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The map label for this gene is trxB [H]

Identifier: 51894008

GI number: 51894008

Start: 3094670

End: 3095902

Strand: Reverse

Name: trxB [H]

Synonym: STH2872

Alternate gene names: 51894008

Gene position: 3095902-3094670 (Counterclockwise)

Preceding gene: 51894009

Following gene: 51894007

Centisome position: 86.81

GC content: 69.34

Gene sequence:

>1233_bases
ATGGCTGAGCGCTGGGATCTCGTGATCATCGGCGGCGGTCCCGCCGGTCTTTCCGCCGCCGTCTACGGGGCCCGGGCACG
GATGTCGACGCTCTTGATTGAAAAGGGACGGCCGGGCGGCCAGGCGGCGACCACCGAGGAGGTGGAGAACTACCCGGGTC
TCGGCCGCACCACCGGACCGGAGTTGATGAAACAGTTCCGGGAGCACGCCGAGGCCCTGGGGGCGACGATCGTCCGCGGC
GAGGTCGGCGCGGTGGAGCTGCAGGGGCCGGTCAAGACGATCCGCACCAAGAAGGGCGAGGTCTACGAGGCCCGCGCGGT
CATCCTCTGCCCCGGCGCCGAGCCCCGCATGCTCGGAGTCAAGGGCGAGGGCCGGCTCCGCGGCAAGGGCGTGTCGTACT
GCGCCACCTGCGACGCCGACTTCTTCACCGATCTGGACGTGGTGGTGGTGGGCAACGGCGACGCCGCCGTGGAGGAAGCC
ATCTACCTCACCCGGTTCGCCAGCAGTGTGACCCTCATCTGCATCCACCCTGAGGGCATCATGGACGCCAACAAGGCCGC
CCAGGAGCGGCTGTTCGCCACGCCCAAGATCAAGGTGATCTGGCAGACCATGGTCGAGGAGATCCTGGGCGAGGACCACG
TGGAGAAGGTGGCGCTCCGTCACCTGGGCACCGGCGAGCGGACGGAGCTTCCCTGCGACGGCGTCTTCGTCTTCGTGGGC
ACGACCCCCCGCACCGAGTTCCTCCGGGGCACCGGGATCGAGCTGGACCGCAAGGGGTACATCATCGCCGACCCCGACAC
GATGGAGACGAACATCCCCGGCGTCTTCGCCGCCGGCGACGCCCGCCGCAAGTGGCTGCGGCAGATCGTGACGGCCGCCG
CCGACGGCGCCATCGCCGCGTGCGCGGCTGAGAAGTTCCTGGCGGAGGAGGAGCAGGTGGACCGGGAAATCCTATCCCCC
GAGGAGCCGGTCCTGGCGGTGTTCTGGAGCCCGGCCGACTCGCTGTCGGTGCACGTGCTGCAGCAGGCGGAGCGCATTGT
GGCCGGGATGGGCGGCCAGATGCGCCTGGCCCGCATCGACTGCTACAAGTCCGCCCGGACGGCGGCCCGCCTCGGCGTGT
TCGACGTGCCGGCGGTGCGCATTTTCCACAAGGGCATTCCCCTGGCCACCCTCACCGAGGACTTCAACCACCTGGAGGAG
TGGGTGGTTGGACACTTGCCGGCCAGGATCTGA

Upstream 100 bases:

>100_bases
GGCCAAACTCTCAGGTGGAGGAGACAGAGGAACGACCAGCTTGCTGGCTCGTTCCTTTTTTTCACATGGGAAAGCAACAC
GCTTTCGGGAGGGGTTTTGC

Downstream 100 bases:

>100_bases
GGAGGTGACCCATGGATGCTGGAGGTCAACAAGGAGAACTTCGAACAGGAGGTGTTGCAGGCGTCCGGCCCGGTGGTGGT
CGACTGGTGGAGCCCCAAGT

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MAERWDLVIIGGGPAGLSAAVYGARARMSTLLIEKGRPGGQAATTEEVENYPGLGRTTGPELMKQFREHAEALGATIVRG
EVGAVELQGPVKTIRTKKGEVYEARAVILCPGAEPRMLGVKGEGRLRGKGVSYCATCDADFFTDLDVVVVGNGDAAVEEA
IYLTRFASSVTLICIHPEGIMDANKAAQERLFATPKIKVIWQTMVEEILGEDHVEKVALRHLGTGERTELPCDGVFVFVG
TTPRTEFLRGTGIELDRKGYIIADPDTMETNIPGVFAAGDARRKWLRQIVTAAADGAIAACAAEKFLAEEEQVDREILSP
EEPVLAVFWSPADSLSVHVLQQAERIVAGMGGQMRLARIDCYKSARTAARLGVFDVPAVRIFHKGIPLATLTEDFNHLEE
WVVGHLPARI

Sequences:

>Translated_410_residues
MAERWDLVIIGGGPAGLSAAVYGARARMSTLLIEKGRPGGQAATTEEVENYPGLGRTTGPELMKQFREHAEALGATIVRG
EVGAVELQGPVKTIRTKKGEVYEARAVILCPGAEPRMLGVKGEGRLRGKGVSYCATCDADFFTDLDVVVVGNGDAAVEEA
IYLTRFASSVTLICIHPEGIMDANKAAQERLFATPKIKVIWQTMVEEILGEDHVEKVALRHLGTGERTELPCDGVFVFVG
TTPRTEFLRGTGIELDRKGYIIADPDTMETNIPGVFAAGDARRKWLRQIVTAAADGAIAACAAEKFLAEEEQVDREILSP
EEPVLAVFWSPADSLSVHVLQQAERIVAGMGGQMRLARIDCYKSARTAARLGVFDVPAVRIFHKGIPLATLTEDFNHLEE
WVVGHLPARI
>Mature_409_residues
AERWDLVIIGGGPAGLSAAVYGARARMSTLLIEKGRPGGQAATTEEVENYPGLGRTTGPELMKQFREHAEALGATIVRGE
VGAVELQGPVKTIRTKKGEVYEARAVILCPGAEPRMLGVKGEGRLRGKGVSYCATCDADFFTDLDVVVVGNGDAAVEEAI
YLTRFASSVTLICIHPEGIMDANKAAQERLFATPKIKVIWQTMVEEILGEDHVEKVALRHLGTGERTELPCDGVFVFVGT
TPRTEFLRGTGIELDRKGYIIADPDTMETNIPGVFAAGDARRKWLRQIVTAAADGAIAACAAEKFLAEEEQVDREILSPE
EPVLAVFWSPADSLSVHVLQQAERIVAGMGGQMRLARIDCYKSARTAARLGVFDVPAVRIFHKGIPLATLTEDFNHLEEW
VVGHLPARI

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=336, Percent_Identity=27.6785714285714, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI226437568, Length=336, Percent_Identity=27.6785714285714, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI65787454, Length=336, Percent_Identity=27.6785714285714, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1787114, Length=311, Percent_Identity=39.871382636656, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI87081763, Length=308, Percent_Identity=34.0909090909091, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320560, Length=317, Percent_Identity=35.0157728706625, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321898, Length=317, Percent_Identity=33.1230283911672, Blast_Score=160, Evalue=3e-40,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 44359; Mature: 44228

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERWDLVIIGGGPAGLSAAVYGARARMSTLLIEKGRPGGQAATTEEVENYPGLGRTTGP
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHCCCCCCCCCCH
ELMKQFREHAEALGATIVRGEVGAVELQGPVKTIRTKKGEVYEARAVILCPGAEPRMLGV
HHHHHHHHHHHHHCCEEEECCCCEEEECCCHHHHHCCCCCEEEEEEEEECCCCCCCEEEE
KGEGRLRGKGVSYCATCDADFFTDLDVVVVGNGDAAVEEAIYLTRFASSVTLICIHPEGI
CCCCCCCCCCCCEEEECCCCHHCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCC
MDANKAAQERLFATPKIKVIWQTMVEEILGEDHVEKVALRHLGTGERTELPCDGVFVFVG
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEE
TTPRTEFLRGTGIELDRKGYIIADPDTMETNIPGVFAAGDARRKWLRQIVTAAADGAIAA
CCCCHHHHCCCCCEECCCCEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCHHHH
CAAEKFLAEEEQVDREILSPEEPVLAVFWSPADSLSVHVLQQAERIVAGMGGQMRLARID
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEH
CYKSARTAARLGVFDVPAVRIFHKGIPLATLTEDFNHLEEWVVGHLPARI
HHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AERWDLVIIGGGPAGLSAAVYGARARMSTLLIEKGRPGGQAATTEEVENYPGLGRTTGP
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHCCCCCCCCCCH
ELMKQFREHAEALGATIVRGEVGAVELQGPVKTIRTKKGEVYEARAVILCPGAEPRMLGV
HHHHHHHHHHHHHCCEEEECCCCEEEECCCHHHHHCCCCCEEEEEEEEECCCCCCCEEEE
KGEGRLRGKGVSYCATCDADFFTDLDVVVVGNGDAAVEEAIYLTRFASSVTLICIHPEGI
CCCCCCCCCCCCEEEECCCCHHCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCC
MDANKAAQERLFATPKIKVIWQTMVEEILGEDHVEKVALRHLGTGERTELPCDGVFVFVG
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEE
TTPRTEFLRGTGIELDRKGYIIADPDTMETNIPGVFAAGDARRKWLRQIVTAAADGAIAA
CCCCHHHHCCCCCEECCCCEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCHHHH
CAAEKFLAEEEQVDREILSPEEPVLAVFWSPADSLSVHVLQQAERIVAGMGGQMRLARID
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEH
CYKSARTAARLGVFDVPAVRIFHKGIPLATLTEDFNHLEEWVVGHLPARI
HHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8223622; 2537814 [H]