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The map label for this gene is fdhA [H]

Identifier: 51894429

GI number: 51894429

Start: 3518947

End: 3520542

Strand: Reverse

Name: fdhA [H]

Synonym: STH3295

Alternate gene names: 51894429

Gene position: 3520542-3518947 (Counterclockwise)

Preceding gene: 51894430

Following gene: 51894428

Centisome position: 98.72

GC content: 67.67

Gene sequence:

>1596_bases
ATGACCAACACCATCAACGAACTGCAGGACATGGGGCCCGGCGATGCCATCTTCGCGATCGGCACCAACACCACCGAGTG
TCACCCGATCATCGGCATCCGCATGCTGGAGGCCCACCGCCGCGGCGCCCGGCTGATCGTGGCCGACCCGCGGGAGACGG
AGCTGGCGAAGCACGCCGACGTGTACATGCGGCACAACCCCGGCTCCGACGTGGCGCTGCTGAACGCCATGATGTACGTC
ATCGTCACCGAGGGGCTGGCGGACGAGGCGTTCATCCGGAGCCGCACGGAGAACTTCGAGGCCTGCCGGGAAACGGTGCT
GAAGTACGCCCCCGAGAAGGTGGAGGGCATCACCGGCGTGCCGGCCGAGAAGGTACGGCAGGCCGCCCGGCTGTTCGCCA
CGGCCGAAAACGCGGCCACCTACTACACCATGGGCATCACCCAGCACACCTCAGGCGTGGACAACGTGCTCTCCATCGCC
AACCTGGCCCTGATGACGGGCAACCTGGGCAAACCCAAGGCGGGCGTCAACCCGCTGCGGGGCCAGAACAACGTGCAGGG
GGCCTGCGACATGGGGGCCCTGCCCAACGTCTACCCGGCCTACCAGCCGGTCACCGATCCCAAGAACCGGGAGAAGTTCG
AGAAGGCCTGGGGCCGACCGCTCAGCGACAGGATGGGCATGGCCATCTCCGACGTGCTCCGGGGCATCGAGGAGGGCAAG
GTCCGGTTCCTTTACGTCATGGGCGAGAACCCCATGCGCTCGGACCCCGACGTCAACCACGTCCGCCACTGCCTGGAGCA
CGTGGACTTCCTGGTGGTGCAGGACATCTTCCTCACCGAATCCGCGGCCCTGGCCGACGTGGTGCTGCCCGGCGCCACCT
GGGCGGAGAAGGACGGGACCTTTACCAATACCGAGCGCCGGGTGCAGCGGGTCCGCAAGGCGATGGAGCCCCAGGGCAAC
GCCCGGCCCGACTGGATGATCCTGCGGGACATCATGCGGGCCATGGATTACCCTGCCGATTACAACTCTCCGAAAGACAT
CTTCAACGAACTGCGCACCCTCGCGCCCTCCTACGCCGGCGTCACCTACGAGCGGCTGGAGAAGCTGGGCGGCCTCCACT
GGCCCTGCCCCAATGAGGAGCACCCGGGCACCCCGATCCTCCACGTGGGCAAGTTCAGCCGGGGCCTCGGCAAGTTCTCC
GCCATCGAGTGGCGCCCGCCGGCGGAGCTGCCCGACGAGGAGTACCCGCTGGTCCTGACGACGGGCCGACGGACGGCGCA
CTACCACACCGGCACGATGACCCGCAACTGCTGGGGCCTGGACGGCGTGGCGCCCGAGGAGTGGGTGGAGATCAACCCCG
CGGACGCGGCATCTCTGGGCGTCGCCCACGGCGACTACGTCCGGGTGACCACACGCCGGGGCTCGGTGGTGGTCCGGGCC
GAGGTGACGGCCCGAGTACCGAAGGGCGTCACCTTCATCACGTTCCACTATACCGAGGCCGCCGGCAACCTGCTGACCAA
CAGCGCCCTGGACCCGGTCTCGAAGACCCCGGAGTACAAGGTCTGTGCCGTACGGGTAGAAAAGGTCAGCGCCTAA

Upstream 100 bases:

>100_bases
CATGCGCGCGGTGGTGGGCACCAACAACGTCGACCACTGCGCCCGTCTCTGACACGCTCCGACGGTGTCCGGTCTGGGCA
CAGCGTTTGGTTCCGGAGCG

Downstream 100 bases:

>100_bases
ACTTCTCGAGAGGAGGCCTGCGACGATGTGCGCGCTCAACGCCTTTGTCGTGGCGGATCCCCATAAGTGTATCGGCTGCA
AGGTCTGTGAGGTTTCCTGC

Product: formate dehydrogenase alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MTNTINELQDMGPGDAIFAIGTNTTECHPIIGIRMLEAHRRGARLIVADPRETELAKHADVYMRHNPGSDVALLNAMMYV
IVTEGLADEAFIRSRTENFEACRETVLKYAPEKVEGITGVPAEKVRQAARLFATAENAATYYTMGITQHTSGVDNVLSIA
NLALMTGNLGKPKAGVNPLRGQNNVQGACDMGALPNVYPAYQPVTDPKNREKFEKAWGRPLSDRMGMAISDVLRGIEEGK
VRFLYVMGENPMRSDPDVNHVRHCLEHVDFLVVQDIFLTESAALADVVLPGATWAEKDGTFTNTERRVQRVRKAMEPQGN
ARPDWMILRDIMRAMDYPADYNSPKDIFNELRTLAPSYAGVTYERLEKLGGLHWPCPNEEHPGTPILHVGKFSRGLGKFS
AIEWRPPAELPDEEYPLVLTTGRRTAHYHTGTMTRNCWGLDGVAPEEWVEINPADAASLGVAHGDYVRVTTRRGSVVVRA
EVTARVPKGVTFITFHYTEAAGNLLTNSALDPVSKTPEYKVCAVRVEKVSA

Sequences:

>Translated_531_residues
MTNTINELQDMGPGDAIFAIGTNTTECHPIIGIRMLEAHRRGARLIVADPRETELAKHADVYMRHNPGSDVALLNAMMYV
IVTEGLADEAFIRSRTENFEACRETVLKYAPEKVEGITGVPAEKVRQAARLFATAENAATYYTMGITQHTSGVDNVLSIA
NLALMTGNLGKPKAGVNPLRGQNNVQGACDMGALPNVYPAYQPVTDPKNREKFEKAWGRPLSDRMGMAISDVLRGIEEGK
VRFLYVMGENPMRSDPDVNHVRHCLEHVDFLVVQDIFLTESAALADVVLPGATWAEKDGTFTNTERRVQRVRKAMEPQGN
ARPDWMILRDIMRAMDYPADYNSPKDIFNELRTLAPSYAGVTYERLEKLGGLHWPCPNEEHPGTPILHVGKFSRGLGKFS
AIEWRPPAELPDEEYPLVLTTGRRTAHYHTGTMTRNCWGLDGVAPEEWVEINPADAASLGVAHGDYVRVTTRRGSVVVRA
EVTARVPKGVTFITFHYTEAAGNLLTNSALDPVSKTPEYKVCAVRVEKVSA
>Mature_530_residues
TNTINELQDMGPGDAIFAIGTNTTECHPIIGIRMLEAHRRGARLIVADPRETELAKHADVYMRHNPGSDVALLNAMMYVI
VTEGLADEAFIRSRTENFEACRETVLKYAPEKVEGITGVPAEKVRQAARLFATAENAATYYTMGITQHTSGVDNVLSIAN
LALMTGNLGKPKAGVNPLRGQNNVQGACDMGALPNVYPAYQPVTDPKNREKFEKAWGRPLSDRMGMAISDVLRGIEEGKV
RFLYVMGENPMRSDPDVNHVRHCLEHVDFLVVQDIFLTESAALADVVLPGATWAEKDGTFTNTERRVQRVRKAMEPQGNA
RPDWMILRDIMRAMDYPADYNSPKDIFNELRTLAPSYAGVTYERLEKLGGLHWPCPNEEHPGTPILHVGKFSRGLGKFSA
IEWRPPAELPDEEYPLVLTTGRRTAHYHTGTMTRNCWGLDGVAPEEWVEINPADAASLGVAHGDYVRVTTRRGSVVVRAE
VTARVPKGVTFITFHYTEAAGNLLTNSALDPVSKTPEYKVCAVRVEKVSA

Specific function: Catalyzes the oxidation of formate [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=536, Percent_Identity=45.7089552238806, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1788534, Length=630, Percent_Identity=28.4126984126984, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI3868719, Length=565, Percent_Identity=24.6017699115044, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI3868720, Length=464, Percent_Identity=25.4310344827586, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI171474008, Length=579, Percent_Identity=25.0431778929188, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1787778, Length=588, Percent_Identity=25.5102040816327, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI87081797, Length=572, Percent_Identity=23.2517482517483, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI145693196, Length=325, Percent_Identity=23.3846153846154, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565758, Length=133, Percent_Identity=36.0902255639098, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 58709; Mature: 58578

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTINELQDMGPGDAIFAIGTNTTECHPIIGIRMLEAHRRGARLIVADPRETELAKHAD
CCCCHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCC
VYMRHNPGSDVALLNAMMYVIVTEGLADEAFIRSRTENFEACRETVLKYAPEKVEGITGV
EEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCCCC
PAEKVRQAARLFATAENAATYYTMGITQHTSGVDNVLSIANLALMTGNLGKPKAGVNPLR
CHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GQNNVQGACDMGALPNVYPAYQPVTDPKNREKFEKAWGRPLSDRMGMAISDVLRGIEEGK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHCHHHHHHHHHHHCCC
VRFLYVMGENPMRSDPDVNHVRHCLEHVDFLVVQDIFLTESAALADVVLPGATWAEKDGT
EEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCC
FTNTERRVQRVRKAMEPQGNARPDWMILRDIMRAMDYPADYNSPKDIFNELRTLAPSYAG
CCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
VTYERLEKLGGLHWPCPNEEHPGTPILHVGKFSRGLGKFSAIEWRPPAELPDEEYPLVLT
CCHHHHHHHCCCCCCCCCCCCCCCCEEEECCHHCCCCCCCEECCCCCCCCCCCCCCEEEE
TGRRTAHYHTGTMTRNCWGLDGVAPEEWVEINPADAASLGVAHGDYVRVTTRRGSVVVRA
CCCCEEEEECCCCCCCCCCCCCCCHHHHEEECCCCHHHHCCCCCCEEEEEECCCCEEEEE
EVTARVPKGVTFITFHYTEAAGNLLTNSALDPVSKTPEYKVCAVRVEKVSA
EEEEECCCCEEEEEEEEHHHHCCHHHCCCCCCCCCCCCCEEEEEEEEECCC
>Mature Secondary Structure 
TNTINELQDMGPGDAIFAIGTNTTECHPIIGIRMLEAHRRGARLIVADPRETELAKHAD
CCCHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCC
VYMRHNPGSDVALLNAMMYVIVTEGLADEAFIRSRTENFEACRETVLKYAPEKVEGITGV
EEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCCCC
PAEKVRQAARLFATAENAATYYTMGITQHTSGVDNVLSIANLALMTGNLGKPKAGVNPLR
CHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GQNNVQGACDMGALPNVYPAYQPVTDPKNREKFEKAWGRPLSDRMGMAISDVLRGIEEGK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHCHHHHHHHHHHHCCC
VRFLYVMGENPMRSDPDVNHVRHCLEHVDFLVVQDIFLTESAALADVVLPGATWAEKDGT
EEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCC
FTNTERRVQRVRKAMEPQGNARPDWMILRDIMRAMDYPADYNSPKDIFNELRTLAPSYAG
CCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
VTYERLEKLGGLHWPCPNEEHPGTPILHVGKFSRGLGKFSAIEWRPPAELPDEEYPLVLT
CCHHHHHHHCCCCCCCCCCCCCCCCEEEECCHHCCCCCCCEECCCCCCCCCCCCCCEEEE
TGRRTAHYHTGTMTRNCWGLDGVAPEEWVEINPADAASLGVAHGDYVRVTTRRGSVVVRA
CCCCEEEEECCCCCCCCCCCCCCCHHHHEEECCCCHHHHCCCCCCEEEEEECCCCEEEEE
EVTARVPKGVTFITFHYTEAAGNLLTNSALDPVSKTPEYKVCAVRVEKVSA
EEEEECCCCEEEEEEEEHHHHCCHHHCCCCCCCCCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]