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The map label for this gene is trxA [H]

Identifier: 51894007

GI number: 51894007

Start: 3094334

End: 3094654

Strand: Reverse

Name: trxA [H]

Synonym: STH2871

Alternate gene names: 51894007

Gene position: 3094654-3094334 (Counterclockwise)

Preceding gene: 51894008

Following gene: 51894006

Centisome position: 86.78

GC content: 67.29

Gene sequence:

>321_bases
ATGCTGGAGGTCAACAAGGAGAACTTCGAACAGGAGGTGTTGCAGGCGTCCGGCCCGGTGGTGGTCGACTGGTGGAGCCC
CAAGTGCGACCCGTGCATGGAGCTGCTGCCTGAGGTGGAGCGGCTGGCCGAAACGTATGGCGACCGGGTGAAGTTCTGCA
AGGTCAACGTGCTGGAGAACCGGCGGCTGGCGATCAGCCAGCGGGTGCTCGGGCTGCCGACGTTCCTCTTCTTCCGGGAC
GGGGAGAAGGTGGCCGAGCTGGCCGGGCCCGAGGCGTGCACGGCGGAGGCCATCGAGGCCGAGCTGCAGCGGCTGGTGTG
A

Upstream 100 bases:

>100_bases
CAAGGGCATTCCCCTGGCCACCCTCACCGAGGACTTCAACCACCTGGAGGAGTGGGTGGTTGGACACTTGCCGGCCAGGA
TCTGAGGAGGTGACCCATGG

Downstream 100 bases:

>100_bases
GGAGGCGAAGGGCCATGAAGCTGGAACTGGGCCGCATCTACATCCGCGACGTGCGCTTCGGCGAGACCACCCGGGTGGAG
GGCGGCGTCCTCACCGTGAA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 106; Mature: 106

Protein sequence:

>106_residues
MLEVNKENFEQEVLQASGPVVVDWWSPKCDPCMELLPEVERLAETYGDRVKFCKVNVLENRRLAISQRVLGLPTFLFFRD
GEKVAELAGPEACTAEAIEAELQRLV

Sequences:

>Translated_106_residues
MLEVNKENFEQEVLQASGPVVVDWWSPKCDPCMELLPEVERLAETYGDRVKFCKVNVLENRRLAISQRVLGLPTFLFFRD
GEKVAELAGPEACTAEAIEAELQRLV
>Mature_106_residues
MLEVNKENFEQEVLQASGPVVVDWWSPKCDPCMELLPEVERLAETYGDRVKFCKVNVLENRRLAISQRVLGLPTFLFFRD
GEKVAELAGPEACTAEAIEAELQRLV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI87082331, Length=89, Percent_Identity=30.3370786516854, Blast_Score=67, Evalue=3e-13,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=33.695652173913, Blast_Score=60, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639826, Length=78, Percent_Identity=37.1794871794872, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12024; Mature: 12024

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEVNKENFEQEVLQASGPVVVDWWSPKCDPCMELLPEVERLAETYGDRVKFCKVNVLEN
CCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCC
RRLAISQRVLGLPTFLFFRDGEKVAELAGPEACTAEAIEAELQRLV
CHHHHHHHHHCCCHHEEEECCHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLEVNKENFEQEVLQASGPVVVDWWSPKCDPCMELLPEVERLAETYGDRVKFCKVNVLEN
CCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCC
RRLAISQRVLGLPTFLFFRDGEKVAELAGPEACTAEAIEAELQRLV
CHHHHHHHHHCCCHHEEEECCHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11271425; 9534247 [H]