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The map label for this gene is mmgB [H]

Identifier: 51894048

GI number: 51894048

Start: 3139102

End: 3139983

Strand: Reverse

Name: mmgB [H]

Synonym: STH2912

Alternate gene names: 51894048

Gene position: 3139983-3139102 (Counterclockwise)

Preceding gene: 51894049

Following gene: 51894046

Centisome position: 88.05

GC content: 66.1

Gene sequence:

>882_bases
ATGATCAAGCGGGTCATGGTGGTGGGCGCGGGCCAGATGGGTTCGGGCATCGCGCAGGTGGCGGCACAGGCCGGGCTGCA
GGTCTGGCTGCGGGACCTCGAGCCGCGCTTTGTCGAGCGGGGCCTTGGGGTGATCGAGAAGAACCTGGCGCGCGACGTGG
CCAAGGGCCGTCGCACCGAGGAGGAGAAGGCCGCGATTCTGGGGCGCATCACGGGCACGACCGAACTCGGGCCGGCCGCC
GAATGCGACCTGGTCATCGAGGCGATCGTGGAGAGCCTGGAGGCCAAGCTTGCGCTCTTCAGGGAGCTGGATTCCATCTG
TCCGGAGGTGACCCTCTTCGCCTCCAACACCTCCAGCCTGCCCATCACCCAGCTGGCGGCGGTGACCCGCCGGCCGGATC
GGTTCATCGGCATGCACTTCATGAACCCGGTGCCGGTCATGAAGCTGGTGGAGGTCATCCGGGGCATCGCGACGTCGGAC
GAGACGTACGCGGCGATCCGGAACCTGGCCGAGGCGATGGGCAAGACCCCGGTCGAGGTCAACGACTTCCCCGGCTTCGT
CTCGAACCGGGTCCTCATGCCCATGCTGAACGAGGCGATGTTCTGCGTGTACGAGGGCATCGCCGGGGTCGAAGAGGTTG
ACACGGTGATGAAGTTGGGCATGAACCATCCGATGGGCCCGCTGACGCTGGCGGACTTCATCGGGCTGGACACCTGCCTG
GCGATCCTGAACGTGCTCTACGAGGGGTTCAAGGATCCCAAGTACCGCCCCTGCCCGCTGCTGGTGCAGATGGTGCAGGC
GGGCTACTTGGGCCGCAAGAGCGGGCGCGGCTTCTACATCTACGACGAGAACGGCGCCACGCCCATGAAGTTCAAGCGGT
GA

Upstream 100 bases:

>100_bases
CGGGCGGGTGCGCCGGACGCGCAGCGAACAGGGCCGCCCCCGGCGGGGAGCGGCCGATGGACGAGCCTGACGGAAGAAGC
TGTGGCAGGAGGGAACGCCG

Downstream 100 bases:

>100_bases
TGGAAACGGGGCCGCTCCGCCGCGGTGAATGCGGCGAGAGCGGCCCTGTTCTGCCCGGCCGCCCGTGCCGCGTTCGCCGC
GGCGGGGGCGGCTCGCATTC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MIKRVMVVGAGQMGSGIAQVAAQAGLQVWLRDLEPRFVERGLGVIEKNLARDVAKGRRTEEEKAAILGRITGTTELGPAA
ECDLVIEAIVESLEAKLALFRELDSICPEVTLFASNTSSLPITQLAAVTRRPDRFIGMHFMNPVPVMKLVEVIRGIATSD
ETYAAIRNLAEAMGKTPVEVNDFPGFVSNRVLMPMLNEAMFCVYEGIAGVEEVDTVMKLGMNHPMGPLTLADFIGLDTCL
AILNVLYEGFKDPKYRPCPLLVQMVQAGYLGRKSGRGFYIYDENGATPMKFKR

Sequences:

>Translated_293_residues
MIKRVMVVGAGQMGSGIAQVAAQAGLQVWLRDLEPRFVERGLGVIEKNLARDVAKGRRTEEEKAAILGRITGTTELGPAA
ECDLVIEAIVESLEAKLALFRELDSICPEVTLFASNTSSLPITQLAAVTRRPDRFIGMHFMNPVPVMKLVEVIRGIATSD
ETYAAIRNLAEAMGKTPVEVNDFPGFVSNRVLMPMLNEAMFCVYEGIAGVEEVDTVMKLGMNHPMGPLTLADFIGLDTCL
AILNVLYEGFKDPKYRPCPLLVQMVQAGYLGRKSGRGFYIYDENGATPMKFKR
>Mature_293_residues
MIKRVMVVGAGQMGSGIAQVAAQAGLQVWLRDLEPRFVERGLGVIEKNLARDVAKGRRTEEEKAAILGRITGTTELGPAA
ECDLVIEAIVESLEAKLALFRELDSICPEVTLFASNTSSLPITQLAAVTRRPDRFIGMHFMNPVPVMKLVEVIRGIATSD
ETYAAIRNLAEAMGKTPVEVNDFPGFVSNRVLMPMLNEAMFCVYEGIAGVEEVDTVMKLGMNHPMGPLTLADFIGLDTCL
AILNVLYEGFKDPKYRPCPLLVQMVQAGYLGRKSGRGFYIYDENGATPMKFKR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=44.9826989619377, Blast_Score=235, Evalue=3e-62,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=42.9967426710098, Blast_Score=226, Evalue=1e-59,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=37.8091872791519, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI261878539, Length=295, Percent_Identity=33.2203389830508, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI68989263, Length=295, Percent_Identity=33.2203389830508, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI115430219, Length=233, Percent_Identity=32.1888412017167, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1787661, Length=281, Percent_Identity=40.5693950177936, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1788682, Length=272, Percent_Identity=37.8676470588235, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1790281, Length=269, Percent_Identity=36.4312267657993, Blast_Score=160, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17553560, Length=286, Percent_Identity=40.2097902097902, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=40.9722222222222, Blast_Score=216, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=40.2777777777778, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI25144276, Length=284, Percent_Identity=37.3239436619718, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17508951, Length=284, Percent_Identity=37.3239436619718, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17508953, Length=284, Percent_Identity=37.3239436619718, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17558304, Length=284, Percent_Identity=35.2112676056338, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71985923, Length=283, Percent_Identity=31.8021201413428, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71985930, Length=282, Percent_Identity=29.7872340425532, Blast_Score=147, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI193203623, Length=193, Percent_Identity=26.4248704663212, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533614, Length=193, Percent_Identity=26.4248704663212, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583077, Length=283, Percent_Identity=36.0424028268551, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24583079, Length=283, Percent_Identity=36.0424028268551, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI19921000, Length=283, Percent_Identity=36.0424028268551, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=29.5833333333333, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI20129993, Length=224, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 32103; Mature: 32103

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKRVMVVGAGQMGSGIAQVAAQAGLQVWLRDLEPRFVERGLGVIEKNLARDVAKGRRTE
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCH
EEKAAILGRITGTTELGPAAECDLVIEAIVESLEAKLALFRELDSICPEVTLFASNTSSL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
PITQLAAVTRRPDRFIGMHFMNPVPVMKLVEVIRGIATSDETYAAIRNLAEAMGKTPVEV
CHHHHHHHHCCCCHHCCHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
NDFPGFVSNRVLMPMLNEAMFCVYEGIAGVEEVDTVMKLGMNHPMGPLTLADFIGLDTCL
CCCCCHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
AILNVLYEGFKDPKYRPCPLLVQMVQAGYLGRKSGRGFYIYDENGATPMKFKR
HHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MIKRVMVVGAGQMGSGIAQVAAQAGLQVWLRDLEPRFVERGLGVIEKNLARDVAKGRRTE
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCH
EEKAAILGRITGTTELGPAAECDLVIEAIVESLEAKLALFRELDSICPEVTLFASNTSSL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
PITQLAAVTRRPDRFIGMHFMNPVPVMKLVEVIRGIATSDETYAAIRNLAEAMGKTPVEV
CHHHHHHHHCCCCHHCCHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
NDFPGFVSNRVLMPMLNEAMFCVYEGIAGVEEVDTVMKLGMNHPMGPLTLADFIGLDTCL
CCCCCHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
AILNVLYEGFKDPKYRPCPLLVQMVQAGYLGRKSGRGFYIYDENGATPMKFKR
HHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]