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The map label for this gene is moeA [C]

Identifier: 51894042

GI number: 51894042

Start: 3131198

End: 3132430

Strand: Reverse

Name: moeA [C]

Synonym: STH2906

Alternate gene names: 51894042

Gene position: 3132430-3131198 (Counterclockwise)

Preceding gene: 51894044

Following gene: 51894041

Centisome position: 87.84

GC content: 72.02

Gene sequence:

>1233_bases
ATGGACTTTTTCACGCTGAAATCTGTCGAGGAGGCCCGGGTCGAGTTCCTCGGCGCCGTCACCCGCCGGATGCCCGCGGA
GCGGGTCGCAAGGGAGGAAGCCCTGGGGCGTATCACCGCCGCCCCCGTGCCCGCTCCCGAGGATCTGCCCCCCTTTCCCC
GCAGCTCAGTGGACGGCTATGCCGTTCTGTCGGCCGACACCTTCGGCGCGTCTGAAGGGCTGCCGGCGTACCTCACCGTT
ACCGCGGAGATCCCCATGGGACAGGTTTCCGCGGTGCCGCTTCACCCTGGCGAGGCGCAGAAGATCGCCACCGGCGGCGC
CCTGCCCGAGGGGGCTGATGCCGTCGTCATGGTGGAGCACACCGAGCAGTCGGCGCCGGATGAGATCGCCGTGCTGCGCC
CCGTGTCGCCGGGCGAGAACGTCATGCAGCGGGGCGAGGACTGCCGGGCCGGCGAGCCGCTGCTCCCGGCCGGACGGATG
ATCCGGGCTCAGGAGGCGGCCCTGCTCGCCCACGCCGGCGTGCGTGAGGTCGACGTGGTGCGGCGGCCGCGGGTGGCCAT
CATCTCCACGGGGGACGAGCTGGTACCCCCGGAGGAGGCGCCGGGGCCCGGGCAGATCCGCGAGTCCAACGGCCAGGCCA
TGCGGGCCCTGGTGCTGCGGGACGGCGGTGAGCCGCACTACCTCGGCCTCGCCCGGGACGACGAGCAGGAGATCCTGTCC
CTGCTCCGTCAAGGCCTGGCCTACGACCTGGTCCTGATCTCCGGCGGCTCCAGCGTGGGCGCCCGCGACCTCACGTCCCG
GCTGATCGACCAGTTGGGCAGCCCCGGGGTGCTGGTGCACGGCGTCCAGCTGAAGCCTGGCAAGCCGACGATCCTGGCGG
TGTGCGACGGGGTTCCGGTGGTCGGACTGCCAGGCCACCCCGTCTCGGCGCAGGTGGTCTACGGCCTGTTCGTCGCCCCG
TTGCTCCGGCAGATGCAGGGGCTGCCGCCGGAGCCGGAGTTCCGGCCCACGGTGCGGGCGAGGCTCACCAAGAACGTCGC
TTCGGCTGCCGGGCGCACCGACGTCGTGCGGGTGCGGCTGTTCCGGAAAGACGGCGAGGTCTGGGCGGAACCGGTGCACG
GCAAGTCCGGCCTGATCTCGACTCTCGTGCGGGCGGACGGGTTCCTCATCATCCCCTCGGCCCGCGAGGGACTGCTGGCC
GGCGACACGGTGGAGGTGGAGGTCCTGGCATGA

Upstream 100 bases:

>100_bases
AAAGGGGCGGAACTGCGGGAGATGCCCGCGTCGTTCTGCTATCTTCCGTTCGGGAGATAGCTTTTTTGCTCCAGGCAGTA
TCGGCGAAGCAGGTGAGGAC

Downstream 100 bases:

>100_bases
GCACGCGCAAGATCTACCTGGAATCGCTGCCCCGCGACGAGGCGCTGAGCCGGTTGCTCCGTGCGCTCGACCAGGCCGGG
TGGGGACCGCAGCGGGAGGT

Product: molybdenum cofactor biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MDFFTLKSVEEARVEFLGAVTRRMPAERVAREEALGRITAAPVPAPEDLPPFPRSSVDGYAVLSADTFGASEGLPAYLTV
TAEIPMGQVSAVPLHPGEAQKIATGGALPEGADAVVMVEHTEQSAPDEIAVLRPVSPGENVMQRGEDCRAGEPLLPAGRM
IRAQEAALLAHAGVREVDVVRRPRVAIISTGDELVPPEEAPGPGQIRESNGQAMRALVLRDGGEPHYLGLARDDEQEILS
LLRQGLAYDLVLISGGSSVGARDLTSRLIDQLGSPGVLVHGVQLKPGKPTILAVCDGVPVVGLPGHPVSAQVVYGLFVAP
LLRQMQGLPPEPEFRPTVRARLTKNVASAAGRTDVVRVRLFRKDGEVWAEPVHGKSGLISTLVRADGFLIIPSAREGLLA
GDTVEVEVLA

Sequences:

>Translated_410_residues
MDFFTLKSVEEARVEFLGAVTRRMPAERVAREEALGRITAAPVPAPEDLPPFPRSSVDGYAVLSADTFGASEGLPAYLTV
TAEIPMGQVSAVPLHPGEAQKIATGGALPEGADAVVMVEHTEQSAPDEIAVLRPVSPGENVMQRGEDCRAGEPLLPAGRM
IRAQEAALLAHAGVREVDVVRRPRVAIISTGDELVPPEEAPGPGQIRESNGQAMRALVLRDGGEPHYLGLARDDEQEILS
LLRQGLAYDLVLISGGSSVGARDLTSRLIDQLGSPGVLVHGVQLKPGKPTILAVCDGVPVVGLPGHPVSAQVVYGLFVAP
LLRQMQGLPPEPEFRPTVRARLTKNVASAAGRTDVVRVRLFRKDGEVWAEPVHGKSGLISTLVRADGFLIIPSAREGLLA
GDTVEVEVLA
>Mature_410_residues
MDFFTLKSVEEARVEFLGAVTRRMPAERVAREEALGRITAAPVPAPEDLPPFPRSSVDGYAVLSADTFGASEGLPAYLTV
TAEIPMGQVSAVPLHPGEAQKIATGGALPEGADAVVMVEHTEQSAPDEIAVLRPVSPGENVMQRGEDCRAGEPLLPAGRM
IRAQEAALLAHAGVREVDVVRRPRVAIISTGDELVPPEEAPGPGQIRESNGQAMRALVLRDGGEPHYLGLARDDEQEILS
LLRQGLAYDLVLISGGSSVGARDLTSRLIDQLGSPGVLVHGVQLKPGKPTILAVCDGVPVVGLPGHPVSAQVVYGLFVAP
LLRQMQGLPPEPEFRPTVRARLTKNVASAAGRTDVVRVRLFRKDGEVWAEPVHGKSGLISTLVRADGFLIIPSAREGLLA
GDTVEVEVLA

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=428, Percent_Identity=34.3457943925234, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI10880983, Length=428, Percent_Identity=34.3457943925234, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1787049, Length=404, Percent_Identity=34.6534653465347, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI25147659, Length=350, Percent_Identity=33.1428571428571, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=395, Percent_Identity=26.3291139240506, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17136978, Length=361, Percent_Identity=31.5789473684211, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24638841, Length=361, Percent_Identity=31.5789473684211, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43326; Mature: 43326

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFFTLKSVEEARVEFLGAVTRRMPAERVAREEALGRITAAPVPAPEDLPPFPRSSVDGY
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCE
AVLSADTFGASEGLPAYLTVTAEIPMGQVSAVPLHPGEAQKIATGGALPEGADAVVMVEH
EEEEECCCCCCCCCCEEEEEEEECCCCCEEEECCCCCCCCEEECCCCCCCCCCEEEEEEC
TEQSAPDEIAVLRPVSPGENVMQRGEDCRAGEPLLPAGRMIRAQEAALLAHAGVREVDVV
CCCCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHH
RRPRVAIISTGDELVPPEEAPGPGQIRESNGQAMRALVLRDGGEPHYLGLARDDEQEILS
CCCCEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEEEECCCCCEEEECCCCCHHHHHH
LLRQGLAYDLVLISGGSSVGARDLTSRLIDQLGSPGVLVHGVQLKPGKPTILAVCDGVPV
HHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCCE
VGLPGHPVSAQVVYGLFVAPLLRQMQGLPPEPEFRPTVRARLTKNVASAAGRTDVVRVRL
ECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEE
FRKDGEVWAEPVHGKSGLISTLVRADGFLIIPSAREGLLAGDTVEVEVLA
EECCCCEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCEECCEEEEEEEC
>Mature Secondary Structure
MDFFTLKSVEEARVEFLGAVTRRMPAERVAREEALGRITAAPVPAPEDLPPFPRSSVDGY
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCE
AVLSADTFGASEGLPAYLTVTAEIPMGQVSAVPLHPGEAQKIATGGALPEGADAVVMVEH
EEEEECCCCCCCCCCEEEEEEEECCCCCEEEECCCCCCCCEEECCCCCCCCCCEEEEEEC
TEQSAPDEIAVLRPVSPGENVMQRGEDCRAGEPLLPAGRMIRAQEAALLAHAGVREVDVV
CCCCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHH
RRPRVAIISTGDELVPPEEAPGPGQIRESNGQAMRALVLRDGGEPHYLGLARDDEQEILS
CCCCEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEEEECCCCCEEEECCCCCHHHHHH
LLRQGLAYDLVLISGGSSVGARDLTSRLIDQLGSPGVLVHGVQLKPGKPTILAVCDGVPV
HHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCCE
VGLPGHPVSAQVVYGLFVAPLLRQMQGLPPEPEFRPTVRARLTKNVASAAGRTDVVRVRL
ECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEE
FRKDGEVWAEPVHGKSGLISTLVRADGFLIIPSAREGLLAGDTVEVEVLA
EECCCCEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCEECCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]