGAGCGTTTGAGA
TGGTGCTCTCCGACATCCGCATGGGCCGGATGTCCGGGATCAACCTGGTGTCGGCGATCCGAAGCCAGGGAGGCGCGCCG
CAGGCTGATGTGGTGCTGTATACGGGCCACCTGGACATCTCCCTGGCCATCGCAGCCTTGCGGGCCGGGGCCTTTGACTA
CCTGACCAAGCCCATCAACATGGCGGAACTGCAGGCGGTGCTGCAGCGGGTCGAGGAGCACCAGCGCTCCCTGGAGGAGC
AGCGCACGCCCCCACCCGGTTACCAGGGGACGGGGGATGACGTGCCCGCCGACGTGCGGCTGCAGATGGCCTACCTGAAG
GACCTGGGCGCCGAGCGGGCCGGTCAGAAGAAGTTCTGCGCCCGCTCCCCGGCCATGCGCCAGGTGGTGGAGCAGGCGCG
GCGGTATCACACGGACCGCTCGCTTCCGGTGCTGATCCAGGGGGAGACGGGCGTGGGCAAGGAGGTCATCGCCCATCTCA
TCCACTATGGCGACCTGGAGGAGGCAGGCCCCTTCGTCGCCATCAACTGCTCGGCCATCACGCCGACGCTGTTCGAGAGC
GAGCTGTTCGGCTATGAACCCGGCGCCTTCACCGGCGGCTCGGCCAGGGGGCAGAAGGGCAAGCTGGACGCGGCACAGGG
GGGCACGCTCTTTCTCGACGAACTGGCGGAGATCCCCGTGGAGCTGCAGGCCAAACTGCTCCGGGTGTTGGAGGAGAAGA
GCTTCTACCGGGTGGGCGGTCTGAAGAAGATCGACGCCGACGTGCGGATCATCGCGGCGACCAACCTGGACATCGAGGAG
CGCATCCGGCAGGGGCTGTTCCGCGTGGACTTGTACTACCGGCTGAACGTCTGCCGCATCGTGATCCCGCCCTTGCGGGA
GCGGAAGGAGGATATCCTTCCGATGGCCCTCATGTACCTCATCGACTTCTCGCGGTCCCGAGGCCGCCGCTTCACCGGCA
TCAGCGACGAGGCGGCTGAGGTGCTGCTCTCCTACCACTGGCCGGGAAATTGCCGGGAGCTCCGGAATCTGATGGAATGG
GTGTCCTTCATGTACGACGACGAGGTGCTCCGGCCCGAGCACCTGCGGCGCATTACGGACGCGGCCGCACGGGCTCAGGT
CGCCGCGGGGACGGAGCCGTTCGGCGGAGGAGCGCCGCATGGGGCGGCTGCGCCGGACTCGGGCGACCTGCCCGCGGCAA
CGGTGGTGCCCTTTCCGCGGGGTTCCCGACGCGACTACAACCTGGAGCACCACACCGAGGCCCTGATTCAGGCCGCGCTG
CAGGAGTACGGGGGCAACAAGACCCTGGCGGCCAGGGCCCTGGGCATCTCCGTGCGCACCCTTTACAACAGGTTGGAACG
GATGGGCCATCGTTAG

Upstream 100 bases:

>100_bases
TAAAGGCCATCGTGGAGAACGCGGACGGCCGCCTCGAGCTGGCCGACGCGCACGGGGGCGGGGCCGTCGTCCGGGTATCG
CTGCCCATCGCCACACCGCC

Downstream 100 bases:

>100_bases
AGCGATTTCGGTCTATGGCGGATGCTCTGCCGGGTGGGGAGCATCCGCCGTCGTGTATCGGCCCCGCGCAGGCTGGCACG
ATCGTTGCTTCAGGCCATCC

Product: sigma-54-dependent transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MRKEARTLRILLVDDDREGRSYLARFLTLDGHAVTECGSAEEALEVYRPGAFEMVLSDIRMGRMSGINLVSAIRSQGGAP
QADVVLYTGHLDISLAIAALRAGAFDYLTKPINMAELQAVLQRVEEHQRSLEEQRTPPPGYQGTGDDVPADVRLQMAYLK
DLGAERAGQKKFCARSPAMRQVVEQARRYHTDRSLPVLIQGETGVGKEVIAHLIHYGDLEEAGPFVAINCSAITPTLFES
ELFGYEPGAFTGGSARGQKGKLDAAQGGTLFLDELAEIPVELQAKLLRVLEEKSFYRVGGLKKIDADVRIIAATNLDIEE
RIRQGLFRVDLYYRLNVCRIVIPPLRERKEDILPMALMYLIDFSRSRGRRFTGISDEAAEVLLSYHWPGNCRELRNLMEW
VSFMYDDEVLRPEHLRRITDAAARAQVAAGTEPFGGGAPHGAAAPDSGDLPAATVVPFPRGSRRDYNLEHHTEALIQAAL
QEYGGNKTLAARALGISVRTLYNRLERMGHR

Sequences:

>Translated_511_residues
MRKEARTLRILLVDDDREGRSYLARFLTLDGHAVTECGSAEEALEVYRPGAFEMVLSDIRMGRMSGINLVSAIRSQGGAP
QADVVLYTGHLDISLAIAALRAGAFDYLTKPINMAELQAVLQRVEEHQRSLEEQRTPPPGYQGTGDDVPADVRLQMAYLK
DLGAERAGQKKFCARSPAMRQVVEQARRYHTDRSLPVLIQGETGVGKEVIAHLIHYGDLEEAGPFVAINCSAITPTLFES
ELFGYEPGAFTGGSARGQKGKLDAAQGGTLFLDELAEIPVELQAKLLRVLEEKSFYRVGGLKKIDADVRIIAATNLDIEE
RIRQGLFRVDLYYRLNVCRIVIPPLRERKEDILPMALMYLIDFSRSRGRRFTGISDEAAEVLLSYHWPGNCRELRNLMEW
VSFMYDDEVLRPEHLRRITDAAARAQVAAGTEPFGGGAPHGAAAPDSGDLPAATVVPFPRGSRRDYNLEHHTEALIQAAL
QEYGGNKTLAARALGISVRTLYNRLERMGHR
>Mature_511_residues
MRKEARTLRILLVDDDREGRSYLARFLTLDGHAVTECGSAEEALEVYRPGAFEMVLSDIRMGRMSGINLVSAIRSQGGAP
QADVVLYTGHLDISLAIAALRAGAFDYLTKPINMAELQAVLQRVEEHQRSLEEQRTPPPGYQGTGDDVPADVRLQMAYLK
DLGAERAGQKKFCARSPAMRQVVEQARRYHTDRSLPVLIQGETGVGKEVIAHLIHYGDLEEAGPFVAINCSAITPTLFES
ELFGYEPGAFTGGSARGQKGKLDAAQGGTLFLDELAEIPVELQAKLLRVLEEKSFYRVGGLKKIDADVRIIAATNLDIEE
RIRQGLFRVDLYYRLNVCRIVIPPLRERKEDILPMALMYLIDFSRSRGRRFTGISDEAAEVLLSYHWPGNCRELRNLMEW
VSFMYDDEVLRPEHLRRITDAAARAQVAAGTEPFGGGAPHGAAAPDSGDLPAATVVPFPRGSRRDYNLEHHTEALIQAAL
QEYGGNKTLAARALGISVRTLYNRLERMGHR

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=504, Percent_Identity=34.7222222222222, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI1790437, Length=502, Percent_Identity=34.6613545816733, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI1790299, Length=508, Percent_Identity=36.0236220472441, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1788905, Length=393, Percent_Identity=37.6590330788804, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1786524, Length=347, Percent_Identity=39.4812680115274, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1789233, Length=321, Percent_Identity=38.6292834890966, Blast_Score=209, Evalue=5e-55,
Organism=Escherichia coli, GI87082117, Length=225, Percent_Identity=47.1111111111111, Blast_Score=198, Evalue=7e-52,
Organism=Escherichia coli, GI87081872, Length=310, Percent_Identity=38.0645161290323, Blast_Score=194, Evalue=9e-51,
Organism=Escherichia coli, GI1789087, Length=343, Percent_Identity=39.067055393586, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1787583, Length=267, Percent_Identity=37.8277153558052, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI87082152, Length=345, Percent_Identity=34.4927536231884, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1789828, Length=236, Percent_Identity=35.5932203389831, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI87081858, Length=252, Percent_Identity=35.3174603174603, Blast_Score=129, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 56683; Mature: 56683

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKEARTLRILLVDDDREGRSYLARFLTLDGHAVTECGSAEEALEVYRPGAFEMVLSDIR
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCHHHHHHHHHH
MGRMSGINLVSAIRSQGGAPQADVVLYTGHLDISLAIAALRAGAFDYLTKPINMAELQAV
HHHHCCHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCHHHHHHCCCCHHHHHHH
LQRVEEHQRSLEEQRTPPPGYQGTGDDVPADVRLQMAYLKDLGAERAGQKKFCARSPAMR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHCCCHHHHHCCHHHH
QVVEQARRYHTDRSLPVLIQGETGVGKEVIAHLIHYGDLEEAGPFVAINCSAITPTLFES
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHCCCEEEEECCCCCCHHHHH
ELFGYEPGAFTGGSARGQKGKLDAAQGGTLFLDELAEIPVELQAKLLRVLEEKSFYRVGG
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHCCHHHHHHHHHHHHHCCHHHHCC
LKKIDADVRIIAATNLDIEERIRQGLFRVDLYYRLNVCRIVIPPLRERKEDILPMALMYL
CEEECCCEEEEEECCCCHHHHHHHHHHEEEHHEEECEEEEECCCHHHHHHHHHHHHHHHH
IDFSRSRGRRFTGISDEAAEVLLSYHWPGNCRELRNLMEWVSFMYDDEVLRPEHLRRITD
HHHHHHCCCCCCCCCHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AAARAQVAAGTEPFGGGAPHGAAAPDSGDLPAATVVPFPRGSRRDYNLEHHTEALIQAAL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
QEYGGNKTLAARALGISVRTLYNRLERMGHR
HHHCCCCEEHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRKEARTLRILLVDDDREGRSYLARFLTLDGHAVTECGSAEEALEVYRPGAFEMVLSDIR
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCHHHHHHHHHH
MGRMSGINLVSAIRSQGGAPQADVVLYTGHLDISLAIAALRAGAFDYLTKPINMAELQAV
HHHHCCHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCHHHHHHCCCCHHHHHHH
LQRVEEHQRSLEEQRTPPPGYQGTGDDVPADVRLQMAYLKDLGAERAGQKKFCARSPAMR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHCCCHHHHHCCHHHH
QVVEQARRYHTDRSLPVLIQGETGVGKEVIAHLIHYGDLEEAGPFVAINCSAITPTLFES
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHCCCEEEEECCCCCCHHHHH
ELFGYEPGAFTGGSARGQKGKLDAAQGGTLFLDELAEIPVELQAKLLRVLEEKSFYRVGG
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHCCHHHHHHHHHHHHHCCHHHHCC
LKKIDADVRIIAATNLDIEERIRQGLFRVDLYYRLNVCRIVIPPLRERKEDILPMALMYL
CEEECCCEEEEEECCCCHHHHHHHHHHEEEHHEEECEEEEECCCHHHHHHHHHHHHHHHH
IDFSRSRGRRFTGISDEAAEVLLSYHWPGNCRELRNLMEWVSFMYDDEVLRPEHLRRITD
HHHHHHCCCCCCCCCHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AAARAQVAAGTEPFGGGAPHGAAAPDSGDLPAATVVPFPRGSRRDYNLEHHTEALIQAAL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
QEYGGNKTLAARALGISVRTLYNRLERMGHR
HHHCCCCEEHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]