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The map label for this gene is mmgA [H]

Identifier: 51894049

GI number: 51894049

Start: 3140089

End: 3141276

Strand: Reverse

Name: mmgA [H]

Synonym: STH2913

Alternate gene names: 51894049

Gene position: 3141276-3140089 (Counterclockwise)

Preceding gene: 51894050

Following gene: 51894048

Centisome position: 88.09

GC content: 72.31

Gene sequence:

>1188_bases
ATGGGCCGGGAAGCCGTCATCGTCAGCGCAGCGCGCACCCCGTTCGGCGCCTTCCAGGGGGCGCTGAAGGATCTGTCCGC
GACCGACCTGGGCGCAGTGGCCATTCGCGAGGCGCTGCGCCGGGTGGAACTCCTGGAGCGGCCGGAGGAGATCGACCAGG
TGCTGATGGGCCAGGTGGTGCAGGCGGGCGCGGGCCAGATCCCCGCGCGACAGGCCGCACACAAGGCCGGGCTGCCGTTC
GGGGTCGTGTCGGCGACCGTCAACAAGGTCTGCGCGTCCAGCCTCTGGGCGGTGAACCTTGCCGACACCCTGATCCGGGC
CGGCGATGCCGACGTGGTGGTGGCCGGCGGCATGGAGTCGATGAGCAACGCGCCCTACCTGCTTCAGGGGGCTCGCCGGG
GATACCGGATGGGCCACGGGCAGCTGATCGACGGCGTAATTCACGACGGCCTGTGGTGCGCTTTCGGCGACGTGCACATG
GGCACCTACGGAGGGCGCGGGGCGCGGGAGTACGGCGTCGCCCGGGAGGAGCTGGACGCCTGGGCCTACCGCAGCCATGT
GCGGGCTGCCGCCGCCTGGGACCGGGGCTTCTTCGCGGAGGAGGTGACCCGGGTGGTGGTACCGCAGAAGAAGGGCGAGA
CCGTCGTGCTGGAGGATGAGCCGATCCGGCGGGACACCTCGCCGGAGAAGCTGGCGGCGTTGCGGCCCGCGTTCGAGCCG
GACGGCCCCATCACCGCCGGCAACGCTCCGGGCCTCTCCGACGGCGCCTCAGCCCTGGTGATCATGTCCCGGGAGAAGGC
AACGGCGCTCGGGCTGGAGGTCCTGGCGACCATCGTCGCGCAGGGGCAGTACTCCGACGAGCCTCACCTGCTGCACGAGG
TGCCCGCCCGGGCGGGGCAGGCGGCCCTGCGCCGCGCCGGCCTCACGGCCAAGGACCTGCACCTGGTCGAGATCAACGAG
GCGTTCGCCTCGGTGACCCTCATCTCAACCCGGTTGCTGGGCGTCGACCCGGAGATCGTCAACGTCAACGGCGGGGCCAT
CGCCCTGGGCCACCCGATCGGGGCCAGTGGCGGCCGCATCCTCATGCACCTGGTGTACGAGCTGCGCCGGAGGGGCGGCG
GCTTCGGCCTGGCGGCCATCTGCTCCGGCGGCGGCCAGGGCGAGGCGACGCTGGTGCGCGTGGACTAG

Upstream 100 bases:

>100_bases
AGGGGCTTTGCTGTTTGCGCGTCCGCTTTCGGGAGGCATCTGCTATAATGGTGAGCGTGAGAAGAATTTCACCATTGCCA
ATCGCAAGGGAGGAGCGCAC

Downstream 100 bases:

>100_bases
CGACACGGGCGGGTGCGCCGGACGCGCAGCGAACAGGGCCGCCCCCGGCGGGGAGCGGCCGATGGACGAGCCTGACGGAA
GAAGCTGTGGCAGGAGGGAA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MGREAVIVSAARTPFGAFQGALKDLSATDLGAVAIREALRRVELLERPEEIDQVLMGQVVQAGAGQIPARQAAHKAGLPF
GVVSATVNKVCASSLWAVNLADTLIRAGDADVVVAGGMESMSNAPYLLQGARRGYRMGHGQLIDGVIHDGLWCAFGDVHM
GTYGGRGAREYGVAREELDAWAYRSHVRAAAAWDRGFFAEEVTRVVVPQKKGETVVLEDEPIRRDTSPEKLAALRPAFEP
DGPITAGNAPGLSDGASALVIMSREKATALGLEVLATIVAQGQYSDEPHLLHEVPARAGQAALRRAGLTAKDLHLVEINE
AFASVTLISTRLLGVDPEIVNVNGGAIALGHPIGASGGRILMHLVYELRRRGGGFGLAAICSGGGQGEATLVRVD

Sequences:

>Translated_395_residues
MGREAVIVSAARTPFGAFQGALKDLSATDLGAVAIREALRRVELLERPEEIDQVLMGQVVQAGAGQIPARQAAHKAGLPF
GVVSATVNKVCASSLWAVNLADTLIRAGDADVVVAGGMESMSNAPYLLQGARRGYRMGHGQLIDGVIHDGLWCAFGDVHM
GTYGGRGAREYGVAREELDAWAYRSHVRAAAAWDRGFFAEEVTRVVVPQKKGETVVLEDEPIRRDTSPEKLAALRPAFEP
DGPITAGNAPGLSDGASALVIMSREKATALGLEVLATIVAQGQYSDEPHLLHEVPARAGQAALRRAGLTAKDLHLVEINE
AFASVTLISTRLLGVDPEIVNVNGGAIALGHPIGASGGRILMHLVYELRRRGGGFGLAAICSGGGQGEATLVRVD
>Mature_394_residues
GREAVIVSAARTPFGAFQGALKDLSATDLGAVAIREALRRVELLERPEEIDQVLMGQVVQAGAGQIPARQAAHKAGLPFG
VVSATVNKVCASSLWAVNLADTLIRAGDADVVVAGGMESMSNAPYLLQGARRGYRMGHGQLIDGVIHDGLWCAFGDVHMG
TYGGRGAREYGVAREELDAWAYRSHVRAAAAWDRGFFAEEVTRVVVPQKKGETVVLEDEPIRRDTSPEKLAALRPAFEPD
GPITAGNAPGLSDGASALVIMSREKATALGLEVLATIVAQGQYSDEPHLLHEVPARAGQAALRRAGLTAKDLHLVEINEA
FASVTLISTRLLGVDPEIVNVNGGAIALGHPIGASGGRILMHLVYELRRRGGGFGLAAICSGGGQGEATLVRVD

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=43.1472081218274, Blast_Score=299, Evalue=4e-81,
Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=43.0769230769231, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=40.6565656565657, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=37.2151898734177, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4504327, Length=427, Percent_Identity=34.4262295081967, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=27.6214833759591, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI87082165, Length=394, Percent_Identity=46.7005076142132, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=48.9795918367347, Blast_Score=320, Evalue=8e-89,
Organism=Escherichia coli, GI1787663, Length=399, Percent_Identity=41.1027568922306, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=39.2947103274559, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI1788683, Length=413, Percent_Identity=35.8353510895884, Blast_Score=187, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25147385, Length=391, Percent_Identity=42.9667519181586, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=38.7755102040816, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=38.9312977099237, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17535917, Length=387, Percent_Identity=34.1085271317829, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=427, Percent_Identity=33.2552693208431, Blast_Score=177, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=40.5, Blast_Score=287, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6322031, Length=394, Percent_Identity=31.2182741116751, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24655093, Length=389, Percent_Identity=45.5012853470437, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=44.5012787723785, Blast_Score=298, Evalue=4e-81,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=34.4473007712082, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=34.1121495327103, Blast_Score=174, Evalue=7e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41494; Mature: 41363

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGREAVIVSAARTPFGAFQGALKDLSATDLGAVAIREALRRVELLERPEEIDQVLMGQVV
CCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
QAGAGQIPARQAAHKAGLPFGVVSATVNKVCASSLWAVNLADTLIRAGDADVVVAGGMES
HCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHH
MSNAPYLLQGARRGYRMGHGQLIDGVIHDGLWCAFGDVHMGTYGGRGAREYGVAREELDA
HCCCCHHHHHHHCCCCCCCCHHHHHHHHCCEEEEECCEEECCCCCCCHHHHCCHHHHHHH
WAYRSHVRAAAAWDRGFFAEEVTRVVVPQKKGETVVLEDEPIRRDTSPEKLAALRPAFEP
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHCCCCCC
DGPITAGNAPGLSDGASALVIMSREKATALGLEVLATIVAQGQYSDEPHLLHEVPARAGQ
CCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
AALRRAGLTAKDLHLVEINEAFASVTLISTRLLGVDPEIVNVNGGAIALGHPIGASGGRI
HHHHHCCCCHHCEEEEEEHHHHHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCCCCHHH
LMHLVYELRRRGGGFGLAAICSGGGQGEATLVRVD
HHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEC
>Mature Secondary Structure 
GREAVIVSAARTPFGAFQGALKDLSATDLGAVAIREALRRVELLERPEEIDQVLMGQVV
CCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
QAGAGQIPARQAAHKAGLPFGVVSATVNKVCASSLWAVNLADTLIRAGDADVVVAGGMES
HCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHH
MSNAPYLLQGARRGYRMGHGQLIDGVIHDGLWCAFGDVHMGTYGGRGAREYGVAREELDA
HCCCCHHHHHHHCCCCCCCCHHHHHHHHCCEEEEECCEEECCCCCCCHHHHCCHHHHHHH
WAYRSHVRAAAAWDRGFFAEEVTRVVVPQKKGETVVLEDEPIRRDTSPEKLAALRPAFEP
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHCCCCCC
DGPITAGNAPGLSDGASALVIMSREKATALGLEVLATIVAQGQYSDEPHLLHEVPARAGQ
CCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
AALRRAGLTAKDLHLVEINEAFASVTLISTRLLGVDPEIVNVNGGAIALGHPIGASGGRI
HHHHHCCCCHHCEEEEEEHHHHHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCCCCHHH
LMHLVYELRRRGGGFGLAAICSGGGQGEATLVRVD
HHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]