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The map label for this gene is nadC [H]

Identifier: 51894320

GI number: 51894320

Start: 3393718

End: 3394581

Strand: Reverse

Name: nadC [H]

Synonym: STH3185

Alternate gene names: 51894320

Gene position: 3394581-3393718 (Counterclockwise)

Preceding gene: 51894321

Following gene: 51894319

Centisome position: 95.19

GC content: 72.45

Gene sequence:

>864_bases
ATGACCCTGAACCCAGTTGCCGTGGAGGAGTTGGTGCGGCGGGCCCTTCTGGAGGACGTGGGCCCCGGCGACCTGGCCAC
GTCGGCCGTGGTGCCGGAAGACGCCCGGTGCACGGCGACGATCGTTGCGGGGGCGGCGGGCGTGCTGTGCGGGCACCCGG
TGGCCCAGGCGGTCTTCCGGGCGGTGGACCCCGAGCTGGTCTATGAGCGGCTCGTGCCGGAGGGCGGCGCCGTCGACGAC
GGCGTCCCCGTGGCCTCGGTCTCCGGTCCTGCACGGCCCATCCTCACGGCCGAGCGGGTGGCGGTCAGCCTGTTGCAGAG
GATGAGCGGCATCGCCACCGCGACCCGCCAGCTGGCCGACGCGATCAAGTACTACCACGCCCGCCTCGTCGCCGGATGGG
AGACGGTCCCCGACCTGCGGGTGATCGCGCAATACGCGGTGCGGATCGGCGGCGGCCAGGTTCAGCCCTACGGACCGACC
GGCGGGATCCTGGTACGGGCGGGCCACCTCGCGCTGGCGGGCGGCGTACGGGAGGCGGTGGTGGCCGCCCGGAAGGGCGC
GCCGCCGACGAGCCGGATCGCCGTGGAGGTGGTGTCGCTGGAGCAGGTGCAGGAGGGGGTCGATGGGGGCGCGGACATCC
TGGTGCTCACCGGCATGGATCCCGAGACCGTGAAGCGGGCCGTGGAGATGGTCGCCGGCAGGGCCGCACTGGAGGTCTGC
GGCTCCGCCGATCCGGCGCACCTCACCGAACTGGCCAAGACGGGCGTGGACATCATCAGCGTCTGCGACCTCGCCCACGC
GGCCAGGCCTCTGCCCTTCCGCCTATCCTTCGGGGATCCGAAAGCGCTGGAAAAAGAAGACTGA

Upstream 100 bases:

>100_bases
GGACCGGCAGTCTTTGCTGAGGCAGATTCAGGGGGTAGAATAAAGCCAATGGGCGGGACGGCCGGCACGGCCGGACAGTG
AAGCCGAGGAGGTCTGCGGA

Downstream 100 bases:

>100_bases
AGATTGACAGGTCACGGGGCCCGGCCATCCGGTATAATAGAGGTACAGGAAGGGACCGAAACCCCAGGCGGAACGGCGGC
GGGCCTTTCCCGCAGGAGTC

Product: nicotinate-mononucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MTLNPVAVEELVRRALLEDVGPGDLATSAVVPEDARCTATIVAGAAGVLCGHPVAQAVFRAVDPELVYERLVPEGGAVDD
GVPVASVSGPARPILTAERVAVSLLQRMSGIATATRQLADAIKYYHARLVAGWETVPDLRVIAQYAVRIGGGQVQPYGPT
GGILVRAGHLALAGGVREAVVAARKGAPPTSRIAVEVVSLEQVQEGVDGGADILVLTGMDPETVKRAVEMVAGRAALEVC
GSADPAHLTELAKTGVDIISVCDLAHAARPLPFRLSFGDPKALEKED

Sequences:

>Translated_287_residues
MTLNPVAVEELVRRALLEDVGPGDLATSAVVPEDARCTATIVAGAAGVLCGHPVAQAVFRAVDPELVYERLVPEGGAVDD
GVPVASVSGPARPILTAERVAVSLLQRMSGIATATRQLADAIKYYHARLVAGWETVPDLRVIAQYAVRIGGGQVQPYGPT
GGILVRAGHLALAGGVREAVVAARKGAPPTSRIAVEVVSLEQVQEGVDGGADILVLTGMDPETVKRAVEMVAGRAALEVC
GSADPAHLTELAKTGVDIISVCDLAHAARPLPFRLSFGDPKALEKED
>Mature_286_residues
TLNPVAVEELVRRALLEDVGPGDLATSAVVPEDARCTATIVAGAAGVLCGHPVAQAVFRAVDPELVYERLVPEGGAVDDG
VPVASVSGPARPILTAERVAVSLLQRMSGIATATRQLADAIKYYHARLVAGWETVPDLRVIAQYAVRIGGGQVQPYGPTG
GILVRAGHLALAGGVREAVVAARKGAPPTSRIAVEVVSLEQVQEGVDGGADILVLTGMDPETVKRAVEMVAGRAALEVCG
SADPAHLTELAKTGVDIISVCDLAHAARPLPFRLSFGDPKALEKED

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=282, Percent_Identity=30.8510638297872, Blast_Score=108, Evalue=8e-24,
Organism=Escherichia coli, GI1786299, Length=273, Percent_Identity=32.2344322344322, Blast_Score=133, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321162, Length=285, Percent_Identity=28.7719298245614, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29661; Mature: 29530

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNPVAVEELVRRALLEDVGPGDLATSAVVPEDARCTATIVAGAAGVLCGHPVAQAVFR
CCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
AVDPELVYERLVPEGGAVDDGVPVASVSGPARPILTAERVAVSLLQRMSGIATATRQLAD
HCCHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIKYYHARLVAGWETVPDLRVIAQYAVRIGGGQVQPYGPTGGILVRAGHLALAGGVREAV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECCHHHHHHHHHHH
VAARKGAPPTSRIAVEVVSLEQVQEGVDGGADILVLTGMDPETVKRAVEMVAGRAALEVC
HHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
GSADPAHLTELAKTGVDIISVCDLAHAARPLPFRLSFGDPKALEKED
CCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCC
>Mature Secondary Structure 
TLNPVAVEELVRRALLEDVGPGDLATSAVVPEDARCTATIVAGAAGVLCGHPVAQAVFR
CCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
AVDPELVYERLVPEGGAVDDGVPVASVSGPARPILTAERVAVSLLQRMSGIATATRQLAD
HCCHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIKYYHARLVAGWETVPDLRVIAQYAVRIGGGQVQPYGPTGGILVRAGHLALAGGVREAV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECCHHHHHHHHHHH
VAARKGAPPTSRIAVEVVSLEQVQEGVDGGADILVLTGMDPETVKRAVEMVAGRAALEVC
HHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
GSADPAHLTELAKTGVDIISVCDLAHAARPLPFRLSFGDPKALEKED
CCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]