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The map label for this gene is fadN [H]

Identifier: 51894148

GI number: 51894148

Start: 3230879

End: 3233263

Strand: Reverse

Name: fadN [H]

Synonym: STH3012

Alternate gene names: 51894148

Gene position: 3233263-3230879 (Counterclockwise)

Preceding gene: 51894149

Following gene: 51894147

Centisome position: 90.67

GC content: 67.25

Gene sequence:

>2385_bases
GTGCCCTACGCGATCCGAAAGGCGGCGGTGTTGGGAGCCGGCGTCATGGGCGCCCAGATTGCGGCGCACCTGGCCAACGT
GGGCATCCCGACCCTGCTCCTGGACATCGTGCCTCGGGAACTCACGCCCGATGAGGCGAAGAAGGGGCTGACGCTGGAGT
CGCCGGCCGTCCGCAACCGGCTGGCGGCGAGCGCCCTGCAGAACCTGCAGAAGCTGAAGCCCTCGCCGCTCTACTCCAAG
GACGTCCTGCGTCTGATCACACCCGGCAACCTGGAGGACGACCTGGCCAAGGTCGCCGAGTGCGACTGGGTGGTCGAGGC
CGTCATCGAGAACCTGCAGATCAAGAAGGACCTGTGGCAACGGGTGGCCGCCCACCACCGCCCGGGGATGATCTGCTCCT
CCAACACCTCCGGCATTTCGATCCAGGCGATGGTGGAGGGCACCCCGGAGAGCTTCCGGCGCCACTTCCTGGGCACCCAC
TTCTTCAACCCGCCTCGCTATATGAAGCTGTTGGAGATCATCCCGACGCCGGACACCGATCCCGAGGTCGTCGCCTTCAT
GGCCGACTTCGGCGAGCGGGTGCTGGGCAAGGGCGTGGTCATGGCCAAGGACACCCCGAACTTCATCGGCAACCGCATCG
GGGTCTACGGCATGATGGTCACCCTGGAGGAGATGAACAGGCTGGGCCTCACCCCCGACGAGGTGGATGCCCTGACGGGC
AAGGCCATCGGCCGTCCCAAGTCGGCCACCTTCCGCACCCTCGACGTAGTCGGCATTGACACCTTCTGCCATGTGGCGGA
CAACTGCCGTGCCACGATCCCCGACCCCGAAGAGGCGAAGATCTTTGTCGTGCCCGAGCCCATCCGCGAGATGGTGAAGC
GGGGCTGGGTCGGCCAGAAGGCCAGGCAGGGCTTCTTTAAGAAGGAAGGCGACCAGATCCTGACCCTCGATCTGGAGACC
ATGGAGTACCGGCCGCGCCGGAAGGCCAGCTTCCCGTCCCTCGAGGCGGCCAAGGCCAATCCGGATCTGCGCAGCCGCGT
GCGCGGCCTCGTCTTCGCCAAGGACAAGGCCGGCGAGTTCCTGTGGGCCATTACCAAGCGGACCCTCCTGTACGCGGCGC
GGAAGGTGGGCGAGATCGCCGATGACGTCGTTGCCATCGACAACGCGATGAAGTGGGGCTACAACTGGGAGCTCGGCCCC
TTCGAGATGTGGGACGCCATCGGCCTCCCGGAGTCCATCGCCCGGATGGAGGCGGAGGGTGAGGCCGTTCCCGACTGGGT
GAAGGAGGCGGCCCGCAAGGGCGGTTTCTACAGGCGGGAGGCCGGGAAGAGCTTCTTCATCAACAAGGGCGAGTACGCGC
CGGTGCCCGTCAGCGACCGGGTCATCGACATCGGCGCCCTGCGGGAGACCGGCCGCGTGGTGCGCGAGAAGAAGGGCGCG
ACCCTGCTGGATATGGGCGACGGCGTGCTCTTGATGGAGACGCACTCGCCCAAGGCGGCCATCGGCTTCGACATCATCAA
CATGTGCAAGGTGGCGGCTGAGGAGCTGGCCAGCGGCCGGTGGAAAGGCCTGGTCATCGGCGCCCGGACCGAGAACTTCT
GCGTCGGCGCCAACGTGGCGATCATGCTCATGGAGGCGCAGGAGGAGGAGTGGGACGAGCTCGAGTTCATGGCGCGTGAG
TTCCAGAACGCGTTCATGGCCTTGAAGCTCGCCCCGAAGCCGGTGGTGGTGGCGCCCTACGGTATGACCCTGGGCGGCGG
CTACGAACTCTGCGCCGTCGCGGACCGGGTCGTCGCTGCGGCGGAGTCGTATATCGGCCTCGTGGAGGTGGGCGTCGGCG
TCATTCCGGGCGCGGGCGGCAACAAGGAGATGCTGATCCGCGGCCTGGAGGGCCTGCCTGCCGGGGCCCAGGTGGACATC
CAGCCCATCCTCAATCGCATCTTCGAGACCATCGCCACGGCCAAGGTGGCCACCTCGGCCCGGGAGGCCCAGGAGATGGG
CTACCTGCGCAAGAGCGACGTGATCGTGGTCAACAAGGACCACCAGCTGTACGAAGCCAAGCGGGTGGTGCTCGCCCTGG
AGGCCGCCGGGTACCGTCCGCCCGAGCCGGCCCTCATCCCGGCGGCCGGGCCGGAAGGCCGGGCGGTGCTGGAGCTGGGC
GCCTACGGCATGTTCATGGGCGGGTGGGCCACCGAGCACGAGCTGTTCATCGCCCGGAAGCTGGCCTACGTGCTGACGGG
CGGCAACGTGCCGGCAGGCACCCTCGTCACCGAGCAGTACCTGCTCGACCTGGAGCGGGAGGCGTTCCTCAGCCTCCTGG
GCACCAAGAAGACTCAGGAGCGCATGGCCCATCTGCTGAAGACCGGCAAGCCGCTGCGGAACTAG

Upstream 100 bases:

>100_bases
TAAGGACGGTCTGCCCCTGGGCAGCAGGGCACGGCGAAGCGGCGCCGACTTGGATCCTTGACCCATAGGTCCCCAACGGA
ACGGTAAGGAGGGAGAGACT

Downstream 100 bases:

>100_bases
GGAGGTGGCGACGAGTTGCGCGAGGCAGTGATTGTGACCGGCGTCCGAACGGCGCTGGGGAAGGCGCCGCGGGGCTCACT
GCGCCATGTGCGGCCGGAGG

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 794; Mature: 793

Protein sequence:

>794_residues
MPYAIRKAAVLGAGVMGAQIAAHLANVGIPTLLLDIVPRELTPDEAKKGLTLESPAVRNRLAASALQNLQKLKPSPLYSK
DVLRLITPGNLEDDLAKVAECDWVVEAVIENLQIKKDLWQRVAAHHRPGMICSSNTSGISIQAMVEGTPESFRRHFLGTH
FFNPPRYMKLLEIIPTPDTDPEVVAFMADFGERVLGKGVVMAKDTPNFIGNRIGVYGMMVTLEEMNRLGLTPDEVDALTG
KAIGRPKSATFRTLDVVGIDTFCHVADNCRATIPDPEEAKIFVVPEPIREMVKRGWVGQKARQGFFKKEGDQILTLDLET
MEYRPRRKASFPSLEAAKANPDLRSRVRGLVFAKDKAGEFLWAITKRTLLYAARKVGEIADDVVAIDNAMKWGYNWELGP
FEMWDAIGLPESIARMEAEGEAVPDWVKEAARKGGFYRREAGKSFFINKGEYAPVPVSDRVIDIGALRETGRVVREKKGA
TLLDMGDGVLLMETHSPKAAIGFDIINMCKVAAEELASGRWKGLVIGARTENFCVGANVAIMLMEAQEEEWDELEFMARE
FQNAFMALKLAPKPVVVAPYGMTLGGGYELCAVADRVVAAAESYIGLVEVGVGVIPGAGGNKEMLIRGLEGLPAGAQVDI
QPILNRIFETIATAKVATSAREAQEMGYLRKSDVIVVNKDHQLYEAKRVVLALEAAGYRPPEPALIPAAGPEGRAVLELG
AYGMFMGGWATEHELFIARKLAYVLTGGNVPAGTLVTEQYLLDLEREAFLSLLGTKKTQERMAHLLKTGKPLRN

Sequences:

>Translated_794_residues
MPYAIRKAAVLGAGVMGAQIAAHLANVGIPTLLLDIVPRELTPDEAKKGLTLESPAVRNRLAASALQNLQKLKPSPLYSK
DVLRLITPGNLEDDLAKVAECDWVVEAVIENLQIKKDLWQRVAAHHRPGMICSSNTSGISIQAMVEGTPESFRRHFLGTH
FFNPPRYMKLLEIIPTPDTDPEVVAFMADFGERVLGKGVVMAKDTPNFIGNRIGVYGMMVTLEEMNRLGLTPDEVDALTG
KAIGRPKSATFRTLDVVGIDTFCHVADNCRATIPDPEEAKIFVVPEPIREMVKRGWVGQKARQGFFKKEGDQILTLDLET
MEYRPRRKASFPSLEAAKANPDLRSRVRGLVFAKDKAGEFLWAITKRTLLYAARKVGEIADDVVAIDNAMKWGYNWELGP
FEMWDAIGLPESIARMEAEGEAVPDWVKEAARKGGFYRREAGKSFFINKGEYAPVPVSDRVIDIGALRETGRVVREKKGA
TLLDMGDGVLLMETHSPKAAIGFDIINMCKVAAEELASGRWKGLVIGARTENFCVGANVAIMLMEAQEEEWDELEFMARE
FQNAFMALKLAPKPVVVAPYGMTLGGGYELCAVADRVVAAAESYIGLVEVGVGVIPGAGGNKEMLIRGLEGLPAGAQVDI
QPILNRIFETIATAKVATSAREAQEMGYLRKSDVIVVNKDHQLYEAKRVVLALEAAGYRPPEPALIPAAGPEGRAVLELG
AYGMFMGGWATEHELFIARKLAYVLTGGNVPAGTLVTEQYLLDLEREAFLSLLGTKKTQERMAHLLKTGKPLRN
>Mature_793_residues
PYAIRKAAVLGAGVMGAQIAAHLANVGIPTLLLDIVPRELTPDEAKKGLTLESPAVRNRLAASALQNLQKLKPSPLYSKD
VLRLITPGNLEDDLAKVAECDWVVEAVIENLQIKKDLWQRVAAHHRPGMICSSNTSGISIQAMVEGTPESFRRHFLGTHF
FNPPRYMKLLEIIPTPDTDPEVVAFMADFGERVLGKGVVMAKDTPNFIGNRIGVYGMMVTLEEMNRLGLTPDEVDALTGK
AIGRPKSATFRTLDVVGIDTFCHVADNCRATIPDPEEAKIFVVPEPIREMVKRGWVGQKARQGFFKKEGDQILTLDLETM
EYRPRRKASFPSLEAAKANPDLRSRVRGLVFAKDKAGEFLWAITKRTLLYAARKVGEIADDVVAIDNAMKWGYNWELGPF
EMWDAIGLPESIARMEAEGEAVPDWVKEAARKGGFYRREAGKSFFINKGEYAPVPVSDRVIDIGALRETGRVVREKKGAT
LLDMGDGVLLMETHSPKAAIGFDIINMCKVAAEELASGRWKGLVIGARTENFCVGANVAIMLMEAQEEEWDELEFMAREF
QNAFMALKLAPKPVVVAPYGMTLGGGYELCAVADRVVAAAESYIGLVEVGVGVIPGAGGNKEMLIRGLEGLPAGAQVDIQ
PILNRIFETIATAKVATSAREAQEMGYLRKSDVIVVNKDHQLYEAKRVVLALEAAGYRPPEPALIPAAGPEGRAVLELGA
YGMFMGGWATEHELFIARKLAYVLTGGNVPAGTLVTEQYLLDLEREAFLSLLGTKKTQERMAHLLKTGKPLRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=306, Percent_Identity=31.0457516339869, Blast_Score=116, Evalue=1e-25,
Organism=Homo sapiens, GI296179427, Length=323, Percent_Identity=30.030959752322, Blast_Score=108, Evalue=3e-23,
Organism=Homo sapiens, GI20127408, Length=312, Percent_Identity=29.8076923076923, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI261878539, Length=259, Percent_Identity=27.027027027027, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI68989263, Length=259, Percent_Identity=27.027027027027, Blast_Score=83, Evalue=1e-15,
Organism=Escherichia coli, GI1790281, Length=309, Percent_Identity=30.42071197411, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1787661, Length=330, Percent_Identity=27.8787878787879, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17553560, Length=302, Percent_Identity=29.1390728476821, Blast_Score=119, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17549919, Length=306, Percent_Identity=29.7385620915033, Blast_Score=117, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17563036, Length=304, Percent_Identity=29.2763157894737, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17558304, Length=304, Percent_Identity=30.9210526315789, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17508953, Length=339, Percent_Identity=30.0884955752212, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17508951, Length=341, Percent_Identity=31.6715542521994, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI25144276, Length=307, Percent_Identity=31.9218241042345, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71985923, Length=259, Percent_Identity=27.7992277992278, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71985930, Length=309, Percent_Identity=22.6537216828479, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24583077, Length=313, Percent_Identity=28.1150159744409, Blast_Score=89, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583079, Length=313, Percent_Identity=28.1150159744409, Blast_Score=89, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19921000, Length=313, Percent_Identity=28.1150159744409, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 86935; Mature: 86804

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYAIRKAAVLGAGVMGAQIAAHLANVGIPTLLLDIVPRELTPDEAKKGLTLESPAVRNR
CCCHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHH
LAASALQNLQKLKPSPLYSKDVLRLITPGNLEDDLAKVAECDWVVEAVIENLQIKKDLWQ
HHHHHHHHHHHCCCCCCCCHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVAAHHRPGMICSSNTSGISIQAMVEGTPESFRRHFLGTHFFNPPRYMKLLEIIPTPDTD
HHHHHCCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCC
PEVVAFMADFGERVLGKGVVMAKDTPNFIGNRIGVYGMMVTLEEMNRLGLTPDEVDALTG
HHHHHHHHHHHHHHHCCCEEEECCCCHHHHCCHHHHHHHEEHHHHHHCCCCHHHHHHHHC
KAIGRPKSATFRTLDVVGIDTFCHVADNCRATIPDPEEAKIFVVPEPIREMVKRGWVGQK
HHCCCCCCCCEEEEEEEEHHHHHHHHCCCCCCCCCCCCCEEEEECHHHHHHHHCCCCCCH
ARQGFFKKEGDQILTLDLETMEYRPRRKASFPSLEAAKANPDLRSRVRGLVFAKDKAGEF
HHCCHHHCCCCEEEEEEEHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCEEEEEECCCCCH
LWAITKRTLLYAARKVGEIADDVVAIDNAMKWGYNWELGPFEMWDAIGLPESIARMEAEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHCCC
EAVPDWVKEAARKGGFYRREAGKSFFINKGEYAPVPVSDRVIDIGALRETGRVVREKKGA
CCCHHHHHHHHHCCCCEEHHCCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCC
TLLDMGDGVLLMETHSPKAAIGFDIINMCKVAAEELASGRWKGLVIGARTENFCVGANVA
EEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCEE
IMLMEAQEEEWDELEFMAREFQNAFMALKLAPKPVVVAPYGMTLGGGYELCAVADRVVAA
EEEEECCCCHHHHHHHHHHHHHHHHEEEEECCCCEEEECCCEEECCCCHHHHHHHHHHHH
AESYIGLVEVGVGVIPGAGGNKEMLIRGLEGLPAGAQVDIQPILNRIFETIATAKVATSA
HHHHHHHHHHCCEEECCCCCCHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
REAQEMGYLRKSDVIVVNKDHQLYEAKRVVLALEAAGYRPPEPALIPAAGPEGRAVLELG
HHHHHHCCEECCCEEEECCCCHHHHHHHHEEEEECCCCCCCCCCEEECCCCCCCEEEEEC
AYGMFMGGWATEHELFIARKLAYVLTGGNVPAGTLVTEQYLLDLEREAFLSLLGTKKTQE
CCHHEECCCCCCHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
RMAHLLKTGKPLRN
HHHHHHHCCCCCCC
>Mature Secondary Structure 
PYAIRKAAVLGAGVMGAQIAAHLANVGIPTLLLDIVPRELTPDEAKKGLTLESPAVRNR
CCHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHH
LAASALQNLQKLKPSPLYSKDVLRLITPGNLEDDLAKVAECDWVVEAVIENLQIKKDLWQ
HHHHHHHHHHHCCCCCCCCHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVAAHHRPGMICSSNTSGISIQAMVEGTPESFRRHFLGTHFFNPPRYMKLLEIIPTPDTD
HHHHHCCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCC
PEVVAFMADFGERVLGKGVVMAKDTPNFIGNRIGVYGMMVTLEEMNRLGLTPDEVDALTG
HHHHHHHHHHHHHHHCCCEEEECCCCHHHHCCHHHHHHHEEHHHHHHCCCCHHHHHHHHC
KAIGRPKSATFRTLDVVGIDTFCHVADNCRATIPDPEEAKIFVVPEPIREMVKRGWVGQK
HHCCCCCCCCEEEEEEEEHHHHHHHHCCCCCCCCCCCCCEEEEECHHHHHHHHCCCCCCH
ARQGFFKKEGDQILTLDLETMEYRPRRKASFPSLEAAKANPDLRSRVRGLVFAKDKAGEF
HHCCHHHCCCCEEEEEEEHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCEEEEEECCCCCH
LWAITKRTLLYAARKVGEIADDVVAIDNAMKWGYNWELGPFEMWDAIGLPESIARMEAEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHCCC
EAVPDWVKEAARKGGFYRREAGKSFFINKGEYAPVPVSDRVIDIGALRETGRVVREKKGA
CCCHHHHHHHHHCCCCEEHHCCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCC
TLLDMGDGVLLMETHSPKAAIGFDIINMCKVAAEELASGRWKGLVIGARTENFCVGANVA
EEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCEE
IMLMEAQEEEWDELEFMAREFQNAFMALKLAPKPVVVAPYGMTLGGGYELCAVADRVVAA
EEEEECCCCHHHHHHHHHHHHHHHHEEEEECCCCEEEECCCEEECCCCHHHHHHHHHHHH
AESYIGLVEVGVGVIPGAGGNKEMLIRGLEGLPAGAQVDIQPILNRIFETIATAKVATSA
HHHHHHHHHHCCEEECCCCCCHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
REAQEMGYLRKSDVIVVNKDHQLYEAKRVVLALEAAGYRPPEPALIPAAGPEGRAVLELG
HHHHHHCCEECCCEEEECCCCHHHHHHHHEEEEECCCCCCCCCCEEECCCCCCCEEEEEC
AYGMFMGGWATEHELFIARKLAYVLTGGNVPAGTLVTEQYLLDLEREAFLSLLGTKKTQE
CCHHEECCCCCCHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
RMAHLLKTGKPLRN
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]